Incidental Mutation 'R4431:Vmn2r22'
ID 328614
Institutional Source Beutler Lab
Gene Symbol Vmn2r22
Ensembl Gene ENSMUSG00000095486
Gene Name vomeronasal 2, receptor 22
Synonyms EG546913
MMRRC Submission 041146-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R4431 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 123586717-123627594 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 123614817 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 258 (T258A)
Ref Sequence ENSEMBL: ENSMUSP00000132043 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170808]
AlphaFold E9Q7S8
Predicted Effect possibly damaging
Transcript: ENSMUST00000170808
AA Change: T258A

PolyPhen 2 Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000132043
Gene: ENSMUSG00000095486
AA Change: T258A

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 473 1.4e-32 PFAM
Pfam:NCD3G 517 570 2.2e-23 PFAM
Pfam:7tm_3 601 838 1.2e-54 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,056,182 (GRCm39) probably benign Het
2510039O18Rik T C 4: 148,026,022 (GRCm39) S181P probably benign Het
4930522L14Rik A T 5: 109,884,440 (GRCm39) C473S possibly damaging Het
4930523C07Rik A T 1: 159,872,149 (GRCm39) noncoding transcript Het
Aak1 A G 6: 86,963,300 (GRCm39) K910R unknown Het
Abca2 A G 2: 25,332,864 (GRCm39) D1521G probably benign Het
Adamts20 C A 15: 94,241,924 (GRCm39) D695Y probably damaging Het
Bag4 C T 8: 26,259,516 (GRCm39) A228T probably benign Het
Bltp3a A G 17: 28,104,905 (GRCm39) N533S probably damaging Het
Bspry T A 4: 62,400,904 (GRCm39) I132N possibly damaging Het
Cfap300 A G 9: 8,027,178 (GRCm39) V120A probably damaging Het
Cfh T C 1: 140,064,004 (GRCm39) Y424C probably damaging Het
Chd2 T C 7: 73,085,709 (GRCm39) R1642G possibly damaging Het
Chrm2 A G 6: 36,501,097 (GRCm39) D318G probably benign Het
Chrna4 A G 2: 180,670,413 (GRCm39) S448P probably damaging Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Dock8 T C 19: 25,042,754 (GRCm39) V112A probably benign Het
Fbxo42 C A 4: 140,927,861 (GRCm39) R714S probably damaging Het
Fmo1 G A 1: 162,661,281 (GRCm39) A334V possibly damaging Het
Gpr68 A T 12: 100,865,650 (GRCm39) probably benign Het
Gramd4 A G 15: 86,014,361 (GRCm39) K345R probably damaging Het
Gtpbp1 T G 15: 79,600,398 (GRCm39) S444A probably damaging Het
Ints12 T C 3: 132,808,242 (GRCm39) Y207H probably damaging Het
Kat2b-ps A T 5: 93,540,443 (GRCm39) noncoding transcript Het
Klhl25 T A 7: 75,515,162 (GRCm39) F23I probably damaging Het
Lamc1 A G 1: 153,097,274 (GRCm39) I1590T probably damaging Het
Lhfpl4 A G 6: 113,170,805 (GRCm39) I127T possibly damaging Het
Lrrc71 A G 3: 87,650,143 (GRCm39) S286P possibly damaging Het
Man1c1 A T 4: 134,430,329 (GRCm39) V151D probably damaging Het
Mipol1 G A 12: 57,350,310 (GRCm39) R36Q possibly damaging Het
Nuggc T A 14: 65,848,659 (GRCm39) W187R probably benign Het
Or4a71 A G 2: 89,357,987 (GRCm39) Y256H probably damaging Het
Pkhd1 G A 1: 20,593,538 (GRCm39) T1525I probably damaging Het
Pomp A G 5: 147,812,289 (GRCm39) E125G probably damaging Het
Ptar1 G T 19: 23,671,695 (GRCm39) G33C probably damaging Het
Ptpn3 A G 4: 57,235,355 (GRCm39) S335P probably damaging Het
Pus7 A G 5: 23,951,487 (GRCm39) Y521H probably benign Het
Shank1 C T 7: 43,969,076 (GRCm39) R324* probably null Het
Slc12a3 A T 8: 95,069,713 (GRCm39) I541F probably damaging Het
Slc12a9 G A 5: 137,319,775 (GRCm39) P580L probably benign Het
Spz1 A G 13: 92,711,837 (GRCm39) L213P probably damaging Het
Strn A G 17: 79,043,891 (GRCm39) V9A probably damaging Het
