Mutagenetix > Incidental Mutation

Incidental Mutation 'R4506:Vmn2r23'

332012

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

MMRRC Submission

041584-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R4506 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

123679780-123719198 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 123679884 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Histidine at position 35 (Q35H)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

probably damaging
Transcript: ENSMUST00000172391
AA Change: Q35H

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: Q35H

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 94.8%

Validation Efficiency

98% (42/43)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700012B07Rik	G	T	11: 109,685,087 (GRCm39)	P137T	probably damaging	Het
Abcc5	A	T	16: 20,152,445 (GRCm39)	I1367N	probably damaging	Het
Ace	T	A	11: 105,867,492 (GRCm39)	L152Q	probably damaging	Het
Adam19	G	A	11: 46,009,271 (GRCm39)	D232N	possibly damaging	Het
Anapc4	A	T	5: 52,993,072 (GRCm39)	N61I	possibly damaging	Het
Ap5m1	T	C	14: 49,311,218 (GRCm39)	V96A	probably damaging	Het
Atr	T	A	9: 95,747,290 (GRCm39)	C191S	probably benign	Het
Carmil3	GGACGA	GGA	14: 55,736,933 (GRCm39)		probably benign	Het
Cnot6l	A	T	5: 96,234,033 (GRCm39)	V326E	possibly damaging	Het
Fcer2a	A	T	8: 3,738,603 (GRCm39)		probably null	Het
Fgfr3	A	G	5: 33,887,343 (GRCm39)	T221A	probably damaging	Het
Gm6632	C	T	5: 59,211,821 (GRCm39)		noncoding transcript	Het
Gpr158	T	A	2: 21,831,810 (GRCm39)	M970K	probably damaging	Het
H2-T5	A	T	17: 36,472,372 (GRCm39)		probably benign	Het
Ip6k3	A	T	17: 27,364,154 (GRCm39)	L298Q	possibly damaging	Het
Itpr1	A	G	6: 108,409,647 (GRCm39)	D1727G	probably damaging	Het
Kdm2b	T	C	5: 123,026,688 (GRCm39)	T589A	possibly damaging	Het
Krtcap2	A	G	3: 89,153,563 (GRCm39)		probably benign	Het
Map3k13	A	G	16: 21,740,928 (GRCm39)	S752G	probably benign	Het
Mvb12a	G	T	8: 71,996,103 (GRCm39)	A86S	probably benign	Het
Nktr	T	A	9: 121,577,949 (GRCm39)		probably benign	Het
Or1e33	A	T	11: 73,738,521 (GRCm39)	C143*	probably null	Het
Or8a1b	C	T	9: 37,622,760 (GRCm39)	V272I	probably benign	Het
Parp4	T	A	14: 56,889,761 (GRCm39)	N1847K	unknown	Het
Pcdhga8	G	C	18: 37,949,816 (GRCm39)	V411L	probably damaging	Het
Piwil4	T	C	9: 14,637,259 (GRCm39)	T352A	probably damaging	Het
Ric8a	A	G	7: 140,438,429 (GRCm39)	I223V	probably benign	Het
Slc25a51	C	T	4: 45,399,768 (GRCm39)	V141M	probably benign	Het
Slc7a5	A	T	8: 122,614,234 (GRCm39)		probably null	Het
Slc7a9	A	T	7: 35,152,845 (GRCm39)	T88S	probably damaging	Het
Tbrg1	T	A	9: 37,565,691 (GRCm39)	E87V	probably damaging	Het
Tnfsf4	T	C	1: 161,244,745 (GRCm39)	S145P	probably damaging	Het
Tomm34	C	A	2: 163,896,292 (GRCm39)		probably null	Het
Trpv3	A	G	11: 73,186,150 (GRCm39)	N647S	probably benign	Het
Upf1	G	A	8: 70,790,216 (GRCm39)	R637C	probably damaging	Het
Wdtc1	C	T	4: 133,036,130 (GRCm39)	V137M	probably damaging	Het
Zfp276	G	A	8: 123,991,666 (GRCm39)		probably null	Het
Zfp90	C	T	8: 107,151,496 (GRCm39)	P403L	possibly damaging	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123,706,684 (GRCm39)	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123,706,555 (GRCm39)	missense	probably benign
IGL01073:Vmn2r23	APN	6	123,689,759 (GRCm39)	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123,681,383 (GRCm39)	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123,681,366 (GRCm39)	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123,718,845 (GRCm39)	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123,718,819 (GRCm39)	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123,718,703 (GRCm39)	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123,718,795 (GRCm39)	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123,681,437 (GRCm39)	missense	probably benign
IGL02831:Vmn2r23	APN	6	123,681,344 (GRCm39)	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123,681,355 (GRCm39)	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123,718,578 (GRCm39)	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123,718,741 (GRCm39)	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123,681,333 (GRCm39)	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123,706,585 (GRCm39)	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123,689,936 (GRCm39)	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123,706,680 (GRCm39)	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123,690,410 (GRCm39)	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123,719,094 (GRCm39)	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123,718,963 (GRCm39)	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123,690,229 (GRCm39)	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123,690,386 (GRCm39)	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123,706,649 (GRCm39)	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123,679,874 (GRCm39)	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123,689,969 (GRCm39)	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123,718,458 (GRCm39)	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123,681,384 (GRCm39)	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123,719,147 (GRCm39)	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123,690,123 (GRCm39)	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123,690,123 (GRCm39)	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123,690,129 (GRCm39)	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123,718,348 (GRCm39)	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123,706,697 (GRCm39)	missense	probably benign
R4652:Vmn2r23	UTSW	6	123,718,689 (GRCm39)	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123,718,785 (GRCm39)	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123,690,033 (GRCm39)	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123,710,308 (GRCm39)	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123,689,936 (GRCm39)	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123,689,961 (GRCm39)	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123,690,410 (GRCm39)	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123,690,033 (GRCm39)	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123,710,232 (GRCm39)	missense	probably benign
R5761:Vmn2r23	UTSW	6	123,689,718 (GRCm39)	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123,710,352 (GRCm39)	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123,689,901 (GRCm39)	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123,718,854 (GRCm39)	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123,681,359 (GRCm39)	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123,689,861 (GRCm39)	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123,690,384 (GRCm39)	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123,710,232 (GRCm39)	missense	probably benign
R6925:Vmn2r23	UTSW	6	123,681,512 (GRCm39)	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123,689,981 (GRCm39)	missense	probably benign
R7215:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123,718,540 (GRCm39)	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123,681,538 (GRCm39)	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123,681,500 (GRCm39)	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123,718,312 (GRCm39)	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123,681,599 (GRCm39)	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123,718,615 (GRCm39)	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123,690,431 (GRCm39)	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123,679,991 (GRCm39)	missense
R8966:Vmn2r23	UTSW	6	123,719,079 (GRCm39)	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123,719,038 (GRCm39)	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123,718,782 (GRCm39)	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123,710,352 (GRCm39)	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123,689,672 (GRCm39)	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123,689,672 (GRCm39)	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123,690,075 (GRCm39)	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123,690,120 (GRCm39)	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123,719,067 (GRCm39)	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123,706,684 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- ACTTGACCCACATGGACCAG -3'
(R):5'- CTCCATGAAGTTGAAGACAGGAGAC -3'

Sequencing Primer
(F):5'- GGACCAGAAAGGCACATGTTTTATC -3'
(R):5'- CAGTAGAGCTGGGAGAGATCAAC -3'

Posted On

2015-07-21