Incidental Mutation 'R4511:Tnrc6c'
| ID |
331179 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnrc6c
|
| Ensembl Gene |
ENSMUSG00000025571 |
| Gene Name |
trinucleotide repeat containing 6C |
| Synonyms |
9930033H14Rik |
| MMRRC Submission |
041586-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4511 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
117545115-117654265 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 117633784 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Isoleucine
at position 1294
(N1294I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101951
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026658]
[ENSMUST00000106344]
[ENSMUST00000138299]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000026658
AA Change: N1294I
PolyPhen 2
Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000026658
Gene: ENSMUSG00000025571
AA Change: N1294I
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
32 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
58 |
N/A |
INTRINSIC |
|
low complexity region
|
110 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
248 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
394 |
408 |
N/A |
INTRINSIC |
|
low complexity region
|
440 |
457 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
472 |
573 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
594 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
632 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
639 |
704 |
5.49e-5 |
PROSPERO |
|
internal_repeat_1
|
799 |
902 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
964 |
981 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
991 |
1051 |
5.49e-5 |
PROSPERO |
|
low complexity region
|
1063 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1125 |
N/A |
INTRINSIC |
|
UBA
|
1145 |
1182 |
3.68e-4 |
SMART |
|
Pfam:M_domain
|
1232 |
1459 |
6.8e-77 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1468 |
1646 |
4.1e-75 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1643 |
1722 |
3.7e-33 |
PFAM |
|
RRM
|
1725 |
1792 |
1.81e-2 |
SMART |
|
low complexity region
|
1813 |
1823 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000106344
AA Change: N1294I
PolyPhen 2
Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000101951
Gene: ENSMUSG00000025571
AA Change: N1294I
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
32 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
58 |
N/A |
INTRINSIC |
|
low complexity region
|
110 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
248 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
394 |
408 |
N/A |
INTRINSIC |
|
low complexity region
|
440 |
457 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
472 |
573 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
594 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
632 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
639 |
704 |
5.49e-5 |
PROSPERO |
|
internal_repeat_1
|
799 |
902 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
964 |
981 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
991 |
1051 |
5.49e-5 |
PROSPERO |
|
low complexity region
|
1063 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1125 |
N/A |
INTRINSIC |
|
UBA
|
1145 |
1182 |
3.68e-4 |
SMART |
|
Pfam:M_domain
|
1232 |
1459 |
6.8e-77 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1468 |
1646 |
4.1e-75 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1643 |
1722 |
3.7e-33 |
PFAM |
|
RRM
|
1725 |
1792 |
1.81e-2 |
SMART |
|
low complexity region
|
1813 |
1823 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000138299
AA Change: N1126I
PolyPhen 2
Score 0.613 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000115221
Gene: ENSMUSG00000025571
