Mutagenetix > Incidental Mutation

Incidental Mutation 'R4436:Vmn1r17'

329522

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r17

Ensembl Gene

ENSMUSG00000115644

Gene Name

vomeronasal 1 receptor 17

Synonyms

V1rc16

MMRRC Submission

041702-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.218) question?

Stock #

R4436 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

57337452-57338363 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to C at 57337719 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 166 (I166M)

Ref Sequence

ENSEMBL: ENSMUSP00000153928 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176395] [ENSMUST00000227186] [ENSMUST00000227966] [ENSMUST00000228156] [ENSMUST00000228294] [ENSMUST00000228342]

AlphaFold

Q8R2D8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000176395
AA Change: I215M

PolyPhen 2 Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000135746
Gene: ENSMUSG00000093411
AA Change: I215M

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	1.4e-53	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000227186
AA Change: I215M

PolyPhen 2 Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000227966
AA Change: I215M

PolyPhen 2 Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228156
AA Change: I166M

PolyPhen 2 Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228294
AA Change: I166M

PolyPhen 2 Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228342
AA Change: I215M

PolyPhen 2 Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.3%

Validation Efficiency

96% (54/56)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts16	G	A	13: 70,927,637 (GRCm39)		probably benign	Het
Aff3	T	C	1: 38,248,768 (GRCm39)	I779V	possibly damaging	Het
Asap1	T	G	15: 64,221,692 (GRCm39)	D15A	probably benign	Het
Ascc2	A	G	11: 4,606,305 (GRCm39)	D193G	probably damaging	Het
Bcl2a1d	A	T	9: 88,613,753 (GRCm39)	M7K	probably benign	Het
Ccdc168	T	C	1: 44,095,276 (GRCm39)	I1941V	probably benign	Het
Ccdc85a	T	C	11: 28,526,457 (GRCm39)	T384A	probably benign	Het
Cd86	T	C	16: 36,441,194 (GRCm39)	N91S	probably benign	Het
Cdk17	T	A	10: 93,047,758 (GRCm39)		probably null	Het
Cemip	T	C	7: 83,636,637 (GRCm39)	D332G	probably null	Het
Ces2f	G	A	8: 105,679,788 (GRCm39)	R427H	probably benign	Het
Clec4a2	G	A	6: 123,105,013 (GRCm39)		probably null	Het
Coa8	T	A	12: 111,717,642 (GRCm39)	D167E	probably benign	Het
Coq9	T	C	8: 95,579,743 (GRCm39)	F198L	probably benign	Het
Ddx24	C	A	12: 103,390,233 (GRCm39)	A253S	probably damaging	Het
Esyt3	A	T	9: 99,240,078 (GRCm39)		probably benign	Het
Fat2	C	A	11: 55,187,024 (GRCm39)	G1274V	probably damaging	Het
Ggn	A	T	7: 28,870,976 (GRCm39)	T132S	probably damaging	Het
Gm11568	T	A	11: 99,749,421 (GRCm39)	C209S	unknown	Het
Gm6931	T	A	16: 49,245,225 (GRCm39)		noncoding transcript	Het
Gpr20	C	T	15: 73,567,649 (GRCm39)	V247I	probably benign	Het
Grm8	A	T	6: 27,761,237 (GRCm39)	V329E	possibly damaging	Het
Gtf2ird2	T	C	5: 134,223,808 (GRCm39)	L114P	possibly damaging	Het
Hivep2	C	A	10: 14,004,713 (GRCm39)	T437K	probably benign	Het
Hivep3	C	T	4: 119,953,120 (GRCm39)	P479S	probably benign	Het
Igkv6-20	A	G	6: 70,313,104 (GRCm39)	V23A	probably damaging	Het
Ikbip	T	A	10: 90,937,751 (GRCm39)	N141K	probably damaging	Het
Irag1	T	C	7: 110,476,124 (GRCm39)	E815G	probably damaging	Het
Krt77	A	T	15: 101,773,904 (GRCm39)	V250E	probably damaging	Het
Ltn1	A	T	16: 87,202,502 (GRCm39)	C1050S	probably benign	Het
Macf1	T	C	4: 123,421,135 (GRCm39)	I40V	probably benign	Het
Or2h2b-ps1	A	G	17: 37,480,727 (GRCm39)	F271L	probably benign	Het
Or4k15b	T	C	14: 50,272,287 (GRCm39)	D191G	probably damaging	Het
Pi4ka	T	C	16: 17,100,246 (GRCm39)	M1885V	probably damaging	Het
Plek	A	G	11: 16,942,972 (GRCm39)	Y107H	probably damaging	Het
Ppp1r15a	C	T	7: 45,174,203 (GRCm39)	V202M	probably damaging	Het
Ppp1r3e	C	A	14: 55,114,007 (GRCm39)	A222S	probably benign	Het
Rac2	G	T	15: 78,454,943 (GRCm39)	Y32*	probably null	Het
Sdf4	T	G	4: 156,093,404 (GRCm39)		probably null	Het
Siah1b	G	A	X: 162,854,688 (GRCm39)	P131S	probably damaging	Het
Spic	T	A	10: 88,512,817 (GRCm39)	R111S	probably benign	Het
Ssh3	A	G	19: 4,315,394 (GRCm39)	F315L	probably damaging	Het
Ttn	T	C	2: 76,595,253 (GRCm39)	K11972R	probably damaging	Het
Tubd1	C	T	11: 86,439,745 (GRCm39)	S30F	probably benign	Het
Vmn2r94	T	C	17: 18,478,645 (GRCm39)	Y34C	probably damaging	Het
Xpo7	G	A	14: 70,906,869 (GRCm39)	T945M	probably damaging	Het
Zfp316	C	A	5: 143,239,803 (GRCm39)	A739S	probably damaging	Het
Zswim3	T	A	2: 164,662,563 (GRCm39)	C348S	probably benign	Het

