Incidental Mutation 'R4471:Slk'
ID 329467
Institutional Source Beutler Lab
Gene Symbol Slk
Ensembl Gene ENSMUSG00000025060
Gene Name STE20-like kinase
Synonyms Etk4, Stk2, 9A2, SLK, mSLK
MMRRC Submission 041728-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4471 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 47568458-47633685 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 47603862 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 202 (V202G)
Ref Sequence ENSEMBL: ENSMUSP00000026043 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026043] [ENSMUST00000051691]
AlphaFold O54988
Predicted Effect probably damaging
Transcript: ENSMUST00000026043
AA Change: V202G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000026043
Gene: ENSMUSG00000025060
AA Change: V202G

DomainStartEndE-ValueType
S_TKc 34 292 3.18e-99 SMART
low complexity region 305 328 N/A INTRINSIC
low complexity region 442 452 N/A INTRINSIC
low complexity region 585 600 N/A INTRINSIC
low complexity region 690 703 N/A INTRINSIC
low complexity region 783 795 N/A INTRINSIC
Pfam:PKK 849 928 1.2e-19 PFAM
Pfam:PKK 986 1127 7.4e-49 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000051691
AA Change: V202G

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000049977
Gene: ENSMUSG00000025060
AA Change: V202G

DomainStartEndE-ValueType
S_TKc 34 292 3.18e-99 SMART
low complexity region 305 328 N/A INTRINSIC
low complexity region 442 452 N/A INTRINSIC
low complexity region 585 600 N/A INTRINSIC
low complexity region 690 703 N/A INTRINSIC
low complexity region 783 795 N/A INTRINSIC
Pfam:PKK 850 988 1.6e-40 PFAM
Pfam:PKK 1018 1158 1.2e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136557
Meta Mutation Damage Score 0.8267 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 99% (69/70)
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trapped allele die by E14.5, exhibiting severe developmental defects, impaired neuronal and skeletal muscle development, abnormal placental differentiation and vascularization, and increased apoptosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk1 A G 3: 127,473,175 (GRCm39) S943P probably damaging Het
Ankdd1a T C 9: 65,410,791 (GRCm39) D398G probably damaging Het
Ankrd13b T A 11: 77,367,040 (GRCm39) K49M probably damaging Het
Asah1 A G 8: 41,796,761 (GRCm39) probably null Het
Cdc34b A G 11: 94,633,064 (GRCm39) E88G probably benign Het
Cdh2 T C 18: 16,907,533 (GRCm39) probably null Het
Ceacam1 T A 7: 25,174,025 (GRCm39) N210I possibly damaging Het
Celf3 A G 3: 94,395,585 (GRCm39) probably null Het
Cfap20dc A G 14: 8,536,571 (GRCm38) L212P probably damaging Het
Cmya5 A T 13: 93,228,833 (GRCm39) M2085K probably benign Het
Cpne6 G A 14: 55,754,089 (GRCm39) V469M probably damaging Het
Cyp2j12 A G 4: 96,021,306 (GRCm39) V100A probably benign Het
Dnajb4 A T 3: 151,890,799 (GRCm39) H333Q probably benign Het
Eif3f T C 7: 108,540,153 (GRCm39) V316A possibly damaging Het
Eml1 T C 12: 108,472,894 (GRCm39) probably benign Het
Ern1 C A 11: 106,310,868 (GRCm39) V302L possibly damaging Het
Fam110b A T 4: 5,799,092 (GRCm39) H170L probably benign Het
Fn3krp T G 11: 121,317,499 (GRCm39) D146E probably benign Het
