Incidental Mutation 'R4351:Lyn'
ID 328503
Institutional Source Beutler Lab
Gene Symbol Lyn
Ensembl Gene ENSMUSG00000042228
Gene Name LYN proto-oncogene, Src family tyrosine kinase
Synonyms Hck-2, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
MMRRC Submission 041106-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4351 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 3676865-3791612 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 3789796 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 443 (R443H)
Ref Sequence ENSEMBL: ENSMUSP00000100075 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041377] [ENSMUST00000103010]
AlphaFold P25911
Predicted Effect possibly damaging
Transcript: ENSMUST00000041377
AA Change: R464H

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000038838
Gene: ENSMUSG00000042228
AA Change: R464H

DomainStartEndE-ValueType
SH3 66 122 9.24e-21 SMART
SH2 127 217 5.38e-33 SMART
TyrKc 247 497 3.25e-137 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000103010
AA Change: R443H

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000100075
Gene: ENSMUSG00000042228
AA Change: R443H

DomainStartEndE-ValueType
SH3 45 101 5.8e-23 SMART
SH2 106 196 3.3e-35 SMART
TyrKc 226 476 1.6e-139 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137943
Meta Mutation Damage Score 0.4853 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 98% (42/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
PHENOTYPE: Homozygotes for targeted null mutations exhibit splenomegaly, reduced numbers of peripheral B cells, impaired immune responses, IgM hyperglobulinemia, autoimmunity with glomerulonephritis, and monocyte/macrophage tumors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 C T 6: 128,557,349 (GRCm39) A115T probably benign Het
Aak1 A G 6: 86,912,519 (GRCm39) probably null Het
Abtb2 T A 2: 103,513,738 (GRCm39) D382E possibly damaging Het
Adamts1 T A 16: 85,599,234 (GRCm39) D122V probably benign Het
Adcy6 A T 15: 98,502,041 (GRCm39) V191E probably benign Het
Adh1 A G 3: 137,986,258 (GRCm39) T82A probably benign Het
Ak6 C T 13: 100,792,111 (GRCm39) Q185* probably null Het
Aldh6a1 A G 12: 84,490,535 (GRCm39) Y27H probably benign Het
Apob A G 12: 8,043,054 (GRCm39) M812V probably benign Het
Arhgef10 C A 8: 15,041,145 (GRCm39) S748* probably null Het
Brd3 A T 2: 27,347,028 (GRCm39) Y369N probably damaging Het
Cracdl A G 1: 37,663,993 (GRCm39) F635S probably benign Het
Dhh A G 15: 98,796,099 (GRCm39) probably benign Het
Disp1 A G 1: 182,881,542 (GRCm39) V200A probably benign Het
Dvl3 T C 16: 20,344,394 (GRCm39) Y257H possibly damaging Het
Dzip1 T C 14: 119,120,938 (GRCm39) D673G probably benign Het
Evx1 A G 6: 52,290,846 (GRCm39) D6G probably damaging Het
Garin1b C G 6: 29,320,800 (GRCm39) I141M probably damaging Het
Gfy T C 7: 44,827,040 (GRCm39) E352G probably benign Het
Hars2 A G 18: 36,919,231 (GRCm39) E123G probably damaging Het
Hsd17b4 A T 18: 50,275,701 (GRCm39) D115V probably damaging Het
Mecom C A 3: 30,020,887 (GRCm39) V452L possibly damaging Het
Nckap1l A G 15: 103,395,246 (GRCm39) T909A probably damaging Het
Ncor1 A G 11: 62,301,644 (GRCm39) probably null Het
Nrp2 A G 1: 62,777,576 (GRCm39) D127G probably damaging Het
Or2v2 A G 11: 49,004,530 (GRCm39) S8P probably damaging Het
Or8g52 T A 9: 39,630,865 (GRCm39) M114K probably damaging Het
Prb1b T G 6: 132,290,624 (GRCm39) Y25S unknown Het
Ptch1 C T 13: 63,682,143 (GRCm39) R537H probably damaging Het
Rabgap1 A G 2: 37,373,794 (GRCm39) T269A probably benign Het
Rnf31 AAC A 14: 55,838,555 (GRCm39) probably null Het
