Incidental Mutation 'R4494:Svop'
ID 330878
Institutional Source Beutler Lab
Gene Symbol Svop
Ensembl Gene ENSMUSG00000042078
Gene Name SV2 related protein
Synonyms msvop, 1110030H18Rik
MMRRC Submission 041582-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4494 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 114164974-114229441 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 114183688 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 195 (T195A)
Ref Sequence ENSEMBL: ENSMUSP00000050730 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058472]
AlphaFold Q8BFT9
Predicted Effect probably damaging
Transcript: ENSMUST00000058472
AA Change: T195A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000050730
Gene: ENSMUSG00000042078
AA Change: T195A

DomainStartEndE-ValueType
Pfam:Sugar_tr 66 347 2.2e-26 PFAM
Pfam:MFS_1 86 346 2e-23 PFAM
Pfam:MFS_1 376 541 2.5e-16 PFAM
Pfam:Sugar_tr 377 523 2.9e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134790
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149480
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele are viable with no phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atf7ip T A 6: 136,540,747 (GRCm39) probably null Het
Cacna1b T C 2: 24,542,950 (GRCm39) T1301A probably damaging Het
Calcr A T 6: 3,708,484 (GRCm39) probably null Het
Camsap1 T C 2: 25,842,770 (GRCm39) D262G probably damaging Het
Ccdc141 A G 2: 76,962,641 (GRCm39) V101A probably damaging Het
Ccdc170 T C 10: 4,464,128 (GRCm39) Y36H probably damaging Het
Cd177 A T 7: 24,451,428 (GRCm39) S492T probably benign Het
Chrna4 T A 2: 180,670,281 (GRCm39) I492F probably damaging Het
Cit T C 5: 116,012,043 (GRCm39) Y217H probably damaging Het
Cnbd1 T A 4: 19,098,150 (GRCm39) D90V probably benign Het
Cryba2 A G 1: 74,929,789 (GRCm39) F116S probably damaging Het
Ctbp1 T C 5: 33,408,213 (GRCm39) T240A possibly damaging Het
D130043K22Rik C T 13: 25,055,339 (GRCm39) S501L probably benign Het
Ddhd2 A G 8: 26,228,261 (GRCm39) F553S probably benign Het
Ddr2 C A 1: 169,815,983 (GRCm39) G575W probably damaging Het
Dip2c T C 13: 9,621,098 (GRCm39) V537A possibly damaging Het
Dnah12 C T 14: 26,593,812 (GRCm39) A752V probably damaging Het
Dnah7a T C 1: 53,488,197 (GRCm39) D3260G probably benign Het
Efemp2 T A 19: 5,530,339 (GRCm39) C309S probably damaging Het
Gse1 G A 8: 121,297,553 (GRCm39) probably benign Het
Hspa4l T C 3: 40,707,636 (GRCm39) S53P possibly damaging Het
Ighv5-4 T C 12: 113,561,204 (GRCm39) D72G probably benign Het
Igkv15-103 A G 6: 68,414,780 (GRCm39) N73S probably benign Het
Igsf11 T G 16: 38,831,703 (GRCm39) N183K possibly damaging Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Kcnk18 T C 19: 59,223,263 (GRCm39) V136A probably damaging Het
Krt75 A T 15: 101,480,136 (GRCm39) Y240* probably null Het
Lyst G A 13: 13,809,968 (GRCm39) R546H probably damaging Het
Man2a2 C T 7: 80,009,023 (GRCm39) probably null Het
Mme A G 3: 63,254,613 (GRCm39) N491S probably benign Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Msi2 T C 11: 88,608,185 (GRCm39) D39G possibly damaging Het
