Incidental Mutation 'R4503:Zfp938'
| ID |
331899 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp938
|
| Ensembl Gene |
ENSMUSG00000062931 |
| Gene Name |
zinc finger protein 938 |
| Synonyms |
B230315N10Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.075)
|
| Stock # |
R4503 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
82060684-82077114 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 82062105 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 172
(S172P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047110
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041264]
[ENSMUST00000156218]
|
| AlphaFold |
E9Q9G3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000041264
AA Change: S172P
PolyPhen 2
Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000047110
Gene: ENSMUSG00000062931
AA Change: S172P
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
5.28e-14 |
SMART |
|
ZnF_C2H2
|
161 |
188 |
2.82e1 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
1.23e0 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
4.65e-1 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
491 |
513 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
519 |
541 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
547 |
569 |
2.4e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156218
|
| SMART Domains |
Protein: ENSMUSP00000121613
Gene: ENSMUSG00000062931
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
5.28e-14 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam21 |
A |
G |
12: 81,607,672 (GRCm39) |
L30P |
probably benign |
Het |
| Adamts20 |
T |
C |
15: 94,277,631 (GRCm39) |
H277R |
probably damaging |
Het |
| Arl6ip1 |
AAAATAAATAAATAAATAAATAAATA |
AAAATAAATAAATAAATAAATAAATAAATA |
7: 117,721,122 (GRCm39) |
|
probably benign |
Het |
| Atp13a5 |
G |
T |
16: 29,112,346 (GRCm39) |
N598K |
probably benign |
Het |
| Ccdc171 |
A |
G |
4: 83,782,560 (GRCm39) |
E1284G |
probably damaging |
Het |
| Cdk5 |
G |
A |
5: 24,624,617 (GRCm39) |
T258M |
possibly damaging |
Het |
| Col3a1 |
T |
C |
1: 45,387,837 (GRCm39) |
|
probably benign |
Het |
| Coro6 |
A |
G |
11: 77,360,272 (GRCm39) |
E414G |
probably benign |
Het |
| Dst |
T |
C |
1: 34,301,334 (GRCm39) |
|
probably null |
Het |
| Fabp3 |
C |
T |
4: 130,206,245 (GRCm39) |
|
probably null |
Het |
| Gpr39 |
G |
A |
1: 125,605,728 (GRCm39) |
V219I |
probably benign |
Het |
| H2bc18 |
A |
T |
3: 96,177,240 (GRCm39) |
K58M |
possibly damaging |
Het |
| Kank4 |
G |
A |
4: 98,665,335 (GRCm39) |
S653L |
possibly damaging |
Het |
| Mapkbp1 |
T |
C |
2: 119,846,187 (GRCm39) |
I451T |
probably damaging |
Het |
| Ncf2 |
A |
G |
1: 152,709,529 (GRCm39) |
E342G |
probably benign |
Het |
| Or5k15 |
T |
C |
16: 58,710,539 (GRCm39) |
I15V |
probably benign |
Het |
| Or6aa1 |
T |
A |
7: 86,044,485 (GRCm39) |
T74S |
possibly damaging |
Het |
| Pds5b |
T |
C |
5: 150,652,399 (GRCm39) |
L222P |
probably damaging |
Het |
| Rpl5 |
T |
C |
5: 108,052,723 (GRCm39) |
F223S |
possibly damaging |
Het |
| Sacs |
A |
G |
14: 61,445,052 (GRCm39) |
N2366S |
probably damaging |
Het |
| Sall2 |
T |
C |
14: 52,550,916 (GRCm39) |
M758V |
probably benign |
Het |
| Sh3tc2 |
A |
G |
18: 62,107,694 (GRCm39) |
E235G |
probably damaging |
Het |
| Slc49a4 |
T |
C |
16: 35,539,787 (GRCm39) |
M345V |
probably benign |
Het |
| Smad2 |
T |
A |
18: 76,435,663 (GRCm39) |
S419T |
probably benign |
Het |
| Sprr3 |
T |
C |
3: 92,364,683 (GRCm39) |
I54V |
possibly damaging |
Het |
| Tbck |
A |
G |
3: 132,456,981 (GRCm39) |
T632A |
probably benign |
Het |
| Tmem131 |
T |
C |
1: 36,864,560 (GRCm39) |
T558A |
probably benign |
Het |
| Tmem178 |
C |
T |
17: 81,293,693 (GRCm39) |
T162I |
probably benign |
Het |
| Zfp619 |
A |
G |
7: 39,186,280 (GRCm39) |
H770R |
probably damaging |
Het |
|
| Other mutations in Zfp938 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00659:Zfp938
|
APN |
10 |
82,063,355 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL00743:Zfp938
|
APN |
10 |
82,062,317 (GRCm39) |
missense |
probably benign |
|
|
IGL01764:Zfp938
|
APN |
10 |
82,063,624 (GRCm39) |
splice site |
probably benign |
|
|
IGL01814:Zfp938
|
APN |
10 |
82,062,052 (GRCm39) |
missense |
probably benign |
|
|
IGL02244:Zfp938
|
APN |
10 |
82,061,906 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02865:Zfp938
|
APN |
10 |
82,062,026 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0372:Zfp938
|
UTSW |
10 |
82,063,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0666:Zfp938
|
UTSW |
10 |
82,061,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0964:Zfp938
|
UTSW |
10 |
82,061,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1453:Zfp938
|
UTSW |
10 |
82,063,632 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1672:Zfp938
|
UTSW |
10 |
82,060,982 (GRCm39) |
missense |
probably benign |
|
|
R1929:Zfp938
|
UTSW |
10 |
82,061,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1959:Zfp938
|
UTSW |
10 |
82,061,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2127:Zfp938
|
UTSW |
10 |
82,061,876 (GRCm39) |
missense |
probably benign |
|
|
R2271:Zfp938
|
UTSW |
10 |
82,061,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2900:Zfp938
|
UTSW |
10 |
82,061,340 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4502:Zfp938
|
UTSW |
10 |
82,062,105 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4886:Zfp938
|
UTSW |
10 |
82,061,957 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4934:Zfp938
|
UTSW |
10 |
82,062,012 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5174:Zfp938
|
UTSW |
10 |
82,061,838 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5410:Zfp938
|
UTSW |
10 |
82,061,092 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6284:Zfp938
|
UTSW |
10 |
82,063,400 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6491:Zfp938
|
UTSW |
10 |
82,063,363 (GRCm39) |
makesense |
probably null |
|
|
R6575:Zfp938
|
UTSW |
10 |
82,061,160 (GRCm39) |
nonsense |
probably null |
|
|
R6649:Zfp938
|
UTSW |
10 |
82,061,232 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7992:Zfp938
|
UTSW |
10 |
82,061,777 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8211:Zfp938
|
UTSW |
10 |
82,062,419 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8313:Zfp938
|
UTSW |
10 |
82,061,422 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8963:Zfp938
|
UTSW |
10 |
82,061,287 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
X0066:Zfp938
|
UTSW |
10 |
82,061,931 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGCAAAGGTTTTACCACATTGATGAT -3'
(R):5'- GCTATGGAAAGAAGCAGTGCAC -3'
Sequencing Primer
(F):5'- CTTTGGTGTAATTGTAAAGAGGCC -3'
(R):5'- TGTAGTCATCCCCACTATGAGAAG -3'
|
| Posted On |
2015-07-21 |
Incidental Mutation