Incidental Mutation 'R4485:Or5p58'
ID 331577
Institutional Source Beutler Lab
Gene Symbol Or5p58
Ensembl Gene ENSMUSG00000059031
Gene Name olfactory receptor family 5 subfamily P member 58
Synonyms Olfr482, MOR204-14, GA_x6K02T2PBJ9-10424354-10423383
MMRRC Submission 041741-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R4485 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 107693804-107694775 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107694222 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 185 (D185G)
Ref Sequence ENSEMBL: ENSMUSP00000150755 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081184] [ENSMUST00000217304]
AlphaFold Q8VG03
Predicted Effect probably benign
Transcript: ENSMUST00000081184
AA Change: D185G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000079948
Gene: ENSMUSG00000059031
AA Change: D185G

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.2e-52 PFAM
Pfam:7tm_1 44 293 8.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207291
Predicted Effect probably benign
Transcript: ENSMUST00000217304
AA Change: D185G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agxt2 A T 15: 10,378,968 (GRCm39) I190L possibly damaging Het
Ahnak2 A G 12: 112,745,944 (GRCm39) probably benign Het
Apol7b C A 15: 77,307,866 (GRCm39) V210L probably benign Het
Banf2 C T 2: 143,915,772 (GRCm39) T71M probably damaging Het
Cacna1s A G 1: 136,004,590 (GRCm39) D130G probably damaging Het
Capn8 T C 1: 182,426,306 (GRCm39) F214L possibly damaging Het
Ccdc168 A G 1: 44,099,283 (GRCm39) L605S probably benign Het
Cdk5rap2 A T 4: 70,157,520 (GRCm39) probably null Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Cpb1 T G 3: 20,303,865 (GRCm39) M400L probably benign Het
Eps15l1 A T 8: 73,153,531 (GRCm39) I52N possibly damaging Het
Gbp9 C G 5: 105,231,674 (GRCm39) G304A probably damaging Het
Gm14226 G A 2: 154,867,191 (GRCm39) V383I probably benign Het
Itprid1 A G 6: 55,864,051 (GRCm39) T126A probably benign Het
Npm2 A T 14: 70,885,749 (GRCm39) V152D possibly damaging Het
Nsd1 T C 13: 55,393,434 (GRCm39) V345A probably benign Het
Or56a3 T A 7: 104,735,808 (GRCm39) V295D probably damaging Het
Or5b107 T C 19: 13,142,855 (GRCm39) V159A possibly damaging Het
Or5b118 T C 19: 13,448,919 (GRCm39) I195T probably benign Het
Otof T A 5: 30,532,344 (GRCm39) H1601L possibly damaging Het
Plat G A 8: 23,262,228 (GRCm39) S84N probably benign Het
Prss30 T C 17: 24,192,130 (GRCm39) D224G probably damaging Het
Psg25 C A 7: 18,260,203 (GRCm39) V232F probably damaging Het
Ptch1 C T 13: 63,682,143 (GRCm39) R537H probably damaging Het
Pus7l G T 15: 94,421,371 (GRCm39) H646Q probably benign Het
Ryr1 C T 7: 28,789,581 (GRCm39) S1511N probably damaging Het
Slc16a1 A G 3: 104,562,794 (GRCm39) K413R probably benign Het
Snrnp48 T A 13: 38,400,304 (GRCm39) M137K probably benign Het
Tecta T A 9: 42,248,570 (GRCm39) H1944L possibly damaging Het
Tmem145 A G 7: 25,006,587 (GRCm39) E65G possibly damaging Het
Vmn2r87 A T 10: 130,315,678 (GRCm39) Y129* probably null Het
Wdr7 A G 18: 63,910,621 (GRCm39) H671R possibly damaging Het
Zfp219 A G 14: 52,244,841 (GRCm39) V518A probably damaging Het
Zfp472 T C 17: 33,196,542 (GRCm39) W206R possibly damaging Het
Other mutations in Or5p58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01400:Or5p58 APN 7 107,694,046 (GRCm39) missense probably damaging 1.00
IGL01482:Or5p58 APN 7 107,694,693 (GRCm39) missense probably benign 0.01
IGL01710:Or5p58 APN 7 107,694,449 (GRCm39) missense probably benign 0.00
IGL02064:Or5p58 APN 7 107,694,454 (GRCm39) missense probably benign 0.20
IGL02930:Or5p58 APN 7 107,694,621 (GRCm39) missense probably damaging 1.00
IGL03206:Or5p58 APN 7 107,694,261 (GRCm39) missense probably damaging 1.00
IGL03255:Or5p58 APN 7 107,694,024 (GRCm39) missense probably damaging 1.00
R0378:Or5p58 UTSW 7 107,694,429 (GRCm39) missense probably benign 0.10
R0552:Or5p58 UTSW 7 107,693,985 (GRCm39) missense probably benign 0.01
R1538:Or5p58 UTSW 7 107,694,493 (GRCm39) missense probably damaging 1.00
R1771:Or5p58 UTSW 7 107,694,816 (GRCm39) splice site probably null
R1939:Or5p58 UTSW 7 107,694,348 (GRCm39) missense probably benign 0.06
R2258:Or5p58 UTSW 7 107,694,402 (GRCm39) missense possibly damaging 0.95
R4169:Or5p58 UTSW 7 107,694,591 (GRCm39) missense probably damaging 1.00
R4170:Or5p58 UTSW 7 107,694,280 (GRCm39) missense probably benign 0.00
R4803:Or5p58 UTSW 7 107,694,666 (GRCm39) missense probably damaging 0.99
R4887:Or5p58 UTSW 7 107,694,303 (GRCm39) missense probably benign 0.18
R5059:Or5p58 UTSW 7 107,694,522 (GRCm39) missense probably damaging 1.00
R5445:Or5p58 UTSW 7 107,693,949 (GRCm39) missense possibly damaging 0.69
R5539:Or5p58 UTSW 7 107,694,433 (GRCm39) missense probably benign 0.23
R5644:Or5p58 UTSW 7 107,694,011 (GRCm39) nonsense probably null
R6200:Or5p58 UTSW 7 107,694,732 (GRCm39) frame shift probably null
R7171:Or5p58 UTSW 7 107,694,342 (GRCm39) missense probably benign 0.00
R8024:Or5p58 UTSW 7 107,694,496 (GRCm39) missense probably benign 0.19
R8316:Or5p58 UTSW 7 107,694,450 (GRCm39) missense probably benign 0.09
R9013:Or5p58 UTSW 7 107,694,471 (GRCm39) missense probably benign 0.02
R9376:Or5p58 UTSW 7 107,694,471 (GRCm39) missense possibly damaging 0.93
X0021:Or5p58 UTSW 7 107,694,166 (GRCm39) missense probably benign 0.20
Z1176:Or5p58 UTSW 7 107,694,201 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACACCACCTTGTTCTGGTC -3'
(R):5'- GCTTTGTAGCAATCTGCAACCC -3'

Sequencing Primer
(F):5'- GAGTAATTTGACTTGGGCATCAC -3'
(R):5'- ACCCACTGCTTTATTCCATCAAAATG -3'
Posted On 2015-07-21