Mutagenetix > Incidental Mutation

Incidental Mutation 'R4454:Nav2'

329086

Institutional Source

Beutler Lab

Gene Symbol

Nav2

Ensembl Gene

ENSMUSG00000052512

Gene Name

neuron navigator 2

Synonyms

Rainb1, HELAD1, Unc53H2, RAINB2, 5330421F07Rik, POMFIL2

MMRRC Submission

041714-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.483) question?

Stock #

R4454 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

48908716-49610090 bp(+) (GRCm38)

Type of Mutation

splice site (3 bp from exon)

DNA Base Change (assembly)

A to T at 49548544 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000139045 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064395] [ENSMUST00000064395] [ENSMUST00000183659] [ENSMUST00000183659] [ENSMUST00000184109] [ENSMUST00000184109] [ENSMUST00000184945] [ENSMUST00000184945]

AlphaFold

E9Q842

Predicted Effect

probably null
Transcript: ENSMUST00000064395

SMART Domains

Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000064395

SMART Domains

Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000183659

SMART Domains

Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
CH	23	126	6.19e-16	SMART
low complexity region	141	149	N/A	INTRINSIC
low complexity region	236	249	N/A	INTRINSIC
low complexity region	276	287	N/A	INTRINSIC
low complexity region	351	363	N/A	INTRINSIC
coiled coil region	425	455	N/A	INTRINSIC
low complexity region	519	530	N/A	INTRINSIC
low complexity region	552	564	N/A	INTRINSIC
low complexity region	579	601	N/A	INTRINSIC
low complexity region	785	796	N/A	INTRINSIC
low complexity region	859	883	N/A	INTRINSIC
low complexity region	886	906	N/A	INTRINSIC
low complexity region	929	943	N/A	INTRINSIC
low complexity region	1001	1013	N/A	INTRINSIC
low complexity region	1282	1299	N/A	INTRINSIC
low complexity region	1307	1324	N/A	INTRINSIC
low complexity region	1356	1371	N/A	INTRINSIC
low complexity region	1393	1405	N/A	INTRINSIC
low complexity region	1465	1479	N/A	INTRINSIC
low complexity region	1553	1567	N/A	INTRINSIC
coiled coil region	1569	1656	N/A	INTRINSIC
low complexity region	1728	1739	N/A	INTRINSIC
coiled coil region	1780	1848	N/A	INTRINSIC
AAA	2032	2186	1.69e-5	SMART
low complexity region	2343	2369	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000183659

SMART Domains

Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
CH	23	126	6.19e-16	SMART
low complexity region	141	149	N/A	INTRINSIC
low complexity region	236	249	N/A	INTRINSIC
low complexity region	276	287	N/A	INTRINSIC
low complexity region	351	363	N/A	INTRINSIC
coiled coil region	425	455	N/A	INTRINSIC
low complexity region	519	530	N/A	INTRINSIC
low complexity region	552	564	N/A	INTRINSIC
low complexity region	579	601	N/A	INTRINSIC
low complexity region	785	796	N/A	INTRINSIC
low complexity region	859	883	N/A	INTRINSIC
low complexity region	886	906	N/A	INTRINSIC
low complexity region	929	943	N/A	INTRINSIC
low complexity region	1001	1013	N/A	INTRINSIC
low complexity region	1282	1299	N/A	INTRINSIC
low complexity region	1307	1324	N/A	INTRINSIC
low complexity region	1356	1371	N/A	INTRINSIC
low complexity region	1393	1405	N/A	INTRINSIC
low complexity region	1465	1479	N/A	INTRINSIC
low complexity region	1553	1567	N/A	INTRINSIC
coiled coil region	1569	1656	N/A	INTRINSIC
low complexity region	1728	1739	N/A	INTRINSIC
coiled coil region	1780	1848	N/A	INTRINSIC
AAA	2032	2186	1.69e-5	SMART
low complexity region	2343	2369	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000184109

SMART Domains

Protein: ENSMUSP00000138846
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
low complexity region	154	171	N/A	INTRINSIC
low complexity region	179	196	N/A	INTRINSIC
low complexity region	228	243	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000184109

SMART Domains

Protein: ENSMUSP00000138846
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
low complexity region	154	171	N/A	INTRINSIC
low complexity region	179	196	N/A	INTRINSIC
low complexity region	228	243	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000184945

