Incidental Mutation 'R4490:Trpm1'
| ID |
330684 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trpm1
|
| Ensembl Gene |
ENSMUSG00000030523 |
| Gene Name |
transient receptor potential cation channel, subfamily M, member 1 |
| Synonyms |
Mlsn1, 4732499L03Rik, LTRPC1, melastatin |
| MMRRC Submission |
041746-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4490 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
64153835-64269775 bp(+) (GRCm38) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 64208912 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 228
(Q228*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146265
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085222]
[ENSMUST00000177102]
[ENSMUST00000205348]
[ENSMUST00000205731]
[ENSMUST00000206263]
[ENSMUST00000206277]
[ENSMUST00000206706]
[ENSMUST00000206314]
[ENSMUST00000205994]
|
| AlphaFold |
Q2TV84 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000032737
AA Change: Q245*
|
| SMART Domains |
Protein: ENSMUSP00000032737
Gene: ENSMUSG00000030523
AA Change: Q245*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
340 |
375 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000083651
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000085222
AA Change: Q361*
|
| SMART Domains |
Protein: ENSMUSP00000082318
Gene: ENSMUSG00000030523
AA Change: Q361*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
transmembrane domain
|
876 |
895 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
907 |
1120 |
6e-16 |
PFAM |
|
transmembrane domain
|
1150 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1216 |
1225 |
N/A |
INTRINSIC |
|
PDB:3E7K|H
|
1228 |
1279 |
1e-7 |
PDB |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000107515
AA Change: Q228*
|
| SMART Domains |
Protein: ENSMUSP00000103139
Gene: ENSMUSG00000030523
AA Change: Q228*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
50 |
62 |
N/A |
INTRINSIC |
|
low complexity region
|
156 |
174 |
N/A |
INTRINSIC |
|
low complexity region
|
323 |
358 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000107519
AA Change: Q245*
|
| SMART Domains |
Protein: ENSMUSP00000103143
Gene: ENSMUSG00000030523
AA Change: Q245*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
340 |
375 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
534 |
N/A |
INTRINSIC |
|
low complexity region
|
707 |
719 |
N/A |
INTRINSIC |
|
transmembrane domain
|
760 |
779 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
791 |
1004 |
1.3e-15 |
PFAM |
|
transmembrane domain
|
1034 |
1051 |
N/A |
INTRINSIC |
|
low complexity region
|
1100 |
1109 |
N/A |
INTRINSIC |
|
PDB:3E7K|H
|
1112 |
1163 |
1e-7 |
PDB |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000107525
AA Change: Q361*
|
| SMART Domains |
Protein: ENSMUSP00000103149
Gene: ENSMUSG00000030523
AA Change: Q361*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
876 |
1138 |
7.6e-22 |
PFAM |
|
transmembrane domain
|
1156 |
1173 |
N/A |
INTRINSIC |
|
Pfam:TRPM_tetra
|
1230 |
1285 |
9.4e-28 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000141574
AA Change: Q417*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000153421
AA Change: Q361*
|
| SMART Domains |
Protein: ENSMUSP00000135595
Gene: ENSMUSG00000030523
AA Change: Q361*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
