|Institutional Source||Beutler Lab|
|Gene Name||cadherin 2|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R4471 (G1)|
|Chromosomal Location||16588877-16809246 bp(-) (GRCm38)|
|Type of Mutation||intron (32 bp from exon)|
|DNA Base Change (assembly)||T to C at 16774476 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000025166 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000025166]|
|Predicted Effect||probably null
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||99% (69/70)|
FUNCTION: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Mice lacking the encoded protein exhibit severe developmental defects resulting in embryonic death. [provided by RefSeq, Oct 2015]
PHENOTYPE: Homozygous mutation of this gene results in death by E10. Mutant embryos exhibit several developmental abnormalities such as growth retardation, an enlarged heart, distended pericardial sacs, abnormal heart tube, wavy neural tube, irregular somite shape,and abnormal embryo turning. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cdh2||
(F):5'- GCGTCTGTCTAAAGTTTCTCGG -3'
(R):5'- TCTTAGTAGAAGGAGGCAGCAATC -3'
(F):5'- GTTTCTCGGTATAAACTGAACAAGG -3'
(R):5'- AATCATTGCCCACATTTTTCTCTTG -3'