AA Change: N1126I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
88 |
97 |
N/A |
INTRINSIC |
|
low complexity region
|
138 |
158 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
297 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
413 |
9.45e-5 |
PROSPERO |
|
low complexity region
|
434 |
454 |
N/A |
INTRINSIC |
|
low complexity region
|
461 |
472 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
639 |
742 |
9.45e-5 |
PROSPERO |
|
low complexity region
|
804 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
919 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
965 |
N/A |
INTRINSIC |
|
UBA
|
985 |
1022 |
3.68e-4 |
SMART |
|
Pfam:M_domain
|
1036 |
1293 |
1.7e-53 |
PFAM |
|
low complexity region
|
1397 |
1406 |
N/A |
INTRINSIC |
|
PDB:3KTP|B
|
1422 |
1443 |
7e-7 |
PDB |
|
low complexity region
|
1507 |
1518 |
N/A |
INTRINSIC |
|
low complexity region
|
1531 |
1552 |
N/A |
INTRINSIC |
|
RRM
|
1557 |
1624 |
1.81e-2 |
SMART |
|
low complexity region
|
1645 |
1655 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140347
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141115
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a gene trap allele exhibit complete neonatal lethality with cyanosis, respiratory distress and thickened mesenchyme in air sacs. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9330159F19Rik |
T |
A |
10: 29,100,819 (GRCm39) |
D397E |
probably benign |
Het |
| Abcc10 |
A |
G |
17: 46,618,136 (GRCm39) |
F1005L |
probably damaging |
Het |
| Ackr4 |
T |
C |
9: 103,975,930 (GRCm39) |
E339G |
probably benign |
Het |
| Adam39 |
G |
T |
8: 41,279,328 (GRCm39) |
C573F |
probably damaging |
Het |
| Anks1b |
A |
G |
10: 90,346,652 (GRCm39) |
T651A |
probably benign |
Het |
| Aoc1 |
C |
A |
6: 48,884,740 (GRCm39) |
H594Q |
probably damaging |
Het |
| Atp4a |
G |
T |
7: 30,423,678 (GRCm39) |
E928* |
probably null |
Het |
| Atp5pf |
T |
C |
16: 84,624,862 (GRCm39) |
D104G |
probably benign |
Het |
| Atp8b5 |
A |
G |
4: 43,320,629 (GRCm39) |
T206A |
probably damaging |
Het |
| Atrn |
G |
A |
2: 130,777,497 (GRCm39) |
W182* |
probably null |
Het |
| Bltp2 |
T |
C |
11: 78,168,154 (GRCm39) |
S1530P |
possibly damaging |
Het |
| Cacna1e |
G |
A |
1: 154,437,579 (GRCm39) |
T257I |
probably damaging |
Het |
| Caskin1 |
G |
A |
17: 24,725,602 (GRCm39) |
S1296N |
probably benign |
Het |
| Crebrf |
A |
G |
17: 26,961,938 (GRCm39) |
Y345C |
probably benign |
Het |
| Cyp26b1 |
G |
A |
6: 84,551,473 (GRCm39) |
R248W |
probably damaging |
Het |
| Dclk3 |
C |
A |
9: 111,297,060 (GRCm39) |
H201Q |
probably benign |
Het |
| Ddx17 |
A |
T |
15: 79,422,793 (GRCm39) |
V315E |
probably damaging |
Het |
| Dhrs11 |
T |
C |
11: 84,716,342 (GRCm39) |
*51W |
probably null |
Het |
| Fgfr4 |
C |
A |
13: 55,309,328 (GRCm39) |
P455Q |
possibly damaging |
Het |
| Gabbr1 |
A |
G |
17: 37,380,103 (GRCm39) |
K697E |
probably damaging |
Het |
| Gcnt1 |
G |
A |
19: 17,307,641 (GRCm39) |
T28I |
probably benign |
Het |
| Gm12185 |
T |
A |
11: 48,799,305 (GRCm39) |
H396L |
possibly damaging |
Het |
| Gm21976 |
A |
G |
13: 98,441,839 (GRCm39) |
R123G |
probably benign |
Het |
| Hecw1 |
A |
C |
13: 14,531,776 (GRCm39) |
V166G |
probably damaging |
Het |
| Hpx |
A |
G |
7: 105,241,295 (GRCm39) |
V372A |
possibly damaging |
Het |
| Igkv2-109 |
A |
G |
6: 68,279,962 (GRCm39) |
Y61C |
probably damaging |
Het |
| Igsf1 |
A |
G |
X: 48,875,050 (GRCm39) |
F789S |
probably damaging |
Het |
| Il4ra |
A |
G |
7: 125,175,280 (GRCm39) |
D496G |
possibly damaging |
Het |
| Ilf3 |
A |
G |
9: 21,310,511 (GRCm39) |
T547A |
possibly damaging |
Het |
| Insrr |
C |
A |
3: 87,715,978 (GRCm39) |
P558T |
possibly damaging |
Het |
| Ints9 |
A |
G |
14: 65,266,381 (GRCm39) |
