Incidental Mutation 'R4457:Mslnl'
ID |
329974 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Mslnl
|
Ensembl Gene |
ENSMUSG00000041062 |
Gene Name |
mesothelin-like |
Synonyms |
|
MMRRC Submission |
041717-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R4457 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
25955016-25967304 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 25961908 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Methionine
at position 128
(V128M)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000049020
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047098]
|
AlphaFold |
Q8C160 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000047098
AA Change: V128M
PolyPhen 2
Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000049020 Gene: ENSMUSG00000041062 AA Change: V128M
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
Pfam:Mesothelin
|
29 |
589 |
2.8e-70 |
PFAM |
low complexity region
|
633 |
653 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000102319
|
Meta Mutation Damage Score |
0.2148 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
Validation Efficiency |
97% (62/64) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 60 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1110008E08Rik |
A |
G |
16: 90,351,260 (GRCm39) |
|
noncoding transcript |
Het |
1700025G04Rik |
T |
C |
1: 151,796,805 (GRCm39) |
R87G |
probably damaging |
Het |
9030619P08Rik |
T |
A |
15: 75,303,249 (GRCm39) |
|
noncoding transcript |
Het |
Akap13 |
A |
G |
7: 75,389,213 (GRCm39) |
D2377G |
probably damaging |
Het |
Arhgef5 |
T |
C |
6: 43,251,027 (GRCm39) |
S593P |
probably damaging |
Het |
Atp4a |
G |
A |
7: 30,419,650 (GRCm39) |
R671Q |
probably benign |
Het |
Cdkn2d |
C |
G |
9: 21,202,185 (GRCm39) |
V21L |
probably benign |
Het |
Cfap73 |
T |
C |
5: 120,768,215 (GRCm39) |
K181R |
possibly damaging |
Het |
Chn1 |
A |
G |
2: 73,443,427 (GRCm39) |
I383T |
probably damaging |
Het |
Cmtr2 |
A |
G |
8: 110,948,884 (GRCm39) |
D398G |
probably benign |
Het |
Dnah12 |
T |
C |
14: 26,537,464 (GRCm39) |
Y2238H |
probably damaging |
Het |
Dnah7c |
A |
G |
1: 46,779,781 (GRCm39) |
N3161S |
probably damaging |
Het |
Dnah8 |
C |
A |
17: 31,032,125 (GRCm39) |
H4148Q |
probably benign |
Het |
Ehbp1l1 |
T |
C |
19: 5,766,321 (GRCm39) |
S397G |
possibly damaging |
Het |
Eya4 |
A |
T |
10: 22,992,566 (GRCm39) |
S462R |
probably damaging |
Het |
Fam227b |
T |
A |
2: 125,988,188 (GRCm39) |
|
probably benign |
Het |
Frrs1 |
G |
A |
3: 116,690,377 (GRCm39) |
V7I |
probably benign |
Het |
Fsip2 |
G |
T |
2: 82,821,120 (GRCm39) |
A5618S |
possibly damaging |
Het |
Gja10 |
A |
T |
4: 32,601,073 (GRCm39) |
M437K |
probably benign |
Het |
Gm2840 |
T |
G |
5: 96,322,187 (GRCm39) |
|
noncoding transcript |
Het |
Gm4956 |
A |
G |
1: 21,368,319 (GRCm39) |
|
noncoding transcript |
Het |
Gria4 |
A |
G |
9: 4,427,074 (GRCm39) |
W789R |
probably damaging |
Het |
Hoxb5 |
A |
G |
11: 96,194,546 (GRCm39) |
D36G |
probably damaging |
Het |
Hps5 |
A |
T |
7: 46,433,037 (GRCm39) |
C228S |
probably benign |
Het |
Hspa4 |
A |
T |
11: 53,171,395 (GRCm39) |
C270S |
probably damaging |
Het |
Htra4 |
C |
A |
8: 25,528,674 (GRCm39) |
A73S |
possibly damaging |
Het |
Ikzf2 |
T |
C |
1: 69,723,347 (GRCm39) |
|
probably benign |
Het |
Ivl |
G |
A |
3: 92,479,673 (GRCm39) |
H131Y |
probably benign |
Het |
Kat6a |
A |
G |
8: 23,422,129 (GRCm39) |
|
probably null |
Het |
Lamp3 |
T |
A |
16: 19,492,279 (GRCm39) |
M322L |
probably benign |
Het |
Letmd1 |
T |
C |
15: 100,373,011 (GRCm39) |
V37A |
possibly damaging |
Het |
Myh1 |
G |
A |
11: 67,111,441 (GRCm39) |
G1627R |
probably benign |
Het |
Myo9b |
A |
G |
8: 71,743,643 (GRCm39) |
I235V |
probably damaging |
Het |
Ndor1 |
A |
G |
2: 25,138,128 (GRCm39) |
