Incidental Mutation 'R4348:Vmn2r120'
ID 328420
Institutional Source Beutler Lab
Gene Symbol Vmn2r120
Ensembl Gene ENSMUSG00000090655
Gene Name vomeronasal 2, receptor 120
Synonyms EG224916
MMRRC Submission 041103-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R4348 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 57815783-57852314 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 57829466 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 477 (F477Y)
Ref Sequence ENSEMBL: ENSMUSP00000129296 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165781]
AlphaFold A0A3Q4EG79
Predicted Effect possibly damaging
Transcript: ENSMUST00000165781
AA Change: F477Y

PolyPhen 2 Score 0.473 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: F477Y

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 80 474 5.9e-42 PFAM
Pfam:NCD3G 517 570 7.5e-22 PFAM
Pfam:7tm_3 598 836 1.3e-54 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 C T 6: 128,557,349 (GRCm39) A115T probably benign Het
Aass A G 6: 23,113,738 (GRCm39) F235L probably benign Het
Adamts1 T A 16: 85,599,234 (GRCm39) D122V probably benign Het
Adcy6 A T 15: 98,502,041 (GRCm39) V191E probably benign Het
Cngb3 G A 4: 19,396,688 (GRCm39) R347Q probably damaging Het
Cntnap4 T A 8: 113,480,554 (GRCm39) C334S probably damaging Het
D7Ertd443e ACCTAGGAGGTCCT ACCT 7: 133,950,682 (GRCm39) probably null Het
Dnah12 T A 14: 26,536,498 (GRCm39) M2138K possibly damaging Het
Ebf2 T C 14: 67,476,871 (GRCm39) I138T probably damaging Het
Ect2l A G 10: 18,012,736 (GRCm39) S784P probably damaging Het
Emilin2 T C 17: 71,587,726 (GRCm39) M129V probably benign Het
Enah A T 1: 181,749,985 (GRCm39) S266T possibly damaging Het
Fhip1b A G 7: 105,034,556 (GRCm39) V422A probably damaging Het
Garem2 G A 5: 30,310,366 (GRCm39) R26H possibly damaging Het
Gfy T C 7: 44,827,040 (GRCm39) E352G probably benign Het
Gpatch11 T C 17: 79,148,446 (GRCm39) L128P probably damaging Het
Inava C T 1: 136,153,946 (GRCm39) V180I probably damaging Het
Kcns3 T C 12: 11,141,382 (GRCm39) N439S possibly damaging Het
Llgl1 C T 11: 60,600,394 (GRCm39) P581L probably benign Het
Mbd1 G T 18: 74,407,487 (GRCm39) R199L probably damaging Het
Mbd5 T A 2: 49,146,339 (GRCm39) M183K probably benign Het
Mecom C A 3: 30,020,887 (GRCm39) V452L possibly damaging Het
Nckap1l A G 15: 103,395,246 (GRCm39) T909A probably damaging Het
Ntrk2 A G 13: 59,026,073 (GRCm39) K464E probably damaging Het
Orc1 C T 4: 108,450,649 (GRCm39) T127I probably damaging Het
Pcdh17 T C 14: 84,685,060 (GRCm39) I509T probably damaging Het
Pcsk7 G A 9: 45,830,646 (GRCm39) A475T probably damaging Het
Prb1b T G 6: 132,290,624 (GRCm39) Y25S unknown Het
Prdm16 A G 4: 154,561,124 (GRCm39) V136A probably benign Het
Ptch1 C T 13: 63,682,143 (GRCm39) R537H probably damaging Het
Ptpn13 T A 5: 103,717,592 (GRCm39) S1879R probably damaging Het
Rasgrp3 A T 17: 75,818,975 (GRCm39) Q388L probably benign Het
Rnf31 AAC A 14: 55,838,555 (GRCm39) probably null Het
Rnf38 A T 4: 44,149,100 (GRCm39) N82K possibly damaging Het
Smco3 T A 6: 136,808,692 (GRCm39) T61S possibly damaging Het
Ssx2ip T C 3: 146,138,245 (GRCm39) V364A probably benign Het
Ttn A G 2: 76,595,109 (GRCm39) I20347T possibly damaging Het
Wee1 A G 7: 109,730,165 (GRCm39) H423R probably damaging Het
Other mutations in Vmn2r120
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01335:Vmn2r120 APN 17 57,832,732 (GRCm39) missense possibly damaging 0.86
IGL01346:Vmn2r120 APN 17 57,852,232 (GRCm39) missense probably benign 0.11
IGL01996:Vmn2r120 APN 17 57,832,222 (GRCm39) missense possibly damaging 0.92
IGL02503:Vmn2r120 APN 17 57,816,385 (GRCm39) missense probably benign 0.40
IGL02582:Vmn2r120 APN 17 57,831,724 (GRCm39) missense probably damaging 0.99
IGL02747:Vmn2r120 APN 17 57,831,719 (GRCm39) missense probably benign 0.19
IGL02896:Vmn2r120 APN 17 57,816,008 (GRCm39) missense probably damaging 1.00
IGL03139:Vmn2r120 APN 17 57,831,742 (GRCm39) missense probably benign 0.39
IGL03342:Vmn2r120 APN 17 57,816,372 (GRCm39) missense probably benign 0.03
A4554:Vmn2r120 UTSW 17 57,832,715 (GRCm39) missense probably benign 0.01
R0207:Vmn2r120 UTSW 17 57,832,052 (GRCm39) missense probably benign 0.17
R0472:Vmn2r120 UTSW 17 57,831,518 (GRCm39) missense probably benign 0.03
R0517:Vmn2r120 UTSW 17 57,815,949 (GRCm39) missense probably damaging 1.00
