Incidental Mutation 'R4431:Strn'
ID 328635
Institutional Source Beutler Lab
Gene Symbol Strn
Ensembl Gene ENSMUSG00000024077
Gene Name striatin, calmodulin binding protein
Synonyms
MMRRC Submission 041146-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.565) question?
Stock # R4431 (G1)
Quality Score 118
Status Validated
Chromosome 17
Chromosomal Location 78957327-79043990 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 79043891 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 9 (V9A)
Ref Sequence ENSEMBL: ENSMUSP00000120830 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000145910]
AlphaFold O55106
Predicted Effect probably damaging
Transcript: ENSMUST00000145910
AA Change: V9A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000120830
Gene: ENSMUSG00000024077
AA Change: V9A

DomainStartEndE-ValueType
low complexity region 17 45 N/A INTRINSIC
Pfam:Striatin 48 177 4.2e-50 PFAM
low complexity region 238 254 N/A INTRINSIC
low complexity region 331 348 N/A INTRINSIC
low complexity region 376 384 N/A INTRINSIC
low complexity region 412 429 N/A INTRINSIC
WD40 452 491 6.04e-8 SMART
WD40 505 544 2.42e-7 SMART
WD40 558 597 1.21e-7 SMART
WD40 646 692 1.28e1 SMART
WD40 695 734 4.4e-10 SMART
WD40 737 780 2.48e-4 SMART
Meta Mutation Damage Score 0.1167 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 100% (52/52)
MGI Phenotype PHENOTYPE: Mice heterozygous for a knock-out allele exhibit increased blood pressure and circulating aldosterone when fed a liberal salt diet. No mice could be generated that were homozygous for the allele. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,056,182 (GRCm39) probably benign Het
2510039O18Rik T C 4: 148,026,022 (GRCm39) S181P probably benign Het
4930522L14Rik A T 5: 109,884,440 (GRCm39) C473S possibly damaging Het
4930523C07Rik A T 1: 159,872,149 (GRCm39) noncoding transcript Het
Aak1 A G 6: 86,963,300 (GRCm39) K910R unknown Het
Abca2 A G 2: 25,332,864 (GRCm39) D1521G probably benign Het
Adamts20 C A 15: 94,241,924 (GRCm39) D695Y probably damaging Het
Bag4 C T 8: 26,259,516 (GRCm39) A228T probably benign Het
Bltp3a A G 17: 28,104,905 (GRCm39) N533S probably damaging Het
Bspry T A 4: 62,400,904 (GRCm39) I132N possibly damaging Het
Cfap300 A G 9: 8,027,178 (GRCm39) V120A probably damaging Het
Cfh T C 1: 140,064,004 (GRCm39) Y424C probably damaging Het
Chd2 T C 7: 73,085,709 (GRCm39) R1642G possibly damaging Het
Chrm2 A G 6: 36,501,097 (GRCm39) D318G probably benign Het
Chrna4 A G 2: 180,670,413 (GRCm39) S448P probably damaging Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Dock8 T C 19: 25,042,754 (GRCm39) V112A probably benign Het
Fbxo42 C A 4: 140,927,861 (GRCm39) R714S probably damaging Het
Fmo1 G A 1: 162,661,281 (GRCm39) A334V possibly damaging Het
Gpr68 A T 12: 100,865,650 (GRCm39) probably benign Het
Gramd4 A G 15: 86,014,361 (GRCm39) K345R probably damaging Het
Gtpbp1 T G 15: 79,600,398 (GRCm39) S444A probably damaging Het
Ints12 T C 3: 132,808,242 (GRCm39) Y207H probably damaging Het
Kat2b-ps A T 5: 93,540,443 (GRCm39) noncoding transcript Het
Klhl25 T A 7: 75,515,162 (GRCm39) F23I probably damaging Het
Lamc1 A G 1: 153,097,274 (GRCm39) I1590T probably damaging Het
Lhfpl4 A G 6: 113,170,805 (GRCm39) I127T possibly damaging Het
Lrrc71 A G 3: 87,650,143 (GRCm39) S286P possibly damaging Het
Man1c1 A T 4: 134,430,329 (GRCm39) V151D probably damaging Het
Mipol1 G A 12: 57,350,310 (GRCm39) R36Q possibly damaging Het
Nuggc T A 14: 65,848,659 (GRCm39) W187R probably benign Het
Or4a71 A G 2: 89,357,987 (GRCm39) Y256H probably damaging Het
Pkhd1 G A 1: 20,593,538 (GRCm39) T1525I probably damaging Het
Pomp A G 5: 147,812,289 (GRCm39) E125G probably damaging Het
Ptar1 G T 19: 23,671,695 (GRCm39) G33C probably damaging Het
Ptpn3 A G 4: 57,235,355 (GRCm39) S335P probably damaging Het
Pus7 A G 5: 23,951,487 (GRCm39) Y521H probably benign Het
Shank1 C T 7: 43,969,076 (GRCm39) R324* probably null Het
Slc12a3 A T 8: 95,069,713 (GRCm39) I541F probably damaging Het
Slc12a9 G A 5: 137,319,775 (GRCm39) P580L probably benign Het
Spz1 A G 13: 92,711,837 (GRCm39) L213P probably damaging Het
Sytl5 A T X: 9,826,262 (GRCm39) N412Y probably damaging Het
Tert T A 13: 73,775,594 (GRCm39) F115Y probably damaging Het
Tmem67 T A 4: 12,051,473 (GRCm39) N785I possibly damaging Het
Trf T C 9: 103,089,075 (GRCm39) N243S possibly damaging Het