Sytl5 A T X: 9,826,262 (GRCm39) N412Y probably damaging Het
Tert T A 13: 73,775,594 (GRCm39) F115Y probably damaging Het
Tmem67 T A 4: 12,051,473 (GRCm39) N785I possibly damaging Het
Trf T C 9: 103,089,075 (GRCm39) N243S possibly damaging Het
Ttc3 T C 16: 94,211,817 (GRCm39) probably null Het
Vps13b A C 15: 35,770,899 (GRCm39) Q2114P probably damaging Het
Wdfy1 T A 1: 79,691,583 (GRCm39) R275* probably null Het
Wnt2b A G 3: 104,860,256 (GRCm39) L217S probably damaging Het
Other mutations in Vmn2r22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01024:Vmn2r22 APN 6 123,615,012 (GRCm39) missense probably damaging 1.00
IGL01764:Vmn2r22 APN 6 123,627,379 (GRCm39) critical splice donor site probably null
IGL02037:Vmn2r22 APN 6 123,626,026 (GRCm39) missense probably damaging 1.00
IGL02183:Vmn2r22 APN 6 123,614,963 (GRCm39) missense probably damaging 1.00
IGL02335:Vmn2r22 APN 6 123,615,051 (GRCm39) missense probably damaging 0.99
IGL02440:Vmn2r22 APN 6 123,614,364 (GRCm39) missense probably benign 0.00
IGL02663:Vmn2r22 APN 6 123,626,117 (GRCm39) missense probably benign 0.11
IGL03101:Vmn2r22 APN 6 123,614,295 (GRCm39) missense probably benign 0.09
R0266:Vmn2r22 UTSW 6 123,614,363 (GRCm39) missense probably damaging 0.99
R0348:Vmn2r22 UTSW 6 123,614,684 (GRCm39) missense probably damaging 1.00
R0780:Vmn2r22 UTSW 6 123,614,933 (GRCm39) missense probably damaging 1.00
R0849:Vmn2r22 UTSW 6 123,614,363 (GRCm39) missense probably damaging 0.99
R1074:Vmn2r22 UTSW 6 123,626,217 (GRCm39) missense probably benign 0.02
R1456:Vmn2r22 UTSW 6 123,614,624 (GRCm39) missense possibly damaging 0.86
R1719:Vmn2r22 UTSW 6 123,614,802 (GRCm39) missense possibly damaging 0.68
R1989:Vmn2r22 UTSW 6 123,614,500 (GRCm39) missense probably damaging 1.00
R2928:Vmn2r22 UTSW 6 123,614,402 (GRCm39) missense probably damaging 0.96
R2939:Vmn2r22 UTSW 6 123,614,594 (GRCm39) missense probably damaging 0.99
R3727:Vmn2r22 UTSW 6 123,627,584 (GRCm39) missense possibly damaging 0.70
R3782:Vmn2r22 UTSW 6 123,627,591 (GRCm39) nonsense probably null
R3873:Vmn2r22 UTSW 6 123,614,339 (GRCm39) missense possibly damaging 0.68
R4344:Vmn2r22 UTSW 6 123,614,756 (GRCm39) missense probably damaging 1.00
R4407:Vmn2r22 UTSW 6 123,614,913 (GRCm39) missense probably damaging 1.00
R4428:Vmn2r22 UTSW 6 123,614,817 (GRCm39) missense possibly damaging 0.47
R4430:Vmn2r22 UTSW 6 123,614,817 (GRCm39) missense possibly damaging 0.47
R4701:Vmn2r22 UTSW 6 123,627,428 (GRCm39) missense probably benign 0.00
R5274:Vmn2r22 UTSW 6 123,627,593 (GRCm39) start codon destroyed probably null 0.93
R5668:Vmn2r22 UTSW 6 123,614,873 (GRCm39) missense probably benign 0.06
R5776:Vmn2r22 UTSW 6 123,614,673 (GRCm39) missense probably damaging 1.00
R6416:Vmn2r22 UTSW 6 123,614,697 (GRCm39) missense probably damaging 1.00
R7788:Vmn2r22 UTSW 6 123,614,559 (GRCm39) missense not run
R8208:Vmn2r22 UTSW 6 123,614,444 (GRCm39) missense probably damaging 1.00
R8267:Vmn2r22 UTSW 6 123,615,000 (GRCm39) missense possibly damaging 0.81
R8400:Vmn2r22 UTSW 6 123,614,486 (GRCm39) nonsense probably null
R8814:Vmn2r22 UTSW 6 123,614,789 (GRCm39) missense probably damaging 0.96
R8850:Vmn2r22 UTSW 6 123,614,454 (GRCm39) missense probably damaging 1.00
R9613:Vmn2r22 UTSW 6 123,615,075 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CCAGAATTTGATCCATGCGATC -3'
(R):5'- TCAGGGAATTATTCAACTGCTGC -3'

Sequencing Primer
(F):5'- AGAAAATGATAATCCTCCACCAAAG -3'
(R):5'- AACTGCTGCTATACTTCACTTGGG -3'
Posted On 2015-07-21