Incidental Mutation 'R0038:Vmn2r15'
ID 32806
Institutional Source Beutler Lab
Gene Symbol Vmn2r15
Ensembl Gene ENSMUSG00000091375
Gene Name vomeronasal 2, receptor 15
Synonyms EG211223
MMRRC Submission 038332-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R0038 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 5
Chromosomal Location 109434135-109445422 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 109441010 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 283 (T283S)
Ref Sequence ENSEMBL: ENSMUSP00000128333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167133]
AlphaFold L7N2A0
Predicted Effect possibly damaging
Transcript: ENSMUST00000167133
AA Change: T283S

PolyPhen 2 Score 0.457 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: T283S

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 75 472 1e-29 PFAM
Pfam:NCD3G 514 568 5.8e-18 PFAM
Pfam:7tm_3 601 836 9.1e-55 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.2%
Validation Efficiency 100% (72/72)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agfg1 T C 1: 82,863,823 (GRCm39) probably benign Het
Ankrd28 A T 14: 31,429,992 (GRCm39) M892K probably damaging Het
Arhgef25 T C 10: 127,022,734 (GRCm39) probably benign Het
Arl9 G A 5: 77,154,322 (GRCm39) E17K probably benign Het
Bbs9 G A 9: 22,415,390 (GRCm39) V105I probably benign Het
Celsr1 A T 15: 85,813,620 (GRCm39) N1997K possibly damaging Het
Cic T A 7: 24,986,565 (GRCm39) S1299T probably damaging Het
Cic C A 7: 24,986,566 (GRCm39) S1299Y probably damaging Het
Cldn8 A G 16: 88,359,922 (GRCm39) M1T probably null Het
Clec11a A G 7: 43,955,906 (GRCm39) probably benign Het
Clstn1 G A 4: 149,719,253 (GRCm39) V361M probably damaging Het
Col19a1 A T 1: 24,598,825 (GRCm39) L56Q unknown Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cyp2b10 G A 7: 25,614,287 (GRCm39) A254T probably benign Het
Ddx39a T C 8: 84,449,127 (GRCm39) L305P probably damaging Het
Depdc5 A G 5: 33,026,197 (GRCm39) E60G probably benign Het
Eif2ak2 T A 17: 79,171,384 (GRCm39) M340L probably benign Het
Etl4 A T 2: 20,748,385 (GRCm39) H39L probably damaging Het
Fat3 T C 9: 15,826,306 (GRCm39) T4549A probably damaging Het
Fbxw28 A T 9: 109,167,608 (GRCm39) W50R probably damaging Het
Ggt7 T C 2: 155,344,701 (GRCm39) D214G probably benign Het
Gramd1b G A 9: 40,228,822 (GRCm39) T252M probably damaging Het
Grin1 T C 2: 25,187,471 (GRCm39) N613S probably null Het
Hcrtr2 A T 9: 76,166,963 (GRCm39) S125T probably benign Het
Hr T C 14: 70,805,525 (GRCm39) L1091P probably damaging Het
Htr2a T G 14: 74,943,687 (GRCm39) S422R probably benign Het
Ighmbp2 A G 19: 3,312,097 (GRCm39) S886P probably damaging Het
Iqcg C A 16: 32,866,012 (GRCm39) L110F probably benign Het
Kirrel3 T A 9: 34,823,066 (GRCm39) probably null Het
Kremen1 A C 11: 5,157,703 (GRCm39) probably benign Het
Lama2 T C 10: 26,862,793 (GRCm39) D2990G probably benign Het
Lin52 C G 12: 84,576,499 (GRCm39) L111V probably damaging Het
Myh15 T C 16: 48,891,504 (GRCm39) probably benign Het
Ncor1 A G 11: 62,283,377 (GRCm39) F437L probably damaging Het
Nlrp1b A G 11: 71,062,997 (GRCm39) S685P possibly damaging Het
Oog4 T C 4: 143,165,514 (GRCm39) D211G probably benign Het
Oscar A G 7: 3,619,072 (GRCm39) V2A probably benign Het
Pdzd8 A G 19: 59,288,028 (GRCm39) I1124T possibly damaging Het
Pgm3 A T 9: 86,446,726 (GRCm39) probably benign Het
Pnpla5 A G 15: 84,006,714 (GRCm39) Y90H probably damaging Het
Polr1b C T 2: 128,957,588 (GRCm39) R548* probably null Het