SMART Domains

Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000184945

SMART Domains

Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.3%

Validation Efficiency

100% (51/51)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010300C02Rik	T	C	1: 37,624,753 (GRCm38)	E163G	probably damaging	Het
AI481877	T	C	4: 59,092,383 (GRCm38)	D266G	possibly damaging	Het
Ap4e1	T	A	2: 127,047,141 (GRCm38)	F509I	probably damaging	Het
Asmt	A	T	X: 170,672,721 (GRCm38)	M19L	probably benign	Het
Atf6	C	T	1: 170,794,039 (GRCm38)	R471Q	probably damaging	Het
Atp4a	G	A	7: 30,720,225 (GRCm38)	R671Q	probably benign	Het
Baiap3	T	A	17: 25,249,536 (GRCm38)	D250V	probably damaging	Het
C2cd4d	T	A	3: 94,363,747 (GRCm38)	F107I	probably damaging	Het
Cdkn2d	C	G	9: 21,290,889 (GRCm38)	V21L	probably benign	Het
Cldn6	T	C	17: 23,681,086 (GRCm38)		probably null	Het
Cpa5	A	G	6: 30,626,324 (GRCm38)	N228S	possibly damaging	Het
Crocc	T	C	4: 141,020,405 (GRCm38)	S1478G	possibly damaging	Het
Csmd1	A	T	8: 15,945,011 (GRCm38)	C2675S	probably damaging	Het
Cthrc1	C	A	15: 39,077,013 (GRCm38)	Q4K	probably benign	Het
Ddo	A	T	10: 40,647,547 (GRCm38)	I178F	probably damaging	Het
Dmxl1	A	G	18: 49,893,332 (GRCm38)	T1836A	probably benign	Het
Dnah9	T	G	11: 66,147,389 (GRCm38)	Q107P	probably damaging	Het
Dusp26	A	G	8: 31,094,144 (GRCm38)	N93S	probably damaging	Het
Egr2	GAA	GA	10: 67,539,903 (GRCm38)		probably null	Het
Epha5	T	C	5: 84,156,444 (GRCm38)	I501V	probably damaging	Het
Eya1	C	T	1: 14,183,196 (GRCm38)	V519M	probably damaging	Het
Fam227b	T	A	2: 126,146,268 (GRCm38)		probably benign	Het
Fgd5	C	T	6: 91,989,186 (GRCm38)	S642F	probably damaging	Het
Fsip2	G	T	2: 82,990,776 (GRCm38)	A5618S	possibly damaging	Het
Gm12034	T	A	11: 20,446,476 (GRCm38)		noncoding transcript	Het
Gm13023	A	G	4: 143,792,824 (GRCm38)	S52G	probably benign	Het
Liph	T	C	16: 21,984,268 (GRCm38)	D17G	probably benign	Het
Mbd3	A	T	10: 80,393,983 (GRCm38)	L164H	probably damaging	Het
Med4	A	G	14: 73,518,062 (GRCm38)		probably benign	Het
Mslnl	G	A	17: 25,742,934 (GRCm38)	V128M	probably damaging	Het
Olfr728	T	C	14: 50,140,496 (GRCm38)	I48V	probably benign	Het
Olfr904	C	A	9: 38,464,642 (GRCm38)	F200L	probably benign	Het
Pcdha11	G	A	18: 37,007,373 (GRCm38)	G685D	probably benign	Het
Pgc	A	G	17: 47,732,410 (GRCm38)	I228V	probably benign	Het
Rad51	C	T	2: 119,131,568 (GRCm38)	H199Y	probably damaging	Het
Robo2	A	T	16: 74,352,519 (GRCm38)		probably benign	Het
Sap130	C	T	18: 31,711,360 (GRCm38)	T861I	probably damaging	Het
Sh3tc2	A	T	18: 62,007,773 (GRCm38)	D1061V	probably damaging	Het
Snapc3	A	G	4: 83,418,759 (GRCm38)	E119G	probably damaging	Het
Sspo	G	A	6: 48,487,225 (GRCm38)	G3862D	probably benign	Het
Tbc1d16	G	A	11: 119,157,873 (GRCm38)	T318M	possibly damaging	Het
Thrb	T	A	14: 18,011,187 (GRCm38)	W188R	probably damaging	Het
Thsd1	T	C	8: 22,243,578 (GRCm38)	Y214H	probably damaging	Het
Tnfrsf13b	T	C	11: 61,141,438 (GRCm38)	V98A	probably benign	Het
Topbp1	T	C	9: 103,344,871 (GRCm38)	Y1314H	probably damaging	Het
Ttn	T	C	2: 76,946,913 (GRCm38)	M1382V	probably benign	Het
Ttn	C	A	2: 76,785,806 (GRCm38)	V8271L	possibly damaging	Het
Utrn	G	T	10: 12,727,840 (GRCm38)	Q599K	possibly damaging	Het
Zfp995	G	A	17: 21,879,951 (GRCm38)	T434I	probably benign	Het
Zfy1	G	T	Y: 725,518 (GRCm38)	T749K	possibly damaging	Het