461 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000177102
AA Change: Q245*
|
| SMART Domains |
Protein: ENSMUSP00000134947
Gene: ENSMUSG00000030523
AA Change: Q245*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
340 |
375 |
N/A |
INTRINSIC |
|
Blast:ANK
|
389 |
417 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000205348
AA Change: Q361*
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205434
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205610
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000205731
AA Change: Q245*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000206263
AA Change: Q245*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000206277
AA Change: Q361*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000206706
AA Change: Q228*
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206314
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205684
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205960
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206404
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206453
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205994
|
| Meta Mutation Damage Score |
0.9717 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
100% (45/45) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abl2 |
T |
C |
1: 156,633,779 |
V417A |
probably damaging |
Het |
| Adgrb2 |
T |
C |
4: 130,012,328 |
V881A |
possibly damaging |
Het |
| Arl5c |
G |
A |
11: 97,995,836 |
R10* |
probably null |
Het |
| Atad1 |
A |
G |
19: 32,695,797 |
C229R |
probably benign |
Het |
| Atp6v0a2 |
T |
C |
5: 124,646,734 |
V319A |
probably damaging |
Het |
| Cage1 |
A |
G |
13: 38,023,417 |
S257P |
possibly damaging |
Het |
| Ccndbp1 |
A |
G |
2: 121,012,395 |
D179G |
probably damaging |
Het |
| Cngb3 |
T |
C |
4: 19,415,684 |
I398T |
probably benign |
Het |
| Crmp1 |
A |
G |
5: 37,276,331 |
D178G |
probably damaging |
Het |
| Csmd3 |
C |
T |
15: 48,314,033 |
V370I |
possibly damaging |
Het |
| Dapk1 |
A |
G |
13: 60,718,128 |
T180A |
probably benign |
Het |
| Dmtf1 |
A |
G |
5: 9,140,379 |
|
probably benign |
Het |
| Dnah12 |
T |
C |
14: 26,734,603 |
L827S |
possibly damaging |
Het |
| F5 |
T |
C |
1: 164,217,395 |
V2084A |
probably benign |
Het |
| Fan1 |
A |
T |
7: 64,369,180 |
S476T |
possibly damaging |
Het |
| Far2 |
T |
C |
6: 148,173,409 |
L380P |
possibly damaging |
Het |
| Gbp2 |
A |
G |
3: 142,623,764 |
N24S |
probably benign |
Het |
| Gm14325 |
T |
C |
2: 177,832,983 |
H101R |
possibly damaging |
Het |
| Gpr55 |
C |
T |
1: 85,941,818 |
V14M |
probably damaging |
Het |
| Herc6 |
A |
T |
6: 57,654,495 |
Y724F |
probably damaging |
Het |
| Impg1 |
T |
A |
9: 80,394,059 |
Q195L |
probably damaging |
Het |
| Inf2 |
T |
C |
12: 112,600,204 |
F68L |
probably damaging |
Het |
| Kcnh8 |
T |
C |
17: 52,961,877 |
|
probably null |
Het |
| Klb |
A |
G |
5: 65,375,794 |
N482S |
probably benign |
Het |
| Kpnb1 |
A |
G |
11: 97,171,598 |
V447A |
probably benign |
Het |
| Nckap5l |
G |
A |
15: 99,426,130 |
P831S |
probably benign |
Het |
| Ncor2 |
A |
G |
5: 125,036,815 |
|
probably null |
Het |
| Olfr32 |
A |
T |
2: 90,138,917 |
V74D |
probably damaging |
Het |
| Pgm3 |
T |
C |
9: 86,561,840 |
Y337C |
probably damaging |
Het |
| Prdm1 |
G |
T |
10: 44,446,907 |
Y197* |
probably null |
Het |
| Prdm4 |
A |
T |
10: 85,900,899 |