R1109:Vmn2r120 UTSW 17 57,832,829 (GRCm39) missense probably benign 0.09
R1316:Vmn2r120 UTSW 17 57,832,939 (GRCm39) missense probably benign 0.28
R1543:Vmn2r120 UTSW 17 57,829,374 (GRCm39) missense probably benign 0.09
R1795:Vmn2r120 UTSW 17 57,832,038 (GRCm39) missense probably benign 0.35
R1850:Vmn2r120 UTSW 17 57,832,826 (GRCm39) missense probably benign 0.19
R1920:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R1921:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R1922:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R2063:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2064:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2065:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2067:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2286:Vmn2r120 UTSW 17 57,815,958 (GRCm39) missense probably damaging 1.00
R2291:Vmn2r120 UTSW 17 57,816,479 (GRCm39) missense probably damaging 1.00
R3416:Vmn2r120 UTSW 17 57,816,241 (GRCm39) missense possibly damaging 0.89
R3874:Vmn2r120 UTSW 17 57,831,954 (GRCm39) missense probably benign 0.40
R4023:Vmn2r120 UTSW 17 57,843,718 (GRCm39) missense possibly damaging 0.92
R4024:Vmn2r120 UTSW 17 57,843,718 (GRCm39) missense possibly damaging 0.92
R4409:Vmn2r120 UTSW 17 57,816,477 (GRCm39) missense probably damaging 1.00
R4610:Vmn2r120 UTSW 17 57,816,120 (GRCm39) missense probably damaging 1.00
R4771:Vmn2r120 UTSW 17 57,831,887 (GRCm39) missense probably damaging 1.00
R4786:Vmn2r120 UTSW 17 57,829,048 (GRCm39) missense probably benign 0.14
R4927:Vmn2r120 UTSW 17 57,816,125 (GRCm39) missense probably damaging 1.00
R5285:Vmn2r120 UTSW 17 57,843,703 (GRCm39) missense probably damaging 1.00
R5566:Vmn2r120 UTSW 17 57,852,290 (GRCm39) missense possibly damaging 0.95
R5578:Vmn2r120 UTSW 17 57,829,514 (GRCm39) missense probably benign 0.01
R5643:Vmn2r120 UTSW 17 57,831,977 (GRCm39) missense probably benign 0.01
R5644:Vmn2r120 UTSW 17 57,831,977 (GRCm39) missense probably benign 0.01
R5781:Vmn2r120 UTSW 17 57,831,938 (GRCm39) missense probably benign 0.00
R6084:Vmn2r120 UTSW 17 57,832,721 (GRCm39) missense probably benign 0.15
R6120:Vmn2r120 UTSW 17 57,832,973 (GRCm39) missense probably benign 0.02
R6160:Vmn2r120 UTSW 17 57,816,418 (GRCm39) missense probably benign 0.03
R6248:Vmn2r120 UTSW 17 57,852,287 (GRCm39) missense probably benign 0.03
R6256:Vmn2r120 UTSW 17 57,831,700 (GRCm39) nonsense probably null
R6730:Vmn2r120 UTSW 17 57,832,012 (GRCm39) missense probably benign 0.03
R6821:Vmn2r120 UTSW 17 57,843,659 (GRCm39) missense probably benign 0.00
R6868:Vmn2r120 UTSW 17 57,852,218 (GRCm39) missense probably benign 0.00
R6880:Vmn2r120 UTSW 17 57,816,187 (GRCm39) missense probably damaging 1.00
R6986:Vmn2r120 UTSW 17 57,816,340 (GRCm39) missense probably damaging 1.00
R7276:Vmn2r120 UTSW 17 57,831,881 (GRCm39) missense probably benign 0.11
R7373:Vmn2r120 UTSW 17 57,816,406 (GRCm39) missense probably benign 0.35
R7653:Vmn2r120 UTSW 17 57,816,258 (GRCm39) missense possibly damaging 0.93
R7667:Vmn2r120 UTSW 17 57,843,657 (GRCm39) missense probably benign 0.04
R7775:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7778:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7797:Vmn2r120 UTSW 17 57,815,874 (GRCm39) missense probably damaging 1.00
R7824:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7902:Vmn2r120 UTSW 17 57,816,244 (GRCm39) missense possibly damaging 0.87
R7922:Vmn2r120 UTSW 17 57,831,683 (GRCm39) missense probably damaging 0.99
R8508:Vmn2r120 UTSW 17 57,832,843 (GRCm39) missense probably benign 0.03
R8847:Vmn2r120 UTSW 17 57,816,217 (GRCm39) missense probably benign 0.01
R8882:Vmn2r120 UTSW 17 57,852,229 (GRCm39) missense probably benign 0.01
R9134:Vmn2r120 UTSW 17 57,832,093 (GRCm39) missense probably damaging 1.00
R9161:Vmn2r120 UTSW 17 57,831,864 (GRCm39) missense
R9336:Vmn2r120 UTSW 17 57,832,201 (GRCm39) missense possibly damaging 0.91
RF005:Vmn2r120 UTSW 17 57,828,991 (GRCm39) missense possibly damaging 0.65
Z1177:Vmn2r120 UTSW 17 57,816,245 (GRCm39) missense probably benign 0.00
Z1188:Vmn2r120 UTSW 17 57,829,436 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCTGGAAAGAGACTACTTAAATACCC -3'
(R):5'- GTTGGGATATTAATTCTGCAGTTCC -3'

Sequencing Primer
(F):5'- ATTAACCCACCTGTTTGTC -3'
(R):5'- GAGATATTTAGGAAAGTCAGGACATC -3'
Posted On 2015-07-07