Mutagenetix > Incidental Mutations

Incidental Mutation 'R4465:Tas2r107'

330304

Institutional Source

Beutler Lab

Gene Symbol

Tas2r107

Ensembl Gene

ENSMUSG00000053389

Gene Name

taste receptor, type 2, member 107

Synonyms

T2R4, Tas2r7, mGR06, STC 5-1, mt2r43, T2R07

MMRRC Submission

041580-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R4465 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

131659118-131660149 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 131660009 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 26 (Y26H)

Ref Sequence

ENSEMBL: ENSMUSP00000067082 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065781]

Predicted Effect

probably benign
Transcript: ENSMUST00000065781
AA Change: Y26H

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000067082
Gene: ENSMUSG00000053389
AA Change: Y26H

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	297	4e-106	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.0%
20x: 94.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610040J01Rik	G	T	5: 63,898,839		probably benign	Het
Acsbg2	A	G	17: 56,861,580	Y180H	probably damaging	Het
Adgrb3	G	T	1: 25,094,366	T1213K	probably damaging	Het
Atrn	A	G	2: 130,960,468	T510A	probably benign	Het
Clasp1	C	A	1: 118,561,078	T857N	probably damaging	Het
Cldn8	A	C	16: 88,562,731	M102R	probably damaging	Het
Col12a1	C	A	9: 79,672,910	V1562F	possibly damaging	Het
Cyp4f40	T	A	17: 32,671,212	D285E	probably benign	Het
Dis3	G	A	14: 99,084,114	S599L	possibly damaging	Het
Dnah11	T	C	12: 117,987,451	T3041A	probably benign	Het
Erbin	T	C	13: 103,844,885	N511D	probably benign	Het
F11	T	A	8: 45,241,474	I617F	probably damaging	Het
Gm11541	A	T	11: 94,704,222	C7S	unknown	Het
Klk12	A	T	7: 43,773,383	R245W	probably damaging	Het
Lao1	C	A	4: 118,965,307	S141R	probably benign	Het
Lrrk2	A	G	15: 91,747,820	K1316E	probably damaging	Het
Map3k6	A	G	4: 133,246,333	Y445C	possibly damaging	Het
Mup6	T	C	4: 60,004,000	I31T	probably damaging	Het
Ndnf	T	A	6: 65,704,196	D486E	probably benign	Het
Olfr1084	A	T	2: 86,639,134	N191K	probably benign	Het
Olfr1097	A	T	2: 86,891,150	N8K	probably benign	Het
Olfr441	T	C	6: 43,115,918	Y59H	probably damaging	Het
Rab19	T	C	6: 39,388,126	S107P	probably damaging	Het
Slc22a29	A	T	19: 8,162,724	L439*	probably null	Het
Slc5a1	A	G	5: 33,146,516	E225G	possibly damaging	Het
Slx4	A	G	16: 3,989,055	V508A	possibly damaging	Het
Snx25	A	G	8: 46,068,229	S373P	possibly damaging	Het
Stag2	A	G	X: 42,233,872	S400G	probably benign	Homo
Tmem181a	T	A	17: 6,295,786	L185H	probably damaging	Het
Zdhhc22	G	A	12: 86,988,223	L152F	probably benign	Het
Zfpm2	T	G	15: 41,096,161	M80R	probably benign	Het

Other mutations in Tas2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02749:Tas2r107	APN	6	131659954	missense	probably damaging	1.00
IGL02751:Tas2r107	APN	6	131659484	missense	probably damaging	1.00
IGL02868:Tas2r107	APN	6	131659286	missense	probably benign	0.11
IGL02943:Tas2r107	APN	6	131659406	missense	probably damaging	0.99
R1564:Tas2r107	UTSW	6	131659822	missense	probably damaging	0.96
R1905:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1906:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1907:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R2185:Tas2r107	UTSW	6	131659603	missense	probably damaging	0.98
R3014:Tas2r107	UTSW	6	131660009	missense	probably benign	0.30
R3824:Tas2r107	UTSW	6	131659330	missense	probably benign	0.00
R5058:Tas2r107	UTSW	6	131659742	missense	probably damaging	1.00
R5646:Tas2r107	UTSW	6	131659708	missense	probably benign	0.02
R5975:Tas2r107	UTSW	6	131659780	missense	probably benign	0.02
R6008:Tas2r107	UTSW	6	131659912	missense	possibly damaging	0.82
R6144:Tas2r107	UTSW	6	131660003	missense	possibly damaging	0.87
R6451:Tas2r107	UTSW	6	131660014	missense	possibly damaging	0.81
R6662:Tas2r107	UTSW	6	131659489	missense	possibly damaging	0.82
R6702:Tas2r107	UTSW	6	131659384	missense	probably benign	0.12
R7032:Tas2r107	UTSW	6	131659190	missense	possibly damaging	0.62
R7635:Tas2r107	UTSW	6	131659600	missense	possibly damaging	0.92

Predicted Primers

PCR Primer
(F):5'- CAGTTATGTTTCCAGAGGTAAGC -3'
(R):5'- GCACCCATAAAGTTCTGAATCTATCAC -3'

Sequencing Primer
(F):5'- TCCAGAGGTAAGCATGTGTG -3'
(R):5'- CTGAATCTATCACATGACAATAGGC -3'

Posted On

2015-07-21