Incidental Mutation 'R4450:Dcp1b'
ID 328921
Institutional Source Beutler Lab
Gene Symbol Dcp1b
Ensembl Gene ENSMUSG00000041477
Gene Name decapping mRNA 1B
Synonyms B930050E02Rik
MMRRC Submission 041711-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.614) question?
Stock # R4450 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 119152214-119198575 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 119183437 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 175 (T175A)
Ref Sequence ENSEMBL: ENSMUSP00000108397 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073909] [ENSMUST00000112777]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000073909
AA Change: T175A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000073568
Gene: ENSMUSG00000041477
AA Change: T175A

DomainStartEndE-ValueType
low complexity region 2 8 N/A INTRINSIC
Pfam:DCP1 10 131 1.3e-53 PFAM
low complexity region 250 260 N/A INTRINSIC
low complexity region 451 462 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112777
AA Change: T175A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000108397
Gene: ENSMUSG00000041477
AA Change: T175A

DomainStartEndE-ValueType
low complexity region 2 8 N/A INTRINSIC
Pfam:DCP1 13 129 3e-46 PFAM
low complexity region 250 260 N/A INTRINSIC
low complexity region 451 462 N/A INTRINSIC
low complexity region 515 526 N/A INTRINSIC
Pfam:mRNA_decap_C 536 578 2.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136437
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149651
Meta Mutation Damage Score 0.0643 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 98% (43/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3930402G23Rik T A 8: 10,976,129 (GRCm39) noncoding transcript Het
Acsl6 A G 11: 54,219,229 (GRCm39) D278G probably damaging Het
Adamdec1 C T 14: 68,810,568 (GRCm39) R196Q probably benign Het
Akap13 T A 7: 75,392,508 (GRCm39) F2450L probably damaging Het
Alg11 C A 8: 22,558,095 (GRCm39) A469E probably benign Het
Angel1 A T 12: 86,768,698 (GRCm39) Y262N probably damaging Het
Arhgef18 A G 8: 3,487,097 (GRCm39) E272G probably damaging Het
Bpifb6 A G 2: 153,748,688 (GRCm39) E228G possibly damaging Het
Brca2 T G 5: 150,459,518 (GRCm39) D264E probably damaging Het
Cdca4 T C 12: 112,785,278 (GRCm39) N150S probably benign Het
Cep162 T C 9: 87,107,861 (GRCm39) S510G probably damaging Het
Cldn12 T C 5: 5,558,398 (GRCm39) T10A probably damaging Het
Clip2 C T 5: 134,531,807 (GRCm39) G631D possibly damaging Het
Col19a1 T A 1: 24,361,116 (GRCm39) T625S probably damaging Het
Col6a5 C T 9: 105,781,720 (GRCm39) G1635D unknown Het
Eln C T 5: 134,754,635 (GRCm39) probably benign Het
Galnt2 A G 8: 125,022,116 (GRCm39) D14G probably benign Het
Gm9894 T A 13: 67,913,199 (GRCm39) noncoding transcript Het
Herc2 T C 7: 55,877,640 (GRCm39) L4569P probably damaging Het
Iqcm T C 8: 76,356,394 (GRCm39) S176P probably damaging Het
Klhl42 G A 6: 146,993,169 (GRCm39) G47D probably benign Het
Lmo2 T C 2: 103,811,407 (GRCm39) Y147H probably damaging Het
Lzts2 A T 19: 45,012,032 (GRCm39) K154* probably null Het
Map4k3 C T 17: 80,911,411 (GRCm39) probably null Het
Mlc1 A G 15: 88,847,693 (GRCm39) F285S probably benign Het
Myo5a T A 9: 75,074,458 (GRCm39) M789K probably benign Het
Nbeal1 T A 1: 60,306,933 (GRCm39) S319T probably damaging Het
Nsun4 A T 4: 115,908,453 (GRCm39) Y702* probably null Het
Or8b52 A T 9: 38,577,050 (GRCm39) V30E probably benign Het
Or8g34 G A 9: 39,373,328 (GRCm39) M200I probably benign Het
Osbpl5 T A 7: 143,248,643 (GRCm39) T640S probably benign Het
Plaat1 C T 16: 29,046,976 (GRCm39) T165M possibly damaging Het
Rangrf A T 11: 68,866,010 (GRCm39) probably benign Het
Rnpc3 T C 3: 113,404,786 (GRCm39) probably benign Het
Ros1 C T 10: 51,954,038 (GRCm39) G1867D probably damaging Het
Slc11a1 C A 1: 74,424,694 (GRCm39) probably benign Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Speer3 C G 5: 13,846,394 (GRCm39) A238G possibly damaging Het
Syt6 A G 3: 103,492,961 (GRCm39) H156R probably benign Het
Tln2 C T 9: 67,251,347 (GRCm39) probably null Het
Trim58 T C 11: 58,542,191 (GRCm39) W384R probably benign Het
Wwc2 A G 8: 48,321,702 (GRCm39) Y471H unknown Het
Other mutations in Dcp1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:Dcp1b APN 6 119,192,319 (GRCm39) missense probably damaging 0.96
IGL01320:Dcp1b APN 6 119,192,036 (GRCm39) missense probably benign 0.29
IGL01348:Dcp1b APN 6 119,160,679 (GRCm39) missense probably damaging 1.00
IGL01635:Dcp1b APN 6 119,183,498 (GRCm39) missense probably damaging 1.00
IGL02888:Dcp1b APN 6 119,197,048 (GRCm39) utr 3 prime probably benign
IGL03280:Dcp1b APN 6 119,157,019 (GRCm39) intron probably benign
R1672:Dcp1b UTSW 6 119,194,872 (GRCm39) missense probably benign
R2395:Dcp1b UTSW 6 119,192,025 (GRCm39) missense probably benign
R2421:Dcp1b UTSW 6 119,192,227 (GRCm39) missense probably benign 0.28
R2512:Dcp1b UTSW 6 119,183,473 (GRCm39) missense possibly damaging 0.69
R2870:Dcp1b UTSW 6 119,191,735 (GRCm39) missense probably benign
R2870:Dcp1b UTSW 6 119,191,735 (GRCm39) missense probably benign
R5394:Dcp1b UTSW 6 119,152,328 (GRCm39) missense probably damaging 1.00
R5688:Dcp1b UTSW 6 119,194,872 (GRCm39) missense probably benign
R7734:Dcp1b UTSW 6 119,192,244 (GRCm39) missense probably benign 0.00
R7752:Dcp1b UTSW 6 119,152,318 (GRCm39) missense possibly damaging 0.64
R7847:Dcp1b UTSW 6 119,192,256 (GRCm39) missense probably benign
R8274:Dcp1b UTSW 6 119,160,612 (GRCm39) missense probably damaging 1.00
R8325:Dcp1b UTSW 6 119,192,397 (GRCm39) nonsense probably null
R9424:Dcp1b UTSW 6 119,196,993 (GRCm39) nonsense probably null
R9576:Dcp1b UTSW 6 119,196,993 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTTAAGTAAGCACATGGCCTCC -3'
(R):5'- GACTTTTGGGATAGCATTGGAAATG -3'

Sequencing Primer
(F):5'- AGCTCCCCAATAGCATGTGG -3'
(R):5'- TTGGGATAGCATTGGAAATGTAAATG -3'
Posted On 2015-07-21