Mutagenetix > Incidental Mutation

Incidental Mutation 'R4504:Taar3'

331933

Institutional Source

Beutler Lab

Gene Symbol

Taar3

Ensembl Gene

ENSMUSG00000069708

Gene Name

trace amine-associated receptor 3

Synonyms

MMRRC Submission

041755-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.121) question?

Stock #

R4504 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

23949558-23950589 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23949573 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 6 (I6V)

Ref Sequence

ENSEMBL: ENSMUSP00000036817 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045152]

AlphaFold

Q5QD16

Predicted Effect

possibly damaging
Transcript: ENSMUST00000045152
AA Change: I6V

PolyPhen 2 Score 0.844 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000036817
Gene: ENSMUSG00000069708
AA Change: I6V

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	42	320	1.8e-13	PFAM
Pfam:7tm_1	48	309	1.4e-53	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

100% (45/45)

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930503E14Rik	A	G	14: 44,170,442	S45P	probably damaging	Het
Adgrg4	C	T	X: 56,916,442	R1124C	possibly damaging	Het
Anxa13	T	C	15: 58,356,203		noncoding transcript	Het
Arhgap32	C	A	9: 32,181,839		probably null	Het
Carm1	T	C	9: 21,569,526	F99L	probably damaging	Het
Dennd1b	A	G	1: 139,085,927	E253G	possibly damaging	Het
Dsg4	A	G	18: 20,461,436	I541V	probably benign	Het
Dstyk	A	G	1: 132,434,389	T186A	possibly damaging	Het
Ear1	A	T	14: 43,819,264	V49D	probably benign	Het
Epha10	A	G	4: 124,915,687		probably benign	Het
Fbxo18	A	G	2: 11,749,017	V838A	possibly damaging	Het
Fndc8	T	A	11: 82,892,400	M69K	probably benign	Het
Gm13023	G	C	4: 143,793,983	E102Q	probably benign	Het
Golga1	T	C	2: 39,023,454	I482V	probably benign	Het
Hivep3	G	A	4: 119,733,793		probably benign	Het
Igkv13-85	A	G	6: 68,930,372	F82L	probably damaging	Het
Itih1	G	A	14: 30,935,885	R410C	probably damaging	Het
Kcnc2	T	C	10: 112,455,794	W296R	probably damaging	Het
Kcnq3	A	T	15: 65,995,342	Y817*	probably null	Het
Kif3b	T	C	2: 153,323,644		probably null	Het
Krtcap2	A	G	3: 89,246,256		probably benign	Het
Lhx5	C	A	5: 120,440,008	H298N	possibly damaging	Het
Notch1	A	G	2: 26,472,177	V1022A	probably benign	Het
Npc1l1	A	G	11: 6,228,741	L223S	possibly damaging	Het
Olfr1258	C	T	2: 89,930,351	P181S	possibly damaging	Het
Olfr160	C	T	9: 37,711,464	V272I	probably benign	Het
Olfr279	T	C	15: 98,498,134	F221L	probably benign	Het
Pbxip1	A	G	3: 89,446,383	D281G	possibly damaging	Het
Pcdhga8	G	C	18: 37,816,763	V411L	probably damaging	Het
Pcsk5	C	T	19: 17,451,955	C1553Y	probably damaging	Het
Pdgfc	A	C	3: 81,174,991	M164L	probably benign	Het
Pdzd8	T	C	19: 59,345,448	Y47C	probably damaging	Het
Pip5k1c	T	A	10: 81,315,111	I633N	probably damaging	Het
Pkn1	G	A	8: 83,692,927	R16*	probably null	Het
Pole2	A	G	12: 69,222,468	V85A	probably benign	Het
Ppp4c	A	C	7: 126,787,465	L150R	probably damaging	Het
Ric8a	A	G	7: 140,858,516	I223V	probably benign	Het
Rnf144a	T	A	12: 26,327,303	R92S	probably benign	Het
Sbno2	C	A	10: 80,060,492	R898L	possibly damaging	Het
Scnn1b	A	C	7: 121,912,475	N370T	probably damaging	Het
Vps13a	T	C	19: 16,695,502	E1302G	possibly damaging	Het

Other mutations in Taar3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01019:Taar3	APN	10	23950432	missense	probably damaging	1.00
IGL01777:Taar3	APN	10	23950005	missense	probably benign	0.39
IGL01940:Taar3	APN	10	23949957	missense	probably damaging	1.00
IGL02120:Taar3	APN	10	23950167	missense	probably benign	0.33
PIT4445001:Taar3	UTSW	10	23949688	missense	possibly damaging	0.85
R0582:Taar3	UTSW	10	23949817	missense	probably damaging	1.00
R1925:Taar3	UTSW	10	23950585	missense	probably benign	0.22
R2261:Taar3	UTSW	10	23950155	missense	probably benign	0.00
R4088:Taar3	UTSW	10	23949859	missense	possibly damaging	0.46
R4505:Taar3	UTSW	10	23949573	missense	possibly damaging	0.84
R4507:Taar3	UTSW	10	23949573	missense	possibly damaging	0.84
R4925:Taar3	UTSW	10	23950543	missense	probably damaging	0.99
R6221:Taar3	UTSW	10	23950072	missense	possibly damaging	0.92
R6451:Taar3	UTSW	10	23949807	missense	possibly damaging	0.96
R7290:Taar3	UTSW	10	23950400	nonsense	probably null
R7414:Taar3	UTSW	10	23949817	missense	probably damaging	1.00
R8432:Taar3	UTSW	10	23950155	missense	probably benign	0.11
X0057:Taar3	UTSW	10	23949646	missense	probably benign	0.13

Predicted Primers

PCR Primer
(F):5'- TGGCAATCTTCCAGTTCACTAC -3'
(R):5'- TGGTTGCCATGGAGAGGATC -3'

Sequencing Primer
(F):5'- GGAAGATCAGCCAGTGTTCTTAACC -3'
(R):5'- TGCCATGGAGAGGATCAGAAAGTTG -3'

Posted On

2015-07-21