Ptprg T A 14: 12,213,710 (GRCm38) M1026K probably damaging Het
Rab5b C T 10: 128,518,772 (GRCm39) R120Q probably benign Het
Rapgef2 T C 3: 78,976,703 (GRCm39) I1368V probably benign Het
Rnf168 T C 16: 32,117,813 (GRCm39) V458A probably benign Het
Rnf32 T C 5: 29,410,652 (GRCm39) probably benign Het
Sclt1 T C 3: 41,583,943 (GRCm39) probably benign Het
Serpina12 A G 12: 104,004,216 (GRCm39) F139L probably damaging Het
Sos2 T G 12: 69,643,467 (GRCm39) Q971P probably damaging Het
Stag3 T A 5: 138,299,298 (GRCm39) probably null Het
Stard5 T C 7: 83,285,951 (GRCm39) probably benign Het
Stard9 T A 2: 120,526,313 (GRCm39) C857S probably benign Het
Suclg1 A G 6: 73,237,486 (GRCm39) E77G probably benign Het
Trpm7 A G 2: 126,637,388 (GRCm39) S204P probably damaging Het
Ush2a G T 1: 188,358,809 (GRCm39) G2112C probably benign Het
Wdr6 A T 9: 108,450,168 (GRCm39) V1120D probably damaging Het
Zfp644 T G 5: 106,782,909 (GRCm39) E1155A probably benign Het
Other mutations in Vmn2r15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01335:Vmn2r15 APN 5 109,434,602 (GRCm39) missense possibly damaging 0.70
IGL01367:Vmn2r15 APN 5 109,441,075 (GRCm39) missense probably damaging 0.99
IGL01844:Vmn2r15 APN 5 109,434,135 (GRCm39) makesense probably null
IGL02190:Vmn2r15 APN 5 109,441,240 (GRCm39) missense probably damaging 1.00
IGL02754:Vmn2r15 APN 5 109,441,134 (GRCm39) nonsense probably null
IGL02797:Vmn2r15 APN 5 109,445,250 (GRCm39) missense probably benign 0.18
IGL03301:Vmn2r15 APN 5 109,445,221 (GRCm39) critical splice donor site probably null
IGL03407:Vmn2r15 APN 5 109,434,185 (GRCm39) nonsense probably null
BB001:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
BB011:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
PIT4445001:Vmn2r15 UTSW 5 109,435,008 (GRCm39) missense probably damaging 0.99
PIT4520001:Vmn2r15 UTSW 5 109,434,871 (GRCm39) missense probably damaging 1.00
R0111:Vmn2r15 UTSW 5 109,435,022 (GRCm39) missense possibly damaging 0.56
R0379:Vmn2r15 UTSW 5 109,434,344 (GRCm39) missense probably damaging 1.00
R0427:Vmn2r15 UTSW 5 109,434,953 (GRCm39) missense probably damaging 1.00
R0639:Vmn2r15 UTSW 5 109,440,881 (GRCm39) missense probably benign 0.22
R0964:Vmn2r15 UTSW 5 109,445,401 (GRCm39) missense probably benign 0.34
R1147:Vmn2r15 UTSW 5 109,441,072 (GRCm39) missense probably damaging 1.00
R1147:Vmn2r15 UTSW 5 109,441,072 (GRCm39) missense probably damaging 1.00
R1232:Vmn2r15 UTSW 5 109,441,168 (GRCm39) missense probably benign 0.39
R1241:Vmn2r15 UTSW 5 109,440,770 (GRCm39) missense probably damaging 1.00
R1244:Vmn2r15 UTSW 5 109,441,092 (GRCm39) nonsense probably null
R1394:Vmn2r15 UTSW 5 109,442,014 (GRCm39) missense probably benign 0.44
R1395:Vmn2r15 UTSW 5 109,442,014 (GRCm39) missense probably benign 0.44
R1423:Vmn2r15 UTSW 5 109,441,093 (GRCm39) missense probably damaging 1.00
R1439:Vmn2r15 UTSW 5 109,441,953 (GRCm39) missense probably damaging 1.00
R1513:Vmn2r15 UTSW 5 109,441,195 (GRCm39) missense probably damaging 1.00
R1777:Vmn2r15 UTSW 5 109,442,136 (GRCm39) missense possibly damaging 0.79
R1844:Vmn2r15 UTSW 5 109,434,860 (GRCm39) nonsense probably null
R2072:Vmn2r15 UTSW 5 109,434,619 (GRCm39) missense possibly damaging 0.65
R2074:Vmn2r15 UTSW 5 109,434,619 (GRCm39) missense possibly damaging 0.65
R2122:Vmn2r15 UTSW 5 109,434,322 (GRCm39) missense probably damaging 1.00
R2208:Vmn2r15 UTSW 5 109,445,309 (GRCm39) missense possibly damaging 0.64
R2268:Vmn2r15 UTSW 5 109,441,073 (GRCm39) missense probably benign 0.31
