Mutagenetix > Incidental Mutation

Incidental Mutation 'R4410:Vmn1r55'

327858

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r55

Ensembl Gene

ENSMUSG00000074402

Gene Name

vomeronasal 1 receptor 55

Synonyms

LOC384522, V1rd5, LOC236535

MMRRC Submission

041692-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

R4410 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

5149489-5150421 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 5150075 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 116 (V116A)

Ref Sequence

ENSEMBL: ENSMUSP00000096443 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098844]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000098844
AA Change: V116A

PolyPhen 2 Score 0.398 (Sensitivity: 0.89; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000096443
Gene: ENSMUSG00000074402
AA Change: V116A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	286	3.7e-14	PFAM
Pfam:7tm_1	20	279	4e-8	PFAM
Pfam:V1R	31	286	5.5e-17	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.0%

Validation Efficiency

96% (46/48)

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap39	A	T	15: 76,609,712 (GRCm39)		probably benign	Het
Arrb1	G	T	7: 99,247,503 (GRCm39)		probably benign	Het
Cadps	A	G	14: 12,822,323 (GRCm38)	M139T	probably damaging	Het
Casr	A	G	16: 36,320,703 (GRCm39)	C482R	probably benign	Het
Cdca4	A	T	12: 112,785,499 (GRCm39)	H76Q	probably benign	Het
Ddias	A	G	7: 92,507,287 (GRCm39)	L876P	probably benign	Het
Dnah9	T	C	11: 65,976,303 (GRCm39)	S1249G	possibly damaging	Het
Dnttip1	A	G	2: 164,609,739 (GRCm39)		probably benign	Het
Eme2	A	G	17: 25,112,598 (GRCm39)	S160P	probably benign	Het
Fbxw24	A	T	9: 109,437,256 (GRCm39)	D210E	probably damaging	Het
Folr2	T	C	7: 101,489,881 (GRCm39)	E129G	probably damaging	Het
Herc6	T	A	6: 57,636,664 (GRCm39)	N793K	possibly damaging	Het
Iqcg	T	G	16: 32,851,186 (GRCm39)	K262Q	possibly damaging	Het
Lhfpl3	A	G	5: 22,980,690 (GRCm39)		probably benign	Het
Lmod2	A	C	6: 24,604,629 (GRCm39)	S535R	probably damaging	Het
Lrp1b	T	A	2: 40,555,094 (GRCm39)	S342C	possibly damaging	Het
Lrrn3	T	A	12: 41,502,583 (GRCm39)	Y578F	possibly damaging	Het
Map3k4	T	A	17: 12,467,885 (GRCm39)	R1050W	probably damaging	Het
Muc6	T	A	7: 141,217,576 (GRCm39)	T2301S	possibly damaging	Het
Mycbp2	T	C	14: 103,372,702 (GRCm39)	E4048G	probably damaging	Het
Myh3	G	C	11: 66,975,858 (GRCm39)	E297Q	possibly damaging	Het
Nkain3	A	G	4: 20,778,284 (GRCm39)	V11A	probably benign	Het
Or4c102	G	A	2: 88,422,765 (GRCm39)	V206I	probably benign	Het
P3h2	G	C	16: 25,924,040 (GRCm39)	R132G	possibly damaging	Het
Pals2	C	T	6: 50,175,248 (GRCm39)	Q520*	probably null	Het
Phgdh	A	G	3: 98,221,591 (GRCm39)	M447T	probably benign	Het
Pmfbp1	G	A	8: 110,258,695 (GRCm39)	A667T	probably benign	Het
Pramel41	A	T	5: 94,593,720 (GRCm39)	Q15L	probably benign	Het
Psmd2	T	G	16: 20,473,776 (GRCm39)	C230G	probably damaging	Het
Rin2	C	T	2: 145,702,366 (GRCm39)	T354I	probably benign	Het
Slc37a3	T	A	6: 39,315,747 (GRCm39)	Y443F	probably benign	Het
Sorl1	C	A	9: 41,915,288 (GRCm39)	G1314*	probably null	Het
Spag7	T	C	11: 70,555,688 (GRCm39)	D83G	probably damaging	Het
St7	C	T	6: 17,854,932 (GRCm39)	R267*	probably null	Het
Syne2	C	T	12: 76,141,167 (GRCm39)	S99L	probably damaging	Het
Tacc2	T	G	7: 130,343,941 (GRCm39)	S2533R	possibly damaging	Het
Tmem59l	A	G	8: 70,939,951 (GRCm39)	L6S	unknown	Het
Uaca	T	G	9: 60,777,173 (GRCm39)	V518G	probably damaging	Het
Usp43	T	C	11: 67,746,716 (GRCm39)	E992G	probably benign	Het
Wdr3	G	A	3: 100,047,543 (GRCm39)	T844M	probably benign	Het
Wdr7	T	A	18: 63,911,320 (GRCm39)	M904K	probably damaging	Het
Zbtb39	A	G	10: 127,578,696 (GRCm39)	I423M	possibly damaging	Het
Zmym1	A	T	4: 126,941,897 (GRCm39)	C830*	probably null	Het