D411G |
possibly damaging |
Het |
| Irak3 |
T |
A |
10: 119,981,813 (GRCm39) |
H393L |
probably damaging |
Het |
| Isx |
G |
A |
8: 75,600,298 (GRCm39) |
M10I |
probably benign |
Het |
| Itga11 |
A |
G |
9: 62,668,870 (GRCm39) |
D709G |
probably damaging |
Het |
| Kcng2 |
G |
T |
18: 80,338,930 (GRCm39) |
R453S |
probably benign |
Het |
| Kif5b |
A |
G |
18: 6,214,011 (GRCm39) |
V664A |
probably benign |
Het |
| Lalba |
A |
G |
15: 98,380,422 (GRCm39) |
L44P |
probably benign |
Het |
| Ldlrad1 |
T |
G |
4: 107,066,715 (GRCm39) |
F17V |
probably benign |
Het |
| Lnx1 |
C |
T |
5: 74,780,853 (GRCm39) |
D382N |
probably damaging |
Het |
| Lrp1 |
T |
C |
10: 127,429,717 (GRCm39) |
Y451C |
probably damaging |
Het |
| Lrp2 |
A |
T |
2: 69,310,406 (GRCm39) |
N2722K |
possibly damaging |
Het |
| Mctp1 |
G |
A |
13: 76,973,391 (GRCm39) |
V431I |
probably benign |
Het |
| Mmrn2 |
T |
C |
14: 34,125,016 (GRCm39) |
F866L |
possibly damaging |
Het |
| Mylk2 |
A |
G |
2: 152,759,330 (GRCm39) |
E367G |
probably damaging |
Het |
| Nfatc1 |
A |
G |
18: 80,678,794 (GRCm39) |
S865P |
probably damaging |
Het |
| Nol6 |
G |
C |
4: 41,123,526 (GRCm39) |
T74R |
probably damaging |
Het |
| Notch2 |
T |
C |
3: 98,053,637 (GRCm39) |
M2100T |
probably benign |
Het |
| Parp1 |
A |
G |
1: 180,418,841 (GRCm39) |
K667R |
possibly damaging |
Het |
| Phlda3 |
A |
G |
1: 135,694,400 (GRCm39) |
T72A |
probably damaging |
Het |
| Polg |
T |
C |
7: 79,105,270 (GRCm39) |
Q758R |
probably benign |
Het |
| Polq |
G |
A |
16: 36,868,925 (GRCm39) |
R765H |
probably damaging |
Het |
| Pramel19 |
A |
T |
4: 101,798,757 (GRCm39) |
M243L |
probably benign |
Het |
| Prkd1 |
T |
C |
12: 50,439,762 (GRCm39) |
D355G |
possibly damaging |
Het |
| Prpf8 |
T |
C |
11: 75,382,652 (GRCm39) |
Y398H |
probably damaging |
Het |
| Ripk1 |
T |
C |
13: 34,210,731 (GRCm39) |
Y309H |
probably damaging |
Het |
| Rngtt |
A |
T |
4: 33,339,032 (GRCm39) |
Q279L |
possibly damaging |
Het |
| Rusf1 |
A |
T |
7: 127,875,312 (GRCm39) |
F319Y |
probably damaging |
Het |
| Samd4 |
T |
A |
14: 47,315,042 (GRCm39) |
V114D |
probably benign |
Het |
| Sec23ip |
G |
A |
7: 128,380,900 (GRCm39) |
E956K |
probably damaging |
Het |
| Slc4a1ap |
A |
T |
5: 31,684,747 (GRCm39) |
T128S |
probably benign |
Het |
| Slc5a11 |
A |
T |
7: 122,834,858 (GRCm39) |
I6F |
probably benign |
Het |
| Slc6a19 |
A |
C |
13: 73,832,094 (GRCm39) |
L494R |
probably damaging |
Het |
| Slc6a21 |
A |
G |
7: 44,936,713 (GRCm39) |
D189G |
probably damaging |
Het |
| Slc7a1 |
G |
T |
5: 148,277,372 (GRCm39) |
A381D |
probably damaging |
Het |
| Smc4 |
T |
A |
3: 68,923,980 (GRCm39) |
|
probably null |
Het |
| Stk19 |
T |
C |
17: 35,051,504 (GRCm39) |
E17G |
probably damaging |
Het |
| Tekt5 |
A |
C |
16: 10,175,877 (GRCm39) |
V556G |
probably benign |
Het |
| Tenm4 |
T |
C |
7: 96,544,070 (GRCm39) |
F2029L |
probably benign |
Het |
| Thnsl1 |
T |
C |
2: 21,217,236 (GRCm39) |
V330A |
probably damaging |
Het |
| Tnfrsf21 |
A |
G |
17: 43,375,910 (GRCm39) |
D432G |
probably damaging |
Het |
| Tnip1 |
T |
A |
11: 54,817,616 (GRCm39) |
S244C |
probably benign |
Het |
| Trpm3 |
A |
G |
19: 22,965,381 (GRCm39) |
I1625M |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,575,773 (GRCm39) |
V25040E |
probably damaging |
Het |
| Vwa5a |
A |
G |
9: 38,633,853 (GRCm39) |
N19D |
possibly damaging |
Het |
| Washc2 |
A |
T |
6: 116,197,517 (GRCm39) |
D250V |
probably damaging |
Het |
| Xpo1 |
A |
G |
11: 23,237,401 (GRCm39) |
T755A |
possibly damaging |
Het |
| Zfp462 |
C |
T |
4: 55,008,934 (GRCm39) |
T300I |
possibly damaging |
Het |
| Zfp937 |
A |
C |
2: 150,080,431 (GRCm39) |
T154P |
probably damaging |
Het |
| Zzef1 |
A |
G |
11: 72,778,996 (GRCm39) |
