Mutagenetix > Incidental Mutation

Incidental Mutation 'R4408:Vmn1r23'

327758

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r23

Ensembl Gene

ENSMUSG00000093376

Gene Name

vomeronasal 1 receptor 23

Synonyms

V1rc24

MMRRC Submission

041690-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.303) question?

Stock #

R4408 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

57925842-57926838 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 57926368 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 142 (I142V)

Ref Sequence

ENSEMBL: ENSMUSP00000135676 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000175817]

AlphaFold

Q8R2D0

Predicted Effect

probably benign
Transcript: ENSMUST00000175817
AA Change: I142V

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000135676
Gene: ENSMUSG00000093376
AA Change: I142V

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	3.1e-57	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.6%

Validation Efficiency

97% (35/36)

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cacna1h	A	G	17: 25,380,627	V1588A	probably damaging	Het
Card6	T	A	15: 5,101,054	M287L	probably damaging	Het
Fam227b	T	A	2: 126,116,125	Y240F	possibly damaging	Het
Fbln1	T	A	15: 85,231,556		probably null	Het
Fndc5	A	G	4: 129,142,529		probably null	Het
Gm10799	C	A	2: 104,068,064	A99S	possibly damaging	Het
Gm27013	A	T	6: 130,677,765	S245T	possibly damaging	Het
Gm5592	A	G	7: 41,286,448	T125A	probably benign	Het
Gml2	T	C	15: 74,824,339		probably benign	Het
Gpbp1	A	T	13: 111,448,964	N149K	possibly damaging	Het
Gprc6a	T	C	10: 51,628,543	I68M	probably benign	Het
Hnrnpu	T	C	1: 178,330,803		probably benign	Het
Irf5	A	G	6: 29,534,001		probably null	Het
Lrp2	T	A	2: 69,467,169	K3149N	probably benign	Het
Lrrn3	A	G	12: 41,454,042	V92A	probably benign	Het
Map3k12	T	C	15: 102,505,402	T45A	probably damaging	Het
Myof	A	G	19: 37,922,978	S1502P	probably damaging	Het
Olfr1283	T	A	2: 111,369,280	I216K	possibly damaging	Het
Olfr466	A	G	13: 65,152,700	T159A	probably benign	Het
Osr2	T	C	15: 35,300,471	Y58H	possibly damaging	Het
Pop5	C	T	5: 115,240,777		probably benign	Het
Ror2	A	G	13: 53,118,961	C211R	probably damaging	Het
Rufy4	T	C	1: 74,147,663	C537R	probably damaging	Het
Sgsm2	C	A	11: 74,851,766	R957L	probably damaging	Het
Slc16a11	A	G	11: 70,215,734		probably null	Het
Spag17	T	A	3: 100,103,378	Y2063N	probably benign	Het
Usp25	A	C	16: 77,115,453	K1020T	probably damaging	Het
Vmn1r235	A	G	17: 21,261,592	K60E	probably damaging	Het
Vmn2r33	A	C	7: 7,551,230	F775V	probably damaging	Het
Vps13b	C	T	15: 35,709,294	P1796S	probably damaging	Het
Vwa3a	G	A	7: 120,778,926	V480I	probably benign	Het

Other mutations in Vmn1r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01563:Vmn1r23	APN	6	57926076	missense	possibly damaging	0.89
IGL01980:Vmn1r23	APN	6	57926490	missense	probably damaging	1.00
IGL02934:Vmn1r23	APN	6	57925929	missense	probably benign	0.26
IGL03153:Vmn1r23	APN	6	57925932	missense	probably damaging	0.98
R0410:Vmn1r23	UTSW	6	57926190	missense	probably benign	0.11
R0452:Vmn1r23	UTSW	6	57926484	missense	possibly damaging	0.90
R0590:Vmn1r23	UTSW	6	57926364	missense	probably benign	0.43
R0647:Vmn1r23	UTSW	6	57926184	missense	probably benign
R0692:Vmn1r23	UTSW	6	57926125	nonsense	probably null
R1674:Vmn1r23	UTSW	6	57926061	missense	possibly damaging	0.75
R1744:Vmn1r23	UTSW	6	57925925	missense	possibly damaging	0.81
R1774:Vmn1r23	UTSW	6	57926690	missense	probably damaging	0.97
R2101:Vmn1r23	UTSW	6	57926452	missense	possibly damaging	0.90
R2202:Vmn1r23	UTSW	6	57926619	missense	probably benign	0.01
R2204:Vmn1r23	UTSW	6	57926619	missense	probably benign	0.01
R2205:Vmn1r23	UTSW	6	57926619	missense	probably benign	0.01
R4282:Vmn1r23	UTSW	6	57926467	missense	probably benign	0.27
R4532:Vmn1r23	UTSW	6	57925929	missense	probably benign	0.21
R4690:Vmn1r23	UTSW	6	57926025	missense	probably benign
R4700:Vmn1r23	UTSW	6	57926205	missense	probably benign	0.17
R4894:Vmn1r23	UTSW	6	57926325	missense	probably benign	0.00
R6164:Vmn1r23	UTSW	6	57926055	missense	possibly damaging	0.90
R6930:Vmn1r23	UTSW	6	57926145	missense	probably benign
R7129:Vmn1r23	UTSW	6	57926076	missense	possibly damaging	0.89
R7731:Vmn1r23	UTSW	6	57926334	missense	probably benign	0.03
R7877:Vmn1r23	UTSW	6	57926556	missense	probably benign
R8751:Vmn1r23	UTSW	6	57926467	missense	probably benign	0.27
R8809:Vmn1r23	UTSW	6	57926367	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- CAGGTGCCTGATGCTATGAAG -3'
(R):5'- CACTAGTAGGGTGATGAGAGGACTC -3'

Sequencing Primer
(F):5'- CCTGATGCTATGAAGATGCTTGC -3'
(R):5'- AGGACTCTCTATGGGCATCACATG -3'

Posted On

2015-07-07