Incidental Mutation 'R4434:Cdc37l1'
ID 328781
Institutional Source Beutler Lab
Gene Symbol Cdc37l1
Ensembl Gene ENSMUSG00000024780
Gene Name cell division cycle 37-like 1
Synonyms 2700033A15Rik, Harc, Hsp90-associating relative of Cdc37
MMRRC Submission 041148-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4434 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 28967752-29004081 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 28985021 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 224 (F224L)
Ref Sequence ENSEMBL: ENSMUSP00000153192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050148] [ENSMUST00000223694] [ENSMUST00000224511] [ENSMUST00000224599] [ENSMUST00000225310] [ENSMUST00000225210]
AlphaFold Q9CZP7
Predicted Effect probably damaging
Transcript: ENSMUST00000050148
AA Change: F224L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000060421
Gene: ENSMUSG00000024780
AA Change: F224L

DomainStartEndE-ValueType
low complexity region 4 14 N/A INTRINSIC
low complexity region 21 40 N/A INTRINSIC
low complexity region 102 115 N/A INTRINSIC
CDC37_M 132 288 7.15e-80 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183196
Predicted Effect probably benign
Transcript: ENSMUST00000223694
Predicted Effect probably benign
Transcript: ENSMUST00000224092
Predicted Effect probably damaging
Transcript: ENSMUST00000224511
AA Change: F224L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect possibly damaging
Transcript: ENSMUST00000224599
AA Change: F224L

