Mutagenetix > Incidental Mutation

Incidental Mutation 'R4413:Vmn1r115'

328016

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r115

Ensembl Gene

ENSMUSG00000091435

Gene Name

vomeronasal 1 receptor 115

Synonyms

Gm8549

MMRRC Submission

041136-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R4413 (G1)

Quality Score

183

Status

Validated

Chromosome

Chromosomal Location

20844098-20844985 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 20844282 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Lysine at position 235 (R235K)

Ref Sequence

ENSEMBL: ENSMUSP00000128692 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169374]

AlphaFold

K7N6Y3

Predicted Effect

probably benign
Transcript: ENSMUST00000169374
AA Change: R235K

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000128692
Gene: ENSMUSG00000091435
AA Change: R235K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	294	1.4e-15	PFAM
Pfam:7tm_1	31	292	3.5e-7	PFAM
Pfam:V1R	41	289	8e-15	PFAM

Meta Mutation Damage Score

0.5519

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.2%
20x: 95.0%

Validation Efficiency

93% (42/45)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	A	G	3: 36,958,681		probably null	Het
Adprhl1	T	C	8: 13,246,114	K144E	probably benign	Het
Bcdin3d	A	G	15: 99,470,733	L195P	probably damaging	Het
Col11a1	T	A	3: 114,108,316	S553R	unknown	Het
Cp	A	T	3: 19,966,353	D170V	probably damaging	Het
Dnah17	C	T	11: 118,025,168	A4303T	probably benign	Het
Dpp4	G	A	2: 62,387,140	R38C	possibly damaging	Het
Dusp6	C	T	10: 99,263,924	T78M	probably damaging	Het
Exoc1	A	G	5: 76,542,019		probably benign	Het
Fbxl13	A	T	5: 21,582,053	C295*	probably null	Het
Gpsm1	G	A	2: 26,319,831		probably benign	Het
Gstm4	T	A	3: 108,043,328	D85V	possibly damaging	Het
Hectd4	A	G	5: 121,350,481	N3612D	possibly damaging	Het
Izumo3	T	C	4: 92,146,899	D27G	probably damaging	Het
Kcna4	T	A	2: 107,295,373	C151S	probably benign	Het
Lrrc10	A	G	10: 117,045,814	N131S	probably damaging	Het
Madd	A	G	2: 91,167,587	S699P	probably damaging	Het
Mcpt4	A	T	14: 56,060,536	V186D	probably damaging	Het
Mrgprx3-ps	T	C	7: 47,309,998		noncoding transcript	Het
Mrm1	G	T	11: 84,819,228	R49S	possibly damaging	Het
Nav2	T	A	7: 49,398,109	N91K	probably benign	Het
Noct	C	T	3: 51,250,335	R365W	probably damaging	Het
Ntn1	C	T	11: 68,385,910	G71S	probably damaging	Het
Olfr417	T	C	1: 174,369,474	S186P	probably damaging	Het
Plekhg3	A	C	12: 76,577,764	T1127P	probably damaging	Het
Rhbdl2	A	T	4: 123,810,087	M52L	probably benign	Het
Slc10a1	T	C	12: 80,958,132	N212S	probably benign	Het
Sohlh2	C	A	3: 55,197,002	T264K	probably damaging	Het
Srrm2	A	G	17: 23,810,468		probably benign	Het
Syn3	C	A	10: 86,055,592		probably benign	Het
Taf5	T	A	19: 47,071,014	V199D	probably damaging	Het
Tas2r136	C	A	6: 132,778,009	V52L	probably damaging	Het
Tex45	T	A	8: 3,483,529	H278Q	probably damaging	Het
Tnk2	C	T	16: 32,669,501	R191C	probably damaging	Het
Ttn	A	G	2: 76,725,776	I21968T	probably damaging	Het
Ubxn6	A	T	17: 56,069,303	V311E	probably damaging	Het
Usp7	C	A	16: 8,708,914	D187Y	probably damaging	Het
Vmn2r50	A	C	7: 10,050,308	F80V	probably damaging	Het
Vmn2r58	T	A	7: 41,861,936	K481M	possibly damaging	Het
Vmn2r86	A	G	10: 130,452,600	I344T	possibly damaging	Het
Vmn2r99	T	A	17: 19,379,260	V402E	probably damaging	Het
Zfp462	A	G	4: 55,012,672	D1546G	probably damaging	Het

Other mutations in Vmn1r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02340:Vmn1r115	APN	7	20844528	missense	possibly damaging	0.70
R0243:Vmn1r115	UTSW	7	20844402	missense	probably benign	0.02
R1901:Vmn1r115	UTSW	7	20844273	missense	probably benign
R2020:Vmn1r115	UTSW	7	20844169	missense	probably null	0.38
R4411:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R4412:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R5226:Vmn1r115	UTSW	7	20844244	missense	probably damaging	1.00
R5570:Vmn1r115	UTSW	7	20844630	missense	possibly damaging	0.87
R5986:Vmn1r115	UTSW	7	20844522	missense	probably benign	0.44
R6180:Vmn1r115	UTSW	7	20844715	missense	probably damaging	0.98
R8169:Vmn1r115	UTSW	7	20844219	missense	probably damaging	1.00
R8310:Vmn1r115	UTSW	7	20844894	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCAGGTCCAACCATTTGCCTAG -3'
(R):5'- CCACTTCTGGATTCATTGTAGGC -3'

Sequencing Primer
(F):5'- ATAGCTGAGTAGTACTCCATTGTG -3'
(R):5'- CATTGTAGGCATTGTCTTCTTGCAG -3'

Posted On

2015-07-07