Incidental Mutation 'R4505:Or5p62'
ID 331972
Institutional Source Beutler Lab
Gene Symbol Or5p62
Ensembl Gene ENSMUSG00000096068
Gene Name olfactory receptor family 5 subfamily P member 62
Synonyms GA_x6K02T2PBJ9-10501920-10500976, MOR204-19, Olfr486
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R4505 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 107771005-107771949 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107771175 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 259 (I259V)
Ref Sequence ENSEMBL: ENSMUSP00000071918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072035]
AlphaFold Q8VFD0
Predicted Effect probably benign
Transcript: ENSMUST00000072035
AA Change: I259V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000071918
Gene: ENSMUSG00000096068
AA Change: I259V

DomainStartEndE-ValueType
Pfam:7tm_4 31 311 6.8e-51 PFAM
Pfam:7tm_1 44 293 6.6e-24 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 96% (50/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 A T 16: 20,152,445 (GRCm39) I1367N probably damaging Het
Acbd4 A G 11: 102,995,605 (GRCm39) probably benign Het
Adarb2 A T 13: 8,747,727 (GRCm39) S428C probably damaging Het
Atl3 T A 19: 7,498,184 (GRCm39) D193E probably benign Het
Bhlhe22 T C 3: 18,109,123 (GRCm39) S58P probably benign Het
Clasrp C A 7: 19,319,165 (GRCm39) probably benign Het
Cylc2 C G 4: 51,229,651 (GRCm39) T331R unknown Het
Epha10 A G 4: 124,809,480 (GRCm39) probably benign Het
Farp2 A T 1: 93,546,732 (GRCm39) N917I probably damaging Het
Fbh1 A G 2: 11,753,828 (GRCm39) V838A possibly damaging Het
Fras1 T A 5: 96,929,207 (GRCm39) N3870K probably damaging Het
Gm6632 C T 5: 59,211,821 (GRCm39) noncoding transcript Het
Gpr20 T C 15: 73,568,321 (GRCm39) T23A probably benign Het
Grb14 A C 2: 64,852,912 (GRCm39) V26G probably damaging Het
H2-T5 A T 17: 36,472,372 (GRCm39) probably benign Het
Itgb4 G A 11: 115,874,087 (GRCm39) silent Het
Jak1 T C 4: 101,011,800 (GRCm39) T1101A probably benign Het
Kcnq3 A T 15: 65,867,191 (GRCm39) Y817* probably null Het
Krtcap2 A G 3: 89,153,563 (GRCm39) probably benign Het
Lhx5 C A 5: 120,578,073 (GRCm39) H298N possibly damaging Het
Lrig3 C T 10: 125,849,216 (GRCm39) P979S probably benign Het
Map3k13 A G 16: 21,740,928 (GRCm39) S752G probably benign Het
Map4 T C 9: 109,861,253 (GRCm39) S206P probably benign Het
Mon2 A G 10: 122,845,494 (GRCm39) S1405P probably damaging Het
Mvb12a G T 8: 71,996,103 (GRCm39) A86S probably benign Het
Or8a1b C T 9: 37,622,760 (GRCm39) V272I probably benign Het
Pithd1 T C 4: 135,706,144 (GRCm39) N37S probably benign Het
Piwil4 T C 9: 14,637,259 (GRCm39) T352A probably damaging Het
Prb1a T A 6: 132,184,533 (GRCm39) R367* probably null Het
Psmb4 A C 3: 94,793,456 (GRCm39) Y142D probably damaging Het
Ptprs T C 17: 56,758,678 (GRCm39) N181S possibly damaging Het
Rcbtb2 T C 14: 73,411,345 (GRCm39) L370P probably damaging Het
Ric8a A G 7: 140,438,429 (GRCm39) I223V probably benign Het
Runx1t1 G T 4: 13,889,676 (GRCm39) C535F probably damaging Het
Samd4b A G 7: 28,106,925 (GRCm39) M329T probably benign Het
Serpinb9g T A 13: 33,670,546 (GRCm39) F11L probably damaging Het
Slc25a51 C T 4: 45,399,768 (GRCm39) V141M probably benign Het
Sp110 T G 1: 85,516,894 (GRCm39) Q201P probably damaging Het
Taar3 A G 10: 23,825,471 (GRCm39) I6V possibly damaging Het
Tjp2 T C 19: 24,086,195 (GRCm39) T776A possibly damaging Het
Tmc1 C T 19: 20,845,738 (GRCm39) V162I probably benign Het
Upf1 G A 8: 70,790,216 (GRCm39) R637C probably damaging Het
Ush2a A G 1: 188,460,793 (GRCm39) T2685A possibly damaging Het
Vmn2r102 C T 17: 19,880,845 (GRCm39) T62I probably benign Het
Vps13c A T 9: 67,846,316 (GRCm39) Q2128L probably benign Het
Zfp26 T C 9: 20,353,561 (GRCm39) E76G probably benign Het
Zfp28 T C 7: 6,397,160 (GRCm39) S532P probably damaging Het
Other mutations in Or5p62
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0033:Or5p62 UTSW 7 107,771,134 (GRCm39) missense probably benign 0.09
R0144:Or5p62 UTSW 7 107,771,178 (GRCm39) missense probably benign 0.00
R0165:Or5p62 UTSW 7 107,771,882 (GRCm39) missense probably benign 0.03
R0739:Or5p62 UTSW 7 107,771,217 (GRCm39) missense probably benign 0.00
R1027:Or5p62 UTSW 7 107,771,348 (GRCm39) missense probably damaging 0.98
R1781:Or5p62 UTSW 7 107,771,090 (GRCm39) missense probably benign 0.06
R3729:Or5p62 UTSW 7 107,771,516 (GRCm39) missense probably benign 0.13
R5223:Or5p62 UTSW 7 107,771,915 (GRCm39) missense probably benign 0.20
R7089:Or5p62 UTSW 7 107,771,701 (GRCm39) missense probably benign 0.01
R7499:Or5p62 UTSW 7 107,771,007 (GRCm39) makesense probably null
R7894:Or5p62 UTSW 7 107,771,391 (GRCm39) missense probably benign
R7995:Or5p62 UTSW 7 107,771,207 (GRCm39) missense probably damaging 1.00
R8807:Or5p62 UTSW 7 107,771,852 (GRCm39) missense possibly damaging 0.93
R9050:Or5p62 UTSW 7 107,771,087 (GRCm39) missense probably damaging 1.00
R9244:Or5p62 UTSW 7 107,771,852 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- CCTTGGCTTATAACCAAACCTG -3'
(R):5'- TGGAACTATCCTGTTCTGATGTGAG -3'

Sequencing Primer
(F):5'- CTTGGCTTATAACCAAACCTGATATG -3'
(R):5'- ATCCTGTTCTGATGTGAGTATCTCAG -3'
Posted On 2015-07-21