Mutagenetix > Incidental Mutation

Incidental Mutation 'R4412:Vmn1r115'

327964

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r115

Ensembl Gene

ENSMUSG00000091435

Gene Name

vomeronasal 1 receptor 115

Synonyms

Gm8549

MMRRC Submission

041135-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R4412 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

20578023-20578910 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 20578207 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Lysine at position 235 (R235K)

Ref Sequence

ENSEMBL: ENSMUSP00000128692 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169374]

AlphaFold

K7N6Y3

Predicted Effect

probably benign
Transcript: ENSMUST00000169374
AA Change: R235K

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000128692
Gene: ENSMUSG00000091435
AA Change: R235K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	294	1.4e-15	PFAM
Pfam:7tm_1	31	292	3.5e-7	PFAM
Pfam:V1R	41	289	8e-15	PFAM

Meta Mutation Damage Score

0.5519

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.2%
20x: 95.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb1	T	C	15: 74,449,302 (GRCm39)		probably benign	Het
Adprhl1	T	C	8: 13,296,114 (GRCm39)	K144E	probably benign	Het
Alpl	A	G	4: 137,485,939 (GRCm39)	I2T	possibly damaging	Het
Chdh	G	T	14: 29,753,672 (GRCm39)	G194C	probably damaging	Het
Cp	A	T	3: 20,020,517 (GRCm39)	D170V	probably damaging	Het
Cpne9	A	G	6: 113,266,962 (GRCm39)	K132E	possibly damaging	Het
Cyp2b9	T	G	7: 25,897,868 (GRCm39)	L224R	probably damaging	Het
Dmxl1	A	G	18: 49,981,828 (GRCm39)	N153S	probably benign	Het
Dnah17	T	C	11: 117,964,509 (GRCm39)	Y2423C	probably damaging	Het
Dnajc14	G	T	10: 128,642,074 (GRCm39)		probably benign	Het
Eipr1	A	T	12: 28,909,372 (GRCm39)	D213V	probably damaging	Het
Fat1	T	C	8: 45,476,636 (GRCm39)	V1894A	probably damaging	Het
Flrt2	G	A	12: 95,747,047 (GRCm39)	V462I	probably benign	Het
Gigyf2	A	G	1: 87,364,582 (GRCm39)	E954G	probably damaging	Het
Glis1	A	G	4: 107,491,915 (GRCm39)	H593R	probably damaging	Het
Gpr21	C	G	2: 37,407,444 (GRCm39)		probably benign	Het
Gsdmc3	A	G	15: 63,738,645 (GRCm39)	M139T	probably benign	Het
Hydin	C	T	8: 111,142,368 (GRCm39)	T749I	probably damaging	Het
Ilf3	C	T	9: 21,310,856 (GRCm39)	P620S	possibly damaging	Het
Khdc3	A	G	9: 73,010,156 (GRCm39)	T71A	possibly damaging	Het
Ms4a12	T	C	19: 11,207,807 (GRCm39)	N33S	probably benign	Het
Nisch	A	G	14: 30,908,615 (GRCm39)		probably benign	Het
Npr2	G	A	4: 43,644,150 (GRCm39)	C593Y	probably damaging	Het
Npr3	G	C	15: 11,905,235 (GRCm39)	T164R	probably benign	Het
Or4c1	A	G	2: 89,133,684 (GRCm39)	I84T	probably benign	Het
Palld	A	G	8: 62,140,406 (GRCm39)	Y534H	probably damaging	Het
Pcdhb10	TC	T	18: 37,547,194 (GRCm39)		probably null	Het
Plekhg3	A	C	12: 76,624,538 (GRCm39)	T1127P	probably damaging	Het
Podnl1	A	T	8: 84,857,294 (GRCm39)	H301L	probably benign	Het
Ripk2	A	G	4: 16,124,511 (GRCm39)	V399A	probably benign	Het
Rpp30	T	A	19: 36,077,655 (GRCm39)	N172K	possibly damaging	Het
Sin3b	C	T	8: 73,466,407 (GRCm39)	A291V	probably benign	Het
Slc12a6	A	T	2: 112,166,233 (GRCm39)	Q204L	possibly damaging	Het
Snx9	C	T	17: 5,958,669 (GRCm39)	T249M	probably damaging	Het
Sohlh2	C	A	3: 55,104,423 (GRCm39)	T264K	probably damaging	Het
Srrm2	A	G	17: 24,029,442 (GRCm39)		probably benign	Het
Syne2	T	A	12: 76,152,834 (GRCm39)	H6674Q	probably benign	Het
Tyw1	T	A	5: 130,364,073 (GRCm39)		probably null	Het
Vmn2r50	A	C	7: 9,784,235 (GRCm39)	F80V	probably damaging	Het
Yme1l1	G	A	2: 23,065,199 (GRCm39)	R236H	probably damaging	Het

Other mutations in Vmn1r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02340:Vmn1r115	APN	7	20,578,453 (GRCm39)	missense	possibly damaging	0.70
R0243:Vmn1r115	UTSW	7	20,578,327 (GRCm39)	missense	probably benign	0.02
R1901:Vmn1r115	UTSW	7	20,578,198 (GRCm39)	missense	probably benign
R2020:Vmn1r115	UTSW	7	20,578,094 (GRCm39)	missense	probably null	0.38
R4411:Vmn1r115	UTSW	7	20,578,207 (GRCm39)	missense	probably benign	0.01
R4413:Vmn1r115	UTSW	7	20,578,207 (GRCm39)	missense	probably benign	0.01
R5226:Vmn1r115	UTSW	7	20,578,169 (GRCm39)	missense	probably damaging	1.00
R5570:Vmn1r115	UTSW	7	20,578,555 (GRCm39)	missense	possibly damaging	0.87
R5986:Vmn1r115	UTSW	7	20,578,447 (GRCm39)	missense	probably benign	0.44
R6180:Vmn1r115	UTSW	7	20,578,640 (GRCm39)	missense	probably damaging	0.98
R8169:Vmn1r115	UTSW	7	20,578,144 (GRCm39)	missense	probably damaging	1.00
R8310:Vmn1r115	UTSW	7	20,578,819 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CAGGTCCAACCATTTGCCTAG -3'
(R):5'- ACTTCTGGATTCATTGTAGGCATTG -3'

Sequencing Primer
(F):5'- ATAGCTGAGTAGTACTCCATTGTG -3'
(R):5'- CATTGTAGGCATTGTCTTCTTGCAG -3'

Posted On

2015-07-07