Git1 A G 11: 77,390,650 (GRCm39) T129A probably benign Het
Glrp1 T A 1: 88,431,196 (GRCm39) Q58L unknown Het
Gpatch2 A G 1: 186,965,337 (GRCm39) E281G probably damaging Het
Hipk2 T A 6: 38,713,857 (GRCm39) probably benign Het
Hydin A G 8: 111,313,764 (GRCm39) N4214S probably damaging Het
Icam5 T A 9: 20,946,802 (GRCm39) C443* probably null Het
Impdh1 G A 6: 29,204,631 (GRCm39) Q307* probably null Het
Ivns1abp C T 1: 151,236,990 (GRCm39) T447M probably benign Het
Lman1 A T 18: 66,124,797 (GRCm39) probably benign Het
Mdn1 A G 4: 32,668,860 (GRCm39) E306G probably benign Het
Msc G C 1: 14,825,902 (GRCm39) P24R probably damaging Het
Mtif2 T C 11: 29,490,053 (GRCm39) probably benign Het
Mvp C T 7: 126,601,130 (GRCm39) M1I probably null Het
Myh7 A T 14: 55,229,311 (GRCm39) Y162* probably null Het
Nemf G A 12: 69,361,216 (GRCm39) H956Y probably benign Het
Nktr T C 9: 121,577,962 (GRCm39) probably benign Het
Nrxn3 T C 12: 90,171,515 (GRCm39) S276P probably damaging Het
Or8d1 T C 9: 38,766,927 (GRCm39) S190P probably damaging Het
Patj A G 4: 98,423,816 (GRCm39) K621E probably damaging Het
Prss2 A G 6: 41,499,780 (GRCm39) I24V probably damaging Het
R3hcc1l T C 19: 42,571,259 (GRCm39) probably benign Het
Rest T C 5: 77,429,027 (GRCm39) V482A probably benign Het
Rexo1 A T 10: 80,378,492 (GRCm39) S476T probably damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Slc16a3 T C 11: 120,846,774 (GRCm39) probably benign Het
Slc5a4b G A 10: 75,894,725 (GRCm39) Q594* probably null Het
Smarca2 T A 19: 26,597,277 (GRCm39) V53D possibly damaging Het
Snrnp200 T A 2: 127,080,673 (GRCm39) V2036E probably benign Het
Sox5 A G 6: 143,790,491 (GRCm39) M523T possibly damaging Het
Syt17 A G 7: 118,036,040 (GRCm39) probably null Het
Taf2 T C 15: 54,922,276 (GRCm39) D337G possibly damaging Het
Tcstv2a G T 13: 120,725,579 (GRCm39) R81L probably benign Het
Tecrl A G 5: 83,461,134 (GRCm39) Y108H probably benign Het
Tln1 A T 4: 43,551,018 (GRCm39) F409L probably benign Het
Tmem59l A G 8: 70,939,951 (GRCm39) L6S unknown Het
Ttc23 G A 7: 67,319,904 (GRCm39) R187Q probably benign Het
Ttl T C 2: 128,923,977 (GRCm39) V230A probably benign Het
Ube2u G A 4: 100,338,843 (GRCm39) W36* probably null Het
Ube4a A T 9: 44,857,830 (GRCm39) probably benign Het
Ulk1 C T 5: 110,937,223 (GRCm39) R691Q probably benign Het
Unc45a A G 7: 79,982,728 (GRCm39) I399T possibly damaging Het
Utp25 C T 1: 192,812,445 (GRCm39) R5Q possibly damaging Het
Wdr59 A C 8: 112,193,419 (GRCm39) probably null Het
Zfp24 A G 18: 24,151,172 (GRCm39) probably benign Het
Zfp777 A T 6: 48,019,041 (GRCm39) W342R probably damaging Het
Zfp979 A T 4: 147,697,913 (GRCm39) C265* probably null Het
Zzef1 T A 11: 72,804,157 (GRCm39) L2633Q probably damaging Het
Other mutations in Slk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00488:Slk APN 19 47,608,148 (GRCm39) missense probably benign 0.00
IGL00515:Slk APN 19 47,630,535 (GRCm39) unclassified probably benign
IGL00755:Slk APN 19 47,597,449 (GRCm39) missense probably damaging 0.99
IGL00990:Slk APN 19 47,568,691 (GRCm39) missense probably damaging 0.98
IGL02283:Slk APN 19 47,630,432 (GRCm39) missense probably damaging 1.00