Other mutations in Nav2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01097:Nav2	APN	7	49,571,194 (GRCm38)	missense	probably damaging	1.00
IGL01150:Nav2	APN	7	49,452,521 (GRCm38)	missense	probably benign	0.17
IGL01649:Nav2	APN	7	49,575,729 (GRCm38)	missense	probably damaging	1.00
IGL01662:Nav2	APN	7	49,571,209 (GRCm38)	missense	probably damaging	1.00
IGL02297:Nav2	APN	7	49,594,229 (GRCm38)	missense	probably damaging	0.98
IGL02313:Nav2	APN	7	49,558,773 (GRCm38)	missense	probably damaging	0.99
IGL02441:Nav2	APN	7	49,452,512 (GRCm38)	missense	probably damaging	1.00
IGL02472:Nav2	APN	7	49,546,041 (GRCm38)	missense	probably damaging	1.00
IGL02477:Nav2	APN	7	49,582,875 (GRCm38)	missense	probably damaging	0.99
IGL02725:Nav2	APN	7	49,565,095 (GRCm38)	missense	probably damaging	1.00
IGL02944:Nav2	APN	7	49,420,256 (GRCm38)	missense	probably damaging	0.99
IGL02953:Nav2	APN	7	49,548,423 (GRCm38)	missense	probably damaging	1.00
IGL03105:Nav2	APN	7	49,464,879 (GRCm38)	missense	probably damaging	1.00
IGL03234:Nav2	APN	7	49,462,008 (GRCm38)	missense	possibly damaging	0.94
IGL03274:Nav2	APN	7	49,362,099 (GRCm38)	missense	probably damaging	1.00
IGL03294:Nav2	APN	7	49,491,457 (GRCm38)	nonsense	probably null
R0006:Nav2	UTSW	7	49,453,230 (GRCm38)	missense	possibly damaging	0.50
R0070:Nav2	UTSW	7	49,570,714 (GRCm38)	missense	probably damaging	1.00
R0113:Nav2	UTSW	7	49,535,953 (GRCm38)	missense	probably damaging	1.00
R0306:Nav2	UTSW	7	49,545,903 (GRCm38)	missense	probably benign	0.01
R0346:Nav2	UTSW	7	49,604,585 (GRCm38)	missense	probably benign	0.11
R0539:Nav2	UTSW	7	49,461,938 (GRCm38)	missense	probably damaging	1.00
R0669:Nav2	UTSW	7	49,408,683 (GRCm38)	missense	probably damaging	1.00
R0785:Nav2	UTSW	7	49,420,333 (GRCm38)	missense	probably benign	0.06
R0970:Nav2	UTSW	7	49,584,153 (GRCm38)	missense	probably damaging	1.00
R1162:Nav2	UTSW	7	49,536,040 (GRCm38)	splice site	probably benign
R1274:Nav2	UTSW	7	49,604,430 (GRCm38)	nonsense	probably null
R1463:Nav2	UTSW	7	49,535,962 (GRCm38)	missense	probably damaging	1.00
R1464:Nav2	UTSW	7	49,362,204 (GRCm38)	missense	probably damaging	1.00
R1464:Nav2	UTSW	7	49,362,204 (GRCm38)	missense	probably damaging	1.00
R1536:Nav2	UTSW	7	49,545,934 (GRCm38)	missense	probably damaging	1.00
R1612:Nav2	UTSW	7	49,571,211 (GRCm38)	missense	probably damaging	1.00
R1638:Nav2	UTSW	7	49,452,465 (GRCm38)	missense	probably benign
R1731:Nav2	UTSW	7	49,548,174 (GRCm38)	missense	probably damaging	1.00
R1734:Nav2	UTSW	7	49,575,720 (GRCm38)	missense	probably damaging	1.00
R1865:Nav2	UTSW	7	49,548,195 (GRCm38)	missense	possibly damaging	0.95
R1945:Nav2	UTSW	7	49,464,872 (GRCm38)	missense	probably damaging	1.00
R1997:Nav2	UTSW	7	49,548,471 (GRCm38)	missense	probably benign	0.16
R2061:Nav2	UTSW	7	49,598,897 (GRCm38)	splice site	probably benign
