Mutagenetix > Incidental Mutation

Incidental Mutation 'R4490:Vmn2r26'

330681

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

MMRRC Submission

041746-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R4490 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

124001717-124038994 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 124027697 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 479 (L479P)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000032238
AA Change: L479P

PolyPhen 2 Score 0.474 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: L479P

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.1%

Validation Efficiency

100% (45/45)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abl2	T	C	1: 156,461,349 (GRCm39)	V417A	probably damaging	Het
Adgrb2	T	C	4: 129,906,121 (GRCm39)	V881A	possibly damaging	Het
Arl5c	G	A	11: 97,886,662 (GRCm39)	R10*	probably null	Het
Atad1	A	G	19: 32,673,197 (GRCm39)	C229R	probably benign	Het
Atp6v0a2	T	C	5: 124,784,674 (GRCm39)	V319A	probably damaging	Het
Cage1	A	G	13: 38,207,393 (GRCm39)	S257P	possibly damaging	Het
Ccndbp1	A	G	2: 120,842,876 (GRCm39)	D179G	probably damaging	Het
Cngb3	T	C	4: 19,415,684 (GRCm39)	I398T	probably benign	Het
Crmp1	A	G	5: 37,433,675 (GRCm39)	D178G	probably damaging	Het
Csmd3	C	T	15: 48,177,429 (GRCm39)	V370I	possibly damaging	Het
Dapk1	A	G	13: 60,865,942 (GRCm39)	T180A	probably benign	Het
Dmtf1	A	G	5: 9,190,379 (GRCm39)		probably benign	Het
Dnah12	T	C	14: 26,455,758 (GRCm39)	L827S	possibly damaging	Het
F5	T	C	1: 164,044,964 (GRCm39)	V2084A	probably benign	Het
Fan1	A	T	7: 64,018,928 (GRCm39)	S476T	possibly damaging	Het
Far2	T	C	6: 148,074,907 (GRCm39)	L380P	possibly damaging	Het
Gbp2	A	G	3: 142,329,525 (GRCm39)	N24S	probably benign	Het
Gm14325	T	C	2: 177,474,776 (GRCm39)	H101R	possibly damaging	Het
Gpr55	C	T	1: 85,869,540 (GRCm39)	V14M	probably damaging	Het
Herc6	A	T	6: 57,631,480 (GRCm39)	Y724F	probably damaging	Het
Impg1	T	A	9: 80,301,341 (GRCm39)	Q195L	probably damaging	Het
Inf2	T	C	12: 112,566,638 (GRCm39)	F68L	probably damaging	Het
Kcnh8	T	C	17: 53,268,905 (GRCm39)		probably null	Het
Klb	A	G	5: 65,533,137 (GRCm39)	N482S	probably benign	Het
Kpnb1	A	G	11: 97,062,424 (GRCm39)	V447A	probably benign	Het
Nckap5l	G	A	15: 99,324,011 (GRCm39)	P831S	probably benign	Het
Ncor2	A	G	5: 125,113,879 (GRCm39)		probably null	Het
Or4b1d	A	T	2: 89,969,261 (GRCm39)	V74D	probably damaging	Het
Pgm3	T	C	9: 86,443,893 (GRCm39)	Y337C	probably damaging	Het
Prdm1	G	T	10: 44,322,903 (GRCm39)	Y197*	probably null	Het
Prdm4	A	T	10: 85,736,763 (GRCm39)	C626S	probably damaging	Het
Prex2	T	A	1: 11,232,487 (GRCm39)	S851R	probably benign	Het
Ranbp6	A	G	19: 29,787,733 (GRCm39)	L873P	probably damaging	Het
Rin2	A	G	2: 145,664,194 (GRCm39)	T23A	possibly damaging	Het
Rxra	G	T	2: 27,631,207 (GRCm39)	R118L	probably damaging	Het
Spice1	T	C	16: 44,202,476 (GRCm39)	L750P	probably damaging	Het
Trpm1	C	T	7: 63,858,660 (GRCm39)	Q228*	probably null	Het
Tsc1	A	G	2: 28,560,937 (GRCm39)	D265G	probably damaging	Het
Usp29	T	C	7: 6,964,949 (GRCm39)	I264T	possibly damaging	Het
Zfp9	A	G	6: 118,442,273 (GRCm39)	S130P	probably benign	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124,038,566 (GRCm39)	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124,038,715 (GRCm39)	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124,030,833 (GRCm39)	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124,027,632 (GRCm39)	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124,038,584 (GRCm39)	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124,038,777 (GRCm39)	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124,003,100 (GRCm39)	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124,003,091 (GRCm39)	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124,016,754 (GRCm39)	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124,027,778 (GRCm39)	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124,016,858 (GRCm39)	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124,038,992 (GRCm39)	makesense	probably null
R0083:Vmn2r26	UTSW	6	124,030,940 (GRCm39)	splice site	probably null