Other mutations in Vmn1r55

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1771:Vmn1r55	UTSW	7	5,149,919 (GRCm39)	missense	probably benign	0.01
R2063:Vmn1r55	UTSW	7	5,150,048 (GRCm39)	missense	possibly damaging	0.91
R2064:Vmn1r55	UTSW	7	5,150,048 (GRCm39)	missense	possibly damaging	0.91
R2066:Vmn1r55	UTSW	7	5,150,048 (GRCm39)	missense	possibly damaging	0.91
R2068:Vmn1r55	UTSW	7	5,150,048 (GRCm39)	missense	possibly damaging	0.91
R3737:Vmn1r55	UTSW	7	5,150,195 (GRCm39)	missense	probably damaging	0.99
R4409:Vmn1r55	UTSW	7	5,150,075 (GRCm39)	missense	probably benign	0.40
R4700:Vmn1r55	UTSW	7	5,149,587 (GRCm39)	missense	probably damaging	0.98
R4700:Vmn1r55	UTSW	7	5,149,586 (GRCm39)	missense	probably damaging	1.00
R4755:Vmn1r55	UTSW	7	5,150,025 (GRCm39)	missense	probably damaging	1.00
R4945:Vmn1r55	UTSW	7	5,150,105 (GRCm39)	missense	probably damaging	1.00
R5064:Vmn1r55	UTSW	7	5,149,928 (GRCm39)	missense	probably benign	0.00
R5186:Vmn1r55	UTSW	7	5,149,985 (GRCm39)	missense	probably damaging	0.99
R5394:Vmn1r55	UTSW	7	5,149,995 (GRCm39)	missense	probably damaging	1.00
R6487:Vmn1r55	UTSW	7	5,149,554 (GRCm39)	missense	probably benign	0.23
R7855:Vmn1r55	UTSW	7	5,149,623 (GRCm39)	missense	probably benign
R8204:Vmn1r55	UTSW	7	5,150,285 (GRCm39)	missense	possibly damaging	0.48
R8376:Vmn1r55	UTSW	7	5,149,869 (GRCm39)	missense	probably benign	0.00
R9586:Vmn1r55	UTSW	7	5,149,770 (GRCm39)	missense	probably benign	0.03
R9688:Vmn1r55	UTSW	7	5,149,669 (GRCm39)	missense	probably benign	0.44

Predicted Primers

PCR Primer
(F):5'- ATTGACCACAGAGATAGAGCAC -3'
(R):5'- TGAGGCCCATACAGGTCATTC -3'

Sequencing Primer
(F):5'- ACATCCTCTTGCCTTGAGAATCAGAG -3'
(R):5'- TGAGGCCCATACAGGTCATTCTAATC -3'

Posted On

2015-07-07