Other mutations in Vmn1r17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00943:Vmn1r17	APN	6	57,338,185 (GRCm39)	missense	possibly damaging	0.48
IGL02073:Vmn1r17	APN	6	57,337,787 (GRCm39)	missense	probably benign	0.00
IGL03117:Vmn1r17	APN	6	57,337,501 (GRCm39)	missense	probably benign	0.08
IGL03168:Vmn1r17	APN	6	57,337,583 (GRCm39)	missense	probably benign	0.01
R0472:Vmn1r17	UTSW	6	57,338,304 (GRCm39)	missense	probably benign
R0590:Vmn1r17	UTSW	6	57,337,999 (GRCm39)	missense	probably benign	0.01
R0648:Vmn1r17	UTSW	6	57,337,460 (GRCm39)	missense	probably damaging	0.98
R1025:Vmn1r17	UTSW	6	57,338,240 (GRCm39)	missense	probably benign	0.05
R1545:Vmn1r17	UTSW	6	57,338,317 (GRCm39)	missense	probably benign	0.01
R2035:Vmn1r17	UTSW	6	57,337,573 (GRCm39)	missense	probably benign	0.13
R2507:Vmn1r17	UTSW	6	57,338,244 (GRCm39)	missense	probably damaging	0.99
R2508:Vmn1r17	UTSW	6	57,337,855 (GRCm39)	missense	possibly damaging	0.76
R3084:Vmn1r17	UTSW	6	57,337,768 (GRCm39)	missense	probably damaging	0.99
R3688:Vmn1r17	UTSW	6	57,337,544 (GRCm39)	missense	probably damaging	0.99
R3696:Vmn1r17	UTSW	6	57,337,523 (GRCm39)	missense	possibly damaging	0.74
R4741:Vmn1r17	UTSW	6	57,338,337 (GRCm39)	nonsense	probably null
R4989:Vmn1r17	UTSW	6	57,337,460 (GRCm39)	missense	possibly damaging	0.47
R5013:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5133:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5134:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5162:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5184:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5185:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5831:Vmn1r17	UTSW	6	57,337,999 (GRCm39)	missense	probably benign	0.01
R6487:Vmn1r17	UTSW	6	57,338,209 (GRCm39)	missense	possibly damaging	0.94
R7436:Vmn1r17	UTSW	6	57,337,862 (GRCm39)	missense	probably benign	0.03
R7600:Vmn1r17	UTSW	6	57,337,906 (GRCm39)	missense	probably benign	0.01
R8944:Vmn1r17	UTSW	6	57,338,142 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGTGGGAAAGGCATACATCAC -3'
(R):5'- TAACCGGATCTTCTATGTTCATGG -3'

Sequencing Primer
(F):5'- CAAACTTCTGAACCTGCAGGATG -3'
(R):5'- TGAGACTAACCAGATGCAGGTCAC -3'

Posted On

2015-07-21