Incidental Mutation 'R4356:Or10al3'
ID 327573
Institutional Source Beutler Lab
Gene Symbol Or10al3
Ensembl Gene ENSMUSG00000059964
Gene Name olfactory receptor family 10 subfamily AL member 3
Synonyms GA_x6K02T2PSCP-2159633-2160598, MOR263-7, Olfr119
MMRRC Submission 041669-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R4356 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 38007576-38012611 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 38011790 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 76 (E76D)
Ref Sequence ENSEMBL: ENSMUSP00000150099 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080483] [ENSMUST00000213732]
AlphaFold Q7TRJ5
Predicted Effect probably damaging
Transcript: ENSMUST00000080483
AA Change: E76D

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000092919
Gene: ENSMUSG00000059964
AA Change: E76D

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 5.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 41 311 1.7e-5 PFAM
Pfam:7tm_1 47 296 3.1e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213732
AA Change: E76D

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
Meta Mutation Damage Score 0.4385 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 T A 3: 59,843,701 (GRCm39) Y132N probably damaging Het
Adam21 T C 12: 81,605,594 (GRCm39) T723A probably damaging Het
Alox5 C T 6: 116,397,219 (GRCm39) V322I probably benign Het
Alpk1 C T 3: 127,523,022 (GRCm39) V7M probably damaging Het
Ankhd1 A T 18: 36,776,096 (GRCm39) K1482* probably null Het
Cacna1e A C 1: 154,319,727 (GRCm39) D1324E probably damaging Het
Ccdc150 A G 1: 54,392,213 (GRCm39) D657G probably damaging Het
Celsr1 A G 15: 85,863,028 (GRCm39) S1335P probably damaging Het
Cfhr4 T A 1: 139,660,048 (GRCm39) K621N probably damaging Het
Cspg5 A G 9: 110,085,245 (GRCm39) D391G probably damaging Het
Defa30 A T 8: 21,624,821 (GRCm39) D48V possibly damaging Het
E2f7 T C 10: 110,595,712 (GRCm39) Y136H probably damaging Het
Fam3d A G 14: 8,349,314 (GRCm38) L212P probably damaging Het
Fbxw25 A T 9: 109,491,153 (GRCm39) C122S probably damaging Het
Fgg A T 3: 82,920,250 (GRCm39) D343V probably damaging Het
Flnb T A 14: 7,922,700 (GRCm38) M1712K probably benign Het
Fnbp4 T C 2: 90,588,683 (GRCm39) S485P probably damaging Het
Ftsj3 G A 11: 106,144,502 (GRCm39) A134V probably benign Het
Gast C A 11: 100,227,373 (GRCm39) S22Y probably damaging Het
Gm20834 T A Y: 10,322,962 (GRCm39) H158L possibly damaging Het
Ids C A X: 69,389,950 (GRCm39) G506C probably damaging Het
Ifna15 G T 4: 88,476,079 (GRCm39) T135N probably benign Het
Igsf9b G A 9: 27,220,774 (GRCm39) V47I possibly damaging Het
Impg2 C T 16: 56,080,527 (GRCm39) T777I probably damaging Het
Kif11 C A 19: 37,399,883 (GRCm39) T790K probably benign Het
Kif24 A G 4: 41,413,827 (GRCm39) probably null Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lrp10 C T 14: 54,705,823 (GRCm39) R338C probably damaging Het
Mib1 A G 18: 10,751,844 (GRCm39) N242S probably benign Het
Nectin1 A G 9: 43,703,802 (GRCm39) D264G probably benign Het
Nipsnap3a T C 4: 52,995,979 (GRCm39) probably null Het
Or5w14 G A 2: 87,542,229 (GRCm39) S7F possibly damaging Het
