Incidental Mutation 'R4498:Acot9'
ID 331727
Institutional Source Beutler Lab
Gene Symbol Acot9
Ensembl Gene ENSMUSG00000025287
Gene Name acyl-CoA thioesterase 9
Synonyms p48, MT-ACT48, Acate2, 0610041P13Rik, U8
MMRRC Submission 041751-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.179) question?
Stock # R4498 (G1)
Quality Score 222
Status Validated
Chromosome X
Chromosomal Location 154045439-154080650 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 154047064 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 18 (L18*)
Ref Sequence ENSEMBL: ENSMUSP00000138519 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026324] [ENSMUST00000131332]
AlphaFold Q9R0X4
Predicted Effect probably benign
Transcript: ENSMUST00000026324
SMART Domains Protein: ENSMUSP00000026324
Gene: ENSMUSG00000025287

DomainStartEndE-ValueType
SCOP:d1lo7a_ 108 222 1e-3 SMART
PDB:4IEN|D 277 400 8e-7 PDB
Predicted Effect probably null
Transcript: ENSMUST00000131332
AA Change: L18*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134662
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 91% (53/58)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aco2 G A 15: 81,779,486 (GRCm39) A97T probably damaging Het
Arhgap12 A T 18: 6,111,774 (GRCm39) C69S probably damaging Het
Ccdc17 G T 4: 116,454,438 (GRCm39) probably benign Het
Ctnnd2 A C 15: 30,620,020 (GRCm39) D124A probably damaging Het
Cux1 T C 5: 136,341,847 (GRCm39) N424S probably damaging Het
Dhrs7c T C 11: 67,706,706 (GRCm39) F214S possibly damaging Het
Fat2 T C 11: 55,160,923 (GRCm39) D3269G possibly damaging Het
Fhod3 T A 18: 25,243,296 (GRCm39) probably null Het
Glul G T 1: 153,782,849 (GRCm39) G187* probably null Het
Gnmt ATTAGGGGATGGTCTTAGGG ATTAGGG 17: 47,036,662 (GRCm39) 294 probably benign Het
H2-Q7 A T 17: 35,658,506 (GRCm39) Y48F probably damaging Het
Hes3 T C 4: 152,371,542 (GRCm39) T136A probably benign Het
Krt40 T C 11: 99,433,900 (GRCm39) T29A possibly damaging Het
Lrrc37a C A 11: 103,392,624 (GRCm39) D934Y probably benign Het
Mctp2 T A 7: 71,833,599 (GRCm39) D581V probably damaging Het
Med27 T C 2: 29,361,354 (GRCm39) S38P probably damaging Het
Mff A G 1: 82,719,501 (GRCm39) probably benign Het
Mmadhc T C 2: 50,170,236 (GRCm39) K292R probably benign Het
Mmp24 A G 2: 155,655,908 (GRCm39) I449V possibly damaging Het
Mthfd1 G T 12: 76,361,764 (GRCm39) L123F probably damaging Het
Mug2 T A 6: 122,059,711 (GRCm39) L1363Q probably damaging Het
Myh4 T C 11: 67,142,578 (GRCm39) I913T probably damaging Het
Myo16 T A 8: 10,485,869 (GRCm39) N649K probably benign Het
Myo7b A G 18: 32,147,282 (GRCm39) I87T probably benign Het
Ndst4 A G 3: 125,232,007 (GRCm39) D192G probably damaging Het
Nup155 A G 15: 8,183,157 (GRCm39) D1239G possibly damaging Het
Or5b21 T C 19: 12,840,033 (GRCm39) V298A probably damaging Het
Or7e173 G C 9: 19,939,029 (GRCm39) N68K possibly damaging Het
Phf10 T A 17: 15,165,377 (GRCm39) N493I probably benign Het
Pramel32 A T 4: 88,547,129 (GRCm39) probably null Het
Prr12 T C 7: 44,695,338 (GRCm39) E1376G unknown Het
Rasa3 T C 8: 13,664,587 (GRCm39) H75R probably benign Het
Rin3 G A 12: 102,335,939 (GRCm39) V537M probably damaging Het
Samd4 C T 14: 47,333,566 (GRCm39) T272I probably damaging Het
Septin5 C T 16: 18,442,142 (GRCm39) G257D probably damaging Het
Serpina6 T C 12: 103,620,326 (GRCm39) K141R probably benign Het
Siglecf T A 7: 43,001,700 (GRCm39) I170N possibly damaging Het
Spopl C T 2: 23,407,957 (GRCm39) V241M probably damaging Het
Stk40 G A 4: 126,023,544 (GRCm39) probably null Het
Syne1 A G 10: 4,981,768 (GRCm39) S8700P probably benign Het
Tbc1d4 C T 14: 101,845,772 (GRCm39) G42E probably damaging Het
Tfap2c C T 2: 172,399,102 (GRCm39) Q425* probably null Het
Tmem255b T C 8: 13,505,998 (GRCm39) S202P probably damaging Het
Traf6 T C 2: 101,514,891 (GRCm39) S16P probably benign Het
Ttc12 A G 9: 49,383,705 (GRCm39) I66T probably damaging Het
Ttc21a G A 9: 119,787,885 (GRCm39) D818N possibly damaging Het
Zfp81 A T 17: 33,553,677 (GRCm39) I379N possibly damaging Het
Zgrf1 C A 3: 127,379,749 (GRCm39) S211* probably null Het
Other mutations in Acot9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00589:Acot9 APN X 154,078,236 (GRCm39) missense possibly damaging 0.50
IGL00987:Acot9 APN X 154,078,177 (GRCm39) missense probably benign 0.00
IGL03218:Acot9 APN X 154,078,207 (GRCm39) missense possibly damaging 0.48
R3745:Acot9 UTSW X 154,054,941 (GRCm39) splice site probably benign
Predicted Primers PCR Primer
(F):5'- CCACATAGGCCATTTTGGTAGATC -3'
(R):5'- TGTTGAAAGGTAACCATGCCG -3'

Sequencing Primer
(F):5'- GGTAGATCTAATTTCCAACTGGCAC -3'
(R):5'- GGTAACCATGCCGTCTTTTAATGAC -3'
Posted On 2015-07-21