Incidental Mutation 'R4459:Olfr1391'
ID330067
Institutional Source Beutler Lab
Gene Symbol Olfr1391
Ensembl Gene ENSMUSG00000101874
Gene Nameolfactory receptor 1391
SynonymsGA_x6K02T2QP88-6107233-6106298, MOR256-27
MMRRC Submission 041579-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.088) question?
Stock #R4459 (G1)
Quality Score225
Status Not validated
Chromosome11
Chromosomal Location49322742-49329810 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 49327876 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Isoleucine at position 155 (N155I)
Ref Sequence ENSEMBL: ENSMUSP00000150635 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000187509] [ENSMUST00000215671]
Predicted Effect probably damaging
Transcript: ENSMUST00000187509
AA Change: N155I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000140343
Gene: ENSMUSG00000101874
AA Change: N155I

DomainStartEndE-ValueType
Pfam:7tm_1 41 289 2.2e-29 PFAM
Pfam:7tm_4 139 282 6.1e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215671
AA Change: N155I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130019O22Rik A G 7: 127,384,745 L395P probably damaging Het
Abcc4 C T 14: 118,599,393 R652Q probably benign Het
Anks1b G A 10: 90,510,844 V669I probably damaging Het
Arsi G A 18: 60,916,651 G202E probably benign Het
Ash1l G A 3: 88,966,234 R108Q probably damaging Het
BC049715 G A 6: 136,840,052 A97T probably damaging Het
Cyp11b1 T A 15: 74,836,359 E422D probably damaging Het
Dmxl1 A T 18: 49,961,216 I2920F possibly damaging Het
Efcab6 C T 15: 83,904,289 G935S probably damaging Het
Esp3 C G 17: 40,633,587 T40S probably null Het
Gc T C 5: 89,441,287 M206V probably benign Het
Gm15446 A T 5: 109,943,241 H453L probably benign Het
Hes6 A G 1: 91,412,339 S132P probably damaging Het
Ighg2b T C 12: 113,306,958 Y184C unknown Het
Itga2 C G 13: 114,843,483 D1061H probably damaging Het
Kcnj5 A G 9: 32,322,395 I208T probably damaging Het
Klhl26 T C 8: 70,451,544 Y538C probably damaging Het
Letm2 A G 8: 25,586,699 C296R probably damaging Het
Lrfn4 C T 19: 4,612,634 V452I probably benign Het
Mypn A G 10: 63,192,432 V284A probably damaging Het
Olfr1110 T C 2: 87,135,661 H220R probably benign Het
Olfr112 G A 17: 37,563,474 T279I probably damaging Het
Olfr898 T A 9: 38,349,992 V297D probably damaging Het
Pcdhgb6 C T 18: 37,742,706 P156S probably benign Het
Pih1d3 A G 1: 31,223,324 D129G probably damaging Het
Pou2f1 A G 1: 165,895,006 F337L probably damaging Het
Prl7a2 A G 13: 27,665,996 V31A probably benign Het
Rasal2 A G 1: 157,175,832 F419S possibly damaging Het
Rmnd5a C T 6: 71,396,881 G310R probably damaging Het
Rrm2b T A 15: 37,945,153 probably null Het
Smg8 T C 11: 87,085,570 D395G probably benign Het
Snx30 A T 4: 59,885,022 R221* probably null Het
Tyk2 T C 9: 21,124,415 E157G probably damaging Het
Wdr90 T A 17: 25,861,002 T120S possibly damaging Het
Zfp804b A T 5: 6,771,481 D491E probably damaging Het
Other mutations in Olfr1391
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01768:Olfr1391 APN 11 49328131 missense probably damaging 1.00
IGL02171:Olfr1391 APN 11 49328035 missense possibly damaging 0.69
IGL03184:Olfr1391 APN 11 49327741 missense probably damaging 0.97
R0471:Olfr1391 UTSW 11 49327917 missense probably damaging 1.00
R0613:Olfr1391 UTSW 11 49327748 missense possibly damaging 0.81
R0616:Olfr1391 UTSW 11 49327756 missense probably damaging 1.00
R0825:Olfr1391 UTSW 11 49327682 missense probably benign 0.00
R1613:Olfr1391 UTSW 11 49327693 missense probably damaging 1.00
R3429:Olfr1391 UTSW 11 49328041 missense probably benign 0.00
R3727:Olfr1391 UTSW 11 49327795 missense probably benign 0.01
R4256:Olfr1391 UTSW 11 49327477 missense probably benign 0.20
R4552:Olfr1391 UTSW 11 49327950 missense probably benign 0.00
R4811:Olfr1391 UTSW 11 49327748 missense possibly damaging 0.81
R4881:Olfr1391 UTSW 11 49328297 missense probably benign 0.43
R5838:Olfr1391 UTSW 11 49327933 missense probably damaging 0.99
R6804:Olfr1391 UTSW 11 49327981 missense probably benign 0.16
R6809:Olfr1391 UTSW 11 49327860 missense probably benign 0.00
R7763:Olfr1391 UTSW 11 49327671 missense probably benign 0.00
R7765:Olfr1391 UTSW 11 49327744 missense probably damaging 1.00
R7783:Olfr1391 UTSW 11 49328202 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCAGCTGTTCAGTGTCCTTG -3'
(R):5'- GACCAGATGTTGACTTGACCTTC -3'

Sequencing Primer
(F):5'- TCAGTGTCCTTGCCCTGGG -3'
(R):5'- TGTGGGCATACGATCCTAGAATC -3'
Posted On2015-07-21