Incidental Mutation 'R4436:Or2h2b-ps1'
ID 329557
Institutional Source Beutler Lab
Gene Symbol Or2h2b-ps1
Ensembl Gene ENSMUSG00000090556
Gene Name olfactory receptor family 2 subfamily H member 2B, pseudogene 1
Synonyms GA_x6K02T2PSCP-1611898-1610960, MOR256-38, Olfr753-ps1
MMRRC Submission 041702-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R4436 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 37480602-37481537 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37480727 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 271 (F271L)
Ref Sequence ENSEMBL: ENSMUSP00000151508 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000174025] [ENSMUST00000174673] [ENSMUST00000208970] [ENSMUST00000219487]
AlphaFold A0A140LHN3
Predicted Effect probably benign
Transcript: ENSMUST00000174025
AA Change: F271L

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000174673
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174813
Predicted Effect probably benign
Transcript: ENSMUST00000208970
AA Change: F271L

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000219487
AA Change: F271L

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.3%
Validation Efficiency 96% (54/56)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Aff3 T C 1: 38,248,768 (GRCm39) I779V possibly damaging Het
Asap1 T G 15: 64,221,692 (GRCm39) D15A probably benign Het
Ascc2 A G 11: 4,606,305 (GRCm39) D193G probably damaging Het
Bcl2a1d A T 9: 88,613,753 (GRCm39) M7K probably benign Het
Ccdc168 T C 1: 44,095,276 (GRCm39) I1941V probably benign Het
Ccdc85a T C 11: 28,526,457 (GRCm39) T384A probably benign Het
Cd86 T C 16: 36,441,194 (GRCm39) N91S probably benign Het
Cdk17 T A 10: 93,047,758 (GRCm39) probably null Het
Cemip T C 7: 83,636,637 (GRCm39) D332G probably null Het
Ces2f G A 8: 105,679,788 (GRCm39) R427H probably benign Het
Clec4a2 G A 6: 123,105,013 (GRCm39) probably null Het
Coa8 T A 12: 111,717,642 (GRCm39) D167E probably benign Het
Coq9 T C 8: 95,579,743 (GRCm39) F198L probably benign Het
Ddx24 C A 12: 103,390,233 (GRCm39) A253S probably damaging Het
Esyt3 A T 9: 99,240,078 (GRCm39) probably benign Het
Fat2 C A 11: 55,187,024 (GRCm39) G1274V probably damaging Het
Ggn A T 7: 28,870,976 (GRCm39) T132S probably damaging Het
Gm11568 T A 11: 99,749,421 (GRCm39) C209S unknown Het
Gm6931 T A 16: 49,245,225 (GRCm39) noncoding transcript Het
Gpr20 C T 15: 73,567,649 (GRCm39) V247I probably benign Het
Grm8 A T 6: 27,761,237 (GRCm39) V329E possibly damaging Het
Gtf2ird2 T C 5: 134,223,808 (GRCm39) L114P possibly damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Hivep3 C T 4: 119,953,120 (GRCm39) P479S probably benign Het
Igkv6-20 A G 6: 70,313,104 (GRCm39) V23A probably damaging Het
Ikbip T A 10: 90,937,751 (GRCm39) N141K probably damaging Het
Irag1 T C 7: 110,476,124 (GRCm39) E815G probably damaging Het
Krt77 A T 15: 101,773,904 (GRCm39) V250E probably damaging Het
Ltn1 A T 16: 87,202,502 (GRCm39) C1050S probably benign Het
Macf1 T C 4: 123,421,135 (GRCm39) I40V probably benign Het
Or4k15b T C 14: 50,272,287 (GRCm39) D191G probably damaging Het
Pi4ka T C 16: 17,100,246 (GRCm39) M1885V probably damaging Het
Plek A G 11: 16,942,972 (GRCm39) Y107H probably damaging Het
Ppp1r15a C T 7: 45,174,203 (GRCm39) V202M probably damaging Het
Ppp1r3e C A 14: 55,114,007 (GRCm39) A222S probably benign Het
Rac2 G T 15: 78,454,943 (GRCm39) Y32* probably null Het
Sdf4 T G 4: 156,093,404 (GRCm39) probably null Het
Siah1b G A X: 162,854,688 (GRCm39) P131S probably damaging Het
Spic T A 10: 88,512,817 (GRCm39) R111S probably benign Het
Ssh3 A G 19: 4,315,394 (GRCm39) F315L probably damaging Het
Ttn T C 2: 76,595,253 (GRCm39) K11972R probably damaging Het
Tubd1 C T 11: 86,439,745 (GRCm39) S30F probably benign Het
Vmn1r17 G C 6: 57,337,719 (GRCm39) I166M possibly damaging Het
Vmn2r94 T C 17: 18,478,645 (GRCm39) Y34C probably damaging Het
Xpo7 G A 14: 70,906,869 (GRCm39) T945M probably damaging Het
Zfp316 C A 5: 143,239,803 (GRCm39) A739S probably damaging Het
Zswim3 T A 2: 164,662,563 (GRCm39) C348S probably benign Het
Other mutations in Or2h2b-ps1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4607:Or2h2b-ps1 UTSW 17 37,481,173 (GRCm39) missense probably damaging 1.00
R4608:Or2h2b-ps1 UTSW 17 37,481,173 (GRCm39) missense probably damaging 1.00
R4910:Or2h2b-ps1 UTSW 17 37,480,934 (GRCm39) missense probably benign
R5085:Or2h2b-ps1 UTSW 17 37,480,858 (GRCm39) missense probably benign 0.00
R5329:Or2h2b-ps1 UTSW 17 37,480,891 (GRCm39) missense probably damaging 1.00
R5646:Or2h2b-ps1 UTSW 17 37,480,808 (GRCm39) missense probably benign 0.03
R6916:Or2h2b-ps1 UTSW 17 37,480,864 (GRCm39) missense probably benign
R7072:Or2h2b-ps1 UTSW 17 37,481,269 (GRCm39) missense probably benign 0.02
R7711:Or2h2b-ps1 UTSW 17 37,480,847 (GRCm39) missense probably damaging 1.00
R8061:Or2h2b-ps1 UTSW 17 37,480,792 (GRCm39) missense probably damaging 0.99
R8987:Or2h2b-ps1 UTSW 17 37,480,990 (GRCm39) missense probably damaging 1.00
R8987:Or2h2b-ps1 UTSW 17 37,480,867 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACTAGGTCTACTGTTGTGGC -3'
(R):5'- TCTTATGGTGCCATTGCCAGG -3'

Sequencing Primer
(F):5'- TGTGGCTTGGAAGAGTAAGTAGACTC -3'
(R):5'- GGCAGTGCTGAAGATAAGCTC -3'
Posted On 2015-07-21