Incidental Mutation 'R4408:Vmn1r23'
| ID |
327758 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r23
|
| Ensembl Gene |
ENSMUSG00000093376 |
| Gene Name |
vomeronasal 1 receptor 23 |
| Synonyms |
V1rc24 |
| MMRRC Submission |
041690-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.157)
|
| Stock # |
R4408 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
57925842-57926838 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 57926368 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 142
(I142V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135676
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000175817]
|
| AlphaFold |
Q8R2D0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175817
AA Change: I142V
PolyPhen 2
Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000135676
Gene: ENSMUSG00000093376
AA Change: I142V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
3.1e-57 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.6%
|
| Validation Efficiency |
97% (35/36) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cacna1h |
A |
G |
17: 25,380,627 (GRCm38) |
V1588A |
probably damaging |
Het |
| Card6 |
T |
A |
15: 5,101,054 (GRCm38) |
M287L |
probably damaging |
Het |
| Fam227b |
T |
A |
2: 126,116,125 (GRCm38) |
Y240F |
possibly damaging |
Het |
| Fbln1 |
T |
A |
15: 85,231,556 (GRCm38) |
|
probably null |
Het |
| Fndc5 |
A |
G |
4: 129,142,529 (GRCm38) |
|
probably null |
Het |
| Gm10799 |
C |
A |
2: 104,068,064 (GRCm38) |
A99S |
possibly damaging |
Het |
| Gm27013 |
A |
T |
6: 130,677,765 (GRCm38) |
S245T |
possibly damaging |
Het |
| Gm5592 |
A |
G |
7: 41,286,448 (GRCm38) |
T125A |
probably benign |
Het |
| Gml2 |
T |
C |
15: 74,824,339 (GRCm38) |
|
probably benign |
Het |
| Gpbp1 |
A |
T |
13: 111,448,964 (GRCm38) |
N149K |
possibly damaging |
Het |
| Gprc6a |
T |
C |
10: 51,628,543 (GRCm38) |
I68M |
probably benign |
Het |
| Hnrnpu |
T |
C |
1: 178,330,803 (GRCm38) |
|
probably benign |
Het |
| Irf5 |
A |
G |
6: 29,534,001 (GRCm38) |
|
probably null |
Het |
| Lrp2 |
T |
A |
2: 69,467,169 (GRCm38) |
K3149N |
probably benign |
Het |
| Lrrn3 |
A |
G |
12: 41,454,042 (GRCm38) |
V92A |
probably benign |
Het |
| Map3k12 |
T |
C |
15: 102,505,402 (GRCm38) |
T45A |
probably damaging |
Het |
| Myof |
A |
G |
19: 37,922,978 (GRCm38) |
S1502P |
probably damaging |
Het |
| Olfr1283 |
T |
A |
2: 111,369,280 (GRCm38) |
I216K |
possibly damaging |
Het |
| Olfr466 |
A |
G |
13: 65,152,700 (GRCm38) |
T159A |
probably benign |
Het |
| Osr2 |
T |
C |
15: 35,300,471 (GRCm38) |
Y58H |
possibly damaging |
Het |
| Pop5 |
C |
T |
5: 115,240,777 (GRCm38) |
|
probably benign |
Het |
| Ror2 |
A |
G |
13: 53,118,961 (GRCm38) |
C211R |
probably damaging |
Het |
| Rufy4 |
T |
C |
1: 74,147,663 (GRCm38) |
C537R |
probably damaging |
Het |
| Sgsm2 |
C |
A |
11: 74,851,766 (GRCm38) |
R957L |
probably damaging |
Het |
| Slc16a11 |
A |
G |
11: 70,215,734 (GRCm38) |
|
probably null |
Het |
| Spag17 |
T |
A |
3: 100,103,378 (GRCm38) |
Y2063N |
probably benign |
Het |
| Usp25 |
A |
C |
16: 77,115,453 (GRCm38) |
K1020T |