Naa60 T A 16: 3,718,585 (GRCm39) C122* probably null Het
Nes A G 3: 87,884,120 (GRCm39) E793G probably damaging Het
Nfkb2 A G 19: 46,296,878 (GRCm39) D316G probably damaging Het
Nme6 C T 9: 109,671,122 (GRCm39) L121F probably damaging Het
Or4k47 T A 2: 111,451,493 (GRCm39) K309* probably null Het
Otud1 C T 2: 19,664,146 (GRCm39) T425I probably damaging Het
Pimreg T C 11: 71,935,964 (GRCm39) V149A probably benign Het
Plbd1 T C 6: 136,590,856 (GRCm39) I437V probably damaging Het
Prlhr A T 19: 60,455,519 (GRCm39) M349K probably benign Het
Slc1a3 G A 15: 8,668,579 (GRCm39) T462I probably damaging Het
Slc25a26 A G 6: 94,575,384 (GRCm39) T198A probably damaging Het
Stkld1 A G 2: 26,836,638 (GRCm39) N268S probably benign Het
Syt6 A G 3: 103,492,946 (GRCm39) E66G probably damaging Het
Tas2r129 A G 6: 132,928,317 (GRCm39) I85V probably benign Het
Tent5a A G 9: 85,207,100 (GRCm39) S233P probably damaging Het
Tprn T C 2: 25,158,904 (GRCm39) S643P probably damaging Het
Ush2a C T 1: 188,285,473 (GRCm39) T2003I possibly damaging Het
Vmn2r17 T A 5: 109,576,335 (GRCm39) V402E probably damaging Het
Vmn2r3 C G 3: 64,182,692 (GRCm39) G336R probably damaging Het
Wdr89 A T 12: 75,679,521 (GRCm39) D244E probably damaging Het
Other mutations in Svop
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02220:Svop APN 5 114,203,589 (GRCm39) missense probably benign 0.02
IGL02612:Svop APN 5 114,166,321 (GRCm39) makesense probably null
R0254:Svop UTSW 5 114,176,600 (GRCm39) missense probably benign
R1705:Svop UTSW 5 114,180,356 (GRCm39) missense probably damaging 1.00
R1826:Svop UTSW 5 114,198,117 (GRCm39) critical splice donor site probably null
R3084:Svop UTSW 5 114,180,299 (GRCm39) missense probably benign
R4575:Svop UTSW 5 114,203,743 (GRCm39) missense probably damaging 1.00
R4576:Svop UTSW 5 114,203,743 (GRCm39) missense probably damaging 1.00
R4578:Svop UTSW 5 114,203,743 (GRCm39) missense probably damaging 1.00
R4725:Svop UTSW 5 114,203,546 (GRCm39) unclassified probably benign
R5433:Svop UTSW 5 114,198,186 (GRCm39) missense probably damaging 1.00
R5731:Svop UTSW 5 114,198,124 (GRCm39) missense probably damaging 0.99
R5783:Svop UTSW 5 114,202,996 (GRCm39) missense possibly damaging 0.73
R5889:Svop UTSW 5 114,203,692 (GRCm39) missense probably benign 0.37
R8134:Svop UTSW 5 114,180,992 (GRCm39) missense probably benign 0.01
R8433:Svop UTSW 5 114,170,822 (GRCm39) missense probably benign 0.21
R8848:Svop UTSW 5 114,183,687 (GRCm39) missense
R8851:Svop UTSW 5 114,192,557 (GRCm39) missense probably damaging 1.00
R8868:Svop UTSW 5 114,170,854 (GRCm39) missense probably damaging 0.98
R8965:Svop UTSW 5 114,173,271 (GRCm39) missense probably benign 0.01
R9109:Svop UTSW 5 114,168,231 (GRCm39) missense probably benign 0.16
R9298:Svop UTSW 5 114,168,231 (GRCm39) missense probably benign 0.16
R9715:Svop UTSW 5 114,198,169 (GRCm39) missense probably benign 0.39
R9732:Svop UTSW 5 114,201,142 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGAAGGAGGACAAAGCATTTATACT -3'
(R):5'- TGATAGTGCATGCTGGGAGAC -3'

Sequencing Primer
(F):5'- AGAATTCCTGGGAGACCT -3'
(R):5'- ATAGTGAGTTTGAAGTCAGCCATG -3'
Posted On 2015-07-21