Incidental Mutation 'R4349:Zfp605'
ID 328435
Institutional Source Beutler Lab
Gene Symbol Zfp605
Ensembl Gene ENSMUSG00000023284
Gene Name zinc finger protein 605
Synonyms A830023I12Rik
MMRRC Submission 041104-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R4349 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 110257958-110277660 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 110276552 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 557 (C557S)
Ref Sequence ENSEMBL: ENSMUSP00000108147 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086686] [ENSMUST00000112528] [ENSMUST00000147631]
AlphaFold E9QAH2
Predicted Effect probably damaging
Transcript: ENSMUST00000086686
AA Change: C557S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083891
Gene: ENSMUSG00000023284
AA Change: C557S

DomainStartEndE-ValueType
KRAB 6 66 3.75e-28 SMART
low complexity region 147 159 N/A INTRINSIC
ZnF_C2H2 200 222 1.36e-2 SMART
ZnF_C2H2 228 250 4.38e1 SMART
ZnF_C2H2 305 327 1.18e-2 SMART
ZnF_C2H2 333 355 5.14e-3 SMART
ZnF_C2H2 361 383 9.73e-4 SMART
ZnF_C2H2 389 411 4.99e1 SMART
ZnF_C2H2 443 465 5.4e1 SMART
ZnF_C2H2 471 493 1.3e-4 SMART
ZnF_C2H2 499 521 4.24e-4 SMART
ZnF_C2H2 527 549 1.95e-3 SMART
ZnF_C2H2 555 577 2.09e-3 SMART
ZnF_C2H2 583 605 1.2e-3 SMART
ZnF_C2H2 611 633 1.79e-2 SMART
ZnF_C2H2 639 661 2.53e-2 SMART
ZnF_C2H2 667 689 2.09e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000112528
AA Change: C557S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000108147
Gene: ENSMUSG00000023284
AA Change: C557S

DomainStartEndE-ValueType
KRAB 6 66 3.75e-28 SMART
low complexity region 147 159 N/A INTRINSIC
ZnF_C2H2 200 222 1.36e-2 SMART
ZnF_C2H2 228 250 4.38e1 SMART
ZnF_C2H2 305 327 1.18e-2 SMART
ZnF_C2H2 333 355 5.14e-3 SMART
ZnF_C2H2 361 383 9.73e-4 SMART
ZnF_C2H2 389 411 4.99e1 SMART
ZnF_C2H2 443 465 5.4e1 SMART
ZnF_C2H2 471 493 1.3e-4 SMART
ZnF_C2H2 499 521 4.24e-4 SMART
ZnF_C2H2 527 549 1.95e-3 SMART
ZnF_C2H2 555 577 2.09e-3 SMART
ZnF_C2H2 583 605 1.2e-3 SMART
ZnF_C2H2 611 633 1.79e-2 SMART
ZnF_C2H2 639 661 2.53e-2 SMART
ZnF_C2H2 667 689 2.09e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144089
Predicted Effect probably benign
Transcript: ENSMUST00000147631
SMART Domains Protein: ENSMUSP00000122236
Gene: ENSMUSG00000023284