|
probably null |
Het |
Ndufa12 |
A |
T |
10: 94,056,680 (GRCm39) |
K136M |
probably damaging |
Het |
Or2t49 |
A |
G |
11: 58,392,944 (GRCm39) |
L146P |
probably damaging |
Het |
Or4a78 |
A |
T |
2: 89,497,427 (GRCm39) |
S268T |
probably benign |
Het |
Or51g2 |
C |
T |
7: 102,622,734 (GRCm39) |
S155N |
probably damaging |
Het |
Or5d44 |
A |
G |
2: 88,141,173 (GRCm39) |
|
probably benign |
Het |
Pcdha2 |
A |
G |
18: 37,073,599 (GRCm39) |
D410G |
probably damaging |
Het |
Pcyox1l |
T |
A |
18: 61,830,939 (GRCm39) |
N311I |
probably benign |
Het |
Pif1 |
A |
G |
9: 65,495,058 (GRCm39) |
|
probably benign |
Het |
Pkp1 |
CTCTTCTT |
CTCTT |
1: 135,803,362 (GRCm39) |
|
probably null |
Het |
Pogz |
G |
A |
3: 94,763,374 (GRCm39) |
V49I |
probably benign |
Het |
Rab36 |
G |
A |
10: 74,880,328 (GRCm39) |
V63I |
probably damaging |
Het |
Rnf4 |
A |
G |
5: 34,508,705 (GRCm39) |
Y189C |
probably benign |
Het |
Rpl31-ps17 |
C |
T |
12: 54,748,397 (GRCm39) |
|
noncoding transcript |
Het |
Sgms2 |
A |
C |
3: 131,118,665 (GRCm39) |
Y273D |
probably damaging |
Het |
Slc25a10 |
G |
A |
11: 120,387,915 (GRCm39) |
V203I |
probably benign |
Het |
Slc4a2 |
T |
A |
5: 24,639,328 (GRCm39) |
|
probably benign |
Het |
Tbc1d13 |
A |
G |
2: 30,025,450 (GRCm39) |
|
probably benign |
Het |
Tdrd7 |
A |
G |
4: 46,007,526 (GRCm39) |
N526S |
probably benign |
Het |
Tet2 |
C |
T |
3: 133,191,324 (GRCm39) |
D1037N |
possibly damaging |
Het |
Thrb |
T |
A |
14: 18,011,187 (GRCm38) |
W188R |
probably damaging |
Het |
Ttn |
T |
C |
2: 76,777,257 (GRCm39) |
M1382V |
probably benign |
Het |
Usp9y |
T |
A |
Y: 1,394,078 (GRCm39) |
I551L |
possibly damaging |
Het |
Vwde |
T |
C |
6: 13,196,100 (GRCm39) |
I308M |
probably damaging |
Het |
Zan |
T |
C |
5: 137,409,778 (GRCm39) |
I3488V |
unknown |
Het |
Zgrf1 |
A |
T |
3: 127,389,578 (GRCm39) |
I375F |
probably damaging |
Het |
Zic4 |
A |
G |
9: 91,261,315 (GRCm39) |
K183R |
probably damaging |
Het |
|
Other mutations in Mslnl |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01621:Mslnl
|
APN |
17 |
25,962,641 (GRCm39) |
unclassified |
probably benign |
|
IGL01629:Mslnl
|
APN |
17 |
25,963,749 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02084:Mslnl
|
APN |
17 |
25,965,125 (GRCm39) |
missense |
probably benign |
0.07 |
IGL02408:Mslnl
|
APN |
17 |
25,966,972 (GRCm39) |
missense |
possibly damaging |
0.80 |
IGL02726:Mslnl
|
APN |
17 |
25,963,077 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03387:Mslnl
|
APN |
17 |
25,963,051 (GRCm39) |
missense |
probably benign |
0.06 |
R0561:Mslnl
|
UTSW |
17 |
25,962,177 (GRCm39) |
nonsense |
probably null |
|
R0881:Mslnl
|
UTSW |
17 |
25,961,939 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1295:Mslnl
|
UTSW |
17 |
25,962,214 (GRCm39) |
missense |
probably damaging |
1.00 |
R1296:Mslnl
|
UTSW |
17 |
25,962,214 (GRCm39) |
missense |
probably damaging |
1.00 |
R1582:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1629:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1630:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1631:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1632:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1794:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1850:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1866:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1876:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R1914:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2166:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2241:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2243:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2247:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2282:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2284:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2852:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2867:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2867:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2877:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2878:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2919:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R2920:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3026:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3405:Mslnl
