Mutagenetix > Incidental Mutation

Incidental Mutation 'R4477:Vmn2r9'

331311

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r9

Ensembl Gene

ENSMUSG00000091624

Gene Name

vomeronasal 2, receptor 9

Synonyms

EG435864

MMRRC Submission

041734-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R4477 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

108990813-109000376 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 108994143 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 502 (E502G)

Ref Sequence

ENSEMBL: ENSMUSP00000129520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170419]

AlphaFold

K7N6Z8

Predicted Effect

probably benign
Transcript: ENSMUST00000170419
AA Change: E502G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: E502G

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	77	412	8.1e-29	PFAM
Pfam:NCD3G	507	561	2.3e-16	PFAM
Pfam:7tm_3	592	829	3.4e-54	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176157

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.2%

Validation Efficiency

93% (39/42)

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg4	A	G	9: 44,186,383 (GRCm39)	S549P	probably damaging	Het
Agfg1	T	C	1: 82,853,061 (GRCm39)	S75P	probably damaging	Het
AK157302	T	A	13: 21,679,861 (GRCm39)	V129E	possibly damaging	Het
Angpt1	A	G	15: 42,331,560 (GRCm39)	Y344H	probably damaging	Het
Ap1m2	A	G	9: 21,209,509 (GRCm39)	V389A	probably benign	Het
Bicd2	T	A	13: 49,531,448 (GRCm39)	I230N	probably damaging	Het
C5ar1	T	C	7: 15,982,789 (GRCm39)	N77S	probably damaging	Het
Cacna1c	C	T	6: 118,607,200 (GRCm39)	V1235M	possibly damaging	Het
Cdh15	A	G	8: 123,591,415 (GRCm39)	H517R	probably benign	Het
D130040H23Rik	C	A	8: 69,755,155 (GRCm39)	H187N	possibly damaging	Het
Dbn1	CCCGCTCCCGGTAGCGCCGCTC	CCCGCTC	13: 55,629,374 (GRCm39)		probably benign	Het
Eif4g1	G	T	16: 20,497,593 (GRCm39)		probably benign	Het
Fmn1	T	A	2: 113,274,744 (GRCm39)		probably benign	Het
Gm3159	T	C	14: 4,398,584 (GRCm38)	Y92H	probably damaging	Het
Gm7138	A	T	10: 77,612,246 (GRCm39)		probably benign	Het
Ift172	C	T	5: 31,422,781 (GRCm39)	A890T	probably benign	Het
Inpp5j	T	C	11: 3,451,625 (GRCm39)	T426A	probably damaging	Het
Katna1	T	C	10: 7,614,594 (GRCm39)	V32A	probably damaging	Het
Lrrc71	G	C	3: 87,649,972 (GRCm39)	R319G	probably damaging	Het
Lyst	G	A	13: 13,809,968 (GRCm39)	R546H	probably damaging	Het
Mmp19	A	T	10: 128,631,506 (GRCm39)	T129S	probably benign	Het
Mrc2	G	A	11: 105,239,257 (GRCm39)		probably null	Het
Neo1	T	C	9: 58,784,582 (GRCm39)	D1458G	probably damaging	Het
Nup35	T	C	2: 80,487,487 (GRCm39)		probably benign	Het
Obscn	T	C	11: 59,022,472 (GRCm39)	R758G	possibly damaging	Het
Pdlim5	C	T	3: 141,964,978 (GRCm39)	S417N	probably benign	Het
Pla2g4f	A	G	2: 120,134,153 (GRCm39)	S478P	probably damaging	Het
Plekhn1	G	A	4: 156,307,856 (GRCm39)	R357W	probably damaging	Het
Pom121	T	C	5: 135,410,842 (GRCm39)	T772A	unknown	Het
Pramel20	A	G	4: 143,297,732 (GRCm39)	I51V	probably benign	Het
Rasgef1a	A	T	6: 118,062,436 (GRCm39)	H232L	possibly damaging	Het
Sdad1	A	G	5: 92,445,019 (GRCm39)	M315T	probably damaging	Het
Syt9	A	G	7: 107,024,428 (GRCm39)	N107S	probably damaging	Het
Traf3	T	C	12: 111,215,036 (GRCm39)	S202P	probably benign	Het
Vps8	A	T	16: 21,363,986 (GRCm39)		probably benign	Het
Zfp770	G	A	2: 114,027,365 (GRCm39)	L235F	probably damaging	Het

