Incidental Mutation 'R4484:Igtp'
ID 331543
Institutional Source Beutler Lab
Gene Symbol Igtp
Ensembl Gene ENSMUSG00000078853
Gene Name interferon gamma induced GTPase
Synonyms Irgm3
MMRRC Submission 041740-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4484 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 58090382-58098417 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 58097824 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 332 (V332I)
Ref Sequence ENSEMBL: ENSMUSP00000047356 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035266] [ENSMUST00000058704] [ENSMUST00000094169] [ENSMUST00000168280]
AlphaFold Q9DCE9
Predicted Effect possibly damaging
Transcript: ENSMUST00000035266
AA Change: V332I

PolyPhen 2 Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000047356
Gene: ENSMUSG00000078853
AA Change: V332I

DomainStartEndE-ValueType
Pfam:IIGP 50 412 4.6e-161 PFAM
Pfam:MMR_HSR1 86 200 1.1e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000058704
SMART Domains Protein: ENSMUSP00000056001
Gene: ENSMUSG00000069874

DomainStartEndE-ValueType
Pfam:IIGP 30 387 8.1e-165 PFAM
Pfam:MMR_HSR1 66 179 9.3e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000094169
Predicted Effect probably benign
Transcript: ENSMUST00000168280
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 98% (46/47)
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. They do have a severely compromised response to Toxoplasma gondii infections however [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox4 T C 1: 58,301,730 (GRCm39) C1101R probably damaging Het
Atp8b5 T C 4: 43,357,016 (GRCm39) I588T probably damaging Het
Bahd1 C T 2: 118,746,887 (GRCm39) P169S probably damaging Het
Cd164l2 T A 4: 132,950,986 (GRCm39) V147E probably damaging Het
Celsr3 G A 9: 108,723,262 (GRCm39) probably null Het
Cr2 T C 1: 194,836,482 (GRCm39) T894A probably damaging Het
Crtc3 T C 7: 80,239,696 (GRCm39) D552G probably damaging Het
Cspg4b A T 13: 113,455,733 (GRCm39) N593I probably damaging Het
Cyp2c50 A G 19: 40,079,083 (GRCm39) E142G probably damaging Het
Dcstamp A G 15: 39,617,620 (GRCm39) I10V probably benign Het
Gm44501 T A 17: 40,887,507 (GRCm39) F8L unknown Het
Gpr179 T C 11: 97,226,537 (GRCm39) S1873G probably benign Het
Gprin2 C A 14: 33,916,754 (GRCm39) A339S probably benign Het
Gucy1b2 T A 14: 62,649,038 (GRCm39) I513F possibly damaging Het
Ighv5-6 T A 12: 113,589,208 (GRCm39) R91* probably null Het
Itfg1 G A 8: 86,452,878 (GRCm39) P497S probably damaging Het
Junb T C 8: 85,704,517 (GRCm39) N181S possibly damaging Het
Lama3 T C 18: 12,614,145 (GRCm39) Y1305H probably benign Het
Lrrcc1 A T 3: 14,616,503 (GRCm39) N44I probably damaging Het
Med15 A T 16: 17,489,428 (GRCm39) probably benign Het
Mkks T C 2: 136,722,494 (GRCm39) E221G probably benign Het
Mtmr10 T C 7: 63,970,379 (GRCm39) V374A possibly damaging Het
Muc5b G T 7: 141,422,187 (GRCm39) C4441F possibly damaging Het
Nim1k G A 13: 120,173,710 (GRCm39) Q395* probably null Het
Nlrp6 A G 7: 140,501,694 (GRCm39) D87G probably damaging Het
Ntng1 C A 3: 110,051,124 (GRCm39) probably benign Het
Padi1 G T 4: 140,544,581 (GRCm39) probably benign Het
Rxrg T C 1: 167,452,596 (GRCm39) S133P probably benign Het
Snx19 T C 9: 30,339,192 (GRCm39) I110T probably benign Het
Strap T C 6: 137,726,334 (GRCm39) probably benign Het
Tasor2 T C 13: 3,631,831 (GRCm39) D890G probably benign Het
Tgtp2 A T 11: 48,950,179 (GRCm39) M131K probably damaging Het
Tppp2 T C 14: 52,156,868 (GRCm39) F82L probably damaging Het
Ttc39c A G 18: 12,863,126 (GRCm39) K397E possibly damaging Het
Txlnb T TTA 10: 17,714,745 (GRCm39) probably null Het
