Incidental Mutation 'R4408:Vmn1r235'
| ID |
327778 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r235
|
| Ensembl Gene |
ENSMUSG00000050102 |
| Gene Name |
vomeronasal 1 receptor 235 |
| Synonyms |
V1rf2 |
| MMRRC Submission |
041690-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
R4408 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
21480689-21483125 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 21481854 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamic Acid
at position 60
(K60E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000061689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060603]
|
| AlphaFold |
A0A494B9T5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000060603
AA Change: K60E
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000061689
Gene: ENSMUSG00000050102
AA Change: K60E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
52 |
322 |
2.1e-19 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.6%
|
| Validation Efficiency |
97% (35/36) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cacna1h |
A |
G |
17: 25,599,601 (GRCm39) |
V1588A |
probably damaging |
Het |
| Card6 |
T |
A |
15: 5,130,536 (GRCm39) |
M287L |
probably damaging |
Het |
| Fam227b |
T |
A |
2: 125,958,045 (GRCm39) |
Y240F |
possibly damaging |
Het |
| Fbln1 |
T |
A |
15: 85,115,757 (GRCm39) |
|
probably null |
Het |
| Fndc5 |
A |
G |
4: 129,036,322 (GRCm39) |
|
probably null |
Het |
| Gm10799 |
C |
A |
2: 103,898,409 (GRCm39) |
A99S |
possibly damaging |
Het |
| Gm27013 |
A |
T |
6: 130,654,728 (GRCm39) |
S245T |
possibly damaging |
Het |
| Gm5592 |
A |
G |
7: 40,935,872 (GRCm39) |
T125A |
probably benign |
Het |
| Gml2 |
T |
C |
15: 74,696,188 (GRCm39) |
|
probably benign |
Het |
| Gpbp1 |
A |
T |
13: 111,585,498 (GRCm39) |
N149K |
possibly damaging |
Het |
| Gprc6a |
T |
C |
10: 51,504,639 (GRCm39) |
I68M |
probably benign |
Het |
| Hnrnpu |
T |
C |
1: 178,158,368 (GRCm39) |
|
probably benign |
Het |
| Irf5 |
A |
G |
6: 29,534,000 (GRCm39) |
|
probably null |
Het |
| Lrp2 |
T |
A |
2: 69,297,513 (GRCm39) |
K3149N |
probably benign |
Het |
| Lrrn3 |
A |
G |
12: 41,504,041 (GRCm39) |
V92A |
probably benign |
Het |
| Map3k12 |
T |
C |
15: 102,413,837 (GRCm39) |
T45A |
probably damaging |
Het |
| Myof |
A |
G |
19: 37,911,426 (GRCm39) |
S1502P |
probably damaging |
Het |
| Or4k77 |
T |
A |
2: 111,199,625 (GRCm39) |
I216K |
possibly damaging |
Het |
| Or9s18 |
A |
G |
13: 65,300,514 (GRCm39) |
T159A |
probably benign |
Het |
| Osr2 |
T |
C |
15: 35,300,617 (GRCm39) |
Y58H |
possibly damaging |
Het |
| Pop5 |
C |
T |
5: 115,378,836 (GRCm39) |
|
probably benign |
Het |
| Ror2 |
A |
G |
13: 53,272,997 (GRCm39) |
C211R |
probably damaging |
Het |
| Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
| Sgsm2 |
C |
A |
11: 74,742,592 (GRCm39) |
R957L |
probably damaging |
Het |
| Slc16a11 |
A |
G |
11: 70,106,560 (GRCm39) |
|
probably null |
Het |
| Spag17 |
T |
A |
3: 100,010,694 (GRCm39) |
Y2063N |
probably benign |
Het |
| Usp25 |
A |
C |
16: 76,912,341 (GRCm39) |
K1020T |
probably damaging |
Het |
| Vmn1r23 |
T |
C |
6: 57,903,353 (GRCm39) |
I142V |
probably benign |
Het |
| Vmn2r33 |
A |
C |
7: 7,554,229 (GRCm39) |
F775V |
probably damaging |
Het |
| Vps13b |
C |
T |
15: 35,709,440 (GRCm39) |
P1796S |
probably damaging |
Het |
| Vwa3a |
G |
A |
7: 120,378,149 (GRCm39) |
V480I |
probably benign |
Het |
|
| Other mutations in Vmn1r235 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0138:Vmn1r235
|
UTSW |
17 |
21,482,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Vmn1r235
|
UTSW |
17 |
21,482,257 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1780:Vmn1r235
|
UTSW |
17 |
21,481,999 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1918:Vmn1r235
|
UTSW |
17 |
21,482,659 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1944:Vmn1r235
|
UTSW |
17 |
21,481,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2151:Vmn1r235
|
UTSW |
17 |
21,482,628 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4296:Vmn1r235
|
UTSW |
17 |
21,482,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4689:Vmn1r235
|
UTSW |
17 |
21,482,623 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5006:Vmn1r235
|
UTSW |
17 |
21,482,467 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5033:Vmn1r235
|
UTSW |
17 |
21,482,550 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5303:Vmn1r235
|
UTSW |
17 |
21,482,268 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5512:Vmn1r235
|
UTSW |
17 |
21,481,677 (GRCm39) |
start codon destroyed |
probably benign |
0.09 |
|
R6999:Vmn1r235
|
UTSW |
17 |
21,482,127 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7133:Vmn1r235
|
UTSW |
17 |
21,482,292 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7471:Vmn1r235
|
UTSW |
17 |
21,482,658 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7552:Vmn1r235
|
UTSW |
17 |
21,481,713 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7577:Vmn1r235
|
UTSW |
17 |
21,481,881 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8716:Vmn1r235
|
UTSW |
17 |
21,482,554 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R8725:Vmn1r235
|
UTSW |
17 |
21,482,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8727:Vmn1r235
|
UTSW |
17 |
21,482,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8729:Vmn1r235
|
UTSW |
17 |
21,481,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8732:Vmn1r235
|
UTSW |
17 |
21,482,439 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9016:Vmn1r235
|
UTSW |
17 |
21,481,969 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9072:Vmn1r235
|
UTSW |
17 |
21,482,271 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9350:Vmn1r235
|
UTSW |
17 |
21,482,190 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9633:Vmn1r235
|
UTSW |
17 |
21,482,330 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9633:Vmn1r235
|
UTSW |
17 |
21,482,329 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9712:Vmn1r235
|
UTSW |
17 |
21,481,960 (GRCm39) |
missense |
probably benign |
0.14 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGAATTTTGTTGGGACAGAAATGC -3'
(R):5'- ATGGCCTGGAAGACACTCATC -3'
Sequencing Primer
(F):5'- AGAAATGCTGTCAGTGCCTC -3'
(R):5'- GCTGCTGCAAATACATGTACC -3'
|
| Posted On |
2015-07-07 |
Incidental Mutation