Incidental Mutation 'R4414:Tmem145'
ID 328063
Institutional Source Beutler Lab
Gene Symbol Tmem145
Ensembl Gene ENSMUSG00000043843
Gene Name transmembrane protein 145
Synonyms B930076A02Rik
MMRRC Submission 041694-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.102) question?
Stock # R4414 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 25005531-25015620 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 25006554 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 54 (Y54C)
Ref Sequence ENSEMBL: ENSMUSP00000104046 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080288] [ENSMUST00000108409] [ENSMUST00000119703]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000080288
SMART Domains Protein: ENSMUSP00000104047
Gene: ENSMUSG00000058741

DomainStartEndE-ValueType
Pfam:Pro-rich_19 1 366 3.3e-196 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000108409
AA Change: Y54C

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000104046
Gene: ENSMUSG00000043843
AA Change: Y54C

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
Pfam:GpcrRhopsn4 157 411 7.5e-81 PFAM
low complexity region 486 503 N/A INTRINSIC
low complexity region 505 516 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000119703
AA Change: Y54C

PolyPhen 2 Score 0.933 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000112676
Gene: ENSMUSG00000043843
AA Change: Y54C

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
Pfam:GpcrRhopsn4 143 397 4.3e-81 PFAM
low complexity region 478 493 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140016
Meta Mutation Damage Score 0.1276 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 100% (50/50)
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit progressive hearing impairment. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503E14Rik T A 14: 44,406,690 (GRCm39) M120L probably benign Het
Aco2 A G 15: 81,773,584 (GRCm39) probably null Het
Acss1 A G 2: 150,501,823 (GRCm39) S115P possibly damaging Het
Ank2 A T 3: 127,019,411 (GRCm39) probably null Het
AU041133 C T 10: 81,987,316 (GRCm39) T323M probably damaging Het
Bdp1 T C 13: 100,167,369 (GRCm39) D2215G probably damaging Het
Bod1l G A 5: 41,977,870 (GRCm39) T1148I probably benign Het
Celsr1 C T 15: 85,847,334 (GRCm39) V1468I probably benign Het
Celsr1 A G 15: 85,812,200 (GRCm39) V2065A probably damaging Het
Cep89 A G 7: 35,115,822 (GRCm39) probably benign Het
Cfap58 A G 19: 47,941,480 (GRCm39) K283E possibly damaging Het
Cog5 C T 12: 31,710,853 (GRCm39) Q78* probably null Het
Col20a1 C T 2: 180,643,043 (GRCm39) R796C possibly damaging Het
Dnah7b A T 1: 46,165,840 (GRCm39) T502S probably benign Het
Dnm1l A G 16: 16,160,559 (GRCm39) probably null Het
Dse A T 10: 34,028,632 (GRCm39) F819L probably benign Het
Eloa G T 4: 135,738,553 (GRCm39) L136I possibly damaging Het
Eloa T A 4: 135,738,576 (GRCm39) H128L probably benign Het
Fbxl6 T C 15: 76,421,924 (GRCm39) E205G possibly damaging Het
Golim4 T G 3: 75,802,347 (GRCm39) N287T probably benign Het
Gpx8 T A 13: 113,179,682 (GRCm39) K206N possibly damaging Het
Iqgap3 G T 3: 88,004,293 (GRCm39) V460F probably benign Het
Kcne4 A T 1: 78,795,651 (GRCm39) M100L probably benign Het
Kmt2a A T 9: 44,721,077 (GRCm39) probably benign Het
Ktn1 G A 14: 47,962,387 (GRCm39) W1117* probably null Het
Lad1 A G 1: 135,756,484 (GRCm39) D364G probably benign Het
Lmln T G 16: 32,930,220 (GRCm39) I559S probably benign Het
Mapk4 A T 18: 74,063,609 (GRCm39) F538I possibly damaging Het
Mlxipl A G 5: 135,166,253 (GRCm39) probably benign Het
Mmrn1 T C 6: 60,921,570 (GRCm39) L9P probably damaging Het
Mnat1 G A 12: 73,228,601 (GRCm39) R155H probably damaging Het
Mtmr11 T C 3: 96,075,207 (GRCm39) probably benign Het
Naaladl1 T C 19: 6,165,581 (GRCm39) L745P probably damaging Het
