Incidental Mutation 'R4427:Tcaim'
ID 328234
Institutional Source Beutler Lab
Gene Symbol Tcaim
Ensembl Gene ENSMUSG00000046603
Gene Name T cell activation inhibitor, mitochondrial
Synonyms D9Ertd402e, LOC382117
MMRRC Submission 041145-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4427 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 122634604-122665399 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 122643561 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 87 (F87S)
Ref Sequence ENSEMBL: ENSMUSP00000120948 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052740] [ENSMUST00000136274]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000052740
AA Change: F87S

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000049759
Gene: ENSMUSG00000046603
AA Change: F87S

DomainStartEndE-ValueType
Pfam:DUF4460 33 144 4.2e-40 PFAM
Pfam:DUF4461 199 503 4.1e-124 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000136274
AA Change: F87S

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000120948
Gene: ENSMUSG00000046603
AA Change: F87S

DomainStartEndE-ValueType
Pfam:DUF4460 31 125 2.7e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149659
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157461
Meta Mutation Damage Score 0.0584 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency 96% (48/50)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik A T 7: 29,278,678 (GRCm39) noncoding transcript Het
A2ml1 T C 6: 128,522,009 (GRCm39) E1271G probably benign Het
Ccdc88b C T 19: 6,827,940 (GRCm39) E878K probably damaging Het
Cfap119 A G 7: 127,187,288 (GRCm39) probably benign Het
Crybg3 T C 16: 59,363,562 (GRCm39) K2441E probably damaging Het
Cryga A T 1: 65,139,775 (GRCm39) I121N probably damaging Het
Dst A T 1: 34,220,541 (GRCm39) Q2115L probably benign Het
Evi2 T A 11: 79,407,182 (GRCm39) Q131L possibly damaging Het
Exoc1 A G 5: 76,711,110 (GRCm39) I61V probably benign Het
Firrm A G 1: 163,781,853 (GRCm39) V858A probably benign Het
Frem2 A G 3: 53,446,583 (GRCm39) probably null Het
Gas2l1 A G 11: 5,013,908 (GRCm39) V184A probably benign Het
Gsto2 T C 19: 47,860,212 (GRCm39) S2P possibly damaging Het
Herc1 T C 9: 66,403,287 (GRCm39) L4402P probably damaging Het
Kcnd2 T A 6: 21,216,896 (GRCm39) I200N probably damaging Het
Klhl30 A G 1: 91,281,426 (GRCm39) D9G probably damaging Het
Ltf C A 9: 110,852,672 (GRCm39) T178K probably damaging Het
Memo1 T A 17: 74,509,302 (GRCm39) Y239F probably benign Het
Ogdh C T 11: 6,305,421 (GRCm39) T972I probably benign Het
Phactr4 T C 4: 132,114,352 (GRCm39) D24G possibly damaging Het
Pi4ka C T 16: 17,098,908 (GRCm39) R1992H probably damaging Het
Poc1b T C 10: 98,991,001 (GRCm39) probably null Het
Ppp1r9b A T 11: 94,892,150 (GRCm39) R188S possibly damaging Het
Pwwp2a T C 11: 43,573,344 (GRCm39) V142A possibly damaging Het
Rab36 G A 10: 74,880,328 (GRCm39) V63I probably damaging Het
Rap1gap2 C A 11: 74,298,148 (GRCm39) A491S possibly damaging Het
Rcsd1 C A 1: 165,483,464 (GRCm39) V206L probably damaging Het
Rps6ka2 T A 17: 7,566,804 (GRCm39) D687E possibly damaging Het
Sgce G A 6: 4,691,459 (GRCm39) A295V probably damaging Het
Siglec15 T G 18: 78,086,836 (GRCm39) E341A possibly damaging Het
Thbs2 C A 17: 14,900,597 (GRCm39) V537L probably benign Het
Timd6 T A 11: 46,475,247 (GRCm39) F147L probably benign Het
Tmx3 T A 18: 90,541,725 (GRCm39) V158D probably damaging Het
Tpm1 A G 9: 66,939,847 (GRCm39) probably benign Het
Trmt2a A G 16: 18,067,093 (GRCm39) probably benign Het
Ugcg T A 4: 59,219,555 (GRCm39) F297L probably benign Het
Utp18 T C 11: 93,757,264 (GRCm39) N467D probably damaging Het
Vmn2r73 A G 7: 85,506,981 (GRCm39) F777S probably damaging Het
Vwc2 A G 11: 11,104,235 (GRCm39) T256A probably damaging Het
Zfp300 C T X: 20,949,405 (GRCm39) V120I possibly damaging Het
Zfp982 A T 4: 147,597,080 (GRCm39) R146* probably null Het
Other mutations in Tcaim
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01389:Tcaim APN 9 122,643,627 (GRCm39) missense possibly damaging 0.69
IGL01775:Tcaim APN 9 122,647,890 (GRCm39) missense probably damaging 1.00
R1193:Tcaim UTSW 9 122,647,895 (GRCm39) missense probably damaging 0.96
R1487:Tcaim UTSW 9 122,647,897 (GRCm39) nonsense probably null
R1592:Tcaim UTSW 9 122,647,838 (GRCm39) critical splice acceptor site probably null
R1639:Tcaim UTSW 9 122,647,838 (GRCm39) critical splice acceptor site probably null
R1642:Tcaim UTSW 9 122,647,838 (GRCm39) critical splice acceptor site probably null
R1853:Tcaim UTSW 9 122,655,271 (GRCm39) missense probably damaging 1.00
R4204:Tcaim UTSW 9 122,662,683 (GRCm39) missense probably benign 0.01
R6547:Tcaim UTSW 9 122,643,531 (GRCm39) missense probably benign 0.22
R6599:Tcaim UTSW 9 122,663,844 (GRCm39) nonsense probably null
R6906:Tcaim UTSW 9 122,663,839 (GRCm39) missense probably benign 0.01
R7158:Tcaim UTSW 9 122,648,055 (GRCm39) missense possibly damaging 0.66
R7286:Tcaim UTSW 9 122,648,092 (GRCm39) critical splice donor site probably null
R7806:Tcaim UTSW 9 122,663,995 (GRCm39) missense probably damaging 1.00
R9368:Tcaim UTSW 9 122,647,928 (GRCm39) missense probably damaging 1.00
R9376:Tcaim UTSW 9 122,655,995 (GRCm39) missense probably damaging 1.00
R9597:Tcaim UTSW 9 122,637,830 (GRCm39) critical splice acceptor site probably null
Z1088:Tcaim UTSW 9 122,662,722 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACAAAACAAAGCAGTGTCTCACT -3'
(R):5'- CAAGGCTCAAATCCCAAGGT -3'

Sequencing Primer
(F):5'- ACAGTGGTTTGGAACTCACC -3'
(R):5'- GGCTCAAATCCCAAGGTATTCTGG -3'
Posted On 2015-07-07