R0682:Vmn2r26	UTSW	6	124,038,129 (GRCm39)	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124,038,603 (GRCm39)	missense	probably benign	0.12
R1077:Vmn2r26	UTSW	6	124,030,872 (GRCm39)	missense	probably benign	0.00
R1263:Vmn2r26	UTSW	6	124,027,667 (GRCm39)	missense	probably benign
R1579:Vmn2r26	UTSW	6	124,016,706 (GRCm39)	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124,038,431 (GRCm39)	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124,038,369 (GRCm39)	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124,001,730 (GRCm39)	missense	probably benign
R1956:Vmn2r26	UTSW	6	124,030,846 (GRCm39)	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124,038,144 (GRCm39)	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124,038,196 (GRCm39)	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124,016,708 (GRCm39)	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124,038,309 (GRCm39)	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124,002,938 (GRCm39)	missense	probably benign
R4629:Vmn2r26	UTSW	6	124,038,150 (GRCm39)	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124,038,375 (GRCm39)	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124,030,924 (GRCm39)	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124,003,070 (GRCm39)	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124,038,832 (GRCm39)	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124,038,285 (GRCm39)	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124,027,676 (GRCm39)	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124,016,408 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124,002,925 (GRCm39)	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124,038,633 (GRCm39)	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124,016,830 (GRCm39)	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124,016,519 (GRCm39)	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124,038,444 (GRCm39)	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124,038,348 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124,003,039 (GRCm39)	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124,038,650 (GRCm39)	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124,016,057 (GRCm39)	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124,016,741 (GRCm39)	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124,038,255 (GRCm39)	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124,016,727 (GRCm39)	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124,038,948 (GRCm39)	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124,002,914 (GRCm39)	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124,016,700 (GRCm39)	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124,016,606 (GRCm39)	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124,016,321 (GRCm39)	missense	probably benign
R7696:Vmn2r26	UTSW	6	124,038,494 (GRCm39)	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124,038,704 (GRCm39)	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124,016,758 (GRCm39)	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124,001,914 (GRCm39)	missense	probably benign	0.00
R8331:Vmn2r26	UTSW	6	124,038,887 (GRCm39)	missense	probably benign	0.22
R8352:Vmn2r26	UTSW	6	124,016,577 (GRCm39)	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124,002,995 (GRCm39)	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124,016,577 (GRCm39)	missense	probably benign	0.09
R8681:Vmn2r26	UTSW	6	124,001,877 (GRCm39)	missense	probably benign	0.00
R8914:Vmn2r26	UTSW	6	124,038,983 (GRCm39)	missense	probably benign
R9333:Vmn2r26	UTSW	6	124,003,009 (GRCm39)	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124,016,333 (GRCm39)	missense	probably benign
R9436:Vmn2r26	UTSW	6	124,002,826 (GRCm39)	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124,038,137 (GRCm39)	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124,016,448 (GRCm39)	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- CCAGGTTTATTTGCATCTCAGTG -3'
(R):5'- GGACAAAGTTAGGGTACTCTCAGC -3'

Sequencing Primer
(F):5'- CATCTCAGTGAGTTGTGCTGCAC -3'
(R):5'- AAAGTTAGGGTACTCTCAGCCTGATG -3'

Posted On

2015-07-21