Obsl1 A T 1: 75,467,546 (GRCm39) D1409E probably benign Het
Oit3 T C 10: 59,263,925 (GRCm39) Y403C probably damaging Het
Pla2g4e A T 2: 120,013,194 (GRCm39) H375Q probably benign Het
Prodh2 G A 7: 30,205,877 (GRCm39) V238M probably damaging Het
Rdh14 G A 12: 10,441,231 (GRCm39) probably null Het
Rho G A 6: 115,912,191 (GRCm39) V76I probably benign Het
Rock1 A T 18: 10,080,514 (GRCm39) M1010K probably damaging Het
Ros1 A G 10: 52,038,800 (GRCm39) probably null Het
Sim1 A T 10: 50,857,708 (GRCm39) D486V probably benign Het
Spmip6 T C 4: 41,505,574 (GRCm39) T183A possibly damaging Het
Src A G 2: 157,306,573 (GRCm39) D192G probably damaging Het
Stox1 T C 10: 62,495,348 (GRCm39) N975S probably benign Het
Try4 C T 6: 41,281,905 (GRCm39) P164S possibly damaging Het
Vegfc A T 8: 54,634,130 (GRCm39) N270Y probably benign Het
Other mutations in Tmem145
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00926:Tmem145 APN 7 25,014,155 (GRCm39) missense possibly damaging 0.88
IGL00958:Tmem145 APN 7 25,006,782 (GRCm39) critical splice donor site probably null
IGL01347:Tmem145 APN 7 25,014,260 (GRCm39) missense probably damaging 0.97
IGL01936:Tmem145 APN 7 25,010,816 (GRCm39) missense probably damaging 0.97
IGL02526:Tmem145 APN 7 25,007,657 (GRCm39) missense probably benign 0.20
IGL02686:Tmem145 APN 7 25,014,150 (GRCm39) missense probably damaging 1.00
IGL03182:Tmem145 APN 7 25,014,304 (GRCm39) missense probably damaging 1.00
R0087:Tmem145 UTSW 7 25,007,268 (GRCm39) missense probably damaging 1.00
R0180:Tmem145 UTSW 7 25,014,124 (GRCm39) missense probably benign 0.05
R0329:Tmem145 UTSW 7 25,008,099 (GRCm39) splice site probably benign
R0504:Tmem145 UTSW 7 25,010,787 (GRCm39) missense probably damaging 1.00
R1488:Tmem145 UTSW 7 25,006,860 (GRCm39) splice site probably null
R1681:Tmem145 UTSW 7 25,014,159 (GRCm39) missense possibly damaging 0.95
R2352:Tmem145 UTSW 7 25,005,598 (GRCm39) missense probably benign
R3834:Tmem145 UTSW 7 25,010,786 (GRCm39) missense probably damaging 1.00
R4175:Tmem145 UTSW 7 25,008,218 (GRCm39) missense probably benign 0.04
R4485:Tmem145 UTSW 7 25,006,587 (GRCm39) missense possibly damaging 0.76
R4631:Tmem145 UTSW 7 25,007,250 (GRCm39) missense probably benign 0.00
R4983:Tmem145 UTSW 7 25,008,027 (GRCm39) missense probably benign 0.03
R4999:Tmem145 UTSW 7 25,008,459 (GRCm39) missense probably benign 0.04
R5772:Tmem145 UTSW 7 25,015,039 (GRCm39) missense probably benign 0.21
R5821:Tmem145 UTSW 7 25,014,946 (GRCm39) missense probably benign 0.30
R5909:Tmem145 UTSW 7 25,007,618 (GRCm39) missense possibly damaging 0.89
R6021:Tmem145 UTSW 7 25,008,270 (GRCm39) splice site probably null
R6430:Tmem145 UTSW 7 25,008,463 (GRCm39) missense possibly damaging 0.84
R6768:Tmem145 UTSW 7 25,008,061 (GRCm39) missense probably damaging 1.00
R6778:Tmem145 UTSW 7 25,010,801 (GRCm39) missense probably benign 0.04
R7428:Tmem145 UTSW 7 25,006,590 (GRCm39) critical splice donor site probably null
R7536:Tmem145 UTSW 7 25,007,294 (GRCm39) missense probably damaging 1.00
R7748:Tmem145 UTSW 7 25,006,753 (GRCm39) nonsense probably null
R7826:Tmem145 UTSW 7 25,006,939 (GRCm39) missense probably damaging 1.00
R8253:Tmem145 UTSW 7 25,006,939 (GRCm39) missense probably damaging 1.00
R8441:Tmem145 UTSW 7 25,008,200 (GRCm39) missense possibly damaging 0.62
R9129:Tmem145 UTSW 7 25,014,265 (GRCm39) missense possibly damaging 0.59
R9277:Tmem145 UTSW 7 25,009,165 (GRCm39) missense probably benign 0.14
R9297:Tmem145 UTSW 7 25,008,257 (GRCm39) missense probably damaging 1.00
Z1177:Tmem145 UTSW 7 25,009,071 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTTGAGGGACATCTGAGGG -3'
(R):5'- ACTGGGATGGGTCGTCAAAG -3'

Sequencing Primer
(F):5'- AAGAATTCTGGAGGTGACTTAGCTGC -3'
(R):5'- TCGTCAAAGTAGAGGAGGATGTTCTG -3'
Posted On 2015-07-07