Usp36 T A 11: 118,176,621 (GRCm39) R66W probably damaging Het
Vmn1r30 A T 6: 58,412,118 (GRCm39) V238E probably damaging Het
Vmn1r6 A G 6: 56,980,174 (GRCm39) I279V probably benign Het
Vmn2r61 G A 7: 41,950,120 (GRCm39) D847N probably benign Het
Zfp622 G A 15: 25,987,137 (GRCm39) probably null Het
Zfp963 T C 8: 70,197,135 (GRCm39) I36V probably benign Het
Zfy2 A G Y: 2,107,351 (GRCm39) Y428H possibly damaging Het
Other mutations in Igtp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01138:Igtp APN 11 58,096,970 (GRCm39) missense possibly damaging 0.66
IGL03326:Igtp APN 11 58,097,054 (GRCm39) missense probably benign 0.01
R0281:Igtp UTSW 11 58,096,880 (GRCm39) missense probably damaging 0.97
R2762:Igtp UTSW 11 58,096,891 (GRCm39) missense possibly damaging 0.91
R3426:Igtp UTSW 11 58,097,419 (GRCm39) missense probably damaging 0.99
R3427:Igtp UTSW 11 58,097,419 (GRCm39) missense probably damaging 0.99
R3428:Igtp UTSW 11 58,097,419 (GRCm39) missense probably damaging 0.99
R4588:Igtp UTSW 11 58,097,508 (GRCm39) missense probably damaging 1.00
R5299:Igtp UTSW 11 58,097,959 (GRCm39) missense possibly damaging 0.79
R5652:Igtp UTSW 11 58,097,455 (GRCm39) missense probably benign 0.07
R5662:Igtp UTSW 11 58,097,105 (GRCm39) missense probably damaging 1.00
R5893:Igtp UTSW 11 58,097,474 (GRCm39) missense probably damaging 1.00
R7657:Igtp UTSW 11 58,097,654 (GRCm39) missense probably benign 0.02
R7738:Igtp UTSW 11 58,097,906 (GRCm39) missense probably benign 0.00
R7989:Igtp UTSW 11 58,097,205 (GRCm39) missense probably damaging 0.99
R8920:Igtp UTSW 11 58,096,999 (GRCm39) missense probably damaging 0.98
R8986:Igtp UTSW 11 58,096,947 (GRCm39) critical splice donor site probably null
R9103:Igtp UTSW 11 58,097,726 (GRCm39) missense
R9180:Igtp UTSW 11 58,098,091 (GRCm39) nonsense probably null
R9375:Igtp UTSW 11 58,097,026 (GRCm39) missense probably damaging 1.00
R9502:Igtp UTSW 11 58,097,800 (GRCm39) missense possibly damaging 0.91
Z1186:Igtp UTSW 11 58,097,169 (GRCm39) missense probably damaging 0.99
Z1186:Igtp UTSW 11 58,097,791 (GRCm39) missense possibly damaging 0.55
Z1186:Igtp UTSW 11 58,097,944 (GRCm39) missense probably benign 0.00
Z1187:Igtp UTSW 11 58,097,944 (GRCm39) missense probably benign 0.00
Z1187:Igtp UTSW 11 58,097,791 (GRCm39) missense possibly damaging 0.55
Z1187:Igtp UTSW 11 58,097,169 (GRCm39) missense probably damaging 0.99
Z1188:Igtp UTSW 11 58,097,944 (GRCm39) missense probably benign 0.00
Z1188:Igtp UTSW 11 58,097,791 (GRCm39) missense possibly damaging 0.55
Z1188:Igtp UTSW 11 58,097,169 (GRCm39) missense probably damaging 0.99
Z1189:Igtp UTSW 11 58,097,944 (GRCm39) missense probably benign 0.00
Z1189:Igtp UTSW 11 58,097,791 (GRCm39) missense possibly damaging 0.55
Z1189:Igtp UTSW 11 58,097,169 (GRCm39) missense probably damaging 0.99
Z1190:Igtp UTSW 11 58,097,791 (GRCm39) missense possibly damaging 0.55
Z1190:Igtp UTSW 11 58,097,416 (GRCm39) missense possibly damaging 0.84
Z1190:Igtp UTSW 11 58,097,169 (GRCm39) missense probably damaging 0.99
Z1190:Igtp UTSW 11 58,097,944 (GRCm39) missense probably benign 0.00
Z1191:Igtp UTSW 11 58,097,944 (GRCm39) missense probably benign 0.00
Z1191:Igtp UTSW 11 58,097,791 (GRCm39) missense possibly damaging 0.55
Z1191:Igtp UTSW 11 58,097,169 (GRCm39) missense probably damaging 0.99
Z1192:Igtp UTSW 11 58,097,944 (GRCm39) missense probably benign 0.00
Z1192:Igtp UTSW 11 58,097,791 (GRCm39) missense possibly damaging 0.55
Z1192:Igtp UTSW 11 58,097,169 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCTCAAGTCTGCGACAAGTG -3'
(R):5'- GTCTTGGTGTTCTCAGCCAC -3'

Sequencing Primer
(F):5'- TCTGCGACAAGTGCATCAG -3'
(R):5'- TCAATGACGAGCTTGTGCC -3'
Posted On 2015-07-21