Incidental Mutation 'R4412:Vmn1r115'
ID 327964
Institutional Source Beutler Lab
Gene Symbol Vmn1r115
Ensembl Gene ENSMUSG00000091435
Gene Name vomeronasal 1 receptor 115
Synonyms Gm8549
MMRRC Submission 041135-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock # R4412 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 20844098-20844985 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 20844282 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Lysine at position 235 (R235K)
Ref Sequence ENSEMBL: ENSMUSP00000128692 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169374]
AlphaFold K7N6Y3
Predicted Effect probably benign
Transcript: ENSMUST00000169374
AA Change: R235K

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000128692
Gene: ENSMUSG00000091435
AA Change: R235K

DomainStartEndE-ValueType
Pfam:TAS2R 8 294 1.4e-15 PFAM
Pfam:7tm_1 31 292 3.5e-7 PFAM
Pfam:V1R 41 289 8e-15 PFAM
Meta Mutation Damage Score 0.5519 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb1 T C 15: 74,577,453 probably benign Het
Adprhl1 T C 8: 13,246,114 K144E probably benign Het
Alpl A G 4: 137,758,628 I2T possibly damaging Het
Chdh G T 14: 30,031,715 G194C probably damaging Het
Cp A T 3: 19,966,353 D170V probably damaging Het
Cpne9 A G 6: 113,290,001 K132E possibly damaging Het
Cyp2b9 T G 7: 26,198,443 L224R probably damaging Het
Dmxl1 A G 18: 49,848,761 N153S probably benign Het
Dnah17 T C 11: 118,073,683 Y2423C probably damaging Het
Dnajc14 G T 10: 128,806,205 probably benign Het
Eipr1 A T 12: 28,859,373 D213V probably damaging Het
Fat1 T C 8: 45,023,599 V1894A probably damaging Het
Flrt2 G A 12: 95,780,273 V462I probably benign Het
Gigyf2 A G 1: 87,436,860 E954G probably damaging Het
Glis1 A G 4: 107,634,718 H593R probably damaging Het
Gpr21 C G 2: 37,517,432 probably benign Het
Gsdmc3 A G 15: 63,866,796 M139T probably benign Het
Hydin C T 8: 110,415,736 T749I probably damaging Het
Ilf3 C T 9: 21,399,560 P620S possibly damaging Het
Khdc3 A G 9: 73,102,874 T71A possibly damaging Het
Ms4a12 T C 19: 11,230,443 N33S probably benign Het
Nisch A G 14: 31,186,658 probably benign Het
Npr2 G A 4: 43,644,150 C593Y probably damaging Het
Npr3 G C 15: 11,905,149 T164R probably benign Het
Olfr1231 A G 2: 89,303,340 I84T probably benign Het
Palld A G 8: 61,687,372 Y534H probably damaging Het
Pcdhb10 TC T 18: 37,414,141 probably null Het
Plekhg3 A C 12: 76,577,764 T1127P probably damaging Het
Podnl1 A T 8: 84,130,665 H301L probably benign Het
Ripk2 A G 4: 16,124,511 V399A probably benign Het
Rpp30 T A 19: 36,100,255 N172K possibly damaging Het
Sin3b C T 8: 72,739,779 A291V probably benign Het
Slc12a6 A T 2: 112,335,888 Q204L possibly damaging Het
Snx9 C T 17: 5,908,394 T249M probably damaging Het
Sohlh2 C A 3: 55,197,002 T264K probably damaging Het
Srrm2 A G 17: 23,810,468 probably benign Het
Syne2 T A 12: 76,106,060 H6674Q probably benign Het
Tyw1 T A 5: 130,335,232 probably null Het
Vmn2r50 A C 7: 10,050,308 F80V probably damaging Het
Yme1l1 G A 2: 23,175,187 R236H probably damaging Het
Other mutations in Vmn1r115
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02340:Vmn1r115 APN 7 20844528 missense possibly damaging 0.70
R0243:Vmn1r115 UTSW 7 20844402 missense probably benign 0.02
R1901:Vmn1r115 UTSW 7 20844273 missense probably benign
R2020:Vmn1r115 UTSW 7 20844169 missense probably null 0.38
R4411:Vmn1r115 UTSW 7 20844282 missense probably benign 0.01
R4413:Vmn1r115 UTSW 7 20844282 missense probably benign 0.01
R5226:Vmn1r115 UTSW 7 20844244 missense probably damaging 1.00
R5570:Vmn1r115 UTSW 7 20844630 missense possibly damaging 0.87
R5986:Vmn1r115 UTSW 7 20844522 missense probably benign 0.44
R6180:Vmn1r115 UTSW 7 20844715 missense probably damaging 0.98
R8169:Vmn1r115 UTSW 7 20844219 missense probably damaging 1.00
R8310:Vmn1r115 UTSW 7 20844894 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGGTCCAACCATTTGCCTAG -3'
(R):5'- ACTTCTGGATTCATTGTAGGCATTG -3'

Sequencing Primer
(F):5'- ATAGCTGAGTAGTACTCCATTGTG -3'
(R):5'- CATTGTAGGCATTGTCTTCTTGCAG -3'
Posted On 2015-07-07