Mutagenetix > Incidental Mutation

Incidental Mutation 'R4411:Vmn1r115'

327915

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r115

Ensembl Gene

ENSMUSG00000091435

Gene Name

vomeronasal 1 receptor 115

Synonyms

Gm8549

MMRRC Submission

041693-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R4411 (G1)

Quality Score

155

Status

Validated

Chromosome

Chromosomal Location

20844098-20844985 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 20844282 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Lysine at position 235 (R235K)

Ref Sequence

ENSEMBL: ENSMUSP00000128692 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169374]

AlphaFold

K7N6Y3

Predicted Effect

probably benign
Transcript: ENSMUST00000169374
AA Change: R235K

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000128692
Gene: ENSMUSG00000091435
AA Change: R235K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	294	1.4e-15	PFAM
Pfam:7tm_1	31	292	3.5e-7	PFAM
Pfam:V1R	41	289	8e-15	PFAM

Meta Mutation Damage Score

0.5519

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 94.9%

Validation Efficiency

95% (62/65)

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	T	C	11: 110,151,955	I423V	probably benign	Het
Abl2	T	C	1: 156,630,082	V306A	possibly damaging	Het
Adcy4	T	C	14: 55,769,443	Y1006C	probably damaging	Het
Adprhl1	T	C	8: 13,246,114	K144E	probably benign	Het
Arid5b	T	C	10: 68,096,689	R885G	probably damaging	Het
Atp9a	A	T	2: 168,661,933	V613E	probably damaging	Het
Atxn7l1	G	T	12: 33,194,887		probably benign	Het
Brd8	C	A	18: 34,623,444		probably benign	Het
Bsnd	C	T	4: 106,486,671	R146H	probably benign	Het
C4b	C	T	17: 34,728,864	R1659H	probably damaging	Het
Duox1	G	A	2: 122,337,634	R1080H	probably benign	Het
Eml2	T	C	7: 19,182,401		probably null	Het
Fbxo44	G	A	4: 148,153,608	R221C	probably damaging	Het
Frem1	T	C	4: 82,963,244	D166G	probably damaging	Het
Galnt5	T	C	2: 57,999,195	L269P	probably benign	Het
Gigyf2	A	G	1: 87,436,860	E954G	probably damaging	Het
Gpc6	T	C	14: 117,951,178	V408A	probably benign	Het
Hspg2	A	G	4: 137,562,224	T3832A	probably benign	Het
Ift88	A	G	14: 57,477,979	N493S	probably damaging	Het
Ighv1-76	A	T	12: 115,848,111	C41S	probably damaging	Het
Igkv12-46	G	A	6: 69,764,946	T16I	probably benign	Het
Igkv3-9	G	T	6: 70,588,563	V49F	probably damaging	Het
Isoc2b	A	T	7: 4,849,434		probably benign	Het
Lcp2	T	A	11: 34,087,173		probably benign	Het
Lmntd1	A	G	6: 145,427,277		probably null	Het
Mdm2	A	T	10: 117,709,789		probably null	Het
Mrgprx3-ps	T	C	7: 47,309,998		noncoding transcript	Het
Msh2	T	C	17: 87,717,604	S637P	probably damaging	Het
Myo5b	T	C	18: 74,698,274	F765S	possibly damaging	Het
Nav2	T	A	7: 49,398,109	N91K	probably benign	Het
Ndor1	G	A	2: 25,248,480	P363S	probably benign	Het
Npr3	G	C	15: 11,905,149	T164R	probably benign	Het
Pcdhb5	T	C	18: 37,321,997	S477P	possibly damaging	Het
Pde3b	GTGATGATGATGATGATGATGATGATG	GTGATGATGATGATGATGATGATG	7: 114,534,749		probably benign	Het
Pnpla7	G	A	2: 25,051,704	W13*	probably null	Het
Pnpla8	T	C	12: 44,283,442	V41A	probably benign	Het
Prdm2	A	T	4: 143,133,670	S1017T	probably benign	Het
Prdm5	T	A	6: 65,901,787	Y108*	probably null	Het
Rab34	T	A	11: 78,188,766		probably null	Het
Smpd5	G	T	15: 76,294,912	R160L	possibly damaging	Het
Srrm2	A	G	17: 23,810,468		probably benign	Het
Taf5	T	A	19: 47,071,014	V199D	probably damaging	Het
Tas2r114	C	T	6: 131,689,622	V148I	probably benign	Het
Tas2r136	C	A	6: 132,778,009	V52L	probably damaging	Het
Tex43	A	G	18: 56,594,648	T65A	probably benign	Het
Tnfrsf25	G	A	4: 152,118,386		probably benign	Het
Tpd52l1	T	C	10: 31,379,319	T11A	possibly damaging	Het
Trmt1l	G	A	1: 151,452,154	E472K	probably benign	Het
Ttc17	T	C	2: 94,342,753	K766E	probably damaging	Het
Ttc37	A	G	13: 76,127,504	E410G	possibly damaging	Het
Ttn	C	T	2: 76,730,289	R29256Q	probably damaging	Het
Ttn	T	C	2: 76,742,070	I26160V	probably damaging	Het
Ubxn6	A	T	17: 56,069,303	V311E	probably damaging	Het
Usp2	T	C	9: 44,091,063	S351P	probably damaging	Het
Usp7	C	A	16: 8,708,914	D187Y	probably damaging	Het
Vmn2r50	A	C	7: 10,050,308	F80V	probably damaging	Het
Vmn2r58	T	A	7: 41,861,936	K481M	possibly damaging	Het
Vmn2r86	A	G	10: 130,452,600	I344T	possibly damaging	Het
Zfp455	A	T	13: 67,207,325	N219I	probably damaging	Het

Other mutations in Vmn1r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02340:Vmn1r115	APN	7	20844528	missense	possibly damaging	0.70
R0243:Vmn1r115	UTSW	7	20844402	missense	probably benign	0.02
R1901:Vmn1r115	UTSW	7	20844273	missense	probably benign
R2020:Vmn1r115	UTSW	7	20844169	missense	probably null	0.38
R4412:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R4413:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R5226:Vmn1r115	UTSW	7	20844244	missense	probably damaging	1.00
R5570:Vmn1r115	UTSW	7	20844630	missense	possibly damaging	0.87
R5986:Vmn1r115	UTSW	7	20844522	missense	probably benign	0.44
R6180:Vmn1r115	UTSW	7	20844715	missense	probably damaging	0.98
R8169:Vmn1r115	UTSW	7	20844219	missense	probably damaging	1.00
R8310:Vmn1r115	UTSW	7	20844894	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGGTCCAACCATTTGCCTAGC -3'
(R):5'- TTCCACTTCTGGATTCATTGTAGGC -3'

Sequencing Primer
(F):5'- ATAGCTGAGTAGTACTCCATTGTG -3'
(R):5'- CATTGTAGGCATTGTCTTCTTGCAG -3'

Posted On

2015-07-07