Mutagenetix > Incidental Mutation

Incidental Mutation 'R4421:Vmn2r72'

327100

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

041142-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R4421 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 85738500 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 619 (N619D)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably damaging
Transcript: ENSMUST00000063425
AA Change: N619D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: N619D

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acy1	G	C	9: 106,435,713 (GRCm38)		probably null	Het
Adgrv1	T	C	13: 81,566,302 (GRCm38)	E234G	probably damaging	Het
Aga	T	C	8: 53,511,826 (GRCm38)	S8P	probably benign	Het
C1s2	T	C	6: 124,625,215 (GRCm38)	D673G	probably benign	Het
Capza3	G	A	6: 140,042,042 (GRCm38)	M122I	probably benign	Het
Cfap44	T	C	16: 44,422,437 (GRCm38)	S735P	probably damaging	Het
Cntn3	A	G	6: 102,464,547 (GRCm38)	F13L	probably damaging	Het
Col6a5	A	T	9: 105,928,473 (GRCm38)	M1078K	unknown	Het
Colgalt2	A	T	1: 152,485,012 (GRCm38)	I267F	probably damaging	Het
Cpped1	T	C	16: 11,805,357 (GRCm38)	*299W	probably null	Het
Cyp3a59	A	G	5: 146,104,903 (GRCm38)		probably null	Het
Ddx42	T	A	11: 106,231,138 (GRCm38)	Y160N	probably damaging	Het
Dhx35	A	T	2: 158,806,401 (GRCm38)	R60W	probably damaging	Het
Gbp10	T	C	5: 105,224,651 (GRCm38)		probably null	Het
Gtf2i	T	C	5: 134,255,037 (GRCm38)	T467A	possibly damaging	Het
Hip1r	G	C	5: 123,997,862 (GRCm38)	G542A	possibly damaging	Het
Hspg2	G	A	4: 137,548,122 (GRCm38)	A2748T	probably benign	Het
Kcnq3	T	C	15: 65,995,511 (GRCm38)	Y761C	probably benign	Het
Krt13	T	G	11: 100,118,935 (GRCm38)	T340P	possibly damaging	Het
Map2k5	A	G	9: 63,164,130 (GRCm38)	C435R	probably damaging	Het
Ms4a4c	T	A	19: 11,416,375 (GRCm38)	I53K	probably damaging	Het
Myh15	T	A	16: 49,109,344 (GRCm38)	F544L	probably damaging	Het
Neurod2	G	T	11: 98,328,200 (GRCm38)	S46*	probably null	Het
Nsd3	T	A	8: 25,641,272 (GRCm38)	S218T	probably damaging	Het
Olfr1184	A	T	2: 88,487,241 (GRCm38)	N170Y	probably damaging	Het
Olfr706	G	T	7: 106,886,453 (GRCm38)	D121E	probably damaging	Het
Prrc2c	TTGCTGCTGCTGCTGCTGCTGCTGCTGC	TTGCTGCTGCTGCTGCTGCTGCTGC	1: 162,709,061 (GRCm38)		probably benign	Het
Prrg3	A	T	X: 71,967,309 (GRCm38)	S141C	probably damaging	Het
Ranbp17	A	T	11: 33,475,056 (GRCm38)	D433E	probably benign	Het
Rbm28	T	C	6: 29,154,837 (GRCm38)	D278G	probably damaging	Het
Sbpl	A	G	17: 23,954,886 (GRCm38)	L8P	unknown	Het
Spopl	C	T	2: 23,517,945 (GRCm38)	V241M	probably damaging	Het
Tdrd3	A	G	14: 87,486,283 (GRCm38)	E311G	probably damaging	Het
Tma16	C	T	8: 66,484,171 (GRCm38)		probably null	Het
Ubr4	A	G	4: 139,461,856 (GRCm38)	N3917D	possibly damaging	Het
Vmn2r68	TCC	TC	7: 85,221,550 (GRCm38)		probably null	Het
Xab2	C	A	8: 3,614,244 (GRCm38)		probably null	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85,749,646 (GRCm38)	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85,738,334 (GRCm38)	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85,749,646 (GRCm38)	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85,738,367 (GRCm38)	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85,750,711 (GRCm38)	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85,737,962 (GRCm38)	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85,750,693 (GRCm38)	missense	probably benign
IGL02514:Vmn2r72	APN	7	85,738,699 (GRCm38)	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85,738,183 (GRCm38)	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85,738,671 (GRCm38)	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85,751,813 (GRCm38)	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85,752,041 (GRCm38)	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85,751,176 (GRCm38)	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85,754,954 (GRCm38)	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85,750,867 (GRCm38)	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85,751,836 (GRCm38)	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85,754,876 (GRCm38)	missense	probably benign
R0655:Vmn2r72	UTSW	7	85,738,111 (GRCm38)	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85,749,739 (GRCm38)	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85,751,309 (GRCm38)	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85,749,188 (GRCm38)	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85,738,257 (GRCm38)	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85,749,211 (GRCm38)	missense	probably benign
