Incidental Mutation 'R4471:Glrp1'
ID 329402
Institutional Source Beutler Lab
Gene Symbol Glrp1
Ensembl Gene ENSMUSG00000062310
Gene Name glutamine repeat protein 1
Synonyms GRP-1
MMRRC Submission 041728-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R4471 (G1)
Quality Score 177
Status Not validated
Chromosome 1
Chromosomal Location 88499871-88510066 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 88503474 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 58 (Q58L)
Ref Sequence ENSEMBL: ENSMUSP00000063883 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067625]
AlphaFold E9Q9S8
Predicted Effect unknown
Transcript: ENSMUST00000067625
AA Change: Q58L
SMART Domains Protein: ENSMUSP00000063883
Gene: ENSMUSG00000062310
AA Change: Q58L

coiled coil region 26 58 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 99% (69/70)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk1 A G 3: 127,679,526 (GRCm38) S943P probably damaging Het
Ankdd1a T C 9: 65,503,509 (GRCm38) D398G probably damaging Het
Ankrd13b T A 11: 77,476,214 (GRCm38) K49M probably damaging Het
Asah1 A G 8: 41,343,724 (GRCm38) probably null Het
Cdc34b A G 11: 94,742,238 (GRCm38) E88G probably benign Het
Cdh2 T C 18: 16,774,476 (GRCm38) probably null Het
Ceacam1 T A 7: 25,474,600 (GRCm38) N210I possibly damaging Het
Celf3 A G 3: 94,488,278 (GRCm38) probably null Het
Cfap20dc A G 14: 8,536,571 (GRCm38) L212P probably damaging Het
Cmya5 A T 13: 93,092,325 (GRCm38) M2085K probably benign Het
Cpne6 G A 14: 55,516,632 (GRCm38) V469M probably damaging Het
Cyp2j12 A G 4: 96,133,069 (GRCm38) V100A probably benign Het
Dnajb4 A T 3: 152,185,162 (GRCm38) H333Q probably benign Het
Eif3f T C 7: 108,940,946 (GRCm38) V316A possibly damaging Het
Eml1 T C 12: 108,506,635 (GRCm38) probably benign Het
Ern1 C A 11: 106,420,042 (GRCm38) V302L possibly damaging Het
Fam110b A T 4: 5,799,092 (GRCm38) H170L probably benign Het
Fn3krp T G 11: 121,426,673 (GRCm38) D146E probably benign Het
Git1 A G 11: 77,499,824 (GRCm38) T129A probably benign Het
Gpatch2 A G 1: 187,233,140 (GRCm38) E281G probably damaging Het
Hipk2 T A 6: 38,736,922 (GRCm38) probably benign Het
Hydin A G 8: 110,587,132 (GRCm38) N4214S probably damaging Het
Icam5 T A 9: 21,035,506 (GRCm38) C443* probably null Het
Impdh1 G A 6: 29,204,632 (GRCm38) Q307* probably null Het
Ivns1abp C T 1: 151,361,239 (GRCm38) T447M probably benign Het
Lman1 A T 18: 65,991,726 (GRCm38) probably benign Het
Mdn1 A G 4: 32,668,860 (GRCm38) E306G probably benign Het
Msc G C 1: 14,755,678 (GRCm38) P24R probably damaging Het
Mtif2 T C 11: 29,540,053 (GRCm38) probably benign Het
Mvp C T 7: 127,001,958 (GRCm38) M1I probably null Het
Myh7 A T 14: 54,991,854 (GRCm38) Y162* probably null Het
Nemf G A 12: 69,314,442 (GRCm38) H956Y probably benign Het
Nktr T C 9: 121,748,896 (GRCm38) probably benign Het
Nrxn3 T C 12: 90,204,741 (GRCm38) S276P probably damaging Het