probably damaging |
Het |
| Vmn1r235 |
A |
G |
17: 21,261,592 (GRCm38) |
K60E |
probably damaging |
Het |
| Vmn2r33 |
A |
C |
7: 7,551,230 (GRCm38) |
F775V |
probably damaging |
Het |
| Vps13b |
C |
T |
15: 35,709,294 (GRCm38) |
P1796S |
probably damaging |
Het |
| Vwa3a |
G |
A |
7: 120,778,926 (GRCm38) |
V480I |
probably benign |
Het |
|
| Other mutations in Vmn1r23 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01563:Vmn1r23
|
APN |
6 |
57,926,076 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
IGL01980:Vmn1r23
|
APN |
6 |
57,926,490 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02934:Vmn1r23
|
APN |
6 |
57,925,929 (GRCm38) |
missense |
probably benign |
0.26 |
|
IGL03153:Vmn1r23
|
APN |
6 |
57,925,932 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0410:Vmn1r23
|
UTSW |
6 |
57,926,190 (GRCm38) |
missense |
probably benign |
0.11 |
|
R0452:Vmn1r23
|
UTSW |
6 |
57,926,484 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R0590:Vmn1r23
|
UTSW |
6 |
57,926,364 (GRCm38) |
missense |
probably benign |
0.43 |
|
R0647:Vmn1r23
|
UTSW |
6 |
57,926,184 (GRCm38) |
missense |
probably benign |
|
|
R0692:Vmn1r23
|
UTSW |
6 |
57,926,125 (GRCm38) |
nonsense |
probably null |
|
|
R1674:Vmn1r23
|
UTSW |
6 |
57,926,061 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R1744:Vmn1r23
|
UTSW |
6 |
57,925,925 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R1774:Vmn1r23
|
UTSW |
6 |
57,926,690 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2101:Vmn1r23
|
UTSW |
6 |
57,926,452 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R2202:Vmn1r23
|
UTSW |
6 |
57,926,619 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2204:Vmn1r23
|
UTSW |
6 |
57,926,619 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2205:Vmn1r23
|
UTSW |
6 |
57,926,619 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4282:Vmn1r23
|
UTSW |
6 |
57,926,467 (GRCm38) |
missense |
probably benign |
0.27 |
|
R4532:Vmn1r23
|
UTSW |
6 |
57,925,929 (GRCm38) |
missense |
probably benign |
0.21 |
|
R4690:Vmn1r23
|
UTSW |
6 |
57,926,025 (GRCm38) |
missense |
probably benign |
|
|
R4700:Vmn1r23
|
UTSW |
6 |
57,926,205 (GRCm38) |
missense |
probably benign |
0.17 |
|
R4894:Vmn1r23
|
UTSW |
6 |
57,926,325 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6164:Vmn1r23
|
UTSW |
6 |
57,926,055 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6930:Vmn1r23
|
UTSW |
6 |
57,926,145 (GRCm38) |
missense |
probably benign |
|
|
R7129:Vmn1r23
|
UTSW |
6 |
57,926,076 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7731:Vmn1r23
|
UTSW |
6 |
57,926,334 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7877:Vmn1r23
|
UTSW |
6 |
57,926,556 (GRCm38) |
missense |
probably benign |
|
|
R8751:Vmn1r23
|
UTSW |
6 |
57,926,467 (GRCm38) |
missense |
probably benign |
0.27 |
|
R8809:Vmn1r23
|
UTSW |
6 |
57,926,367 (GRCm38) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGGTGCCTGATGCTATGAAG -3'
(R):5'- CACTAGTAGGGTGATGAGAGGACTC -3'
Sequencing Primer
(F):5'- CCTGATGCTATGAAGATGCTTGC -3'
(R):5'- AGGACTCTCTATGGGCATCACATG -3'
|
| Posted On |
2015-07-07 |
Incidental Mutation