Incidental Mutation 'R4465:Or8k37'
ID 330291
Institutional Source Beutler Lab
Gene Symbol Or8k37
Ensembl Gene ENSMUSG00000110804
Gene Name olfactory receptor family 8 subfamily K member 37
Synonyms MOR192-3, MOR192-2, GA_x6K02T2Q125-48121788-48120847, Olfr1084
MMRRC Submission 041580-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.221) question?
Stock # R4465 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 86469109-86470062 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86469478 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 191 (N191K)
Gene Model predicted gene model for transcript(s): [ENSMUST00000216851]
AlphaFold A0A1L1STZ9
Predicted Effect probably benign
Transcript: ENSMUST00000099880
AA Change: N191K

PolyPhen 2 Score 0.279 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000097465
Gene: ENSMUSG00000075177
AA Change: N191K

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.9e-48 PFAM
Pfam:7tm_1 41 290 7.6e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216851
AA Change: N191K

PolyPhen 2 Score 0.236 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,056,182 (GRCm39) probably benign Het
Acsbg2 A G 17: 57,168,580 (GRCm39) Y180H probably damaging Het
Adgrb3 G T 1: 25,133,447 (GRCm39) T1213K probably damaging Het
Atrn A G 2: 130,802,388 (GRCm39) T510A probably benign Het
Clasp1 C A 1: 118,488,808 (GRCm39) T857N probably damaging Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Col12a1 C A 9: 79,580,192 (GRCm39) V1562F possibly damaging Het
Cyp4f40 T A 17: 32,890,186 (GRCm39) D285E probably benign Het
Dis3 G A 14: 99,321,550 (GRCm39) S599L possibly damaging Het
Dnah11 T C 12: 117,951,186 (GRCm39) T3041A probably benign Het
Erbin T C 13: 103,981,393 (GRCm39) N511D probably benign Het
F11 T A 8: 45,694,511 (GRCm39) I617F probably damaging Het
Gm11541 A T 11: 94,595,048 (GRCm39) C7S unknown Het
Klk12 A T 7: 43,422,807 (GRCm39) R245W probably damaging Het
Lao1 C A 4: 118,822,504 (GRCm39) S141R probably benign Het
Lrrk2 A G 15: 91,632,023 (GRCm39) K1316E probably damaging Het
Map3k6 A G 4: 132,973,644 (GRCm39) Y445C possibly damaging Het
Mup6 T C 4: 60,004,000 (GRCm39) I31T probably damaging Het
Ndnf T A 6: 65,681,180 (GRCm39) D486E probably benign Het
Or2a54 T C 6: 43,092,852 (GRCm39) Y59H probably damaging Het
Or8h7 A T 2: 86,721,494 (GRCm39) N8K probably benign Het
Rab19 T C 6: 39,365,060 (GRCm39) S107P probably damaging Het
Slc22a29 A T 19: 8,140,088 (GRCm39) L439* probably null Het
Slc5a1 A G 5: 33,303,860 (GRCm39) E225G possibly damaging Het
Slx4 A G 16: 3,806,919 (GRCm39) V508A possibly damaging Het
Snx25 A G 8: 46,521,266 (GRCm39) S373P possibly damaging Het
Stag2 A G X: 41,322,749 (GRCm39) S400G probably benign Homo
Tas2r107 A G 6: 131,636,972 (GRCm39) Y26H probably benign Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Zdhhc22 G A 12: 87,034,997 (GRCm39) L152F probably benign Het
Zfpm2 T G 15: 40,959,557 (GRCm39) M80R probably benign Het
Other mutations in Or8k37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01132:Or8k37 APN 2 86,469,510 (GRCm39) missense probably benign 0.01
IGL01376:Or8k37 APN 2 86,469,953 (GRCm39) missense probably benign 0.00
IGL01387:Or8k37 APN 2 86,469,594 (GRCm39) missense probably benign 0.03
IGL01549:Or8k37 APN 2 86,469,876 (GRCm39) missense possibly damaging 0.95
IGL01549:Or8k37 APN 2 86,469,705 (GRCm39) missense probably benign 0.29
IGL01572:Or8k37 APN 2 86,469,283 (GRCm39) missense possibly damaging 0.92
IGL02084:Or8k37 APN 2 86,469,980 (GRCm39) missense possibly damaging 0.89
IGL02289:Or8k37 APN 2 86,469,863 (GRCm39) missense probably damaging 1.00
IGL02422:Or8k37 APN 2 86,469,560 (GRCm39) missense probably damaging 0.99
IGL02691:Or8k37 APN 2 86,469,182 (GRCm39) missense probably damaging 1.00
IGL02829:Or8k37 APN 2 86,469,599 (GRCm39) missense possibly damaging 0.60
IGL02859:Or8k37 APN 2 86,469,992 (GRCm39) missense probably benign 0.01
R0441:Or8k37 UTSW 2 86,469,674 (GRCm39) missense probably damaging 1.00
R0546:Or8k37 UTSW 2 86,469,573 (GRCm39) missense possibly damaging 0.86
R1186:Or8k37 UTSW 2 86,469,807 (GRCm39) missense probably damaging 1.00
R4554:Or8k37 UTSW 2 86,469,123 (GRCm39) missense possibly damaging 0.74
R4670:Or8k37 UTSW 2 86,469,512 (GRCm39) missense possibly damaging 0.95
R4945:Or8k37 UTSW 2 86,469,833 (GRCm39) missense probably damaging 0.99
R5348:Or8k37 UTSW 2 86,469,150 (GRCm39) missense probably benign 0.39
R5888:Or8k37 UTSW 2 86,469,488 (GRCm39) missense probably damaging 0.98
R7001:Or8k37 UTSW 2 86,469,495 (GRCm39) missense probably benign 0.20
R7258:Or8k37 UTSW 2 86,469,345 (GRCm39) nonsense probably null
R7526:Or8k37 UTSW 2 86,470,013 (GRCm39) missense possibly damaging 0.93
R7646:Or8k37 UTSW 2 86,469,513 (GRCm39) missense probably damaging 1.00
R7915:Or8k37 UTSW 2 86,469,110 (GRCm39) makesense probably null
Predicted Primers PCR Primer
(F):5'- GTGTCCCATAGAATATTGTAACCAC -3'
(R):5'- CGCTATGTGGCCATATGTAAGC -3'

Sequencing Primer
(F):5'- GAATATTGTAACCACTGTCAGGTG -3'
(R):5'- GTGGCCATATGTAAGCCTCTGC -3'
Posted On 2015-07-21