R1632:Vmn2r72	UTSW	7	85,751,792 (GRCm38)	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85,738,170 (GRCm38)	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85,749,161 (GRCm38)	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85,738,236 (GRCm38)	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85,738,341 (GRCm38)	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85,738,256 (GRCm38)	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85,750,953 (GRCm38)	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85,751,269 (GRCm38)	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85,749,642 (GRCm38)	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85,738,077 (GRCm38)	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85,738,077 (GRCm38)	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85,749,735 (GRCm38)	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85,751,131 (GRCm38)	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85,749,809 (GRCm38)	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85,738,500 (GRCm38)	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85,737,828 (GRCm38)	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85,737,911 (GRCm38)	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85,737,861 (GRCm38)	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85,750,598 (GRCm38)	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85,751,109 (GRCm38)	missense	probably benign
R4991:Vmn2r72	UTSW	7	85,751,130 (GRCm38)	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85,738,485 (GRCm38)	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85,737,853 (GRCm38)	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85,737,840 (GRCm38)	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85,738,254 (GRCm38)	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85,750,897 (GRCm38)	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85,751,942 (GRCm38)	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85,737,850 (GRCm38)	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85,737,929 (GRCm38)	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85,737,929 (GRCm38)	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85,750,539 (GRCm38)	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85,751,174 (GRCm38)	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85,749,684 (GRCm38)	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85,737,996 (GRCm38)	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85,749,803 (GRCm38)	splice site	probably null
R7189:Vmn2r72	UTSW	7	85,754,917 (GRCm38)	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85,738,274 (GRCm38)	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85,750,563 (GRCm38)	missense	probably benign
R7426:Vmn2r72	UTSW	7	85,751,140 (GRCm38)	missense	probably benign
R7606:Vmn2r72	UTSW	7	85,751,154 (GRCm38)	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85,751,938 (GRCm38)	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85,754,890 (GRCm38)	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85,750,626 (GRCm38)	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85,749,630 (GRCm38)	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85,751,233 (GRCm38)	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85,751,019 (GRCm38)	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85,751,960 (GRCm38)	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85,738,175 (GRCm38)	missense	probably benign
R8989:Vmn2r72	UTSW	7	85,754,926 (GRCm38)	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85,749,180 (GRCm38)	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85,738,256 (GRCm38)	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85,751,203 (GRCm38)	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85,754,814 (GRCm38)	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85,754,867 (GRCm38)	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85,749,191 (GRCm38)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- AAGCAGCCACCTCATTCTTC -3'
(R):5'- TGAAGTGTCGAGAAGATCAATATGC -3'

Sequencing Primer
(F):5'- GAATGCTAGTAGAACAGTAATCGTC -3'
(R):5'- TGCAAATGAAGACCATACTCTCTTC -3'

Posted On

2015-07-07