R2117:Nav2	UTSW	7	49,464,580 (GRCm38)	missense	probably benign	0.00
R2174:Nav2	UTSW	7	49,452,663 (GRCm38)	missense	probably damaging	0.99
R2182:Nav2	UTSW	7	49,597,254 (GRCm38)	missense	probably benign	0.38
R2251:Nav2	UTSW	7	49,453,277 (GRCm38)	missense	probably damaging	1.00
R2283:Nav2	UTSW	7	49,491,404 (GRCm38)	missense	probably damaging	1.00
R2343:Nav2	UTSW	7	49,598,817 (GRCm38)	missense	possibly damaging	0.82
R2472:Nav2	UTSW	7	49,408,884 (GRCm38)	missense	probably benign
R2568:Nav2	UTSW	7	49,597,564 (GRCm38)	missense	probably damaging	1.00
R2656:Nav2	UTSW	7	49,545,942 (GRCm38)	missense	probably damaging	1.00
R2964:Nav2	UTSW	7	49,557,032 (GRCm38)	missense	probably damaging	1.00
R2966:Nav2	UTSW	7	49,557,032 (GRCm38)	missense	probably damaging	1.00
R3817:Nav2	UTSW	7	49,464,562 (GRCm38)	missense	probably benign	0.00
R3834:Nav2	UTSW	7	49,545,858 (GRCm38)	missense	possibly damaging	0.91
R4207:Nav2	UTSW	7	49,597,231 (GRCm38)	missense	probably damaging	1.00
R4207:Nav2	UTSW	7	49,572,298 (GRCm38)	splice site	probably null
R4411:Nav2	UTSW	7	49,398,109 (GRCm38)	missense	probably benign	0.37
R4413:Nav2	UTSW	7	49,398,109 (GRCm38)	missense	probably benign	0.37
R4440:Nav2	UTSW	7	49,575,263 (GRCm38)	splice site	probably benign
R4440:Nav2	UTSW	7	49,552,037 (GRCm38)	missense	possibly damaging	0.86
R4729:Nav2	UTSW	7	49,452,819 (GRCm38)	missense	probably benign	0.17
R4801:Nav2	UTSW	7	49,545,852 (GRCm38)	missense	possibly damaging	0.94
R4802:Nav2	UTSW	7	49,545,852 (GRCm38)	missense	possibly damaging	0.94
R4824:Nav2	UTSW	7	49,409,001 (GRCm38)	intron	probably benign
R4887:Nav2	UTSW	7	49,548,434 (GRCm38)	nonsense	probably null
R4908:Nav2	UTSW	7	49,604,510 (GRCm38)	missense	probably damaging	1.00
R4952:Nav2	UTSW	7	49,304,540 (GRCm38)	intron	probably benign
R4965:Nav2	UTSW	7	49,552,877 (GRCm38)	nonsense	probably null
R5169:Nav2	UTSW	7	49,548,483 (GRCm38)	nonsense	probably null
R5224:Nav2	UTSW	7	49,551,725 (GRCm38)	missense	probably benign	0.00
R5249:Nav2	UTSW	7	49,535,913 (GRCm38)	missense	probably damaging	1.00
R5285:Nav2	UTSW	7	49,548,234 (GRCm38)	missense	probably damaging	1.00
R5314:Nav2	UTSW	7	49,408,692 (GRCm38)	small deletion	probably benign
R5320:Nav2	UTSW	7	49,491,373 (GRCm38)	missense	probably benign	0.00
R5377:Nav2	UTSW	7	49,589,160 (GRCm38)	missense	probably benign	0.02
R5471:Nav2	UTSW	7	49,548,169 (GRCm38)	missense	probably damaging	1.00
R5754:Nav2	UTSW	7	49,557,046 (GRCm38)	missense	probably damaging	1.00
R5832:Nav2	UTSW	7	49,548,069 (GRCm38)	splice site	probably null
R5884:Nav2	UTSW	7	49,597,169 (GRCm38)	nonsense	probably null
R5921:Nav2	UTSW	7	49,304,576 (GRCm38)	intron	probably benign
R6180:Nav2	UTSW	7	49,458,167 (GRCm38)	missense	probably benign	0.39
R6208:Nav2	UTSW	7	49,564,103 (GRCm38)	missense	probably damaging	0.99
R6373:Nav2	UTSW	7	49,453,175 (GRCm38)	missense	probably damaging	1.00