C626S |
probably damaging |
Het |
| Prex2 |
T |
A |
1: 11,162,263 |
S851R |
probably benign |
Het |
| Ranbp6 |
A |
G |
19: 29,810,333 |
L873P |
probably damaging |
Het |
| Rin2 |
A |
G |
2: 145,822,274 |
T23A |
possibly damaging |
Het |
| Rxra |
G |
T |
2: 27,741,195 |
R118L |
probably damaging |
Het |
| Spice1 |
T |
C |
16: 44,382,113 |
L750P |
probably damaging |
Het |
| Tsc1 |
A |
G |
2: 28,670,925 |
D265G |
probably damaging |
Het |
| Usp29 |
T |
C |
7: 6,961,950 |
I264T |
possibly damaging |
Het |
| Vmn2r26 |
T |
C |
6: 124,050,738 |
L479P |
possibly damaging |
Het |
| Zfp9 |
A |
G |
6: 118,465,312 |
S130P |
probably benign |
Het |
|
| Other mutations in Trpm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00093:Trpm1
|
APN |
7 |
64243450 |
missense |
probably damaging |
1.00 |
|
IGL00465:Trpm1
|
APN |
7 |
64247467 |
missense |
possibly damaging |
0.94 |
|
IGL01118:Trpm1
|
APN |
7 |
64235824 |
missense |
probably benign |
0.24 |
|
IGL01148:Trpm1
|
APN |
7 |
64243564 |
missense |
probably damaging |
1.00 |
|
IGL01303:Trpm1
|
APN |
7 |
64210830 |
critical splice acceptor site |
probably benign |
0.00 |
|
IGL01432:Trpm1
|
APN |
7 |
64235019 |
missense |
probably benign |
0.18 |
|
IGL01433:Trpm1
|
APN |
7 |
64204528 |
missense |
probably damaging |
1.00 |
|
IGL01506:Trpm1
|
APN |
7 |
64243581 |
missense |
probably damaging |
1.00 |
|
IGL01626:Trpm1
|
APN |
7 |
64268889 |
missense |
probably damaging |
1.00 |
|
IGL01640:Trpm1
|
APN |
7 |
64226897 |
missense |
probably damaging |
1.00 |
|
IGL01899:Trpm1
|
APN |
7 |
64234994 |
missense |
probably benign |
0.24 |
|
IGL01959:Trpm1
|
APN |
7 |
64208975 |
missense |
possibly damaging |
0.81 |
|
IGL02210:Trpm1
|
APN |
7 |
64210865 |
missense |
probably damaging |
1.00 |
|
IGL02268:Trpm1
|
APN |
7 |
64217614 |
missense |
probably damaging |
0.96 |
|
IGL02331:Trpm1
|
APN |
7 |
64235052 |
missense |
probably benign |
0.30 |
|
IGL02334:Trpm1
|
APN |
7 |
64245942 |
critical splice acceptor site |
probably null |
|
|
IGL02407:Trpm1
|
APN |
7 |
64219121 |
missense |
probably damaging |
1.00 |
|
IGL02425:Trpm1
|
APN |
7 |
64240427 |
missense |
probably damaging |
0.96 |
|
IGL02485:Trpm1
|
APN |
7 |
64269114 |
missense |
possibly damaging |
0.52 |
|
IGL02635:Trpm1
|
APN |
7 |
64199224 |
missense |
probably benign |
0.00 |
|
IGL02640:Trpm1
|
APN |
7 |
64219133 |
missense |
probably damaging |
0.97 |
|
IGL02827:Trpm1
|
APN |
7 |
64219160 |
missense |
probably null |
1.00 |
|
PIT4458001:Trpm1
|
UTSW |
7 |
64268561 |
missense |
possibly damaging |
0.94 |
|
PIT4544001:Trpm1
|
UTSW |
7 |
64199250 |
intron |
probably benign |
|
|
R0012:Trpm1
|
UTSW |
7 |
64268591 |
missense |
possibly damaging |
0.88 |
|
R0014:Trpm1
|
UTSW |
7 |
64248222 |
missense |
probably damaging |
1.00 |
|
R0056:Trpm1
|
UTSW |
7 |
64243586 |
missense |
probably damaging |
1.00 |
|
R0445:Trpm1
|
UTSW |
7 |
64244842 |
unclassified |
probably benign |
|
|
R0463:Trpm1
|
UTSW |
7 |
64220254 |
missense |
probably benign |
0.05 |
|
R0469:Trpm1
|
UTSW |
7 |
64223758 |
missense |
probably damaging |
1.00 |
|
R0510:Trpm1
|
UTSW |
7 |
64223758 |
missense |
probably damaging |
1.00 |
|
R1301:Trpm1
|
UTSW |
7 |
64203053 |
splice site |
probably null |
|
|
R1397:Trpm1
|
UTSW |
7 |
64217658 |
missense |
probably damaging |
1.00 |
|
R1588:Trpm1
|
UTSW |
7 |
64223817 |
missense |
possibly damaging |
