Incidental Mutation 'R4407:Or4p7'
ID 327690
Institutional Source Beutler Lab
Gene Symbol Or4p7
Ensembl Gene ENSMUSG00000056995
Gene Name olfactory receptor family 4 subfamily P member 7
Synonyms Olfr1178, GA_x6K02T2Q125-49870417-49871388, MOR225-6P
MMRRC Submission 041689-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R4407 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88221593-88222564 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 88222427 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 279 (M279L)
Ref Sequence ENSEMBL: ENSMUSP00000150036 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075640] [ENSMUST00000214040]
AlphaFold Q7TR20
Predicted Effect probably benign
Transcript: ENSMUST00000075640
AA Change: M279L

PolyPhen 2 Score 0.370 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000075066
Gene: ENSMUSG00000056995
AA Change: M279L

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.5e-49 PFAM
Pfam:7tm_1 39 285 7.2e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214040
AA Change: M279L

PolyPhen 2 Score 0.370 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217346
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219086
Meta Mutation Damage Score 0.2167 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830035A12Rik T C 11: 107,422,881 (GRCm39) noncoding transcript Het
Bbs10 A G 10: 111,135,720 (GRCm39) T278A probably benign Het
Bcl6b A G 11: 70,116,929 (GRCm39) L450P probably damaging Het
Braf T G 6: 39,592,654 (GRCm39) K674Q probably damaging Het
Cep112 C T 11: 108,410,027 (GRCm39) T481I possibly damaging Het
Cep135 T A 5: 76,772,514 (GRCm39) M633K probably benign Het
Cpped1 T C 16: 11,623,285 (GRCm39) Y278C probably damaging Het
Depdc5 T A 5: 33,061,878 (GRCm39) probably null Het
Dolpp1 C T 2: 30,286,464 (GRCm39) A128V possibly damaging Het
E2f5 T A 3: 14,668,823 (GRCm39) D238E probably benign Het
Fat4 A T 3: 39,012,689 (GRCm39) D2328V probably benign Het
Fbln1 T A 15: 85,115,757 (GRCm39) probably null Het
Fkbp3 T C 12: 65,116,778 (GRCm39) T53A probably damaging Het
Flg2 G T 3: 93,122,176 (GRCm39) G1449C unknown Het
G530012D18Rik G C 1: 85,504,923 (GRCm39) probably benign Het
Glyctk A T 9: 106,034,307 (GRCm39) probably benign Het
Gm6430 T C 1: 96,953,297 (GRCm39) noncoding transcript Het
Golga1 C A 2: 38,909,653 (GRCm39) probably null Het
Gucy2g A T 19: 55,226,269 (GRCm39) F216I probably benign Het
L3mbtl3 A G 10: 26,189,782 (GRCm39) V494A unknown Het
Lama2 AATCAGACAGGAG A 10: 27,088,124 (GRCm39) probably benign Het
Lemd3 A T 10: 120,761,335 (GRCm39) L907Q possibly damaging Het
Lrp2 A T 2: 69,332,861 (GRCm39) V1552D probably damaging Het
Map3k12 T C 15: 102,413,837 (GRCm39) T45A probably damaging Het
Mycbp2 A T 14: 103,524,664 (GRCm39) D665E probably damaging Het
Myof A G 19: 37,911,426 (GRCm39) S1502P probably damaging Het
Pcdhac2 G T 18: 37,277,499 (GRCm39) V160L probably benign Het
Pcnt T C 10: 76,210,704 (GRCm39) E2473G possibly damaging Het
Pitpnm2 T A 5: 124,290,678 (GRCm39) I3L possibly damaging Het
Prkd3 C A 17: 79,290,987 (GRCm39) W176L probably damaging Het
Prpf39 C T 12: 65,103,040 (GRCm39) A438V probably damaging Het