DomainStartEndE-ValueType
KRAB 6 66 3.75e-28 SMART
Meta Mutation Damage Score 0.8922 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 97% (36/37)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd6 G T 1: 155,562,827 (GRCm39) R276L probably benign Het
Bahcc1 G A 11: 120,150,027 (GRCm39) R103Q probably damaging Het
Cd101 G A 3: 100,920,630 (GRCm39) T423M possibly damaging Het
Cdh20 A G 1: 104,906,814 (GRCm39) D547G probably damaging Het
Cntn3 T C 6: 102,176,312 (GRCm39) E801G probably damaging Het
Dzip1 T C 14: 119,120,938 (GRCm39) D673G probably benign Het
Enam T C 5: 88,651,407 (GRCm39) L972P probably damaging Het
Espl1 C A 15: 102,228,039 (GRCm39) T1630N probably benign Het
Fra10ac1 A G 19: 38,188,053 (GRCm39) S248P probably benign Het
Grik1 T C 16: 87,754,431 (GRCm39) R385G probably damaging Het
Gtpbp8 T A 16: 44,566,560 (GRCm39) probably null Het
Kif23 C T 9: 61,839,396 (GRCm39) V284M probably damaging Het
Klhdc7a A G 4: 139,693,588 (GRCm39) V453A possibly damaging Het
Klhl35 G A 7: 99,122,926 (GRCm39) V517M probably benign Het
Llgl1 C T 11: 60,600,394 (GRCm39) P581L probably benign Het
Marchf7 T C 2: 60,064,539 (GRCm39) S272P probably benign Het
Milr1 T C 11: 106,654,708 (GRCm39) S84P possibly damaging Het
Nrp2 A G 1: 62,777,576 (GRCm39) D127G probably damaging Het
Or12j5 A T 7: 140,084,270 (GRCm39) L34* probably null Het
Otog A T 7: 45,923,613 (GRCm39) Q1082L probably damaging Het
Pacsin1 G A 17: 27,925,978 (GRCm39) V107I possibly damaging Het
Pcnx2 T C 8: 126,489,590 (GRCm39) H1668R probably damaging Het
Pigv T C 4: 133,392,127 (GRCm39) T348A probably benign Het
Ptch1 C T 13: 63,682,143 (GRCm39) R537H probably damaging Het
Rbm25 A G 12: 83,721,947 (GRCm39) D711G probably damaging Het
Rnf31 AAC A 14: 55,838,555 (GRCm39) probably null Het
Sec24a G T 11: 51,605,976 (GRCm39) Q692K probably benign Het
Sidt2 C T 9: 45,857,011 (GRCm39) D205N possibly damaging Het
Skint10 T C 4: 112,626,968 (GRCm39) *113W probably null Het
Tet3 T C 6: 83,380,257 (GRCm39) E637G probably benign Het
Vmn2r94 T A 17: 18,464,605 (GRCm39) I562F probably benign Het
Zfp593 T C 4: 133,972,367 (GRCm39) T78A probably benign Het
Other mutations in Zfp605
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02388:Zfp605 APN 5 110,275,506 (GRCm39) missense possibly damaging 0.95
R0010:Zfp605 UTSW 5 110,275,400 (GRCm39) missense probably benign 0.03
R0357:Zfp605 UTSW 5 110,272,245 (GRCm39) missense probably benign
R0383:Zfp605 UTSW 5 110,276,720 (GRCm39) missense probably damaging 1.00
R1017:Zfp605 UTSW 5 110,275,860 (GRCm39) missense probably benign 0.42
R1663:Zfp605 UTSW 5 110,275,451 (GRCm39) missense probably benign 0.02
R1688:Zfp605 UTSW 5 110,276,907 (GRCm39) missense possibly damaging 0.83
R1752:Zfp605 UTSW 5 110,271,639 (GRCm39) missense probably damaging 1.00
R1994:Zfp605 UTSW 5 110,275,418 (GRCm39) missense probably damaging 1.00
R2173:Zfp605 UTSW 5 110,275,323 (GRCm39) missense probably benign 0.00
R3740:Zfp605 UTSW 5 110,276,564 (GRCm39) missense probably damaging 1.00
R3742:Zfp605 UTSW 5 110,276,564 (GRCm39) missense probably damaging 1.00
R3981:Zfp605 UTSW 5 110,275,604 (GRCm39) missense probably damaging 1.00
R4095:Zfp605 UTSW 5 110,275,602 (GRCm39) missense probably damaging 1.00
R4669:Zfp605 UTSW 5 110,275,227 (GRCm39) missense possibly damaging 0.94
R4914:Zfp605 UTSW 5 110,275,567 (GRCm39) nonsense probably null
R4994:Zfp605 UTSW 5 110,275,352 (GRCm39) missense probably damaging 1.00
R6672:Zfp605 UTSW 5 110,275,863 (GRCm39) missense probably damaging 1.00
R6814:Zfp605 UTSW 5 110,275,311 (GRCm39) missense probably benign 0.00
R6872:Zfp605 UTSW 5 110,275,311 (GRCm39) missense probably benign 0.00
R7251:Zfp605 UTSW 5 110,275,826 (GRCm39) missense probably damaging 1.00
R7395:Zfp605 UTSW 5 110,259,885 (GRCm39) start gained probably benign
R7560:Zfp605 UTSW 5 110,275,157 (GRCm39) nonsense probably null
R7623:Zfp605 UTSW 5 110,275,386 (GRCm39) missense probably benign 0.03
R7965:Zfp605 UTSW 5 110,275,316 (GRCm39) missense probably benign 0.00
R7999:Zfp605 UTSW 5 110,276,300 (GRCm39) missense probably damaging 1.00
R8307:Zfp605 UTSW 5 110,276,063 (GRCm39) missense probably damaging 1.00
R8355:Zfp605 UTSW 5 110,259,848 (GRCm39) start gained probably benign
R8455:Zfp605 UTSW 5 110,259,848 (GRCm39) start gained probably benign
X0063:Zfp605 UTSW 5 110,271,714 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ATGTTATGGCTTTGAAGAAGTCTTTT -3'
(R):5'- TCTGATAAGGTGTGACTTCTTGTTGA -3'

Sequencing Primer
(F):5'- ACATTCCCTGGAAGGTCATCG -3'
(R):5'- AAGTATAAGGTCTCTCTCCCGTATGG -3'
Posted On 2015-07-07