D1819G |
probably benign |
Het |
|
| Other mutations in Tnrc6c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00839:Tnrc6c
|
APN |
11 |
117,605,011 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01013:Tnrc6c
|
APN |
11 |
117,612,855 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01092:Tnrc6c
|
APN |
11 |
117,612,811 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01383:Tnrc6c
|
APN |
11 |
117,605,083 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL01395:Tnrc6c
|
APN |
11 |
117,613,939 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01726:Tnrc6c
|
APN |
11 |
117,640,161 (GRCm39) |
splice site |
probably benign |
|
|
IGL01869:Tnrc6c
|
APN |
11 |
117,646,274 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02108:Tnrc6c
|
APN |
11 |
117,612,025 (GRCm39) |
missense |
probably benign |
0.29 |
|
IGL02457:Tnrc6c
|
APN |
11 |
117,613,803 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02612:Tnrc6c
|
APN |
11 |
117,633,826 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02748:Tnrc6c
|
APN |
11 |
117,622,996 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03160:Tnrc6c
|
APN |
11 |
117,640,651 (GRCm39) |
splice site |
probably benign |
|
|
rodion
|
UTSW |
11 |
117,629,176 (GRCm39) |
critical splice donor site |
probably null |
|
|
F5770:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
K3955:Tnrc6c
|
UTSW |
11 |
117,651,564 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0015:Tnrc6c
|
UTSW |
11 |
117,612,284 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0143:Tnrc6c
|
UTSW |
11 |
117,643,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0277:Tnrc6c
|
UTSW |
11 |
117,630,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0323:Tnrc6c
|
UTSW |
11 |
117,630,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0464:Tnrc6c
|
UTSW |
11 |
117,651,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0699:Tnrc6c
|
UTSW |
11 |
117,613,447 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1015:Tnrc6c
|
UTSW |
11 |
117,612,748 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1201:Tnrc6c
|
UTSW |
11 |
117,612,500 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1297:Tnrc6c
|
UTSW |
11 |
117,624,529 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1560:Tnrc6c
|
UTSW |
11 |
117,650,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1596:Tnrc6c
|
UTSW |
11 |
117,648,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Tnrc6c
|
UTSW |
11 |
117,651,556 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1892:Tnrc6c
|
UTSW |
11 |
117,605,188 (GRCm39) |
missense |
probably benign |
|
|
R1901:Tnrc6c
|
UTSW |
11 |
117,613,831 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1936:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1937:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1940:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R3622:Tnrc6c
|
UTSW |
11 |
117,640,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3711:Tnrc6c
|
UTSW |
11 |
117,613,950 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3725:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3775:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3776:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3836:Tnrc6c
|
UTSW |
11 |
117,614,055 (GRCm39) |
missense |
probably benign |
0.20 |
|
R3844:Tnrc6c
|
UTSW |
11 |
117,646,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3852:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3928:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3929:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3937:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3943:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4501:Tnrc6c
|
UTSW |
11 |