P3h4 A G 11: 100,304,452 (GRCm39) F263S probably damaging Het
Pcdhga4 C T 18: 37,820,664 (GRCm39) H738Y probably damaging Het
Prickle2 A T 6: 92,388,490 (GRCm39) I304K probably damaging Het
Ptprq A T 10: 107,444,225 (GRCm39) Y1460N probably damaging Het
Rbl2 A G 8: 91,833,735 (GRCm39) D812G probably damaging Het
Rbm19 A G 5: 120,278,427 (GRCm39) T737A possibly damaging Het
Rbsn G A 6: 92,184,029 (GRCm39) L95F possibly damaging Het
Sall4 T C 2: 168,597,400 (GRCm39) E480G probably benign Het
Scfd1 T A 12: 51,486,068 (GRCm39) N541K probably benign Het
Scube3 G A 17: 28,383,283 (GRCm39) G442S probably benign Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Smarcc1 A G 9: 110,025,324 (GRCm39) D667G probably damaging Het
Sned1 A T 1: 93,193,113 (GRCm39) probably null Het
Spsb1 T C 4: 149,991,232 (GRCm39) H112R probably damaging Het
Sun3 A G 11: 8,966,328 (GRCm39) V231A probably damaging Het
Vmn2r106 A T 17: 20,499,910 (GRCm39) D108E probably benign Het
Xdh A G 17: 74,222,685 (GRCm39) V560A probably benign Het
Zfp352 T A 4: 90,112,071 (GRCm39) H70Q possibly damaging Het
Zfp40 C A 17: 23,396,164 (GRCm39) C73F probably benign Het
Zfp975 A C 7: 42,311,251 (GRCm39) L454R probably damaging Het
Zik1 A T 7: 10,224,268 (GRCm39) C276* probably null Het
Other mutations in Or10al3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02209:Or10al3 APN 17 38,011,883 (GRCm39) missense probably damaging 1.00
IGL03339:Or10al3 APN 17 38,011,682 (GRCm39) missense probably damaging 0.99
R0092:Or10al3 UTSW 17 38,011,696 (GRCm39) missense probably damaging 0.98
R0207:Or10al3 UTSW 17 38,011,949 (GRCm39) nonsense probably null
R0378:Or10al3 UTSW 17 38,011,932 (GRCm39) missense probably damaging 1.00
R0408:Or10al3 UTSW 17 38,012,190 (GRCm39) missense probably benign
R0483:Or10al3 UTSW 17 38,012,188 (GRCm39) missense probably benign 0.01
R1595:Or10al3 UTSW 17 38,012,004 (GRCm39) missense probably benign 0.03
R1901:Or10al3 UTSW 17 38,012,312 (GRCm39) missense probably damaging 1.00
R1902:Or10al3 UTSW 17 38,012,312 (GRCm39) missense probably damaging 1.00
R2845:Or10al3 UTSW 17 38,011,714 (GRCm39) missense probably damaging 1.00
R2846:Or10al3 UTSW 17 38,011,714 (GRCm39) missense probably damaging 1.00
R4381:Or10al3 UTSW 17 38,011,790 (GRCm39) missense probably damaging 0.97
R6744:Or10al3 UTSW 17 38,012,336 (GRCm39) nonsense probably null
R7674:Or10al3 UTSW 17 38,011,573 (GRCm39) missense probably benign 0.03
R7677:Or10al3 UTSW 17 38,011,957 (GRCm39) missense probably damaging 1.00
R7994:Or10al3 UTSW 17 38,012,326 (GRCm39) missense probably damaging 0.99
R8305:Or10al3 UTSW 17 38,012,389 (GRCm39) missense probably benign 0.10
R8512:Or10al3 UTSW 17 38,012,071 (GRCm39) missense probably damaging 1.00
R9300:Or10al3 UTSW 17 38,011,815 (GRCm39) missense probably damaging 1.00
R9760:Or10al3 UTSW 17 38,012,434 (GRCm39) missense probably damaging 1.00
Z1177:Or10al3 UTSW 17 38,011,944 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- GCCAAGTTCTCTGAGGTTCC -3'
(R):5'- CCCATGAAACTATTGCCAAATGG -3'

Sequencing Primer
(F):5'- AGGTTCCTGGAGAATGCTTCCTC -3'
(R):5'- CCACTACTCATTCGTGTTGGATAGTG -3'
Posted On 2015-07-07