Mutagenetix > Incidental Mutation

Incidental Mutation 'R4468:Rps6-ps2'

329276

Institutional Source

Beutler Lab

Gene Symbol

Rps6-ps2

Ensembl Gene

ENSMUSG00000056772

Gene Name

ribosomal protein S6, pseudogene 2

Synonyms

Gm16406

MMRRC Submission

041725-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.372) question?

Stock #

R4468 (G1)

Quality Score

139

Status

Validated

Chromosome

Chromosomal Location

89533019-89533765 bp(+) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

A to G at 89533319 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000079841

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.9%

Validation Efficiency

100% (39/39)

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aanat	A	T	11: 116,487,781 (GRCm39)	D160V	possibly damaging	Het
Abca2	A	G	2: 25,334,914 (GRCm39)	Y1962C	probably damaging	Het
Adgrv1	T	A	13: 81,522,375 (GRCm39)	M5921L	probably benign	Het
Bmp2	T	C	2: 133,396,374 (GRCm39)	V10A	probably benign	Het
Ccdc33	A	G	9: 57,937,235 (GRCm39)	S655P	possibly damaging	Het
Ccdc33	G	T	9: 57,977,155 (GRCm39)	T282K	possibly damaging	Het
Chd1	T	C	17: 15,980,657 (GRCm39)	I1308T	probably damaging	Het
Clec4f	A	G	6: 83,629,415 (GRCm39)	I381T	probably damaging	Het
Ifit1bl2	G	A	19: 34,596,468 (GRCm39)	Q383*	probably null	Het
Igkv6-15	A	G	6: 70,383,957 (GRCm39)	V7A	probably benign	Het
Kirrel1	C	T	3: 86,996,458 (GRCm39)	M380I	probably null	Het
Lancl2	T	A	6: 57,690,019 (GRCm39)	L75H	probably damaging	Het
Mtmr11	T	C	3: 96,075,207 (GRCm39)		probably benign	Het
Or12d14-ps1	A	G	17: 37,673,528 (GRCm39)	I170M	possibly damaging	Het
Or13c7	G	A	4: 43,854,737 (GRCm39)	V143M	probably benign	Het
Or7g29	C	T	9: 19,286,944 (GRCm39)	V78I	probably benign	Het
Pcdha5	T	C	18: 37,095,233 (GRCm39)	S581P	probably benign	Het
Phf10	T	C	17: 15,173,037 (GRCm39)		probably null	Het
Ppp2r3c	C	T	12: 55,344,668 (GRCm39)	W100*	probably null	Het
Prxl2b	T	G	4: 154,981,507 (GRCm39)	K190T	probably benign	Het
Pwwp3a	C	T	10: 80,076,570 (GRCm39)		probably benign	Het
Rad9a	G	A	19: 4,250,293 (GRCm39)	H143Y	probably benign	Het
Riox2	T	A	16: 59,296,357 (GRCm39)		probably benign	Het
Ros1	T	A	10: 51,994,452 (GRCm39)	Y1276F	probably damaging	Het
Rps12-ps24	A	G	8: 36,493,268 (GRCm39)		noncoding transcript	Het
Scn11a	G	A	9: 119,584,053 (GRCm39)	L1521F	probably damaging	Het
Shoc2	A	G	19: 54,014,845 (GRCm39)	Y346C	probably damaging	Het
Skp1	C	T	11: 52,135,905 (GRCm39)	T138I	probably benign	Het
Snx29	T	A	16: 11,238,565 (GRCm39)		probably null	Het
Sos1	A	G	17: 80,761,240 (GRCm39)	I152T	probably damaging	Het
Spag17	A	T	3: 99,992,682 (GRCm39)	D1726V	probably damaging	Het
Tns4	A	T	11: 98,961,241 (GRCm39)	C646S	probably benign	Het
Txndc11	T	C	16: 10,893,087 (GRCm39)	H881R	probably benign	Het
Wls	C	A	3: 159,578,564 (GRCm39)	A42E	probably damaging	Het

Other mutations in Rps6-ps2

Allele	Source	Chr	Coord	Type	Predicted Effect
R4091:Rps6-ps2	UTSW	8	89,533,319 (GRCm39)	exon	noncoding transcript
R4092:Rps6-ps2	UTSW	8	89,533,319 (GRCm39)	exon	noncoding transcript
R4461:Rps6-ps2	UTSW	8	89,533,319 (GRCm39)	exon	noncoding transcript
R4469:Rps6-ps2	UTSW	8	89,533,319 (GRCm39)	exon	noncoding transcript
R4653:Rps6-ps2	UTSW	8	89,533,319 (GRCm39)	exon	noncoding transcript
R4846:Rps6-ps2	UTSW	8	89,533,206 (GRCm39)	exon	noncoding transcript
R5687:Rps6-ps2	UTSW	8	89,533,112 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- AAGCTCCGCACCTTCTATG -3'
(R):5'- GCATACTGGCAGGCATCATC -3'

Sequencing Primer
(F):5'- TTCTATGAGAAACGCATGGCC -3'
(R):5'- CAGGCATCATCTTCTTTGGAGAG -3'

Posted On

2015-07-21