117,613,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Tnrc6c
|
UTSW |
11 |
117,633,784 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4654:Tnrc6c
|
UTSW |
11 |
117,611,797 (GRCm39) |
missense |
probably benign |
|
|
R4765:Tnrc6c
|
UTSW |
11 |
117,633,753 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4824:Tnrc6c
|
UTSW |
11 |
117,613,731 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5004:Tnrc6c
|
UTSW |
11 |
117,611,872 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5094:Tnrc6c
|
UTSW |
11 |
117,611,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5130:Tnrc6c
|
UTSW |
11 |
117,629,176 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5234:Tnrc6c
|
UTSW |
11 |
117,651,555 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5235:Tnrc6c
|
UTSW |
11 |
117,651,555 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5345:Tnrc6c
|
UTSW |
11 |
117,614,113 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5359:Tnrc6c
|
UTSW |
11 |
117,649,731 (GRCm39) |
splice site |
silent |
|
|
R5428:Tnrc6c
|
UTSW |
11 |
117,591,588 (GRCm39) |
start codon destroyed |
probably null |
|
|
R5548:Tnrc6c
|
UTSW |
11 |
117,651,669 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5587:Tnrc6c
|
UTSW |
11 |
117,640,097 (GRCm39) |
nonsense |
probably null |
|
|
R5875:Tnrc6c
|
UTSW |
11 |
117,650,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5947:Tnrc6c
|
UTSW |
11 |
117,613,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6135:Tnrc6c
|
UTSW |
11 |
117,626,831 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6354:Tnrc6c
|
UTSW |
11 |
117,640,440 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6389:Tnrc6c
|
UTSW |
11 |
117,613,567 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7027:Tnrc6c
|
UTSW |
11 |
117,624,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7048:Tnrc6c
|
UTSW |
11 |
117,612,800 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7098:Tnrc6c
|
UTSW |
11 |
117,604,952 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7315:Tnrc6c
|
UTSW |
11 |
117,614,354 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7378:Tnrc6c
|
UTSW |
11 |
117,632,606 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7386:Tnrc6c
|
UTSW |
11 |
117,612,780 (GRCm39) |
missense |
probably benign |
|
|
R7515:Tnrc6c
|
UTSW |
11 |
117,632,507 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7665:Tnrc6c
|
UTSW |
11 |
117,611,777 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7755:Tnrc6c
|
UTSW |
11 |
117,648,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8679:Tnrc6c
|
UTSW |
11 |
117,604,961 (GRCm39) |
missense |
probably benign |
|
|
R8824:Tnrc6c
|
UTSW |
11 |
117,630,680 (GRCm39) |
splice site |
probably benign |
|
|
R8971:Tnrc6c
|
UTSW |
11 |
117,640,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9261:Tnrc6c
|
UTSW |
11 |
117,605,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9283:Tnrc6c
|
UTSW |
11 |
117,591,630 (GRCm39) |
missense |
unknown |
|
|
R9342:Tnrc6c
|
UTSW |
11 |
117,630,720 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9633:Tnrc6c
|
UTSW |
11 |
117,638,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9761:Tnrc6c
|
UTSW |
11 |
117,623,136 (GRCm39) |
missense |
probably benign |
|
|
V7580:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7581:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7582:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7583:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnrc6c
|
UTSW |
11 |
117,623,003 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGACACGTTAAAATGCAGTCATG -3'
(R):5'- GATCCAGCCAGATCCAGATC -3'
Sequencing Primer
(F):5'- GATCATAGGCAGTTCCCTAAGCTG -3'
(R):5'- TCAAAACCATACCAAGTACAGTGTG -3'
|
| Posted On |
2015-07-21 |
Incidental Mutation