Incidental Mutation 'R4496:Or6c5c'
ID 330985
Institutional Source Beutler Lab
Gene Symbol Or6c5c
Ensembl Gene ENSMUSG00000096497
Gene Name olfactory receptor family 6 subfamily C member 5C
Synonyms MOR111-10, GA_x6K02T2PULF-11141498-11142436, Olfr787
MMRRC Submission 041749-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R4496 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129297809-129299485 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 129299430 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 295 (V295G)
Ref Sequence ENSEMBL: ENSMUSP00000149391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077836] [ENSMUST00000213329]
AlphaFold Q7TRI1
Predicted Effect possibly damaging
Transcript: ENSMUST00000077836
AA Change: V295G

PolyPhen 2 Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000077005
Gene: ENSMUSG00000096497
AA Change: V295G

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 4e-49 PFAM
Pfam:7tm_1 39 288 2.1e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213329
AA Change: V295G

PolyPhen 2 Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T A 17: 24,602,947 (GRCm39) L514H possibly damaging Het
Abca7 T C 10: 79,838,768 (GRCm39) F647S probably damaging Het
Ahi1 A G 10: 20,841,444 (GRCm39) K244E probably benign Het
Ankhd1 G A 18: 36,693,839 (GRCm39) D17N probably damaging Het
Arvcf G T 16: 18,223,932 (GRCm39) K890N probably damaging Het
Atosa T A 9: 74,938,813 (GRCm39) S1038T probably damaging Het
Atp11c T C X: 59,326,104 (GRCm39) D478G probably damaging Het
Clasrp C A 7: 19,319,165 (GRCm39) probably benign Het
Clca3a2 C T 3: 144,797,926 (GRCm39) D180N possibly damaging Het
Comt T C 16: 18,230,437 (GRCm39) probably null Het
Cylc2 C G 4: 51,229,651 (GRCm39) T331R unknown Het
Cyp2d11 C T 15: 82,276,149 (GRCm39) probably benign Het
Fam169b G T 7: 68,007,954 (GRCm39) C289F possibly damaging Het
Fastkd5 T C 2: 130,458,501 (GRCm39) T30A probably benign Het
Fchsd2 A C 7: 100,931,702 (GRCm39) T753P probably benign Het
Gatd3a T C 10: 77,999,377 (GRCm39) I145V probably damaging Het
Glis3 G A 19: 28,643,527 (GRCm39) S5L possibly damaging Het
Gpr158 T A 2: 21,831,810 (GRCm39) M970K probably damaging Het
Gpt A T 15: 76,582,663 (GRCm39) Q276L probably damaging Het
Gtf3c3 G T 1: 54,463,291 (GRCm39) S302R probably benign Het
Hnrnpc A G 14: 52,312,888 (GRCm39) S229P probably benign Het
Ikzf5 T C 7: 130,998,393 (GRCm39) probably null Het
Mal2 T C 15: 54,461,835 (GRCm39) V110A probably damaging Het
Mideas C T 12: 84,203,245 (GRCm39) G886S probably benign Het
Myo3b A G 2: 70,084,748 (GRCm39) D702G probably benign Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Nat10 T A 2: 103,588,084 (GRCm39) I14F probably damaging Het
Nat14 C T 7: 4,926,918 (GRCm39) T30M probably damaging Het
Ndst4 C A 3: 125,476,922 (GRCm39) A49D probably damaging Het
Nnt A T 13: 119,518,301 (GRCm39) M292K probably damaging Het
Obox7 C T 7: 14,399,299 (GRCm39) T175I probably benign Het
Or2t26 T A 11: 49,039,214 (GRCm39) N43K possibly damaging Het
Plekhm3 T C 1: 64,900,395 (GRCm39) E634G probably damaging Het
Plxdc2 T A 2: 16,517,040 (GRCm39) I107K probably damaging Het
Psmb10 T A 8: 106,662,660 (GRCm39) R226S probably damaging Het
Ptprr T A 10: 116,065,407 (GRCm39) V160E possibly damaging Het
Sema5a T A 15: 32,641,133 (GRCm39) L649H probably damaging Het
Sephs1 T A 2: 4,911,494 (GRCm39) I356K probably benign Het
Serpinb3d C T 1: 107,007,022 (GRCm39) V229M probably damaging Het
Slc7a4 T C 16: 17,393,676 (GRCm39) D41G probably damaging Het
Sort1 T C 3: 108,217,461 (GRCm39) V121A probably benign Het
Tcf20 C A 15: 82,739,185 (GRCm39) Q755H probably damaging Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Ttll13 A T 7: 79,906,667 (GRCm39) Y445F probably benign Het
Usp40 T C 1: 87,923,459 (GRCm39) I271V possibly damaging Het
Vmn1r72 A G 7: 11,403,791 (GRCm39) I219T probably damaging Het
Other mutations in Or6c5c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0384:Or6c5c UTSW 10 129,298,909 (GRCm39) nonsense probably null
R1851:Or6c5c UTSW 10 129,299,370 (GRCm39) missense probably damaging 1.00
R2211:Or6c5c UTSW 10 129,298,809 (GRCm39) missense probably damaging 1.00
R3613:Or6c5c UTSW 10 129,298,937 (GRCm39) missense probably benign 0.29
R3701:Or6c5c UTSW 10 129,298,821 (GRCm39) missense probably damaging 1.00
R3702:Or6c5c UTSW 10 129,298,821 (GRCm39) missense probably damaging 1.00
R5745:Or6c5c UTSW 10 129,299,307 (GRCm39) missense probably damaging 1.00
R6791:Or6c5c UTSW 10 129,299,023 (GRCm39) missense probably benign 0.00
R7190:Or6c5c UTSW 10 129,298,626 (GRCm39) missense probably benign 0.00
R7278:Or6c5c UTSW 10 129,298,620 (GRCm39) missense probably damaging 1.00
R7313:Or6c5c UTSW 10 129,298,856 (GRCm39) missense probably damaging 0.98
R7369:Or6c5c UTSW 10 129,299,390 (GRCm39) missense probably benign
R7824:Or6c5c UTSW 10 129,298,665 (GRCm39) missense probably damaging 1.00
R7851:Or6c5c UTSW 10 129,299,429 (GRCm39) missense probably benign 0.36
R8961:Or6c5c UTSW 10 129,299,225 (GRCm39) missense probably damaging 1.00
R9635:Or6c5c UTSW 10 129,299,463 (GRCm39) missense probably benign 0.00
R9775:Or6c5c UTSW 10 129,298,677 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAGCACCATTCTGAGGTTCC -3'
(R):5'- GCAACCATACTGTAGCATCTTTCAG -3'

Sequencing Primer
(F):5'- CAGAGGAAAAAGGCTTTCTCCACTTG -3'
(R):5'- CAGCATAGATGCCTGAGA -3'
Posted On 2015-07-21