R0140:Slk UTSW 19 47,610,774 (GRCm39) missense probably damaging 1.00
R0364:Slk UTSW 19 47,608,628 (GRCm39) nonsense probably null
R0944:Slk UTSW 19 47,597,432 (GRCm39) missense probably damaging 1.00
R1756:Slk UTSW 19 47,611,116 (GRCm39) missense probably damaging 0.97
R1795:Slk UTSW 19 47,608,973 (GRCm39) missense possibly damaging 0.72
R1869:Slk UTSW 19 47,613,891 (GRCm39) missense probably damaging 1.00
R1980:Slk UTSW 19 47,600,428 (GRCm39) missense probably damaging 1.00
R2261:Slk UTSW 19 47,625,791 (GRCm39) missense probably damaging 0.99
R2278:Slk UTSW 19 47,608,188 (GRCm39) missense probably damaging 0.97
R3746:Slk UTSW 19 47,608,248 (GRCm39) missense possibly damaging 0.88
R3748:Slk UTSW 19 47,608,248 (GRCm39) missense possibly damaging 0.88
R3749:Slk UTSW 19 47,608,248 (GRCm39) missense possibly damaging 0.88
R3750:Slk UTSW 19 47,608,248 (GRCm39) missense possibly damaging 0.88
R4024:Slk UTSW 19 47,610,809 (GRCm39) splice site probably null
R4647:Slk UTSW 19 47,608,713 (GRCm39) missense possibly damaging 0.71
R4825:Slk UTSW 19 47,608,395 (GRCm39) missense probably benign
R5205:Slk UTSW 19 47,613,899 (GRCm39) missense possibly damaging 0.91
R5228:Slk UTSW 19 47,613,771 (GRCm39) missense probably damaging 1.00
R5372:Slk UTSW 19 47,613,832 (GRCm39) missense probably damaging 1.00
R5665:Slk UTSW 19 47,624,896 (GRCm39) missense probably damaging 1.00
R5688:Slk UTSW 19 47,608,451 (GRCm39) missense probably benign 0.00
R5859:Slk UTSW 19 47,597,481 (GRCm39) missense probably benign 0.37
R6279:Slk UTSW 19 47,630,443 (GRCm39) missense probably damaging 1.00
R6368:Slk UTSW 19 47,608,622 (GRCm39) missense possibly damaging 0.85
R6431:Slk UTSW 19 47,609,327 (GRCm39) missense probably damaging 1.00
R6563:Slk UTSW 19 47,624,908 (GRCm39) critical splice donor site probably null
R6705:Slk UTSW 19 47,597,498 (GRCm39) missense probably benign 0.01
R6790:Slk UTSW 19 47,624,007 (GRCm39) missense probably damaging 0.96
R7495:Slk UTSW 19 47,627,417 (GRCm39) missense probably damaging 1.00
R7598:Slk UTSW 19 47,624,901 (GRCm39) missense probably damaging 1.00
R7728:Slk UTSW 19 47,609,255 (GRCm39) missense probably damaging 1.00
R7850:Slk UTSW 19 47,610,796 (GRCm39) missense probably damaging 1.00
R7860:Slk UTSW 19 47,630,510 (GRCm39) missense possibly damaging 0.65
R7911:Slk UTSW 19 47,603,668 (GRCm39) missense
R8000:Slk UTSW 19 47,597,344 (GRCm39) missense
R8847:Slk UTSW 19 47,607,632 (GRCm39) missense
R8944:Slk UTSW 19 47,600,057 (GRCm39) missense probably damaging 0.99
R8962:Slk UTSW 19 47,610,748 (GRCm39) missense probably damaging 1.00
R8988:Slk UTSW 19 47,608,712 (GRCm39) missense probably benign 0.00
R9028:Slk UTSW 19 47,608,512 (GRCm39) missense probably benign
R9093:Slk UTSW 19 47,603,883 (GRCm39) missense
R9747:Slk UTSW 19 47,608,346 (GRCm39) missense possibly damaging 0.71
X0052:Slk UTSW 19 47,609,372 (GRCm39) missense probably benign 0.05
Z1176:Slk UTSW 19 47,610,715 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCGGATTTTGGAGTATCAGC -3'
(R):5'- ACCATTTTGATGGCTGTGCTAATG -3'

Sequencing Primer
(F):5'- GAGGGATTCATTTATTGGCACACC -3'
(R):5'- CTAATGTTGGGGGCTCAGATTTTGC -3'
Posted On 2015-07-21