0.93 |
|
R1618:Trpm1
|
UTSW |
7 |
64240535 |
missense |
probably damaging |
1.00 |
|
R1724:Trpm1
|
UTSW |
7 |
64235821 |
nonsense |
probably null |
|
|
R1827:Trpm1
|
UTSW |
7 |
64235007 |
missense |
probably damaging |
1.00 |
|
R1829:Trpm1
|
UTSW |
7 |
64226782 |
missense |
probably damaging |
1.00 |
|
R1835:Trpm1
|
UTSW |
7 |
64230268 |
missense |
probably damaging |
1.00 |
|
R1864:Trpm1
|
UTSW |
7 |
64268016 |
missense |
probably damaging |
1.00 |
|
R1895:Trpm1
|
UTSW |
7 |
64223808 |
missense |
probably damaging |
1.00 |
|
R1946:Trpm1
|
UTSW |
7 |
64223808 |
missense |
probably damaging |
1.00 |
|
R1959:Trpm1
|
UTSW |
7 |
64230230 |
missense |
probably damaging |
1.00 |
|
R1960:Trpm1
|
UTSW |
7 |
64230230 |
missense |
probably damaging |
1.00 |
|
R1980:Trpm1
|
UTSW |
7 |
64208434 |
missense |
possibly damaging |
0.83 |
|
R1989:Trpm1
|
UTSW |
7 |
64209032 |
intron |
probably null |
|
|
R2054:Trpm1
|
UTSW |
7 |
64240555 |
missense |
possibly damaging |
0.69 |
|
R2156:Trpm1
|
UTSW |
7 |
64234988 |
missense |
probably damaging |
1.00 |
|
R2251:Trpm1
|
UTSW |
7 |
64209976 |
missense |
probably damaging |
1.00 |
|
R3051:Trpm1
|
UTSW |
7 |
64269101 |
missense |
probably damaging |
1.00 |
|
R3148:Trpm1
|
UTSW |
7 |
64235012 |
missense |
probably benign |
0.00 |
|
R3195:Trpm1
|
UTSW |
7 |
64199313 |
nonsense |
probably null |
|
|
R3615:Trpm1
|
UTSW |
7 |
64243570 |
missense |
probably damaging |
1.00 |
|
R3616:Trpm1
|
UTSW |
7 |
64243570 |
missense |
probably damaging |
1.00 |
|
R3623:Trpm1
|
UTSW |
7 |
64244853 |
missense |
probably damaging |
1.00 |
|
R3624:Trpm1
|
UTSW |
7 |
64244853 |
missense |
probably damaging |
1.00 |
|
R3721:Trpm1
|
UTSW |
7 |
64217727 |
intron |
probably benign |
|
|
R3822:Trpm1
|
UTSW |
7 |
64217703 |
intron |
probably benign |
|
|
R4441:Trpm1
|
UTSW |
7 |
64201918 |
missense |
probably damaging |
1.00 |
|
R4666:Trpm1
|
UTSW |
7 |
64203034 |
missense |
probably damaging |
1.00 |
|
R4701:Trpm1
|
UTSW |
7 |
64243500 |
missense |
probably damaging |
1.00 |
|
R4781:Trpm1
|
UTSW |
7 |
64235052 |
missense |
probably benign |
0.30 |
|
R4811:Trpm1
|
UTSW |
7 |
64208306 |
missense |
probably damaging |
1.00 |
|
R5017:Trpm1
|
UTSW |
7 |
64244832 |
unclassified |
probably benign |
|
|
R5030:Trpm1
|
UTSW |
7 |
64235831 |
missense |
probably damaging |
1.00 |
|
R5195:Trpm1
|
UTSW |
7 |
64237693 |
missense |
possibly damaging |
0.84 |
|
R5238:Trpm1
|
UTSW |
7 |
64268954 |
missense |
probably damaging |
1.00 |
|
R5304:Trpm1
|
UTSW |
7 |
64208946 |
missense |
probably benign |
0.00 |
|
R5575:Trpm1
|
UTSW |
7 |
64220270 |
missense |
possibly damaging |
0.95 |
|
R5613:Trpm1
|
UTSW |
7 |
64208411 |
missense |
probably damaging |
1.00 |
|
R5855:Trpm1
|
UTSW |
7 |
64268962 |
nonsense |
probably null |
|
|
R5947:Trpm1
|
UTSW |
7 |
64223799 |
missense |
probably benign |
0.07 |
|
R5988:Trpm1
|
UTSW |
7 |
64226805 |
missense |
probably benign |
0.16 |
|
R6054:Trpm1
|
UTSW |
7 |
64268702 |
missense |
probably benign |
0.00 |
|
R6088:Trpm1
|
UTSW |
7 |
64267976 |
missense |
probably damaging |
0.98 |
|
R6259:Trpm1
|
UTSW |
7 |
64268478 |
missense |
possibly damaging |
0.47 |
|
R6379:Trpm1
|
UTSW |
7 |
64199194 |
missense |
probably benign |
0.00 |
|
R6380:Trpm1
|
UTSW |
7 |
64268297 |
missense |
probably benign |
0.24 |
|
R6429:Trpm1
|
UTSW |
7 |
64268504 |
missense |