PolyPhen 2 Score 0.894 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000224830
Predicted Effect probably damaging
Transcript: ENSMUST00000225310
AA Change: F224L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000225210
AA Change: F224L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225598
Meta Mutation Damage Score 0.7650 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 A T 8: 111,781,253 (GRCm39) Q907L probably null Het
Adam6b A C 12: 113,454,281 (GRCm39) Q366P probably damaging Het
AI597479 C T 1: 43,139,959 (GRCm39) Q62* probably null Het
Akap9 T A 5: 4,082,708 (GRCm39) M1944K probably damaging Het
Akr1c19 T C 13: 4,292,615 (GRCm39) V212A probably benign Het
Ank3 C T 10: 69,822,900 (GRCm39) S523L probably damaging Het
Antxrl G A 14: 33,793,574 (GRCm39) probably benign Het
Arhgap21 A G 2: 20,972,146 (GRCm39) C26R probably benign Het
Csmd3 G A 15: 47,763,191 (GRCm39) T1215I possibly damaging Het
Dnah7c G A 1: 46,705,442 (GRCm39) R2485H probably damaging Het
Dnah9 T A 11: 65,998,901 (GRCm39) N1049I possibly damaging Het
Dnaja3 T G 16: 4,507,859 (GRCm39) Y120* probably null Het
Ehbp1l1 G T 19: 5,766,276 (GRCm39) R412S possibly damaging Het
Fam169a A G 13: 97,263,248 (GRCm39) D567G probably damaging Het
Gcnt4 T A 13: 97,082,850 (GRCm39) Y49N probably benign Het
Gm5849 T A 3: 90,685,182 (GRCm39) K1M probably null Het
Gngt1 A G 6: 3,994,282 (GRCm39) D20G probably benign Het
Gnptab A G 10: 88,248,484 (GRCm39) N104S probably damaging Het
Gpn3 A G 5: 122,520,115 (GRCm39) D223G probably benign Het
Hectd1 A T 12: 51,798,835 (GRCm39) I2095K probably damaging Het
Hephl1 C T 9: 14,988,092 (GRCm39) R672H probably damaging Het
Hpse2 A G 19: 43,282,708 (GRCm39) S182P probably benign Het
Itgb4 T A 11: 115,890,640 (GRCm39) S1109R probably benign Het
Itgbl1 A T 14: 124,209,611 (GRCm39) D330V probably damaging Het
Krt77 A T 15: 101,773,904 (GRCm39) V250E probably damaging Het
Mycbp2 T A 14: 103,371,225 (GRCm39) N4108Y probably damaging Het
Nampt T C 12: 32,888,362 (GRCm39) I171T probably damaging Het
Nckap5l A C 15: 99,320,744 (GRCm39) S1270A probably benign Het
Opa1 A G 16: 29,430,801 (GRCm39) I500M probably damaging Het
Or10j5 C T 1: 172,785,111 (GRCm39) H250Y probably damaging Het
Pax8 G A 2: 24,319,621 (GRCm39) P350L possibly damaging Het
Plxnb2 A G 15: 89,047,006 (GRCm39) C772R probably damaging Het
Prh1 A T 6: 132,548,841 (GRCm39) H116L unknown Het
Rgsl1 C T 1: 153,678,087 (GRCm39) A114T possibly damaging Het
Rln1 A T 19: 29,311,962 (GRCm39) F12Y possibly damaging Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Scube1 A T 15: 83,606,125 (GRCm39) I49N probably damaging Het
Shank3 C A 15: 89,387,562 (GRCm39) L244I probably damaging Het
Shc3 T C 13: 51,603,302 (GRCm39) T268A probably benign Het
Sp7 A G 15: 102,267,536 (GRCm39) L90P probably damaging Het
Tacc2 G A 7: 130,225,271 (GRCm39) S652N probably damaging Het
Tacstd2 A G 6: 67,512,128 (GRCm39) V188A possibly damaging Het
Tasor G A 14: 27,171,818 (GRCm39) probably null Het
Tex26 T C 5: 149,376,820 (GRCm39) S70P probably benign Het
Tmc4 C T 7: 3,675,006 (GRCm39) V222M probably benign Het
Tnc T C 4: 63,926,066 (GRCm39) T905A possibly damaging Het
Trim65 G A 11: 116,018,435 (GRCm39) Q253* probably null Het
Tuba3a A T 6: 125,258,506 (GRCm39) Y161* probably null Het
Zfand2b A G 1: 75,147,330 (GRCm39) S197G possibly damaging Het
Zfp109 T A 7: 23,928,771 (GRCm39) T213S probably benign Het
Zfp985 A C 4: 147,668,368 (GRCm39) D412A probably benign Het
Zswim3 T A 2: 164,662,563 (GRCm39) C348S probably benign Het
Other mutations in Cdc37l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02612:Cdc37l1 APN 19 28,993,502 (GRCm39) makesense probably null
R2260:Cdc37l1 UTSW 19 28,984,448 (GRCm39) missense probably benign 0.05
R4043:Cdc37l1 UTSW 19 28,968,028 (GRCm39) missense possibly damaging 0.83
R4437:Cdc37l1 UTSW 19 28,985,021 (GRCm39) missense probably damaging 1.00
R4438:Cdc37l1 UTSW 19 28,985,021 (GRCm39) missense probably damaging 1.00
R4829:Cdc37l1 UTSW 19 28,967,983 (GRCm39) missense probably benign
R5385:Cdc37l1 UTSW 19 28,989,343 (GRCm39) missense possibly damaging 0.95
R5537:Cdc37l1 UTSW 19 28,972,518 (GRCm39) missense probably damaging 1.00
R5906:Cdc37l1 UTSW 19 28,989,386 (GRCm39) missense probably benign 0.42
R7385:Cdc37l1 UTSW 19 28,968,071 (GRCm39) critical splice donor site probably null
R7610:Cdc37l1 UTSW 19 28,985,132 (GRCm39) missense possibly damaging 0.90
R9142:Cdc37l1 UTSW 19 28,989,402 (GRCm39) missense possibly damaging 0.86
R9317:Cdc37l1 UTSW 19 28,972,518 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGTAGGTAGTTATTCTGGTCCATG -3'
(R):5'- TACAATGTTAGCAGCCTCCTGG -3'

Sequencing Primer
(F):5'- CTGGTCCATGTAATAGCATTAAGATG -3'
(R):5'- GCTAACCAGCCTCCTGATGAG -3'
Posted On 2015-07-21