|Institutional Source||Beutler Lab|
|Gene Name||G protein-coupled receptor 39|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4502 (G1)|
|Chromosomal Location||125676995-125873862 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to A at 125677991 bp|
|Amino Acid Change||Valine to Isoleucine at position 219 (V219I)|
|Ref Sequence||ENSEMBL: ENSMUSP00000027581 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000027581]|
|Predicted Effect||probably benign
AA Change: V219I
PolyPhen 2 Score 0.337 (Sensitivity: 0.90; Specificity: 0.89)
AA Change: V219I
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]
PHENOTYPE: Mice homozygous for a null mutation display abnormal glucose homeostasis when fed a high sugar diet. Mice homozygous for a different null allele have accelerated gastric emptying, decreased fasting-induced hyperphagia, and increasedbody weight after oneyear of age. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gpr39||
(F):5'- AGGTGAAACTGCTGATTGGC -3'
(R):5'- ACTCAGGAATATGATGGTCTGTC -3'
(F):5'- TGTATGGGTCACCTCCGC -3'
(R):5'- CAGGAATATGATGGTCTGTCTTCTTG -3'