Incidental Mutation 'R4432:Nmur1'
ID328638
Institutional Source Beutler Lab
Gene Symbol Nmur1
Ensembl Gene ENSMUSG00000026237
Gene Nameneuromedin U receptor 1
SynonymsGpr66, NMU1R, NmU-R, FM-3
MMRRC Submission 041701-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R4432 (G1)
Quality Score225
Status Validated
Chromosome1
Chromosomal Location86386303-86426228 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 86387565 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 160 (S160P)
Ref Sequence ENSEMBL: ENSMUSP00000148301 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027440] [ENSMUST00000212058] [ENSMUST00000212541] [ENSMUST00000212614]
Predicted Effect probably damaging
Transcript: ENSMUST00000027440
AA Change: S193P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027440
Gene: ENSMUSG00000026237
AA Change: S193P

DomainStartEndE-ValueType
Pfam:7tm_4 40 231 4.1e-8 PFAM
Pfam:7TM_GPCR_Srsx 48 349 2.6e-8 PFAM
Pfam:7tm_1 54 334 7.8e-50 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212058
AA Change: S216P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000212541
AA Change: S160P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000212614
Meta Mutation Damage Score 0.5073 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 100% (42/42)
MGI Phenotype PHENOTYPE: Homozygous null mice are healthy and viable. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430573F11Rik A T 8: 36,498,478 I51F probably damaging Het
Abca6 T C 11: 110,241,588 M294V probably benign Het
Abcc5 A T 16: 20,368,187 probably null Het
Acsm4 A C 7: 119,711,387 E499A probably damaging Het
Adamtsl4 T C 3: 95,681,759 probably null Het
Ank2 A T 3: 126,947,806 probably benign Het
Anks6 G A 4: 47,044,905 Q334* probably null Het
Cadps2 T A 6: 23,626,738 I155L probably damaging Het
Casp4 G A 9: 5,323,653 R74H probably damaging Het
Cdk14 A G 5: 5,036,427 W298R probably damaging Het
Chia1 A G 3: 106,115,325 N12D probably benign Het
Cyp3a59 A G 5: 146,104,786 D380G probably benign Het
Dnm2 T C 9: 21,491,304 probably benign Het
Dnm3 T C 1: 161,991,997 probably benign Het
Dpp4 A G 2: 62,345,112 Y660H probably damaging Het
Fam92b C A 8: 120,174,855 R37L probably damaging Het
H6pd T G 4: 149,995,758 Y202S probably damaging Het
Hnrnpa0 T C 13: 58,127,937 K126R probably benign Het
Insc C T 7: 114,769,055 probably benign Het
Lrrc45 G A 11: 120,715,221 probably null Het
Mapkap1 T C 2: 34,619,863 L263P probably damaging Het
Olfr1254 A T 2: 89,788,734 M206K possibly damaging Het
Olfr1288 T A 2: 111,479,412 C209* probably null Het
Pcdhb15 A G 18: 37,475,512 N599S probably damaging Het
Pcid2 T C 8: 13,085,421 D196G probably damaging Het
Pcolce2 T C 9: 95,681,557 F199L probably damaging Het
Phf11c A T 14: 59,390,935 N88K possibly damaging Het
Prl8a8 T A 13: 27,510,480 Y109F probably benign Het
Rasa2 A G 9: 96,542,407 probably benign Het
Samhd1 T C 2: 157,104,893 D558G probably damaging Het
Slc1a1 T C 19: 28,902,709 F263S probably benign Het
Slc27a3 G A 3: 90,387,340 T408M probably damaging Het
Slc4a7 T A 14: 14,757,323 N520K probably damaging Het
Szt2 A G 4: 118,384,231 S1679P probably damaging Het
Vmn1r218 T C 13: 23,137,242 F173S possibly damaging Het
Vmn2r32 T A 7: 7,479,919 N19Y probably damaging Het
Other mutations in Nmur1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00391:Nmur1 APN 1 86386471 missense probably damaging 0.99
IGL00494:Nmur1 APN 1 86386362 missense probably benign
IGL01420:Nmur1 APN 1 86387391 missense probably benign 0.01
IGL02505:Nmur1 APN 1 86386335 missense probably benign 0.00
R0391:Nmur1 UTSW 1 86387678 missense probably damaging 0.99
R1235:Nmur1 UTSW 1 86386693 missense probably damaging 1.00
R4213:Nmur1 UTSW 1 86387784 missense probably damaging 1.00
R4583:Nmur1 UTSW 1 86386645 missense possibly damaging 0.90
R4718:Nmur1 UTSW 1 86387741 missense probably damaging 0.99
R6027:Nmur1 UTSW 1 86387331 nonsense probably null
R7025:Nmur1 UTSW 1 86387848 missense possibly damaging 0.94
R7097:Nmur1 UTSW 1 86387508 missense probably damaging 1.00
R7173:Nmur1 UTSW 1 86386468 missense probably benign 0.00
R7436:Nmur1 UTSW 1 86386378 missense probably benign 0.04
R7601:Nmur1 UTSW 1 86388019 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATCCTTCTGTGGGAGGTCTC -3'
(R):5'- AATGTCACAGCCCTGAGTGTG -3'

Sequencing Primer
(F):5'- AGGTCTCCTGGGTTGCTGC -3'
(R):5'- CCCTGAGTGTGGAGCGTTATG -3'
Posted On2015-07-21