Or8d1 T C 9: 38,855,631 (GRCm38) S190P probably damaging Het
Patj A G 4: 98,535,579 (GRCm38) K621E probably damaging Het
Prss2 A G 6: 41,522,846 (GRCm38) I24V probably damaging Het
R3hcc1l T C 19: 42,582,820 (GRCm38) probably benign Het
Rest T C 5: 77,281,180 (GRCm38) V482A probably benign Het
Rexo1 A T 10: 80,542,658 (GRCm38) S476T probably damaging Het
Rin2 C T 2: 145,860,446 (GRCm38) T354I probably benign Het
Slc16a3 T C 11: 120,955,948 (GRCm38) probably benign Het
Slc5a4b G A 10: 76,058,891 (GRCm38) Q594* probably null Het
Slk T G 19: 47,615,423 (GRCm38) V202G probably damaging Het
Smarca2 T A 19: 26,619,877 (GRCm38) V53D possibly damaging Het
Snrnp200 T A 2: 127,238,753 (GRCm38) V2036E probably benign Het
Sox5 A G 6: 143,844,765 (GRCm38) M523T possibly damaging Het
Syt17 A G 7: 118,436,817 (GRCm38) probably null Het
Taf2 T C 15: 55,058,880 (GRCm38) D337G possibly damaging Het
Tcstv2a G T 13: 120,264,043 (GRCm38) R81L probably benign Het
Tecrl A G 5: 83,313,287 (GRCm38) Y108H probably benign Het
Tln1 A T 4: 43,551,018 (GRCm38) F409L probably benign Het
Tmem59l A G 8: 70,487,301 (GRCm38) L6S unknown Het
Ttc23 G A 7: 67,670,156 (GRCm38) R187Q probably benign Het
Ttl T C 2: 129,082,057 (GRCm38) V230A probably benign Het
Ube2u G A 4: 100,481,646 (GRCm38) W36* probably null Het
Ube4a A T 9: 44,946,532 (GRCm38) probably benign Het
Ulk1 C T 5: 110,789,357 (GRCm38) R691Q probably benign Het
Unc45a A G 7: 80,332,980 (GRCm38) I399T possibly damaging Het
Utp25 C T 1: 193,130,137 (GRCm38) R5Q possibly damaging Het
Wdr59 A C 8: 111,466,787 (GRCm38) probably null Het
Zfp24 A G 18: 24,018,115 (GRCm38) probably benign Het
Zfp777 A T 6: 48,042,107 (GRCm38) W342R probably damaging Het
Zfp979 A T 4: 147,613,456 (GRCm38) C265* probably null Het
Zzef1 T A 11: 72,913,331 (GRCm38) L2633Q probably damaging Het
Other mutations in Glrp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02890:Glrp1 APN 1 88,509,788 (GRCm38) splice site probably null
IGL02997:Glrp1 APN 1 88,509,785 (GRCm38) splice site probably benign
R1824:Glrp1 UTSW 1 88,509,789 (GRCm38) critical splice donor site probably null
R2852:Glrp1 UTSW 1 88,503,275 (GRCm38) small insertion probably benign
R3155:Glrp1 UTSW 1 88,503,254 (GRCm38) missense unknown
R3156:Glrp1 UTSW 1 88,503,254 (GRCm38) missense unknown
R4371:Glrp1 UTSW 1 88,503,275 (GRCm38) small insertion probably benign
R5183:Glrp1 UTSW 1 88,509,852 (GRCm38) missense unknown
R5206:Glrp1 UTSW 1 88,503,275 (GRCm38) small deletion probably benign
R5396:Glrp1 UTSW 1 88,503,344 (GRCm38) small deletion probably benign
R6223:Glrp1 UTSW 1 88,503,442 (GRCm38) nonsense probably null
R7019:Glrp1 UTSW 1 88,503,168 (GRCm38) missense unknown
R7209:Glrp1 UTSW 1 88,503,282 (GRCm38) missense unknown
R8514:Glrp1 UTSW 1 88,503,320 (GRCm38) small deletion probably benign
Z1177:Glrp1 UTSW 1 88,509,802 (GRCm38) missense not run
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-07-21