probably benign |
0.00 |
|
R6600:Trpm1
|
UTSW |
7 |
64154033 |
start codon destroyed |
probably null |
0.56 |
|
R6622:Trpm1
|
UTSW |
7 |
64240595 |
missense |
probably damaging |
0.96 |
|
R6939:Trpm1
|
UTSW |
7 |
64268297 |
missense |
probably benign |
0.03 |
|
R6944:Trpm1
|
UTSW |
7 |
64243433 |
missense |
probably damaging |
1.00 |
|
R7025:Trpm1
|
UTSW |
7 |
64226714 |
critical splice acceptor site |
probably null |
|
|
R7112:Trpm1
|
UTSW |
7 |
64235845 |
missense |
probably damaging |
0.97 |
|
R7168:Trpm1
|
UTSW |
7 |
64268697 |
missense |
probably benign |
0.01 |
|
R7219:Trpm1
|
UTSW |
7 |
64204585 |
missense |
possibly damaging |
0.68 |
|
R7224:Trpm1
|
UTSW |
7 |
64219106 |
critical splice acceptor site |
probably null |
|
|
R7285:Trpm1
|
UTSW |
7 |
64209981 |
nonsense |
probably null |
|
|
R7367:Trpm1
|
UTSW |
7 |
64268801 |
missense |
probably benign |
0.06 |
|
R7449:Trpm1
|
UTSW |
7 |
64208975 |
missense |
probably benign |
0.14 |
|
R7466:Trpm1
|
UTSW |
7 |
64240582 |
missense |
probably damaging |
0.99 |
|
R7498:Trpm1
|
UTSW |
7 |
64208909 |
missense |
possibly damaging |
0.93 |
|
R7581:Trpm1
|
UTSW |
7 |
64204555 |
missense |
probably benign |
0.00 |
|
R7776:Trpm1
|
UTSW |
7 |
64248191 |
missense |
probably benign |
0.04 |
|
R8062:Trpm1
|
UTSW |
7 |
64201941 |
missense |
probably benign |
0.18 |
|
R8069:Trpm1
|
UTSW |
7 |
64208970 |
missense |
possibly damaging |
0.55 |
|
R8157:Trpm1
|
UTSW |
7 |
64199269 |
missense |
probably damaging |
1.00 |
|
R8219:Trpm1
|
UTSW |
7 |
64201951 |
missense |
probably benign |
0.35 |
|
R8258:Trpm1
|
UTSW |
7 |
64269029 |
missense |
probably benign |
0.10 |
|
R8259:Trpm1
|
UTSW |
7 |
64269029 |
missense |
probably benign |
0.10 |
|
R8320:Trpm1
|
UTSW |
7 |
64268793 |
missense |
possibly damaging |
0.56 |
|
R8536:Trpm1
|
UTSW |
7 |
64247407 |
missense |
probably damaging |
1.00 |
|
R8544:Trpm1
|
UTSW |
7 |
64224608 |
splice site |
probably null |
|
|
R8813:Trpm1
|
UTSW |
7 |
64202008 |
missense |
possibly damaging |
0.68 |
|
R8912:Trpm1
|
UTSW |
7 |
64268880 |
missense |
probably benign |
0.06 |
|
R8954:Trpm1
|
UTSW |
7 |
64208341 |
missense |
probably damaging |
0.98 |
|
R9139:Trpm1
|
UTSW |
7 |
64199195 |
missense |
probably benign |
0.00 |
|
R9205:Trpm1
|
UTSW |
7 |
64240571 |
missense |
possibly damaging |
0.66 |
|
R9258:Trpm1
|
UTSW |
7 |
64234965 |
missense |
probably benign |
0.01 |
|
R9283:Trpm1
|
UTSW |
7 |
64223875 |
missense |
probably benign |
0.18 |
|
R9394:Trpm1
|
UTSW |
7 |
64268732 |
missense |
probably benign |
0.00 |
|
R9430:Trpm1
|
UTSW |
7 |
64223698 |
missense |
probably benign |
0.38 |
|
R9537:Trpm1
|
UTSW |
7 |
64153868 |
unclassified |
probably benign |
|
|
R9616:Trpm1
|
UTSW |
7 |
64208384 |
missense |
probably damaging |
0.99 |
|
R9774:Trpm1
|
UTSW |
7 |
64248293 |
missense |
possibly damaging |
0.90 |
|
X0026:Trpm1
|
UTSW |
7 |
64268910 |
missense |
probably benign |
0.05 |
|
Z1176:Trpm1
|
UTSW |
7 |
64203131 |
critical splice donor site |
probably null |
|
|
Z1176:Trpm1
|
UTSW |
7 |
64204594 |
critical splice donor site |
probably null |
|
|
Z1177:Trpm1
|
UTSW |
7 |
64217691 |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTCTTGCAAAGAGCTAAACGC -3'
(R):5'- TGGCCCATCAAGCAAGCATG -3'
Sequencing Primer
(F):5'- GCAGGCCAATTTTTAATGCTGC -3'
(R):5'- GCATGGCAGAGCTAGACAC -3'
|
| Posted On |
2015-07-21 |
Incidental Mutation