R2831:Vmn2r15 UTSW 5 109,434,458 (GRCm39) missense probably damaging 1.00
R3848:Vmn2r15 UTSW 5 109,445,312 (GRCm39) missense probably benign 0.00
R4058:Vmn2r15 UTSW 5 109,441,312 (GRCm39) missense probably damaging 0.99
R4615:Vmn2r15 UTSW 5 109,441,348 (GRCm39) missense possibly damaging 0.91
R4663:Vmn2r15 UTSW 5 109,441,940 (GRCm39) missense probably benign
R4681:Vmn2r15 UTSW 5 109,434,488 (GRCm39) missense probably damaging 0.97
R4751:Vmn2r15 UTSW 5 109,434,620 (GRCm39) missense probably benign 0.01
R5095:Vmn2r15 UTSW 5 109,436,317 (GRCm39) critical splice acceptor site probably null
R5300:Vmn2r15 UTSW 5 109,441,974 (GRCm39) missense probably damaging 0.99
R5309:Vmn2r15 UTSW 5 109,440,956 (GRCm39) missense probably damaging 0.99
R5335:Vmn2r15 UTSW 5 109,434,673 (GRCm39) missense probably damaging 0.99
R5421:Vmn2r15 UTSW 5 109,434,401 (GRCm39) missense probably damaging 1.00
R5805:Vmn2r15 UTSW 5 109,434,806 (GRCm39) missense possibly damaging 0.88
R6280:Vmn2r15 UTSW 5 109,441,291 (GRCm39) missense possibly damaging 0.65
R6324:Vmn2r15 UTSW 5 109,434,137 (GRCm39) makesense probably null
R6383:Vmn2r15 UTSW 5 109,441,092 (GRCm39) nonsense probably null
R6772:Vmn2r15 UTSW 5 109,434,238 (GRCm39) missense probably damaging 0.99
R6991:Vmn2r15 UTSW 5 109,441,180 (GRCm39) missense probably damaging 1.00
R7194:Vmn2r15 UTSW 5 109,440,649 (GRCm39) missense probably damaging 1.00
R7365:Vmn2r15 UTSW 5 109,445,388 (GRCm39) missense probably benign 0.15
R7365:Vmn2r15 UTSW 5 109,441,105 (GRCm39) missense probably benign 0.19
R7423:Vmn2r15 UTSW 5 109,445,394 (GRCm39) missense probably benign 0.00
R7552:Vmn2r15 UTSW 5 109,440,774 (GRCm39) nonsense probably null
R7619:Vmn2r15 UTSW 5 109,436,190 (GRCm39) critical splice donor site probably null
R7892:Vmn2r15 UTSW 5 109,434,217 (GRCm39) missense probably damaging 1.00
R7924:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
R8058:Vmn2r15 UTSW 5 109,440,956 (GRCm39) missense probably damaging 0.99
R8099:Vmn2r15 UTSW 5 109,441,185 (GRCm39) missense possibly damaging 0.58
R8189:Vmn2r15 UTSW 5 109,434,713 (GRCm39) missense probably benign 0.02
R8275:Vmn2r15 UTSW 5 109,434,150 (GRCm39) missense probably benign 0.08
R8277:Vmn2r15 UTSW 5 109,441,310 (GRCm39) missense probably damaging 1.00
R8277:Vmn2r15 UTSW 5 109,440,970 (GRCm39) missense probably benign 0.00
R8465:Vmn2r15 UTSW 5 109,445,302 (GRCm39) missense probably damaging 1.00
R8679:Vmn2r15 UTSW 5 109,434,779 (GRCm39) missense probably benign 0.31
R8682:Vmn2r15 UTSW 5 109,441,938 (GRCm39) missense probably damaging 0.98
R8809:Vmn2r15 UTSW 5 109,434,874 (GRCm39) missense probably benign 0.22
R9016:Vmn2r15 UTSW 5 109,442,109 (GRCm39) missense probably benign 0.01
R9372:Vmn2r15 UTSW 5 109,441,953 (GRCm39) missense possibly damaging 0.60
R9596:Vmn2r15 UTSW 5 109,440,791 (GRCm39) missense probably benign 0.01
R9619:Vmn2r15 UTSW 5 109,440,622 (GRCm39) missense possibly damaging 0.58
R9685:Vmn2r15 UTSW 5 109,440,598 (GRCm39) missense probably benign 0.05
R9716:Vmn2r15 UTSW 5 109,445,224 (GRCm39) missense possibly damaging 0.88
R9772:Vmn2r15 UTSW 5 109,434,923 (GRCm39) missense probably damaging 1.00
X0065:Vmn2r15 UTSW 5 109,441,174 (GRCm39) missense probably damaging 1.00
Z1187:Vmn2r15 UTSW 5 109,434,529 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTGGGCCACAGCATATACAGC -3'
(R):5'- CCTGAGTGACCATGACCAGTTTCC -3'

Sequencing Primer
(F):5'- AGTGCTGTCCATTCCAATGTG -3'
(R):5'- TATGTCCATCAGGTAGCCATCAAG -3'
Posted On 2013-05-09