Ttc3 T C 16: 94,211,817 (GRCm39) probably null Het
Vmn2r22 T C 6: 123,614,817 (GRCm39) T258A possibly damaging Het
Vps13b A C 15: 35,770,899 (GRCm39) Q2114P probably damaging Het
Wdfy1 T A 1: 79,691,583 (GRCm39) R275* probably null Het
Wnt2b A G 3: 104,860,256 (GRCm39) L217S probably damaging Het
Other mutations in Strn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00722:Strn APN 17 78,999,849 (GRCm39) missense possibly damaging 0.89
IGL02165:Strn APN 17 78,995,049 (GRCm39) missense probably damaging 1.00
IGL02424:Strn APN 17 78,991,780 (GRCm39) missense probably damaging 1.00
IGL02473:Strn APN 17 78,991,722 (GRCm39) missense possibly damaging 0.71
IGL03306:Strn APN 17 78,974,652 (GRCm39) missense probably damaging 0.98
R0053:Strn UTSW 17 78,964,363 (GRCm39) missense possibly damaging 0.92
R0053:Strn UTSW 17 78,964,363 (GRCm39) missense possibly damaging 0.92
R0165:Strn UTSW 17 78,984,803 (GRCm39) missense possibly damaging 0.89
R1156:Strn UTSW 17 78,964,360 (GRCm39) missense probably damaging 0.99
R1191:Strn UTSW 17 78,999,855 (GRCm39) missense possibly damaging 0.82
R1256:Strn UTSW 17 78,972,046 (GRCm39) critical splice donor site probably null
R1700:Strn UTSW 17 78,999,831 (GRCm39) missense probably damaging 1.00
R1878:Strn UTSW 17 78,984,755 (GRCm39) missense possibly damaging 0.81
R1897:Strn UTSW 17 78,990,271 (GRCm39) missense probably benign 0.01
R1912:Strn UTSW 17 78,991,824 (GRCm39) missense probably damaging 1.00
R1975:Strn UTSW 17 78,999,928 (GRCm39) splice site probably null
R2357:Strn UTSW 17 78,963,028 (GRCm39) missense probably damaging 1.00
R3054:Strn UTSW 17 78,990,321 (GRCm39) missense probably damaging 0.99
R3693:Strn UTSW 17 78,964,421 (GRCm39) missense probably damaging 1.00
R3694:Strn UTSW 17 78,964,421 (GRCm39) missense probably damaging 1.00
R3695:Strn UTSW 17 78,964,421 (GRCm39) missense probably damaging 1.00
R3941:Strn UTSW 17 78,965,369 (GRCm39) missense probably damaging 0.99
R4570:Strn UTSW 17 78,984,801 (GRCm39) missense possibly damaging 0.95
R4678:Strn UTSW 17 78,984,780 (GRCm39) missense probably damaging 1.00
R4729:Strn UTSW 17 78,965,390 (GRCm39) missense probably damaging 0.98
R4947:Strn UTSW 17 78,969,208 (GRCm39) missense probably damaging 0.98
R5470:Strn UTSW 17 78,964,374 (GRCm39) missense probably benign 0.01
R5710:Strn UTSW 17 78,995,028 (GRCm39) missense probably damaging 1.00
R5943:Strn UTSW 17 78,977,276 (GRCm39) missense probably damaging 0.96
R6173:Strn UTSW 17 79,008,298 (GRCm39) missense probably damaging 1.00
R6800:Strn UTSW 17 78,977,787 (GRCm39) intron probably benign
R6846:Strn UTSW 17 79,043,886 (GRCm39) missense probably damaging 0.97
R7716:Strn UTSW 17 78,963,204 (GRCm39) missense probably damaging 0.99
R7746:Strn UTSW 17 78,984,801 (GRCm39) missense probably benign 0.11
R7950:Strn UTSW 17 78,977,852 (GRCm39) missense
R7997:Strn UTSW 17 78,991,672 (GRCm39) missense probably benign 0.01
R8344:Strn UTSW 17 78,980,076 (GRCm39) missense probably damaging 1.00
R9074:Strn UTSW 17 79,043,790 (GRCm39) missense probably benign 0.00
R9523:Strn UTSW 17 78,967,575 (GRCm39) missense probably benign 0.17
R9538:Strn UTSW 17 78,972,219 (GRCm39) missense possibly damaging 0.68
RF006:Strn UTSW 17 78,984,700 (GRCm39) frame shift probably null
RF008:Strn UTSW 17 78,984,716 (GRCm39) frame shift probably null
RF017:Strn UTSW 17 78,984,717 (GRCm39) frame shift probably null
RF018:Strn UTSW 17 78,984,712 (GRCm39) frame shift probably null
RF031:Strn UTSW 17 78,984,706 (GRCm39) frame shift probably null
RF035:Strn UTSW 17 78,984,714 (GRCm39) frame shift probably null
RF036:Strn UTSW 17 78,984,706 (GRCm39) frame shift probably null
RF038:Strn UTSW 17 78,984,711 (GRCm39) frame shift probably null
RF039:Strn UTSW 17 78,984,707 (GRCm39) frame shift probably null
RF044:Strn UTSW 17 78,984,717 (GRCm39) frame shift probably null
RF045:Strn UTSW 17 78,984,711 (GRCm39) frame shift probably null
RF047:Strn UTSW 17 78,984,703 (GRCm39) frame shift probably null
RF047:Strn UTSW 17 78,984,699 (GRCm39) frame shift probably null
RF048:Strn UTSW 17 78,984,716 (GRCm39) frame shift probably null
X0022:Strn UTSW 17 79,008,378 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATTCTGGAAGTGATGGGCGC -3'
(R):5'- ACTACATTTCCCGGCAAGCC -3'

Sequencing Primer
(F):5'- GAGGGTCTTTACCTGCAGCTC -3'
(R):5'- AGTTGACCCACTTCCCGG -3'
Posted On 2015-07-21