Rpgrip1 T A 14: 52,384,856 (GRCm39) F655I probably damaging Het
Rrp12 T C 19: 41,880,990 (GRCm39) Y147C probably damaging Het
Sec23b A T 2: 144,416,638 (GRCm39) N429Y possibly damaging Het
Slc2a10 T A 2: 165,356,684 (GRCm39) S115T probably damaging Het
Spg11 A C 2: 121,905,813 (GRCm39) D1277E probably benign Het
Sspo A G 6: 48,437,454 (GRCm39) D1279G probably damaging Het
St18 T C 1: 6,898,061 (GRCm39) I621T probably benign Het
Tbc1d31 T A 15: 57,783,438 (GRCm39) D112E possibly damaging Het
Tdpoz6 C A 3: 93,599,419 (GRCm39) V317L probably benign Het
Tgm4 A T 9: 122,885,595 (GRCm39) D379V probably damaging Het
Thyn1 A T 9: 26,914,893 (GRCm39) D15V possibly damaging Het
Timd6 A G 11: 46,468,207 (GRCm39) T94A probably damaging Het
Tm4sf19 T C 16: 32,226,712 (GRCm39) V167A possibly damaging Het
Trim38 A C 13: 23,975,474 (GRCm39) Q471P probably benign Het
Trmt1 T A 8: 85,424,384 (GRCm39) probably benign Het
Ubqlnl C T 7: 103,798,925 (GRCm39) V191M probably benign Het
Usp9y T C Y: 1,336,375 (GRCm39) I1500V probably benign Het
Vgll4 C T 6: 114,867,573 (GRCm39) probably null Het
Vmn1r173 T A 7: 23,402,441 (GRCm39) N225K probably damaging Het
Vmn2r22 C T 6: 123,614,913 (GRCm39) G226R probably damaging Het
Wnk3 C A X: 150,016,209 (GRCm39) P555Q probably benign Het
Yes1 T G 5: 32,797,929 (GRCm39) Y83D possibly damaging Het
Zdhhc15 G A X: 103,604,294 (GRCm39) R322* probably null Het
Other mutations in Or4p7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01017:Or4p7 APN 2 88,222,245 (GRCm39) missense possibly damaging 0.79
IGL02261:Or4p7 APN 2 88,221,725 (GRCm39) missense probably benign 0.05
IGL03023:Or4p7 APN 2 88,221,687 (GRCm39) missense probably damaging 1.00
IGL03053:Or4p7 APN 2 88,221,938 (GRCm39) missense probably damaging 1.00
IGL03168:Or4p7 APN 2 88,221,938 (GRCm39) missense probably damaging 1.00
R0432:Or4p7 UTSW 2 88,222,377 (GRCm39) missense probably damaging 0.98
R1738:Or4p7 UTSW 2 88,221,671 (GRCm39) missense probably benign 0.01
R2051:Or4p7 UTSW 2 88,221,882 (GRCm39) missense possibly damaging 0.49
R2136:Or4p7 UTSW 2 88,221,663 (GRCm39) missense probably benign 0.24
R3236:Or4p7 UTSW 2 88,221,750 (GRCm39) missense probably benign 0.01
R4930:Or4p7 UTSW 2 88,222,284 (GRCm39) missense probably benign 0.12
R4959:Or4p7 UTSW 2 88,221,674 (GRCm39) missense probably benign 0.37
R4973:Or4p7 UTSW 2 88,221,674 (GRCm39) missense probably benign 0.37
R5178:Or4p7 UTSW 2 88,221,819 (GRCm39) missense possibly damaging 0.50
R5411:Or4p7 UTSW 2 88,221,605 (GRCm39) missense probably benign 0.01
R6282:Or4p7 UTSW 2 88,221,877 (GRCm39) nonsense probably null
R7289:Or4p7 UTSW 2 88,222,050 (GRCm39) missense probably damaging 0.99
R7493:Or4p7 UTSW 2 88,222,224 (GRCm39) missense possibly damaging 0.94
R7591:Or4p7 UTSW 2 88,222,220 (GRCm39) missense probably benign 0.17
R8060:Or4p7 UTSW 2 88,221,848 (GRCm39) missense probably benign 0.00
R8242:Or4p7 UTSW 2 88,222,418 (GRCm39) missense possibly damaging 0.50
Z1176:Or4p7 UTSW 2 88,222,377 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTAACTCTGGCCTAATGGG -3'
(R):5'- ACAGGACATTTGTCTTTTGCTG -3'

Sequencing Primer
(F):5'- TGTGATCTTATACACTGTCAGGTC -3'
(R):5'- GGACATTTGTCTTTTGCTGATTAAAG -3'
Posted On 2015-07-07