Incidental Mutation 'R4491:Meioc'
ID 330745
Institutional Source Beutler Lab
Gene Symbol Meioc
Ensembl Gene ENSMUSG00000051455
Gene Name meiosis specific with coiled-coil domain
Synonyms Gm1564, LOC380729, LOC268491
MMRRC Submission 041747-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R4491 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 102663716-102682237 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 102674920 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 398 (D398G)
Ref Sequence ENSEMBL: ENSMUSP00000116246 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100378] [ENSMUST00000156590]
AlphaFold A2AG06
Predicted Effect possibly damaging
Transcript: ENSMUST00000100378
AA Change: D454G

PolyPhen 2 Score 0.755 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000097947
Gene: ENSMUSG00000051455
AA Change: D454G

DomainStartEndE-ValueType
low complexity region 526 537 N/A INTRINSIC
low complexity region 712 728 N/A INTRINSIC
Pfam:DUF4582 757 922 5.1e-89 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155813
Predicted Effect possibly damaging
Transcript: ENSMUST00000156590
AA Change: D398G

PolyPhen 2 Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000116246
Gene: ENSMUSG00000051455
AA Change: D398G

DomainStartEndE-ValueType
low complexity region 470 481 N/A INTRINSIC
Meta Mutation Damage Score 0.0841 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 98% (64/65)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit infertility with small gonads, absent germ cells and arrested meiosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik C A 5: 63,898,469 (GRCm38) P183T probably damaging Het
6430573F11Rik G A 8: 36,505,606 (GRCm38) C70Y probably damaging Het
Bcan G A 3: 87,990,233 (GRCm38) R682* probably null Het
Bzw1 T A 1: 58,404,259 (GRCm38) L410Q probably damaging Het
Cdh5 A T 8: 104,113,040 (GRCm38) I48F probably damaging Het
Cdhr5 T C 7: 141,274,057 (GRCm38) N173D possibly damaging Het
Cfap74 T C 4: 155,429,171 (GRCm38) M480T probably benign Het
Col6a5 C T 9: 105,940,012 (GRCm38) A367T unknown Het
Colca2 A G 9: 51,270,655 (GRCm38) F206L probably benign Het
Cpsf1 A C 15: 76,597,722 (GRCm38) Y1064D possibly damaging Het
Defb6 A T 8: 19,228,074 (GRCm38) H54L probably benign Het
Dmtf1 A G 5: 9,140,379 (GRCm38) probably benign Het
Dnah12 T C 14: 26,734,603 (GRCm38) L827S possibly damaging Het
Dsc3 T C 18: 20,001,865 (GRCm38) T21A probably benign Het
Epb41l1 G T 2: 156,522,168 (GRCm38) D866Y probably benign Het
Epha1 T C 6: 42,360,666 (GRCm38) M860V probably damaging Het
Far2 T C 6: 148,173,409 (GRCm38) L380P possibly damaging Het
Fgd5 A G 6: 91,989,299 (GRCm38) I680V possibly damaging Het
Fnbp4 T C 2: 90,752,968 (GRCm38) probably null Het
Focad G A 4: 88,359,905 (GRCm38) probably null Het
Gm14180 T A 11: 99,730,313 (GRCm38) probably benign Het
Hbb-bh2 T C 7: 103,840,415 (GRCm38) T5A probably benign Het
Ighv7-2 A G 12: 113,912,480 (GRCm38) F2L probably benign Het
Igsf5 A G 16: 96,364,081 (GRCm38) T19A probably benign Het
Kcnd3 C T 3: 105,658,766 (GRCm38) A421V probably damaging Het
Klb A G 5: 65,375,794 (GRCm38) N482S probably benign Het
Lipo2 A C 19: 33,721,700 (GRCm38) L310R probably damaging Het
Mc3r A G 2: 172,249,203 (GRCm38) H115R possibly damaging Het
Olfr1130 G A 2: 87,607,392 (GRCm38) M1I probably null Het
Olfr1353 T C 10: 78,970,317 (GRCm38) S223P probably damaging Het
Olfr683 A T 7: 105,143,776 (GRCm38) C172* probably null Het
Pds5a T C 5: 65,635,437 (GRCm38) T718A probably benign Het
Pdzd2 C T 15: 12,385,637 (GRCm38) D1016N possibly damaging Het
Pla2g2c T C 4: 138,734,408 (GRCm38) probably null Het
Plch1 T C 3: 63,740,739 (GRCm38) I404V probably damaging Het
Ppp2r5c A T 12: 110,580,522 (GRCm38) D522V possibly damaging Het
Prex2 T A 1: 11,162,263 (GRCm38) S851R probably benign Het
Rapgef1 C T 2: 29,719,656 (GRCm38) P702S possibly damaging Het
Rasal3 T A 17: 32,391,385 (GRCm38) D976V probably damaging Het
Rasef A C 4: 73,734,503 (GRCm38) L587R probably damaging Het
Rptn A T 3: 93,396,511 (GRCm38) R384* probably null Het
