Incidental Mutation 'R4505:Taar3'
ID 331981
Institutional Source Beutler Lab
Gene Symbol Taar3
Ensembl Gene ENSMUSG00000069708
Gene Name trace amine-associated receptor 3
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.197) question?
Stock # R4505 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 23949558-23950589 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23949573 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 6 (I6V)
Ref Sequence ENSEMBL: ENSMUSP00000036817 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045152]
AlphaFold Q5QD16
Predicted Effect possibly damaging
Transcript: ENSMUST00000045152
AA Change: I6V

PolyPhen 2 Score 0.844 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000036817
Gene: ENSMUSG00000069708
AA Change: I6V

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 42 320 1.8e-13 PFAM
Pfam:7tm_1 48 309 1.4e-53 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 96% (50/52)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 A T 16: 20,333,695 I1367N probably damaging Het
Acbd4 A G 11: 103,104,779 probably benign Het
Adarb2 A T 13: 8,697,691 S428C probably damaging Het
Atl3 T A 19: 7,520,819 D193E probably benign Het
Bhlhe22 T C 3: 18,054,959 S58P probably benign Het
Clasrp C A 7: 19,585,240 probably benign Het
Cylc2 C G 4: 51,229,651 T331R unknown Het
Epha10 A G 4: 124,915,687 probably benign Het
Farp2 A T 1: 93,619,010 N917I probably damaging Het
Fbxo18 A G 2: 11,749,017 V838A possibly damaging Het
Fras1 T A 5: 96,781,348 N3870K probably damaging Het
Gm6632 C T 5: 59,054,478 noncoding transcript Het
Gm8909 A T 17: 36,161,480 probably benign Het
Gpr20 T C 15: 73,696,472 T23A probably benign Het
Grb14 A C 2: 65,022,568 V26G probably damaging Het
Itgb4 G A 11: 115,983,261 silent Het
Jak1 T C 4: 101,154,603 T1101A probably benign Het
Kcnq3 A T 15: 65,995,342 Y817* probably null Het
Krtcap2 A G 3: 89,246,256 probably benign Het
Lhx5 C A 5: 120,440,008 H298N possibly damaging Het
Lrig3 C T 10: 126,013,347 P979S probably benign Het
Map3k13 A G 16: 21,922,178 S752G probably benign Het
Map4 T C 9: 110,032,185 S206P probably benign Het
Mon2 A G 10: 123,009,589 S1405P probably damaging Het
Mvb12a G T 8: 71,543,459 A86S probably benign Het
Olfr160 C T 9: 37,711,464 V272I probably benign Het
Olfr486 T C 7: 108,171,968 I259V probably benign Het
Pithd1 T C 4: 135,978,833 N37S probably benign Het
Piwil4 T C 9: 14,725,963 T352A probably damaging Het
Prb1 T A 6: 132,207,570 R367* probably null Het
Psmb4 A C 3: 94,886,145 Y142D probably damaging Het
Ptprs T C 17: 56,451,678 N181S possibly damaging Het
Rcbtb2 T C 14: 73,173,905 L370P probably damaging Het
Ric8a A G 7: 140,858,516 I223V probably benign Het
Runx1t1 G T 4: 13,889,676 C535F probably damaging Het
Samd4b A G 7: 28,407,500 M329T probably benign Het
Serpinb9g T A 13: 33,486,563 F11L probably damaging Het
Slc25a51 C T 4: 45,399,768 V141M probably benign Het
Sp110 T G 1: 85,589,173 Q201P probably damaging Het
Tjp2 T C 19: 24,108,831 T776A possibly damaging Het
Tmc1 C T 19: 20,868,374 V162I probably benign Het
Upf1 G A 8: 70,337,566 R637C probably damaging Het
Ush2a A G 1: 188,728,596 T2685A possibly damaging Het
Vmn2r102 C T 17: 19,660,583 T62I probably benign Het
Vps13c A T 9: 67,939,034 Q2128L probably benign Het
Zfp26 T C 9: 20,442,265 E76G probably benign Het
Zfp28 T C 7: 6,394,161 S532P probably damaging Het
Other mutations in Taar3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Taar3 APN 10 23950432 missense probably damaging 1.00
IGL01777:Taar3 APN 10 23950005 missense probably benign 0.39
IGL01940:Taar3 APN 10 23949957 missense probably damaging 1.00
IGL02120:Taar3 APN 10 23950167 missense probably benign 0.33
PIT4445001:Taar3 UTSW 10 23949688 missense possibly damaging 0.85
R0582:Taar3 UTSW 10 23949817 missense probably damaging 1.00
R1925:Taar3 UTSW 10 23950585 missense probably benign 0.22
R2261:Taar3 UTSW 10 23950155 missense probably benign 0.00
R4088:Taar3 UTSW 10 23949859 missense possibly damaging 0.46
R4504:Taar3 UTSW 10 23949573 missense possibly damaging 0.84
R4507:Taar3 UTSW 10 23949573 missense possibly damaging 0.84
R4925:Taar3 UTSW 10 23950543 missense probably damaging 0.99
R6221:Taar3 UTSW 10 23950072 missense possibly damaging 0.92
R6451:Taar3 UTSW 10 23949807 missense possibly damaging 0.96
R7290:Taar3 UTSW 10 23950400 nonsense probably null
R7414:Taar3 UTSW 10 23949817 missense probably damaging 1.00
R8432:Taar3 UTSW 10 23950155 missense probably benign 0.11
X0057:Taar3 UTSW 10 23949646 missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- TGGCAATCTTCCAGTTCACTAC -3'
(R):5'- TGGTTGCCATGGAGAGGATC -3'

Sequencing Primer
(F):5'- GGAAGATCAGCCAGTGTTCTTAACC -3'
(R):5'- TGCCATGGAGAGGATCAGAAAGTTG -3'
Posted On 2015-07-21