Incidental Mutation 'R4437:Cdc37l1'
ID 329597
Institutional Source Beutler Lab
Gene Symbol Cdc37l1
Ensembl Gene ENSMUSG00000024780
Gene Name cell division cycle 37-like 1
Synonyms 2700033A15Rik, Harc, Hsp90-associating relative of Cdc37
MMRRC Submission 041150-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4437 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 28967752-29004081 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 28985021 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 224 (F224L)
Ref Sequence ENSEMBL: ENSMUSP00000153192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050148] [ENSMUST00000223694] [ENSMUST00000224511] [ENSMUST00000224599] [ENSMUST00000225310] [ENSMUST00000225210]
AlphaFold Q9CZP7
Predicted Effect probably damaging
Transcript: ENSMUST00000050148
AA Change: F224L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000060421
Gene: ENSMUSG00000024780
AA Change: F224L

DomainStartEndE-ValueType
low complexity region 4 14 N/A INTRINSIC
low complexity region 21 40 N/A INTRINSIC
low complexity region 102 115 N/A INTRINSIC
CDC37_M 132 288 7.15e-80 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183196
Predicted Effect probably benign
Transcript: ENSMUST00000223694
Predicted Effect probably benign
Transcript: ENSMUST00000224092
Predicted Effect probably damaging
Transcript: ENSMUST00000224511
AA Change: F224L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect possibly damaging
Transcript: ENSMUST00000224599
AA Change: F224L

PolyPhen 2 Score 0.894 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000224830
Predicted Effect probably damaging
Transcript: ENSMUST00000225310
AA Change: F224L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000225210
AA Change: F224L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225598
Meta Mutation Damage Score 0.7650 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6b A C 12: 113,454,281 (GRCm39) Q366P probably damaging Het
Arhgef16 A G 4: 154,364,153 (GRCm39) probably null Het
Bcar1 G A 8: 112,442,021 (GRCm39) T273M probably damaging Het
Bcl2a1d A T 9: 88,613,753 (GRCm39) M7K probably benign Het
Bptf A G 11: 106,965,300 (GRCm39) V1235A possibly damaging Het
Camsap1 G A 2: 25,828,658 (GRCm39) T1022I possibly damaging Het
Col4a1 G T 8: 11,256,387 (GRCm39) C1493* probably null Het
Cul9 A G 17: 46,813,085 (GRCm39) L2378P probably damaging Het
D630003M21Rik G A 2: 158,055,382 (GRCm39) P585L probably damaging Het
Fam169a A G 13: 97,263,248 (GRCm39) D567G probably damaging Het
Frem3 A G 8: 81,339,236 (GRCm39) I510V probably benign Het
Garin2 T A 12: 78,761,824 (GRCm39) F163I probably damaging Het
Gm2381 A T 7: 42,469,268 (GRCm39) H285Q probably damaging Het
Gm4884 A G 7: 40,692,514 (GRCm39) Q161R probably damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Igkv1-99 T G 6: 68,519,318 (GRCm39) S91A probably benign Het
Itga6 T C 2: 71,655,982 (GRCm39) L302P probably benign Het
Mdga2 T C 12: 66,519,972 (GRCm39) probably null Het
Myoc A G 1: 162,476,681 (GRCm39) M462V possibly damaging Het
Nkx2-4 T C 2: 146,926,179 (GRCm39) T228A possibly damaging Het
Npr1 T G 3: 90,363,593 (GRCm39) D810A probably damaging Het
Or4a68 T G 2: 89,269,698 (GRCm39) R308S possibly damaging Het
Or4k15b T C 14: 50,272,287 (GRCm39) D191G probably damaging Het
Or51a24 T C 7: 103,734,128 (GRCm39) E53G possibly damaging Het
Pde4dip G A 3: 97,673,885 (GRCm39) L344F possibly damaging Het
Pfas A G 11: 68,879,243 (GRCm39) L1218P probably damaging Het
Rimoc1 T C 15: 4,021,318 (GRCm39) E79G probably damaging Het
Rln1 A T 19: 29,311,962 (GRCm39) F12Y possibly damaging Het
Robo2 T C 16: 73,770,132 (GRCm39) T531A possibly damaging Het
Siah1b G A X: 162,854,688 (GRCm39) P131S probably damaging Het
Tsc2 G A 17: 24,818,687 (GRCm39) P1450L probably benign Het
Vps33a A T 5: 123,669,947 (GRCm39) I519N probably benign Het
Other mutations in Cdc37l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02612:Cdc37l1 APN 19 28,993,502 (GRCm39) makesense probably null
R2260:Cdc37l1 UTSW 19 28,984,448 (GRCm39) missense probably benign 0.05
R4043:Cdc37l1 UTSW 19 28,968,028 (GRCm39) missense possibly damaging 0.83
R4434:Cdc37l1 UTSW 19 28,985,021 (GRCm39) missense probably damaging 1.00
R4438:Cdc37l1 UTSW 19 28,985,021 (GRCm39) missense probably damaging 1.00
R4829:Cdc37l1 UTSW 19 28,967,983 (GRCm39) missense probably benign
R5385:Cdc37l1 UTSW 19 28,989,343 (GRCm39) missense possibly damaging 0.95
R5537:Cdc37l1 UTSW 19 28,972,518 (GRCm39) missense probably damaging 1.00
R5906:Cdc37l1 UTSW 19 28,989,386 (GRCm39) missense probably benign 0.42
R7385:Cdc37l1 UTSW 19 28,968,071 (GRCm39) critical splice donor site probably null
R7610:Cdc37l1 UTSW 19 28,985,132 (GRCm39) missense possibly damaging 0.90
R9142:Cdc37l1 UTSW 19 28,989,402 (GRCm39) missense possibly damaging 0.86
R9317:Cdc37l1 UTSW 19 28,972,518 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGTAGGTAGTTATTCTGGTCCATG -3'
(R):5'- ACAATGTTAGCAGCCTCCTGG -3'

Sequencing Primer
(F):5'- CTGGTCCATGTAATAGCATTAAGATG -3'
(R):5'- GCTAACCAGCCTCCTGATGAG -3'
Posted On 2015-07-21