Other mutations in Vmn2r9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00920:Vmn2r9	APN	5	108,995,890 (GRCm39)	missense	possibly damaging	0.79
IGL00972:Vmn2r9	APN	5	108,996,903 (GRCm39)	missense	probably benign	0.02
IGL01102:Vmn2r9	APN	5	108,990,811 (GRCm39)	splice site	probably null
IGL01892:Vmn2r9	APN	5	108,995,700 (GRCm39)	missense	probably damaging	1.00
IGL02086:Vmn2r9	APN	5	108,995,433 (GRCm39)	missense	probably damaging	1.00
IGL02118:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02119:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02120:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02121:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02123:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02131:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02132:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02171:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02185:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02186:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02346:Vmn2r9	APN	5	108,990,850 (GRCm39)	missense	probably benign	0.07
IGL02508:Vmn2r9	APN	5	108,996,067 (GRCm39)	missense	possibly damaging	0.70
IGL02815:Vmn2r9	APN	5	108,990,856 (GRCm39)	missense	possibly damaging	0.69
IGL03077:Vmn2r9	APN	5	108,996,173 (GRCm39)	splice site	probably benign
IGL03269:Vmn2r9	APN	5	108,995,820 (GRCm39)	missense	probably damaging	1.00
IGL03293:Vmn2r9	APN	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r9	UTSW	5	108,990,991 (GRCm39)	missense	probably damaging	1.00
R0328:Vmn2r9	UTSW	5	108,995,405 (GRCm39)	missense	probably benign	0.11
R0382:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R0521:Vmn2r9	UTSW	5	108,996,154 (GRCm39)	nonsense	probably null
R0975:Vmn2r9	UTSW	5	108,991,169 (GRCm39)	missense	probably damaging	1.00
R1216:Vmn2r9	UTSW	5	108,995,440 (GRCm39)	missense	probably damaging	1.00
R1458:Vmn2r9	UTSW	5	108,996,850 (GRCm39)	missense	probably benign	0.44
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1704:Vmn2r9	UTSW	5	108,994,266 (GRCm39)	missense	probably damaging	1.00
R1967:Vmn2r9	UTSW	5	108,995,388 (GRCm39)	missense	probably benign	0.03
R1991:Vmn2r9	UTSW	5	108,994,305 (GRCm39)	missense	probably damaging	0.99
R2410:Vmn2r9	UTSW	5	108,996,123 (GRCm39)	missense	probably damaging	1.00
R3419:Vmn2r9	UTSW	5	108,994,299 (GRCm39)	missense	probably damaging	0.96
R3852:Vmn2r9	UTSW	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R3873:Vmn2r9	UTSW	5	108,995,701 (GRCm39)	missense	probably benign	0.14
R3905:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3908:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3921:Vmn2r9	UTSW	5	108,996,921 (GRCm39)	missense	probably benign
R4156:Vmn2r9	UTSW	5	108,995,743 (GRCm39)	missense	possibly damaging	0.64
R4478:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4544:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4546:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4627:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R5215:Vmn2r9	UTSW	5	108,994,351 (GRCm39)	missense	probably benign	0.03
R5361:Vmn2r9	UTSW	5	108,995,929 (GRCm39)	missense	probably damaging	1.00
R5587:Vmn2r9	UTSW	5	108,995,427 (GRCm39)	missense	probably damaging	1.00
R6054:Vmn2r9	UTSW	5	108,996,126 (GRCm39)	missense	probably damaging	0.99
R6106:Vmn2r9	UTSW	5	108,992,902 (GRCm39)	missense	probably benign
R6125:Vmn2r9	UTSW	5	108,990,836 (GRCm39)	missense	probably benign	0.01
R6137:Vmn2r9	UTSW	5	108,996,882 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r9	UTSW	5	108,996,912 (GRCm39)	missense	possibly damaging	0.72
R7579:Vmn2r9	UTSW	5	108,992,948 (GRCm39)	missense	probably damaging	1.00
R8683:Vmn2r9	UTSW	5	108,996,873 (GRCm39)	missense	probably benign
R8964:Vmn2r9	UTSW	5	108,996,031 (GRCm39)	missense	probably benign	0.05
R9022:Vmn2r9	UTSW	5	108,992,923 (GRCm39)	missense	possibly damaging	0.90
R9118:Vmn2r9	UTSW	5	108,990,937 (GRCm39)	missense	probably damaging	0.99
R9125:Vmn2r9	UTSW	5	108,996,047 (GRCm39)	missense
R9240:Vmn2r9	UTSW	5	108,996,099 (GRCm39)	missense	possibly damaging	0.78
R9327:Vmn2r9	UTSW	5	108,996,841 (GRCm39)	missense	probably damaging	0.96
R9412:Vmn2r9	UTSW	5	108,991,484 (GRCm39)	missense	probably damaging	1.00
R9499:Vmn2r9	UTSW	5	108,995,584 (GRCm39)	missense	probably damaging	1.00
R9757:Vmn2r9	UTSW	5	108,995,908 (GRCm39)	missense	possibly damaging	0.87
R9790:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99
R9791:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

Posted On

2015-07-21