Sptbn5 T C 2: 119,913,680 (GRCm39) noncoding transcript Het
Sst A G 16: 23,708,565 (GRCm39) S89P probably damaging Het
Tm2d3 A G 7: 65,344,939 (GRCm39) Y49C probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Wdr81 A G 11: 75,332,638 (GRCm39) L1921P probably damaging Het
Other mutations in Lyn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01752:Lyn APN 4 3,743,286 (GRCm39) missense probably benign
IGL02744:Lyn APN 4 3,738,808 (GRCm39) missense probably benign 0.00
IGL02860:Lyn APN 4 3,745,594 (GRCm39) missense possibly damaging 0.77
IGL03328:Lyn APN 4 3,745,327 (GRCm39) missense probably benign 0.01
IGL03370:Lyn APN 4 3,780,931 (GRCm39) missense possibly damaging 0.81
bibb UTSW 4 3,783,055 (GRCm39) missense probably damaging 1.00
butterhead UTSW 4 3,748,765 (GRCm39) missense probably benign 0.11
Cress UTSW 4 3,789,908 (GRCm39) nonsense probably null
Friede UTSW 4 3,789,834 (GRCm39) nonsense probably null
Kohlrabi UTSW 4 3,783,089 (GRCm39) missense possibly damaging 0.74
lechuga UTSW 4 3,783,050 (GRCm39) missense probably damaging 1.00
Lemon UTSW 4 3,746,768 (GRCm39) missense probably damaging 1.00
Pacific UTSW 4 3,745,330 (GRCm39) missense probably damaging 1.00
water UTSW 4 3,748,787 (GRCm39) missense possibly damaging 0.93
R0079:Lyn UTSW 4 3,746,768 (GRCm39) missense probably damaging 1.00
R0089:Lyn UTSW 4 3,748,768 (GRCm39) missense probably benign 0.23
R0582:Lyn UTSW 4 3,743,296 (GRCm39) missense probably damaging 1.00
R0747:Lyn UTSW 4 3,745,638 (GRCm39) splice site probably benign
R1460:Lyn UTSW 4 3,789,908 (GRCm39) nonsense probably null
R1615:Lyn UTSW 4 3,748,765 (GRCm39) missense probably benign 0.11
R1654:Lyn UTSW 4 3,789,912 (GRCm39) missense probably damaging 0.99
R1703:Lyn UTSW 4 3,738,867 (GRCm39) splice site probably null
R2301:Lyn UTSW 4 3,780,959 (GRCm39) missense probably damaging 1.00
R2421:Lyn UTSW 4 3,748,787 (GRCm39) missense possibly damaging 0.93
R2512:Lyn UTSW 4 3,745,542 (GRCm39) missense probably benign 0.01
R3418:Lyn UTSW 4 3,746,833 (GRCm39) missense probably damaging 0.97
R3419:Lyn UTSW 4 3,746,833 (GRCm39) missense probably damaging 0.97
R3701:Lyn UTSW 4 3,742,455 (GRCm39) missense probably benign
R3702:Lyn UTSW 4 3,742,455 (GRCm39) missense probably benign
R3736:Lyn UTSW 4 3,745,330 (GRCm39) missense probably damaging 1.00
R4350:Lyn UTSW 4 3,789,796 (GRCm39) missense probably damaging 0.99
R4352:Lyn UTSW 4 3,789,796 (GRCm39) missense probably damaging 0.99
R4649:Lyn UTSW 4 3,738,850 (GRCm39) missense probably benign
R5738:Lyn UTSW 4 3,782,987 (GRCm39) missense probably damaging 1.00
R5875:Lyn UTSW 4 3,745,631 (GRCm39) splice site probably null
R6375:Lyn UTSW 4 3,745,527 (GRCm39) missense probably damaging 1.00
R7029:Lyn UTSW 4 3,782,996 (GRCm39) missense probably damaging 0.98
R7621:Lyn UTSW 4 3,789,834 (GRCm39) nonsense probably null
R7726:Lyn UTSW 4 3,756,428 (GRCm39) nonsense probably null
R7940:Lyn UTSW 4 3,783,089 (GRCm39) missense possibly damaging 0.74
R8169:Lyn UTSW 4 3,783,050 (GRCm39) missense probably damaging 1.00
R8341:Lyn UTSW 4 3,743,304 (GRCm39) critical splice donor site probably null
R8782:Lyn UTSW 4 3,783,055 (GRCm39) missense probably damaging 1.00
R9056:Lyn UTSW 4 3,780,925 (GRCm39) missense possibly damaging 0.89
R9353:Lyn UTSW 4 3,746,804 (GRCm39) missense possibly damaging 0.71
R9567:Lyn UTSW 4 3,746,757 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCAACCTGTAAGTAGACTCAAGG -3'
(R):5'- TAGTTAGCTCCTCCAAGGCTG -3'

Sequencing Primer
(F):5'- GAGCAGGGCTTCTAAACT -3'
(R):5'- GCTGCTTTTCCAACTACCTACAATAG -3'
Posted On 2015-07-07