Incidental Mutation 'R4465:Tas2r107'
| ID |
330304 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tas2r107
|
| Ensembl Gene |
ENSMUSG00000053389 |
| Gene Name |
taste receptor, type 2, member 107 |
| Synonyms |
mGR06, mt2r43, Tas2r7, T2R07, T2R4, STC 5-1 |
| MMRRC Submission |
041580-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.053)
|
| Stock # |
R4465 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
131636081-131637112 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 131636972 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 26
(Y26H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000067082
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000065781]
|
| AlphaFold |
Q7M725 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000065781
AA Change: Y26H
PolyPhen 2
Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000067082
Gene: ENSMUSG00000053389
AA Change: Y26H
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
297 |
4e-106 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610040J01Rik |
G |
T |
5: 64,056,182 (GRCm39) |
|
probably benign |
Het |
| Acsbg2 |
A |
G |
17: 57,168,580 (GRCm39) |
Y180H |
probably damaging |
Het |
| Adgrb3 |
G |
T |
1: 25,133,447 (GRCm39) |
T1213K |
probably damaging |
Het |
| Atrn |
A |
G |
2: 130,802,388 (GRCm39) |
T510A |
probably benign |
Het |
| Clasp1 |
C |
A |
1: 118,488,808 (GRCm39) |
T857N |
probably damaging |
Het |
| Cldn8 |
A |
C |
16: 88,359,619 (GRCm39) |
M102R |
probably damaging |
Het |
| Col12a1 |
C |
A |
9: 79,580,192 (GRCm39) |
V1562F |
possibly damaging |
Het |
| Cyp4f40 |
T |
A |
17: 32,890,186 (GRCm39) |
D285E |
probably benign |
Het |
| Dis3 |
G |
A |
14: 99,321,550 (GRCm39) |
S599L |
possibly damaging |
Het |
| Dnah11 |
T |
C |
12: 117,951,186 (GRCm39) |
T3041A |
probably benign |
Het |
| Erbin |
T |
C |
13: 103,981,393 (GRCm39) |
N511D |
probably benign |
Het |
| F11 |
T |
A |
8: 45,694,511 (GRCm39) |
I617F |
probably damaging |
Het |
| Gm11541 |
A |
T |
11: 94,595,048 (GRCm39) |
C7S |
unknown |
Het |
| Klk12 |
A |
T |
7: 43,422,807 (GRCm39) |
R245W |
probably damaging |
Het |
| Lao1 |
C |
A |
4: 118,822,504 (GRCm39) |
S141R |
probably benign |
Het |
| Lrrk2 |
A |
G |
15: 91,632,023 (GRCm39) |
K1316E |
probably damaging |
Het |
| Map3k6 |
A |
G |
4: 132,973,644 (GRCm39) |
Y445C |
possibly damaging |
Het |
| Mup6 |
T |
C |
4: 60,004,000 (GRCm39) |
I31T |
probably damaging |
Het |
| Ndnf |
T |
A |
6: 65,681,180 (GRCm39) |
D486E |
probably benign |
Het |
| Or2a54 |
T |
C |
6: 43,092,852 (GRCm39) |
Y59H |
probably damaging |
Het |
| Or8h7 |
A |
T |
2: 86,721,494 (GRCm39) |
N8K |
probably benign |
Het |
| Or8k37 |
A |
T |
2: 86,469,478 (GRCm39) |
N191K |
probably benign |
Het |
| Rab19 |
T |
C |
6: 39,365,060 (GRCm39) |
S107P |
probably damaging |
Het |
| Slc22a29 |
A |
T |
19: 8,140,088 (GRCm39) |
L439* |
probably null |
Het |
| Slc5a1 |
A |
G |
5: 33,303,860 (GRCm39) |
E225G |
possibly damaging |
Het |
| Slx4 |
A |
G |
16: 3,806,919 (GRCm39) |
V508A |
possibly damaging |
Het |
| Snx25 |
A |
G |
8: 46,521,266 (GRCm39) |
S373P |
possibly damaging |
Het |
| Stag2 |
A |
G |
X: 41,322,749 (GRCm39) |
S400G |
probably benign |
Homo |
| Tmem181a |
T |
A |
17: 6,346,061 (GRCm39) |
L185H |
probably damaging |
Het |
| Zdhhc22 |
G |
A |
12: 87,034,997 (GRCm39) |
L152F |
probably benign |
Het |
| Zfpm2 |
T |
G |
15: 40,959,557 (GRCm39) |
M80R |
probably benign |
Het |
|
| Other mutations in Tas2r107 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02749:Tas2r107
|
APN |
6 |
131,636,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02751:Tas2r107
|
APN |
6 |
131,636,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02868:Tas2r107
|
APN |
6 |
131,636,249 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02943:Tas2r107
|
APN |
6 |
131,636,369 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1564:Tas2r107
|
UTSW |
6 |
131,636,785 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1905:Tas2r107
|
UTSW |
6 |
131,636,951 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1906:Tas2r107
|
UTSW |
6 |
131,636,951 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1907:Tas2r107
|
UTSW |
6 |
131,636,951 (GRCm39) |
missense |
probably benign |
0.20 |
|
R2185:Tas2r107
|
UTSW |
6 |
131,636,566 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3014:Tas2r107
|
UTSW |
6 |
131,636,972 (GRCm39) |
missense |
probably benign |
0.30 |
|
R3824:Tas2r107
|
UTSW |
6 |
131,636,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5058:Tas2r107
|
UTSW |
6 |
131,636,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5646:Tas2r107
|
UTSW |
6 |
131,636,671 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5975:Tas2r107
|
UTSW |
6 |
131,636,743 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6008:Tas2r107
|
UTSW |
6 |
131,636,875 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6144:Tas2r107
|
UTSW |
6 |
131,636,966 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6451:Tas2r107
|
UTSW |
6 |
131,636,977 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6662:Tas2r107
|
UTSW |
6 |
131,636,452 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6702:Tas2r107
|
UTSW |
6 |
131,636,347 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7032:Tas2r107
|
UTSW |
6 |
131,636,153 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7635:Tas2r107
|
UTSW |
6 |
131,636,563 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8303:Tas2r107
|
UTSW |
6 |
131,636,585 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9156:Tas2r107
|
UTSW |
6 |
131,636,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9497:Tas2r107
|
UTSW |
6 |
131,636,549 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9789:Tas2r107
|
UTSW |
6 |
131,636,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGTTATGTTTCCAGAGGTAAGC -3'
(R):5'- GCACCCATAAAGTTCTGAATCTATCAC -3'
Sequencing Primer
(F):5'- TCCAGAGGTAAGCATGTGTG -3'
(R):5'- CTGAATCTATCACATGACAATAGGC -3'
|
| Posted On |
2015-07-21 |
Incidental Mutation