Sema6a G A 18: 47,306,457 (GRCm38) probably benign Het
Sycp2 G T 2: 178,374,985 (GRCm38) T608K probably damaging Het
Syde1 C T 10: 78,590,228 (GRCm38) R35H probably benign Het
Taf1 G T X: 101,543,059 (GRCm38) M313I possibly damaging Het
Taf15 A T 11: 83,484,694 (GRCm38) T31S probably benign Het
Tktl2 T C 8: 66,512,012 (GRCm38) V74A probably damaging Het
Tle4 A G 19: 14,454,865 (GRCm38) V489A probably damaging Het
Tmem30a T C 9: 79,777,285 (GRCm38) H95R probably damaging Het
Vmn1r75 C A 7: 11,880,982 (GRCm38) Q214K probably damaging Het
Vps13c C T 9: 67,910,193 (GRCm38) T1049M probably benign Het
Wdr78 T C 4: 103,066,399 (GRCm38) E411G probably benign Het
Zfp37 T C 4: 62,192,128 (GRCm38) Q274R probably benign Het
Zfp648 T G 1: 154,205,127 (GRCm38) L344R probably damaging Het
Other mutations in Meioc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01391:Meioc APN 11 102,674,287 (GRCm38) missense probably benign 0.33
IGL01952:Meioc APN 11 102,672,185 (GRCm38) missense possibly damaging 0.79
IGL02006:Meioc APN 11 102,674,266 (GRCm38) missense probably damaging 1.00
IGL02195:Meioc APN 11 102,674,857 (GRCm38) missense possibly damaging 0.91
IGL02339:Meioc APN 11 102,668,448 (GRCm38) missense probably benign 0.18
IGL02935:Meioc APN 11 102,672,191 (GRCm38) missense probably benign 0.06
IGL03294:Meioc APN 11 102,680,669 (GRCm38) missense probably damaging 1.00
PIT4519001:Meioc UTSW 11 102,679,957 (GRCm38) missense probably damaging 1.00
R0285:Meioc UTSW 11 102,672,191 (GRCm38) missense probably benign 0.06
R0964:Meioc UTSW 11 102,680,031 (GRCm38) missense probably damaging 1.00
R1074:Meioc UTSW 11 102,675,393 (GRCm38) missense probably damaging 1.00
R2024:Meioc UTSW 11 102,675,358 (GRCm38) missense probably benign 0.00
R4012:Meioc UTSW 11 102,675,828 (GRCm38) missense probably damaging 0.99
R4429:Meioc UTSW 11 102,675,720 (GRCm38) missense probably damaging 1.00
R4594:Meioc UTSW 11 102,674,166 (GRCm38) missense probably damaging 1.00
R4752:Meioc UTSW 11 102,674,433 (GRCm38) missense probably benign 0.00
R5301:Meioc UTSW 11 102,680,045 (GRCm38) missense probably damaging 1.00
R5352:Meioc UTSW 11 102,675,313 (GRCm38) missense probably benign 0.03
R5646:Meioc UTSW 11 102,675,257 (GRCm38) missense possibly damaging 0.94
R5958:Meioc UTSW 11 102,675,153 (GRCm38) missense probably benign 0.41
R5968:Meioc UTSW 11 102,675,831 (GRCm38) missense probably damaging 0.99
R6157:Meioc UTSW 11 102,668,401 (GRCm38) missense probably damaging 1.00
R6410:Meioc UTSW 11 102,675,034 (GRCm38) missense probably benign 0.00
R6644:Meioc UTSW 11 102,668,460 (GRCm38) critical splice donor site probably null
R7285:Meioc UTSW 11 102,666,342 (GRCm38) missense probably benign 0.00
R7440:Meioc UTSW 11 102,674,237 (GRCm38) missense possibly damaging 0.67
R7815:Meioc UTSW 11 102,675,588 (GRCm38) missense probably damaging 1.00
R7984:Meioc UTSW 11 102,674,606 (GRCm38) missense possibly damaging 0.94
R8009:Meioc UTSW 11 102,676,743 (GRCm38) missense probably damaging 1.00
R8078:Meioc UTSW 11 102,668,400 (GRCm38) nonsense probably null
R8195:Meioc UTSW 11 102,675,067 (GRCm38) nonsense probably null
R8429:Meioc UTSW 11 102,674,206 (GRCm38) missense probably benign 0.06
R8797:Meioc UTSW 11 102,676,860 (GRCm38) nonsense probably null
R8854:Meioc UTSW 11 102,675,763 (GRCm38) missense probably damaging 0.98
R8891:Meioc UTSW 11 102,668,420 (GRCm38) missense probably benign 0.43
R9081:Meioc UTSW 11 102,674,175 (GRCm38) missense probably benign 0.00
R9360:Meioc UTSW 11 102,674,953 (GRCm38) missense probably benign 0.13
R9539:Meioc UTSW 11 102,674,680 (GRCm38) missense probably damaging 0.99
R9549:Meioc UTSW 11 102,665,724 (GRCm38) intron probably benign
R9751:Meioc UTSW 11 102,675,593 (GRCm38) nonsense probably null
Z1177:Meioc UTSW 11 102,666,364 (GRCm38) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TGTGGAAGCAGATGCCTATACG -3'
(R):5'- CCTTTTGAAGCTGCACTTAAATGAC -3'

Sequencing Primer
(F):5'- GACCAGCAGAATTTTGCATTTCC -3'
(R):5'- TGAAGCTGCACTTAAATGACTATTC -3'
Posted On 2015-07-21