|
UTSW |
17 |
25,965,155 (GRCm39) |
missense |
probably damaging |
1.00 |
R3406:Mslnl
|
UTSW |
17 |
25,965,155 (GRCm39) |
missense |
probably damaging |
1.00 |
R3411:Mslnl
|
UTSW |
17 |
25,963,491 (GRCm39) |
missense |
probably benign |
0.05 |
R3434:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3546:Mslnl
|
UTSW |
17 |
25,963,943 (GRCm39) |
missense |
probably damaging |
0.98 |
R3612:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3729:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3730:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3802:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3804:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3894:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R3895:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4454:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4455:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4456:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4561:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4562:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4564:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4600:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4601:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4610:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
R4704:Mslnl
|
UTSW |
17 |
25,957,952 (GRCm39) |
missense |
possibly damaging |
0.73 |
R5155:Mslnl
|
UTSW |
17 |
25,957,942 (GRCm39) |
nonsense |
probably null |
|
R5257:Mslnl
|
UTSW |
17 |
25,965,139 (GRCm39) |
missense |
probably benign |
0.00 |
R5456:Mslnl
|
UTSW |
17 |
25,962,133 (GRCm39) |
missense |
probably damaging |
0.98 |
R5645:Mslnl
|
UTSW |
17 |
25,956,816 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6007:Mslnl
|
UTSW |
17 |
25,965,749 (GRCm39) |
missense |
probably benign |
0.00 |
R6083:Mslnl
|
UTSW |
17 |
25,956,876 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6142:Mslnl
|
UTSW |
17 |
25,963,531 (GRCm39) |
missense |
probably damaging |
1.00 |
R6761:Mslnl
|
UTSW |
17 |
25,965,047 (GRCm39) |
missense |
probably damaging |
1.00 |
R7058:Mslnl
|
UTSW |
17 |
25,962,186 (GRCm39) |
missense |
probably benign |
0.03 |
R7156:Mslnl
|
UTSW |
17 |
25,962,184 (GRCm39) |
missense |
probably benign |
0.20 |
R7467:Mslnl
|
UTSW |
17 |
25,955,895 (GRCm39) |
start codon destroyed |
probably benign |
0.33 |
R7687:Mslnl
|
UTSW |
17 |
25,962,157 (GRCm39) |
missense |
probably damaging |
0.97 |
R7807:Mslnl
|
UTSW |
17 |
25,965,751 (GRCm39) |
missense |
probably benign |
0.03 |
R8682:Mslnl
|
UTSW |
17 |
25,965,962 (GRCm39) |
missense |
probably benign |
|
R8735:Mslnl
|
UTSW |
17 |
25,964,062 (GRCm39) |
missense |
probably benign |
0.09 |
R8742:Mslnl
|
UTSW |
17 |
25,964,047 (GRCm39) |
missense |
probably damaging |
1.00 |
R9208:Mslnl
|
UTSW |
17 |
25,961,694 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9264:Mslnl
|
UTSW |
17 |
25,961,506 (GRCm39) |
intron |
probably benign |
|
RF007:Mslnl
|
UTSW |
17 |
25,962,202 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Predicted Primers |
PCR Primer
(F):5'- CTGCCATCAGAAGGGAGGTTTG -3'
(R):5'- ACAGGTCTGAAGCACTGAGC -3'
Sequencing Primer
(F):5'- TTTGAACCCAGGACTGAGGTGAC -3'
(R):5'- GCCCTGCCGAGACAGTAG -3'
|
Posted On |
2015-07-21 |