R6450:Nav2	UTSW	7	49,594,366 (GRCm38)	missense	probably damaging	1.00
R6522:Nav2	UTSW	7	49,597,533 (GRCm38)	missense	probably damaging	1.00
R6626:Nav2	UTSW	7	49,594,352 (GRCm38)	missense	probably damaging	1.00
R6695:Nav2	UTSW	7	49,464,904 (GRCm38)	missense	probably benign	0.04
R6705:Nav2	UTSW	7	49,551,916 (GRCm38)	missense	probably damaging	1.00
R6842:Nav2	UTSW	7	49,458,169 (GRCm38)	missense	possibly damaging	0.91
R6847:Nav2	UTSW	7	49,491,456 (GRCm38)	missense	probably benign	0.14
R7287:Nav2	UTSW	7	49,420,328 (GRCm38)	missense	probably benign	0.01
R7312:Nav2	UTSW	7	49,461,924 (GRCm38)	missense	possibly damaging	0.55
R7315:Nav2	UTSW	7	49,548,289 (GRCm38)	missense	possibly damaging	0.61
R7337:Nav2	UTSW	7	49,551,773 (GRCm38)	missense	possibly damaging	0.56
R7366:Nav2	UTSW	7	49,554,203 (GRCm38)	splice site	probably null
R7451:Nav2	UTSW	7	49,552,829 (GRCm38)	splice site	probably null
R7545:Nav2	UTSW	7	49,582,857 (GRCm38)	missense	probably damaging	1.00
R7706:Nav2	UTSW	7	49,594,319 (GRCm38)	missense	probably benign	0.35
R7730:Nav2	UTSW	7	49,572,397 (GRCm38)	missense	probably damaging	1.00
R7812:Nav2	UTSW	7	49,597,173 (GRCm38)	missense	probably benign	0.13
R8097:Nav2	UTSW	7	49,587,777 (GRCm38)	missense	probably damaging	1.00
R8110:Nav2	UTSW	7	49,551,950 (GRCm38)	nonsense	probably null
R8119:Nav2	UTSW	7	49,453,484 (GRCm38)	missense	probably damaging	0.99
R8298:Nav2	UTSW	7	49,554,261 (GRCm38)	critical splice donor site	probably null
R8306:Nav2	UTSW	7	49,546,017 (GRCm38)	missense	probably benign	0.33
R8331:Nav2	UTSW	7	49,452,623 (GRCm38)	missense	probably benign
R8402:Nav2	UTSW	7	49,453,437 (GRCm38)	missense	probably benign	0.43
R8421:Nav2	UTSW	7	49,452,521 (GRCm38)	missense	probably benign
R8478:Nav2	UTSW	7	49,461,985 (GRCm38)	missense	probably damaging	0.99
R8724:Nav2	UTSW	7	49,491,436 (GRCm38)	missense	possibly damaging	0.82
R8753:Nav2	UTSW	7	49,452,572 (GRCm38)	missense	probably benign
R8835:Nav2	UTSW	7	49,598,803 (GRCm38)	missense	possibly damaging	0.83
R8933:Nav2	UTSW	7	49,461,957 (GRCm38)	missense	probably damaging	1.00
R8957:Nav2	UTSW	7	49,571,216 (GRCm38)	missense	probably damaging	1.00
R9069:Nav2	UTSW	7	49,558,813 (GRCm38)	missense	probably damaging	0.99
R9095:Nav2	UTSW	7	49,604,545 (GRCm38)	missense	probably damaging	1.00
R9223:Nav2	UTSW	7	49,552,851 (GRCm38)	missense	probably damaging	1.00
R9261:Nav2	UTSW	7	49,597,156 (GRCm38)	missense	probably damaging	1.00
X0023:Nav2	UTSW	7	49,547,899 (GRCm38)	missense	possibly damaging	0.47
Z1177:Nav2	UTSW	7	49,594,223 (GRCm38)	missense	probably benign	0.01
Z1177:Nav2	UTSW	7	49,452,761 (GRCm38)	missense	possibly damaging	0.47

Predicted Primers

PCR Primer
(F):5'- TACCAGGGCTTGTCAACCAG -3'
(R):5'- ACTGTGGACTCCAATGAACAGTAAG -3'

Sequencing Primer
(F):5'- GTCAACCAGACGGACAAGG -3'
(R):5'- CCTTGAACTCAGCGTTAC -3'

Posted On

2015-07-21